Chapter 11 : Yeasts

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Yeasts, Page 1 of 2

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The number of yeast species documented to cause invasive infections in humans has increased. Several uncommon species have now been described to cause invasive infection in humans. A case of cryptococcosis due to the Vancouver Island strain of acquired in Washington State was also recently reported. Other species are also increasingly being recognized as causes of invasive disease among immunocompromised hosts. A list of ascomycetous yeasts such as , and reported to cause human disease have been discussed in the chapter. Compared to ascomycetes, yeasts of the phylum Basidiomycota are generally less frequently implicated in human disease. and are some of the basidiomycetous yeasts that have been discussed in the chapter. Culture methods remain the most frequently utilized laboratory tools for the diagnosis of invasive yeast infections. Various diagnostic approaches including chromogenic media, rapid biochemical assays, commercial biochemical panels, in vitro susceptibility testing, and molecular identification techniques are analyzed in the chapter.

Citation: Bishop J, Merz W. 2009. Yeasts, p 221-251. In Hayden R, Carroll K, Tang Y, Wolk D (ed), Diagnostic Microbiology of the Immunocompromised Host. ASM Press, Washington, DC. doi: 10.1128/9781555815455.ch11

Key Concept Ranking

TaqMan Real-Time PCR Assay
Nucleic Acid Amplification Techniques
Central Nervous System Diseases
Restriction Fragment Length Polymorphism
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Image of Figure 1.
Figure 1.

Flow chart of host-yeast () interactions and types of infection or colonization.

Citation: Bishop J, Merz W. 2009. Yeasts, p 221-251. In Hayden R, Carroll K, Tang Y, Wolk D (ed), Diagnostic Microbiology of the Immunocompromised Host. ASM Press, Washington, DC. doi: 10.1128/9781555815455.ch11
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Image of Figure 2.
Figure 2.

Algorithm for direct detection, with or without direct identification, of yeasts in clinical specimens.

Citation: Bishop J, Merz W. 2009. Yeasts, p 221-251. In Hayden R, Carroll K, Tang Y, Wolk D (ed), Diagnostic Microbiology of the Immunocompromised Host. ASM Press, Washington, DC. doi: 10.1128/9781555815455.ch11
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Image of Figure 3.
Figure 3.

Algorithm for definitive identification of yeasts recovered from clinical specimens.

Citation: Bishop J, Merz W. 2009. Yeasts, p 221-251. In Hayden R, Carroll K, Tang Y, Wolk D (ed), Diagnostic Microbiology of the Immunocompromised Host. ASM Press, Washington, DC. doi: 10.1128/9781555815455.ch11
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1. Ahmad, S.,, Z. Khan,, A. S. Mustafa, and, Z. U. Khan. 2002. Seminested PCR for diagnosis of candidemia: comparison with culture, antigen detection, and biochemical methods for species identification. J. Clin. Microbiol. 40:24832489.
2. Alexander, B. D.,, E. D. Ashley,, L. B. Reller, and, S. D. Reed. 2006. Cost savings with implementation of PNA FISH testing for identification of Candida albicans in blood cultures. Diagn. Microbiol. Infect. Dis. 54:277282.
3. Alexander, B. D.,, T. C. Byrne,, K. L. Smith,, K. E. Hanson,, K. J. Anstrom,, J. R. Perfect, and, L. B. Reller. 2007. Comparative evaluation of Etestin and Sensititre YeastOne panels against the clinical and laboratory standards institute M27-A2 reference broth microdilution method for testing Candida susceptibility to seven antifungal agents. J. Clin. Microbiol. 45:698706.
4. Arago, P. A.,, I. C. Oshiro,, E. I. Mannique,, C. C. Gomes,, L. L. Matsuo,, C. Leone,, M. L. Moretti-Branchini,, A. S. Levin, and IRIS Study Group. 2001. Pichia anomala outbreak in a nursery: exogenous source? Pediatr. Infect. Dis. J. 20:843848.
5. Araj, G. F.,, R. L. Hopfer,, S. Chesnut,, V. Fainstein, and, G. P. Bodey, Sr. 1982. Diagnostic value of the enzyme-linked immunosorbent assay for detection of Candida albicans cytoplasmic antigen in sera of cancer patients. J. Clin. Microbiol. 16:4652.
6. Archer-Dubon, C.,, E. Icaza-Chivez,, R. Orozco-Topete,, E. Reyes,, R. Baez-Martinez, and, S. Ponce de Leon. 1999. An epidemic outbreak of Malassezia folliculitis in three adult patients in an intensive care unit: a previously unrecognized nosocomial infection. Int. J. Dermatol. 38:453456.
7. Arikan, S. 2007. Current status of antifungal susceptibility testing methods. Med. Mycol. 45:569587.
8. Aspiroz, C.,, M. Ara,, M. Varea,, A. Rezusta, and, C. Rubio. 2002. Isolation of Malassezia globosa and M. sympodialis from patients with pityriasis versicolor in Spain. Mycopathologia 154:111117.
9. Averbuch, D.,, T. Boekhoutt,, R. Falk,, D. Engelhard,, M. Shapiro,, C. Block, and, I. Polacheck. 2002. Fungemia in a cancer patient caused by fluconazole-resistant Cryptococcus laurentii. Med. Mycol. 40:479484.
10. Back O.,, J. Faergemann, and, R Hørnquist. 1985. Pityrosporum folliculitis: a common disease of the young and middle-aged. J. Am. Acad. Dermatol. 12:5661.
11. Baixench, M. T.,, A. Taillandier, and, A. Paugam. 2006. Clinical and experimental evaluation of a new chromogenic medium (OCCA, Oxoid) for direct identification of Candida albicans, C. tropicalis, and C. krusei. Mycoses 49:311315.
12. Barber G. R.,, A. E. Brown,, T. E. Kiehn,, F. F. Edwards, and, D. Armstrong. 1993. Catheter-related Malassezia furfur fungemia in immunocompromised patients. Am. J. Med. 95:365370.
13. Barchiesi, F.,, G. Caggiano,, F. Di Francesco,, M. T. Montagna,, S. Barbuti, and, G. Scalise. 2004. Outbreak of fungemia due to Candida parapsilosis in a pediatric oncology unit. Diagn. Microbiol. Infect. Dis. 49:269271.
14. Baughman, R. P.,, J. C. Rhodes,, M. N. Dohn,, H. Henderson, and, P. T. Frame. 1992. Detection of cryptococcal antigen in bronchoalveolar lavage fluid: a prospective study of diagnostic utility. Am. Rev. Respir. Dis. 145:12261229.
15. Baumgartner, C.,, A.-M. Freydiere, and, Y. Gille. 1996. Direct identification and recognition of yeast species from clinical material by using Albicans ID and CHROMagar Candida plates. J. Clin. Microbiol. 34:454456.
16. Bergman, M. M.,, D. Gagnon, and, G. V. Doern. 1998. Pichia ohmeri fungemia. Diagn. Microbiol. Infect. Dis. 30:229231.
17. Bernal, S.,, E. Martin Mazuelos,, M. Garcia,, A. I. Aller,, M. A. Martinez, and, M. J. Gutierrez. 1996. Evaluation of CHRO-Magar Candida medium for the isolation and presumptive identification of species of Candida of clinical importance. Diagn. Microbiol. Infect. Dis. 24:201204.
18. Bernard, E. M.,, K. J. Christiansen,, S.-F. Tsang,, T. E. Kiehn, and, D. Armstrong. 1981. Rate of arabinitol production by pathogenic yeast species. J. Clin. Microbiol. 14:189194.
19. Bhally, H. S.,, C. Shields,, N. Halsey,, E. Cristofalo, and, W. G. Merz. 2006. Infection in a neonate caused by Pichia fabianii: importance of molecular identification. Med. Mycol. 44:185187.
20. Birinci, A.,, L. Akkurt,, C. Acuner,, M. Unlu, and, B. Durupinar. 2004. Rapid identification of the Candida species from direct blood cultures by CHROMagar Candida. J. Int. Med. Res. 32:484487.
21. Boom, W. H.,, D. J. Piper,, K. L. Ruoff, and, M. J. Ferro. 1985. New cause for false-positive results with the cryptococcal antigen test by latex agglutination. J. Clin. Microbiol. 22:856857.
22. Bouchara, J. P.,, P. Declerck,, B. Cimon,, C. Planchenault,, L. deGentile, and, D. Chabasse. 1996. Routine use of CHRO-Magar Candida medium for presumptive identification of Candida yeast species and detection of mixed fungal populations. Clin. Microbiol. Infect. 2:202208.
23. Bu, R.,, R. K. Sathiapalan,, M. M. Ibrahim,, I. Al-Mohsen,, E. Almodavar,, M. I. Gutierrez, and, K. Bhatia. 2005. Monochrome LightCycler PCR assay for detection and quantification of five common species of Candida and Aspergillus. J. Med. Microbiol. 54:243248.
24. Buchman, T. G.,, M. Rossier,, W. G. Merz, and, P. Charache. 1990. Detection of surgical pathogens by in vitro DNA amplification. I. Rapid identification of Candida albicans by in vitro amplification of a fungus-specific gene. Surgery 108:338347.
25. Burgener-Kairuz, P.,, J.-P. Zuber,, P. Jaunin,, T. G. Buchman,, J. Bille, and, M. Rossier. 1994. Rapid detection and identification of Candida albicans and Torulopsis (Candida) glabrata in clinical specimens by species-specific nested PCR amplification of a cytochrome P-450 lanosterol-(-demethylase (L1A1) gene fragment. J. Clin. Microbiol. 32:19021907.
26. Burnie, J. P.,, N. Golbang, and, R. C. Matthews. 1997. Semi-quantitative polymerase chain reaction enzyme immunoassay for diagnosis of disseminated candidiasis. Eur. J. Clin. Microbiol. Infect. Dis. 19:346350.
27. Burnik, C.,, N. D. Altintas,, G. Ozkaya,, T. Serter,, Z. T. Selcuk,, P. Firat,, S. Arikan,, M. Cuenca-Estrella, and, A. Topeli. 2007. Acute respiratory distress syndrome due to Cryptococcus albidus pneumonia: case report and review of the literature. Med. Mycol. 45:469473.
28. Cardenes, C. D.,, A. J. Carrillo-Munoz,, A. Arias,, C. Rodriguez-Alvarez,, A. Torres-Lana,, A. Sierra, and, M. P. Arevalo. 2004. Comparative evaluation of four commercial tests for presumptive identification of Candida albicans. J. Microbiol. Methods 59:293297.
29. Carricajo, A.,, S. Boiste,, J. Thore,, G. Aubert,, Y. Gille, and, A. M. Freydiere. 1999. Comparative evaluation of five chromogenic media for detection, enumeration and identification of urinary tract pathogens. Eur. J. Clin. Microbiol. Dis. 18:796803.
30. Chakrabarti, A.,, K. Singh,, A. Narang,, S. Singhi,, R. Batra,, K. L. Rao,, P. Ray,, S. Gopalan,, S. Das,, V. Gupta,, A. K. Gupta,, S. M. Bose, and, M. M. McNeil. 2001. Outbreak of Pichia anomala infection in the pediatric service of a tertiary-care center in northern India. J. Clin. Microbiol. 39:17021706.
31. Chang, H. C.,, S. N. Leaw,, A. H. Huang,, T. L. Wu, and, T. C. Chang. 2001. Rapid identification of yeasts in positive blood cultures by a multiplex PCR method. J. Clin. Microbiol. 39:34663471.
32. Chang H. J.,, H. L. Miller,, N. Watkins,, M. J. Arduino,, D. A. Ashford,, G. Midgely,, S. M. Aquero,, R. Pinto-Powell,, C. F. von Reyn,, W. Edwards,, M. M. McNeil, and, W. R. Jarvis. 1998. An epidemic of Malassezia pachydermatis in an intensive care nursery associated with colonization of health care workers’ pet dogs. N. Engl. J. Med. 338:706711.
33. Chayakulkeeree, M.,, and J. R. Perfect. 2006. Cryptococcosis. Infect. Dis. Clin. N. Am. 20:507544.
34. Chen, S. C. A.,, C. L. Halliday, and, W. Meyer. 2002. A review of nucleic acid-based diagnostic tests for systemic mycoses with an emphasis on polymerase chain reaction-based assays. Med. Mycol. 40:333357.
35. Chen, Y. C.,, J. D. Eisner,, M. M. Kattar,, S. L. Rassoulian-Barrett,, K. LaFe,, S. L. Yarfitz,, A. P. Limaye, and, B. T. Cook-son. 2000. Identification of medically important yeasts using PCR-based detection of DNA sequence polymorphisms in the internal transcribed spacer 2 region of the rRNA genes. J. Clin. Microbiol. 38:23022310.
36. Cheng, M. F.,, C. C. Chiou,, Y. C. Liu,, H. Z. Wang, and, K. S. Hsieh. 2001. Cryptococcus laurentii fungemia in a premature neonate. J. Clin. Microbiol. 39:16081611.
37. Choy, B. Y.,, S. S. Wong,, T. M. Chan, and, K. N. Lai. 2000. Pichia ohmeri peritonitis in a patient on CAPD: response to treatment with amphotericin. Perit. Dial. Int. 20:91.
38. Ciardo, D. E.,, G. Schar,, E. C. Bottger,, M. Altwegg, and, P. P. Bosshard. 2006. Internal transcribed spacer sequencing versus biochemical profiling for identification of medically important yeasts. J. Clin. Microbiol. 44:7784.
39. CLSI. 2002. CLSI document M27-A2. CLSI, Wayne, PA.
40. Coignard, C.,, S. F. Hurst,, L. E. Benjamin,, M. E. Brandt,, D. W. Warnock, and, C. J. Morrison. 2004. Resolution of discrepant results for Candida species identification by using DNA probes. J. Clin. Microbiol. 42:858861.
41. Cooke, V. M.,, R. J. Miles,, R. G. Price,, G. Midgley,, W. Khamri, and, A. C. Richardson. 2002. New chromogenic agar medium for the identification of Candida spp. Appl. Environ. Microbiol. 68:36223627.
42. Correia, A.,, P. Sampaio,, S. James, and, C. Pais. 2006. Candida bracarensis sp. nov., a novel anamorphic yeast species phenotypically similar to Candida glabrata. Int. J. Syst. Evol. Microbiol. 56:313317.
43. Crampin, A. C.,, and R. C. Matthews. 1993. Amplification of the polymerase chain reaction to the diagnosis of candidosis by amplification of HSP 90 gene fragment. J. Med. Microbiol. 39:233238.
44. de Baere, T.,, G. Claeys,, D. Swinne,, C. Massonet,, G. Verschraegen,, A. Muylaert, and, M. Vaneechoutte. 2002. Identification of cultured isolates of clinically important yeast species using fluorescent fragment length analysis of the amplified internally transcribed rRNA spacer 2 region. BMC Microbiol. 2:2128.
45. de Castro, L. E. F.,, O. A. Sarraf,, J. M. Lally,, H. P. Sandoval,, K. D. Solomon, and, D. T. Vroman. 2005. Cryptococcus albidus keratitis after corneal transplantation. Cornea 24:882883.
46. de Llanos Frutos, R.,, M. T. Fernandez-Espinar, and, A. Querol. 2004. Identification of species of the genus Candida by analysis of the 5.8S rRNA gene and the two ribosomal internal transcribed spacers. Antonie van Leeuwenhoek 85:175185.
47. de Repentigny, L. 1992. Serodiagnosis of candidiasis, aspergillosis, and cryptococcosis. Clin. Infect. Dis. 14:S11S22.
48. Diaz, M. R.,, and J. W. Fell. 2004. High-throughput detection of pathogenic yeasts of the genus Trichosporon. J. Clin. Microbiol. 42:36963706.
49. Diekema, D. J.,, S. A. Messer,, R. J. Hollis,, R. P. Wenzel, and, M. A. Pfaller. 1997. An outbreak of Candida parapsilosis prosthetic valve endocarditis. Diagn. Microbiol. Infect. Dis. 29:147153.
50. Digby, J.,, J. Kalbfleisch,, A. Glenn,, A. Larsen,, W. Browder, and, D. Williams. 2003. Serum glucan levels are not specific for presence of fungal infections in intensive care unit patients. Clin. Diagn. Lab. Immunol. 10:882885.
51. Dooley, D. P.,, M. L. Beckius,, C. K. McAllister, and, B. S. Jeffrey. 1990. Prostatitis caused by Hansenula fabianii. J. Infect. Dis. 161:10401041.
52. Einsele, H.,, H. Hebart,, G. Roller,, J. Loffler,, I. Rothenhofer,, C. A. Muller,, R. A Bowden,, J. A. Van Burik,, D. Engelhard,, L. Kanz, and, U. Schumacher. 1997. Detection and identification of fungal pathogens in blood by using molecular probes. J. Clin. Microbiol. 35:13531360.
53. Elie, C. M.,, T. J. Lott,, E. Reiss, and, C. J. Morrison. 1998. Rapid identification of Candida species with species-specific DNA probes. J. Clin. Microbiol. 36:32603265.
54. Ellepola, A. N. B.,, and C. J. Morrison. 2005. Laboratory diagnosis of invasive candidiasis. J. Clin. Microbiol. 43:S65S84.
55. Ellis, D. H.,, and T. J. Pfeiffer. 1990. Ecology, life cycle, and infectious propagule of Cryptococcus neoformans. Lancet 336:923925.
56. Enache-Angoulvant, A.,, and C. Hennequin. 2005. Invasive Saccharomyces infection: a comprehensive review. Clin. Infect. Dis. 41:15591568.
57. Espinel-Ingroff, A.,, L. Stockman,, G. Roberts,, D. Pincus,, J. Pollack, and, J. Marler. 1998. Comparison of RapID Yeast Plus system with API 20C system for identification of common, new, and emerging yeast pathogens. J. Clin. Microbiol. 36:883886.
58. Esteve-Zarzoso B.,, C. Belloch,, F. Uruburu, and, A. Querol. 1999. Identification of yeasts by RFLP analysis of the 5.8S rRNA gene 184 and the two ribosomal internal transcribed spacers. Int. J. Syst. Bacteriol. 49:329337.
59. Fell, J. W.,, T. Boekhout,, A. Fonseca,, G. Scorzetti, and, A. Statzell-Tallman. 2000. Biodiversity and systematics of basidiomycetous yeasts as determined by large-subunit rDNA D1/D2 domain sequence analysis. Int. J. Syst. Evol. Microbiol. 50:13511371.
60. Fidel, P. 2007. History and update on host defenses against vaginal candidiasis. Am. J. Reprod. Immunol. 57:212.
61. Flahaut, M.,, D. Sanglard,, M. Monod,, J. Bille, and, M. Rossier. 1998. Rapid detection of Candida albicans in clinical samples by DNA amplification of common regions from C. albicans-secreted aspartic proteinase genes. J. Clin. Microbiol. 36:395401.
62. Forrest, G. N.,, K. Mankes,, M. A. Jabra-Rizk,, E. Weekes,, J. K. Johnson,, D. P. Lincalis, and, R. A. Venezia. 2006. Peptide nucleic acid fluorescence in situ hybridization-based identification of Candida albicans and its impact on mortality and antifungal therapy costs. J. Clin. Microbiol. 44:33813383.
63. Freydiere, A. M.,, L. Buchaille, and, Y. Gille. 1997. Comparison of three commercial media for direct identification and discrimination of Candida species in clinical specimens. Eur. J. Clin. Microbiol. Infect. Dis. 16:464467.
64. Freydiere, A.-M.,, R. Guinet, and, P. Boiron. 2001. Yeast identification in the clinical microbiology laboratory: phenotypic methods. Med. Mycol. 39:933.
65. Gade, W.,, S. W. Hinnefeld,, L. S. Babcock,, P. Gilligan,, W. Kelly,, K. Wait,, D. Greer,, M. Pinilla, and, R. L. Kaplan. 1991. Comparison of the Premier cryptococcal antigen enzyme immunoassay and the latex agglutination assay for detection of cryptococcal antigens. J. Clin. Microbiol. 29:16161619.
66. Garau, M.,, M. Pereito, Jr., and, A. del Palacio. 2003. In vitro susceptibilities of Malassezia species to a new triazole, alba-conazole (UR-9825), and other antifungal compounds. Antimicrob. Agents Chemother. 47:23422344.
67. Girmenia, C.,, L. Pagano,, B. Martino,, D. D’Antonio,, R. Fanci,, G. Specchia,, L. Melillo,, M. Buelli,, G. Pizzarelli,, M. Venditti,, P. Martino, and GIMEMA Infection Program. 2005. Invasive infections caused by Trichosporon species and Geotrichum capitatum in patients with hematological malignancies: a retrospective multicenter study from Italy and review of the literature. J. Clin. Microbiol. 43:18181828.
68. Gold, J. W. M.,, B. Wong,, E. M. Bernard,, T. E. Kiehn, and, D. Armstrong. 1983. Serum arabinitol concentrations and arabinitol/creatinine ratios in invasive candidiasis. J. Infect. Dis. 147:504513.
69. Gray, L. D.,, and G. D. Roberts. 1988. Experience with the use of pronase to eliminate interference factors in the latex agglutination for cryptococcal antigen. J. Clin. Microbiol. 26:24502451.
70. Gueho, E.,, G. Midgley, and, J. Guillot. 1996. The genus Malassezia with description of four new species. Antonie van Leeuwenhoek 69:337355.
71. Guiver, M.,, K. Levi, and, B. A. Oppenheim. 2001. Rapid identification of Candida species by TaqMan PCR. J. Clin. Pathol. 54:362366.
72. Hage, C. A.,, K. L. Wood,, H. T. Winer-Muram,, S. J. Wilson,, G. Sarosi, and, K. S. Knox. 2003. Pulmonary cryptococcosis after initiation of anti tumor necrosis factor-alpha therapy. Chest 124:23952397.
73. Hageage, G. J.,, and B. J. Harrington. 1984. Use of calcofluor white in clinical mycology. Lab. Med. 15:109112.
74. Haidle, C. W.,, and R. Storck. 1966. Control of dimorphism in Mucor rouxii. J. Bacteriol. 92:12361244.
75. Hajjeh, R. A.,, A. N. Sofair,, L. H. Harrison,, G. M. Lyon,, B. A. Arthington-Skaggs,, S. A. Mirza,, M. Phelan,, J. Morgan,, W. Lee-Yang,, M. A. Ciblak,, L. E. Benjamin,, L. T. Sanza,, S. Huie,, S. F. Yeo,, M. E. Brandt, and, D. W. Warnock. 2004. Incidence of bloodstream infections due to Candida species and in vitro susceptibilities of isolates collected from 1998 to 2000 in a population-based active surveillance program. J. Clin. Microbiol. 42:15191527.
76. Hall, L.,, S. Wohlfiel, and, G. D. Roberts. 2003. Experience with the MicroSeq D2 large-subunit ribosomal DNA sequencing kit for identification of commonly encountered, clinically important yeast species. J. Clin. Microbiol. 41:50995102.
77. Han, X. Y.,, J. J. Tarrand, and, E. Escudero. 2004. Infections by the yeast Kodomaee (Pichia) ohmeri: two cases and literature review. Eur. J. Clin. Microbiol. Infect. Dis. 23:127130.
78. Hanzen, J.,, and V. Krcmery. 2002. Polyfungal candidaemia due to Candida rugosa and Candida pelliculosa in a haemodialyzed neonate. Scand. J. Infect. Dis. 34:555.
79. Hayden, R. T.,, X. Qian,, G. W. Procop,, G. D. Roberts, and, R. V. Lloyd. 2002. In situ hybridization for the identification of filamentous fungi in tissue section. Diagn. Mol. Pathol. 11:119126.
80. Hazen, K. C.,, and S. A. Howell. 2007. Candida, Cryptococcus, and other yeasts of medical importance, p. 1762–1788. In P. R. Murray,, E. J. Baron,, J. H. Jorgensen,, M. L. Landry, and, M. A. Pfaller (ed.), Manual of Clinical Microbiology, 9th ed. ASM Press, Washington, DC.
81. Herent, P.,, D. Stynen,, F. Hernando,, J. Fruit, and, D. Poulain. 1992. Retrospective evaluation of two latex agglutination tests for detection of circulating antigens during invasive candidosis. J. Clin. Microbiol. 8:21582164.
82. Heymann, W. R.,, and D. J. Wolf. 1986. Malassezia (Pity-rosporum) folliculitis occurring during pregnancy. Int. J. Dermatol. 25:4951.
83. Hirai, A.,, R. Kano,, K. Makimura,, E. R. Duarte,, J. S. Hamdan,, M. A. Lachance,, H. Yamaguchi, and, A. Hasegawa. 2004. Malassezia nana sp. nov., a novel lipid dependent yeast species isolated from animals. Int. J. Syst. Evol. Microbiol. 54:623627.
84. Hoang, J. K.,, and J. J. Burruss. 2007. Localized cutaneous Cryptococcus albidus infection in a 14-year-old boy on etanercept therapy. Pediatr. Dermatol. 24:285288.
85. Hoang, L. M.,, J. A. Maguire,, P. Doyle,, M. Fyfe, and, D. L. Roscoe. 2004. Cryptococcus neoformans infections at Vancouver Hospital and Health Sciences Centre (1997–2002): epidemiology, microbiology and histopathology. J. Med. Microbiol. 53:935940.
86. Hospenthal, D. R.,, M. L. Beckius,, K. L. Floyd,, L. L. Horvath, and, C. K. Murray. 2006. Presumptive identification of Candida species other than C. albicans, C. krusei, and C. tropicalis with the chromogenic medium CHROMagar Candida. Ann. Clin. Microbiol. Antimicrob. 5:15.
87. Huffnagle, K. E.,, and R. M. Gander. 1993. Evaluation of Gen-Probe’s Histoplasma capsulatum and Cryptococcus neoformans AccuProbes. J. Clin. Microbiol. 31:419421.
88. Husain, S.,, M. M. Wagener, and, N. Singh. 2001. Cryptococcus neoformans infection in organ transplant recipients: variables influencing clinical characteristics and outcome. Emerg. Infect. Dis. 7:375381.
89. Iyampillai, T.,, S. Michael,, E. Mathai, and, M. S. Mathews. 2004. Use of CHROMagar medium in the differentiation of Candida species: is it cost effective in developing countries? Ann. Trop. Med. Parasitol. 98:279282.
90. Jabra-Rizk, M. A.,, T. M. Brenner,, M. Romagnoli,, A. A. M.A. Baqui,, W. G. Merz,, W. A. Falkler, Jr., and, T. F. Meiller. 2001. Evaluation of reformulated CHROMagar Candida. J. Clin. Microbiol. 39:20152016.
91. Jordan, J. A. 1994. PCR identification of four medically important Candida species by using a single primer pair. J. Clin. Microbiol. 32:29622967.
92. Kalenic, S.,, M. Jandrlic,, V. Vegar,, N. Zuech,, A. Sekulic, and, E. Mlinaric-Missoni. 2001. Hansenula anomala outbreak at a surgical intensive care unit: a search for risk factors. Eur. J. Epidemiol. 17:491496.
93. Kan, V. L. 1993. Polymerase chain reaction for the diagnosis of candidemia. J. Infect. Dis. 168:779783.
94. Khan, Z. U.,, N. A. Al-Sweih,, S. Amad,, N. Al-Kazemi,, S. Khan,, L. Joseph, and, R. Chandy. 2007. Outbreak of fungemia among neonates caused by Candida haemulonii resistant to amphotericin B, itraconazole, and fluconazole. J. Clin. Microbiol. 45:20252027.
95. Kidd, S. E.,, F. Hagen,, R. L. Tscharke,, M. Huynh,, K. H. Bartlett,, M. Fyfe,, L. Macdougall,, T. Boekhout,, K. J. Kwon-Chung, and, W. Meyer. 2004. A rare genotype of Cryptococcus gattii caused the cryptococcosis outbreak on Vancouver Island (British Columbia, Canada). Proc. Nat. Acad. Sci. USA 101:1725817263.
96. Kiehn, T. E.,, E. M. Bernard,, J. W. M. Gold, and, D. Armstrong. 1979. Candidiasis: detection by gas-liquid chromatography of d-arabinitol, a fungal metabolite, in human serum. Science 206:577580.
97. Kohno, S.,, K. Mitsutake,, S. Maesaki,, A. Yasuoka,, T. Miyazaki,, M. Kaku,, H. Koga, and, K. Hara. 1993. An evaluation of serodiagnostic tests in patients with candidemia: beta-glucan, mannan, Candida antigen by Cand-Tec and d-arabinitol. Microbiol. Immunol. 37:207212.
98. Kondori, N.,, L. Edebo, and, I. Mattsby-Baltzer. 2004. Circulating β-(1-3)-glucan and immunoglobulin G subclass antibodies to Candida albicans cell wall antigens in patients with systemic candidiasis. Clin. Diagn. Lab. Immunol. 11:344350.
99. Kontoyiannis, D. P.,, H. A. Torres,, M. Chagua,, R. Hachem,, J. J. Tarrand,, G. P. Bodey, and, I. I. Raad. 2004. Trichosporonosis in a tertiary care cancer center: risk factors, changing spectrum and determinants of outcome. Scand. J. Infect. Dis. 36:564569.
100. Kordossis, T.,, A. Avlami,, A. Velegraki,, I. Stefanou,, G. Georgakopoulos,, C. Papalambrou, and, N. J. Legakis. 1998. First report of Cryptococcus laurentii meningitis and a fatal case of Cryptococcus albidus cryptococcaemia in AIDS patients. Med. Mycol. 36:335339.
101. Krcmery, V. 1997. Nosocomial Cryptococcus laurentii fungemia in a bone marrow transplant patient after prophylaxis with ketoconazole successfully treated with oral fluconazole. Infection 25:130.
102. Krcmery, V.,, E. Oravcova,, S. Spanik,, M. Mrazova-Studena,, J. Trupl,, A. Kunova,, K. Stopkova-Grey,, E. Kukuckova,, I. Krupova,, A. Demitrovicova, and, K. Kralovicova. 1998. Nosocomial breakthrough fungaemia during antifungal prophylaxis or empirical antifungal therapy in 41 cancer patients receiving antineoplastic chemotherapy: analysis of aetiology risk factors and outcome. J. Antimicrob. Chem-other. 41:373380.
103. Kunova, A.,, and V. Krcmery. 1999. Fungaemia due to thermophilic cryptococci: 3 cases of Cryptococcus laurentii bloodstream infections in cancer patients receiving antifungals. Scand. J. Infect. Dis. 31:328.
104. Kurtzman, C. P.,, and J. W. Fell (ed.). 1984. The Yeasts, a Taxonomic Study, 3rd ed. Elsevier, New York, NY.
105. Kurtzman, C. P.,, and J. W. Fell (ed.). 1998. The Yeasts, a Taxonomic Study, 4th ed. Elsevier, New York, NY.
106. Kurtzman, C. P.,, and C. J. Robnett. 1998. Identification and phylogeny of ascomycetous yeasts from analysis of nuclear large subunit (26S) ribosomal DNA partial sequences. Antonie van Leeuwenhoek 73:331371.
107. Larsson, L.,, C. Pehrson.,, T. Wiebe, and, B. Christensson. 1994. Gas chromatographic determination of d-arabinitol/L-arabinitol ratios in urine: a potential method for diagnosis of disseminated candidiasis. J. Clin. Microbiol. 32:18551859.
108. Leaw, S. N.,, H. C. Chang,, H. F. Sun,, R. Barton,, J.-P. Boucara, and, T. C. Chang. 2006. Identification of medically important yeast species by sequence analysis of the internal transcribed spacer regions. J. Clin. Microbiol. 44:693699.
109. Leaw, S. N.,, H. C. Chang,, R. Barton,, J.-P. Bouchara, and, T. C. Chang. 2007. Identification of medically important Candida and non-Candida yeast species by an oligonucleotide array. J. Clin. Microbiol. 45:22202229.
110. Lee, Y. A.,, H. J. Kim,, T. W. Lee,, M. J. Kim,, M. H. Lee,, J. H. Lee, and, C. G. Ihm. 2004. First report of Cryptococcus albidus-induced disseminated cryptococcosis in a renal transplant recipient. Korean J. Intern. Med. 19:5357.
111. Linton, C. J.,, A. M. Borman,, G. Cheung,, A. D. Holmes,, A. Szekely,, M. D. Palmer,, P. D. Bridge,, C. K. Campbell, and, E. M. Johnson. 2007. Molecular identification of unusual pathogenic yeast isolates by large ribosomal subunit gene sequencing: 2 years of experience at the United Kingdom mycology reference laboratory. J. Clin. Microbiol. 45:11521158.
112. Lischewski, A.,, R. I. Amann,, D. Harmsen,, H. Merkert,, J. Hacker, and, J. Morschhauser. 1996. Specific detection of Candida albicans and Candida tropicalis by fluorescent in situ hybridization with an 18S rRNA-targeted oligonucleotide probe. Microbiology 142:27312740.
113. Lischewski, A.,, M. Kretschmar,, H. Hof,, R. Amann,, J. Hacker, and, J. Morschhauser. 1997. Detection and identification of Candida species in experimentally infected tissue and human blood by rRNA-specific fluorescent in situ hybridization. J. Clin. Microbiol. 35:29432948.
114. Loeffler, J.,, C. Dorn,, H. Hebart,, P. Cox,, S. Magga, and, H. Einsele. 2003. Development and evaluation of the Nuclisens basic kit NASBA for the detection of RNA from Candida species frequently resistant to antifungal drugs. Diagn. Microbiol. Infect. Dis. 45:217220.
115. Loison, J.,, P. Bouchara,, E. Gueho,, L. de Gentile,, B. Cimon,, J. M. Chennebault, and, D. Chabasse. 1996. First report of Cryptococcus albidus septicaemia in an HIV patient. J. Infect. 33:139140.
116. Ma, J. S.,, P. Y. Chen,, C. H. Chen, and, C. S. Chi. 2000. Neonatal fungemia caused by Hansenula anomala: a case report. J. Microbiol. Immunol. Infect. 33:267270.
117. Maaroufi, Y.,, C. Heymans,, J.-M. DeBruyne,, V. Duchateau,, H. Rodriguez-Villalobos,, M. Aoun, and, F. Crokaert. 2003. Rapid detection of Candida albicans in clinical blood samples by using a TaqMan-based PCR assay. J. Clin. Microbiol. 41:32933298.
118. Maaroufi, Y.,, N. Ahariz,, M. Husson and, F. Crokaert. 2004. Comparison of different methods of isolation of DNA of commonly encountered Candida species and its quantitation by using a real-time PCR-based assay. J. Clin. Microbiol. 42:31593163.
119. Marty, F. M.,, D. H. Barouch,, E. P. Coakley, and, L. R. Baden. 2003. Disseminated trichosporonosis caused by Trichosporon loubieri. J. Clin. Microbiol. 41:53175320.
120. Marty, F. M.,, C. M. Lowry,, S. J. Lempitski,, D. W. Kubiak,, M. A. Finkelman, and, L. R. Baden. 2006. Reactivity of (1→3)-β-d-glucan assay with commonly used intravenous antimicrobials. Antimicrob. Agents Chemother. 50:34503453.
121. Matthews, R.,, and J. Burnie. 1988. Diagnosis of systemic candidiasis by an enzyme-linked immunobinding assay for a circulating immunodominant 47-kilodalton antigen. J. Clin. Microbiol. 26:459463.
122. McCarthy, K. M.,, J. Morgan,, K. A. Wannemuehler,, S. A. Mirza,, S. M. Gould,, N. Mhlongo,, P. Moeng,, B. R. Maloba,, H. H. Crewe-Brown,, M. E. Brandt, and, R. A. Hajjeh. 2006. Population-based surveillance for cryptococcosis in an anti-retroviral-naive South African province with a high HIV seroprevalence. AIDS 20:21992206.
123. McManus, E. J.,, and J. M. Jones. 1985. Detection of a Trichosporon beigelii antigen cross-reactive with Cryptococcus neoformans capsular polysaccharide in serum from a patient with disseminated Trichosporon infection. J. Clin. Microbiol. 21:681685.
124. Melcher, C. P.,, K. D. Reed,, M. G. Rinaldi,, J. W. Lee,, P. A. Pizzo, and, T. J. Walsh. 1991. Demonstration of a cell wall antigen cross-reacting with cryptococcal polysaccharide in experimental disseminated trichosporonosis. J. Clin. Microbiol. 29:192196.
125. Merz, W. G.,, J. E. Karp,, D. Schron, and, R. Saral. 1986. Increased incidence of fungemia caused by Candida krusei. J. Clin. Microbiol. 24:581584.
126. Metwally, L.,, G. Hogg,, P. V. Coyle,, R. J. Hay,, S. Hedder-wick,, B. McCloskey,, H. J. O’Neill,, G. M. Ong,, G. Thompson,, C. H. Webb, and, R. McMullan. 2007. Rapid differentiation between fluconazole-sensitive and -resistant species of Candida directly from positive blood-culture bottles by realtime PCR. J. Med. Microbiol. 56:964970.
127. Meurman, O.,, A. Koskensalo, and, K. Rantakokko-Jalava. 2006. Evaluation of Vitek 2 for identification of yeasts in the clinical laboratory. Clin. Microbiol. Infect. 12:591593.
128. Midgley, G. 2000. The lipophilic yeasts: state of the art and prospects. Med. Mycol. 38(Suppl. 1):916.
129. Mirhendi, H.,, K. Makimura,, M. Khoramizadeh, and, H. Yamaguchi. 2006. One enzyme PCR-RFLP assay for identification of six medically important Candida species. Jpn. J. Med. Mycol. 47:225229.
130. Mirza, S. A.,, M. Phelan,, D. Rimland,, E. Graviss,, R. Hamill,, M. E. Brandt,, T. Gardner,, M. Sattah,, G. P. de Leon,, W. Baughman, and, R. A. Hajjeh. 2003. The changing epidemiology of cryptococcosis: an update from population-based active surveillance in 2 large metropolitan areas, 1992–2000. Clin. Infect. Dis. 36:789794.
131. Misaki, H.,, H. Iwasaki, and, T. Ueda. 2003. A comparison of the specificity and sensitivity of two Candida antigen assay systems for the diagnosis of deep candidiasis in patients with hematologic diseases. Med. Sci. Monit. 9:MT1MT7.
132. Mitchell, T. G.,, E. Z. Freedman,, T. J. White, and, J. W. Taylor. 1994. Unique oligonucleotide primers in PCR for identification of Cryptococcus neoformans. J. Clin. Microbiol. 32:253255.
133. Mitsutake, K.,, T. Miyazaki,, T. Tashiro,, Y. Yamamoto,, H. Kakeya,, T. Otsubo,, S. Kawamura,, M. A. Hossain,, T. Noda,, Y. Hirakata, and, S. Kohno. 1996. Enolase antigen, mannan antigen, Cand-Tec antigen, and _-glucan in patients with candidemia. J. Clin. Microbiol. 34:19181921.
134. Miyazaki, T. S. Kohno,, H. Koga,, M. Kaku,, K. Mitsutake,, S. Maesaki,, A. Yasuoka,, K. Hara,, S. Tanaka, and, H. Tamura. 1992. G test, a new method for diagnosis of Candida infection: comparison with assays for beta-glucan and mannan antigen in a rabbit model of systemic candidiasis. J. Clin. Lab. Anal. 6:315318.
135. Miyazaki, T.,, S. Kohno,, K. Mitsutake,, S. Maesaki,, K.-I. Tanaka,, N. Ishikawa, and, K. Hara. 1995. Plasma (1→3)-β-d-glucan and fungal antigenemia in patients with candidemia, aspergillosis, and cryptococcosis. J. Clin. Microbiol. 33:31153118.
136. Morace, G.,, G. Amato,, F. Bistoni,, G. Fadda,, P. Marone,, M. T. Montagna,, S. Oliveri,, L. Polonelli,, R. Rigoli,, I. Mancuso,, S. La Face,, L. Masucci,, L. Romano,, C. Napoli,, D. Tato,, M. G. Muscema,, C. M. C. Belli,, M. M. Piccirillo,, S. Conti,, S. Covan,, F. Fanti,, C. Cavanna,, F. D’Alo, and, L. Pitzurra. 2002. Multicenter comparative evaluation of six commercial systems and the National Committee for Clinical Laboratory Standards M27-A broth microdilution method for fluconazole susceptibility testing of Candida species. J. Clin. Microbiol. 40:29532958.
137. Morace, G.,, L. Pagano,, M. Sanguinetti,, B. Posteraro,, L. Mele,, F. Equitani,, G. D’Amore,, G. Leone, and, G. Fadda. 1999. PCR-restriction enzyme analysis for detection of Candida DNA in blood from febrile patients with hematological malignancies. J. Clin. Microbiol. 37:18711875.
138. Morace, G.,, M. Sanquinetti,, B. Posteraro,, G. Lo Cascio, and, G. Fadda. 1997. Identification of various medically important Candida species in clinical specimens by PCR restriction enzyme analysis. J. Clin. Microbiol. 35:667672.
139. Moreira-Oliveira, M. S.,, Y. Mikami,, M. Miyaji,, T. Imai,, A. Z. Schreiber, and, M. L. Moretti. 2005. Diagnosis of candidemia by polymerase chain reaction and blood culture: prospective study in a high-risk population and identification of variables associated with development of candidemia. Eur. J. Clin. Microbiol. Infect. Dis. 24:721726.
140. Morgan, J.,, M. I. Meltzer,, B. D. Plikaytis,, A. N. Sofair,, S. Huie-White,, S. Wilcox,, L. H. Harrison,, E. C. Seaberg,, R. A. Hajjeh, and, S. M. Teutsch. 2005. Excess mortality, hospital stay, and cost due to candidemia: a case-control study using data from population-based candidemia surveillance. Infect. Control Hosp. Epidemiol. 26:540547.
141. Mori, T.,, H. Ikemoto,, M. Matsumura,, M. Yoshida,, K. Inada,, S. Endo,, A. Ito,, S. Watanabe,, H. Yamaguchi,, M. Mitsuya,, M. Kodama,, T. Tani,, T. Yokota,, T. Kobayashi,, J. Kambayashi,, T. Nakamura,, T. Masoaka,, H. Teshima,, T. Yoshinaga,, S. Kohno,, K. Hara, and, S. Miyazaki. 1997. Evaluation of plasma (1→3)-β-d-glucan measurement by the kinetic turbidimetric Limulus test, for the clinical diagnosis of mycotic infections. Eur. J. Clin. Chem. Clin. Biochem. 35:553560.
142. Morris J. T.,, M. Beekius, and, C. K. McAllister. 1991. Sporobolomyces infection in an AIDS patient. J. Infect. Dis. 164:623-624.
143. Morrow, J. D. 1994. Prosthetic cranioplasty infection due to Sporobolomyces. J. Tenn. Med. Assoc. 87:466.
144. Munoz, P.,, E. Bouza, and, M. Cuenca-Estrella. 2005. Saccharomyces cerevisiae fungemia: an emerging infectious disease. Clin. Infect. Dis. 40:16251634.
145. Munoz, P.,, M. E. Garcia Leoni,, J. Berenguer,, J. C. Bernaldo de Quiros, and, E. Bouza. 1989. Catheter-related fungemia by Hansenula anomala. Arch. Intern. Med. 149:709713.
146. Murphy, N.,, C. R. Buchanan,, V. Damjanovic,, R. Whitaker,, C. A. Hart, and, R. W. Cooke. 1986. Infection and colonization of neonates by Hansenula anomala. Lancet i:291293.
147. Murray, C. K.,, M. L. Beckius,, J. A. Green, and, D. R. Hospenthal. 2005. Use of chromogenic medium in the isolation of yeasts from clinical specimens. J. Med. Microbiol. 54:981985.
148. Mwaba, P.,, J. Mwansa,, C. Chintu,, J. Pobee,, M. Scarborough,, S. Portsmouth, and, A. Zumla. 2001. Clinical presentation, natural history, and cumulative death rates of 230 adults with primary cryptococcal meningitis in Zambian AIDS patients treated under local conditions. Postgrad. Med. J. 77:769773.
149. Nakabayashi A.,, Y. Sei, and, J. Guillot. 2000. Identification of Malassezia species isolated from patients with seborrhoeic dermatitis, atopic dermatidis, pityriasis versicolor and normal subjects. Med. Mycol. 38:337341.
150. Nettles, R. E.,, L. S. Nichols,, K. Bell-McGuinn,, M. R. Pipeling,, P. J. Scheel, Jr., and, W. G. Merz. 2003. Successful treatment of Trichosporon mucoides infection with fluconazole in a heart and kidney transplant recipient. Clin. Infect. Dis. 36:e63e66.
151. Ngyuen, M. H.,, J. E. Peacock, Jr.,, A. J. Morris,, D. C. Tanner,, M. L. Nguyen,, D. R. Snydman,, M. M. Wagener,, M. G. Rinaldi, and, V. L. Yu. 1996. The changing face of candidemia: emergence of non-Candida albicans species and antifungal resistance. Am. J. Med. 6:617623.
152. Nohinek, B.,, C. S. Zu-Cheng,, W. G. Barnes,, L. Dall, and, H. R. Gibbs. 1987. Infective endocarditis of a bicuspid aortic valve caused by Hansenula anomala. Am. J. Med. 82:165168.
153. Nucci, M.,, and A. L. Colombo. 2007. Candidemia due to Candida tropicalis: clinical, epidemiologic, and microbio-logic characteristics of 188 episodes occurring in tertiary care hospitals. Diagn. Microbiol. Infect. Dis. 58:7782.
154. Obayashi, T.,, M. Yoshida,, T. Mori,, H. Goto,, A. Yasuoka,, H. Iwasaki,, H. Teshima,, S. Kohno,, A. Horiuchi,, A. Ito,, H. Yamaguchi,, K. Shimada, and, T. Kawai. 1995. Plasma (1→3)-β-d-glucan measurement in diagnosis of invasive deep mycosis and fungal febrile episodes. Lancet 345:1720.
155. Odabasi, Z.,, G. Mattiuzzi,, E. Estey,, H. Kantarjian,, F. Saeki,, R. J. Ridge,, P. A. Ketchum,, M. A. Finkelman,, J. H. Rex, and, L. Ostrosky-Zeichner. 2005. (1→3)-β-d-glucan as a diagnostic adjunct for invasive fungal infections: validation, cutoff development, and performance in patients with acute myelogenous leukemia and myelodysplastic syndrome. Clin. Infect. Dis. 39:199205.
156. Odds, F. C.,, and R. Bernaerts. 1994. CHROMagar Candida, a new differential isolation medium for presumptive identification of clinically important Candida species. J. Clin. Microbiol. 32:19231929.
157. Odds, F. C.,, and A. Davidson. 2000. “Room temperature” use of CHROMagar Candida. Diagn. Microbiol. Infect. Dis. 38:147150.
158. Oliveira, K.,, G. Haase,, C. Kurtzman,, J. J. Hyldig-Nielson, and, H. Stender. 2001. Differentiation of Candida albicans and Candida dubliniensis by fluorescent in situ hybridization with peptide nucleic acid probes. J. Clin. Microbiol. 39:41384141.
159. Olver, W. J.,, J. Stafford,, P. Cheetham, and, T. C. Boswell. 2002. Comparison of Candida ID medium with Sabouraud-chloramphenicol agar for the isolation of yeasts from clinical haematology surveillance specimens. J. Med. Microbiol. 51:221224.
160. Ostrosky-Zeichner, L.,, B. D. Alexander,, D. H. Kett,, J. Vazquez,, P. G. Pappas,, F. Saeki,, P. A. Ketchum,, J. Wingard,, S. Schiff,, H. Tamura,, M. A. Finkelman, and, J. H. Rex. 2005. Multicenter clinical evaluation of the (1→3) d-glucan assay as an aid to diagnosis of fungal infections in humans. Clin. Infect. Dis. 41:654659.
161. Otag, F.,, N. Kuyucu,, Z. Erturan,, S. Sen,, G. Emekdas, and, T. Sugita. 2005. An outbreak of Pichia ohmeri infection in the paediatric intensive care unit: case reports and review of the literature. Mycoses 48:265269.
162. Page, B. T.,, and C. P. Kurtzman. 2005. Rapid identification of Candida species and other clinically important yeast species by flow cytometry. J. Clin. Microbiol. 43:45074514.
163. Page, B. T.,, C. E. Shields,, W. G. Merz, and, C. P. Kurtzman. 2006. Rapid identification of ascomycetous yeasts from clinical specimens by a molecular method based on flow cytometry and comparison with identifications from phenotypic assays. J. Clin. Microbiol. 44:31673171.
164. Pasqualotto, A. C.,, T. C. T. Sukiennik,, L. C. Severo,, C. S. de Amorim, and, A. L. Colombo. 2005. An outbreak of Pichia anomala fungemia in a Brazilian pediatric intensive care unit. Infect. Control Hosp. Epidemiol. 26:553558.
165. Patterson, T. F. 2002. Fungal susceptibility testing: where are we now? Transpl. Infect. Dis. 4:3845.
166. Perfect, J. R.,, and G. M. Cox. 2005. Cryptococcosis, p. 637–658. In W. G. Merz and, R. J. Hay (ed.), Topley and Wilson’s Microbiology and Microbial Infections: Medical Mycology. Hodder Publishing, London, United Kingdom.
167. Pfaller, M. A.,, L. Boyken,, R. J. Hollis,, S. A. Messer,, S. Tendolkar, and, D. J. Diekema. 2005. In vitro activities of anidulafungin against more than 2,500 clinical isolates of Candida spp., including 315 isolates resistant to fluconazole. J. Clin. Microbiol. 43:54255427.
168. Pfaller, M. A.,, L. Boyken,, R. J. Hollis,, S. A. Messer,, S. Tendolkar, and, D. J. Diekema. 2006. Global surveillance of in vitro activity of micafungin against Candida: a comparison with caspofungin by CLSI-recommended methods. J. Clin. Microbiol. 44:35333538.
169. Pfaller, M. A.,, L. Boyken,, R. J. Hollis,, S. A. Messer,, S. Tendolkar, and, D. J. Diekema. 2006. In vitro susceptibilities of Candida spp. to caspofungin: four years of global surveillance. J. Clin. Microbiol. 44:760763.
170. Pfaller, M. A.,, I. Cabezudo,, B. Buschelman,, M. Bale,, T. Howe,, M. Vitug,, H. J. Linton, and, M. Densel. 1993. Value of the Hybritech ICON Candida assay in the diagnosis of invasive candidiasis in high risk patients. Diagn. Microbiol. Infect. 16:5360.
171. Pfaller, M. A.,, and J. Diekema. 2007. Epidemiology of invasive candidiasis: a persistent public health problem. Clin. Microbiol. Rev. 20:133163.
172. Pfaller, M. A.,, A. Houston, and, S. Coffman. 1996. Application of CHROMagar Candida for rapid screening of clinical specimens for Candida albicans, Candida tropicalis, Candida krusei, and Candida (Torulopsis) glabrata. J. Clin. Microbiol. 34:5861.
173. Pickering, J. W.,, H. W. Sant,, C. A. P. Bowles,, W. L. Roberts, and, G. L. Woods. 2005. Evaluation of a (1→3)-β-d-glucan assay for diagnosis of invasive fungal infections. J. Clin. Microbiol. 43:59575962.
174. Piens, M. A.,, J. D. Perry,, H. Raberin,, F. Parant, and, A. M. Freydiere. 2003. Routine use of a one minute trehalase and maltase test for the identification of Candida glabrata in four laboratories. J. Clin. Pathol. 56:687689.
175. Plazas, J.,, J. Portilla,, V. Boix, and, M. Parez-Mateo. 1994. Sporobolomyces salmonicolor lymphadenitis in AIDS patient. Pathogen or passenger? AIDS 8:387388.
176. Powell, H. L.,, C. A. Sand, and, R. P. Rennie. 1998. Evaluation of CHROMagar Candida for presumptive identification of clinically important Candida species. Diagn. Microbiol. Infect. Dis. 32:201204.
177. Pryce, T. M.,, I. D. Kay,, S. Palladino, and, C. H. Heath. 2003. Real-time automated polymerase chain reaction (PCR) to detect Candida albicans and Aspergillus fumigatus DNA in whole blood from high-risk patients. Diagn. Microbiol. Infect. Dis. 47:487496.
178. Puerto, J. L.,, P. Garcia-Martos, and, A. Saldarreaga. 2002. First report of urinary tract infection due to Pichia ohmeri. Eur. J. Clin. Microbiol. Infect. Dis. 21:630631.
179. Qadri, S. M. H.,, A. L. Dayel,, M. J. Strampfer, and, B. A. Cunha. 1988. Urinary tract infection caused by Hansenula anomala. Mycopathologia 104:99101.
180. Rand, K. H.,, H. Houck, and, M. Wolff. 1994. Detection of candidemia by polymerase chain reaction. Mol. Cell. Probes 8:215222.
181. Reina, J. P.,, D. H. Larone,, J. R. Sabetta,, K. K. Krieger, and, B. J. Hartman. 2002. Pichia ohmeri prosthetic valve endocarditis and review of literature. Scand. J. Infect. Dis. 34:140141.
182. Reiss, E.,, and C. J. Morrison. 1993. Nonculture methods for diagnosis of disseminated candidiasis. Clin. Microbiol. Rev. 6:311323.
183. Reiss, E.,, K. Tanaka,, G. Bruker,, V. Chazalet,, D. Coleman,, J. P. Debeaupuis,, R. Hanazawa,, J.-P. Latge,, J. Lortholary,, K. Makimura,, C. J. Morrison,, S. Y. Murayama,, S. Naoe,, S. Paris,, J. Sarfari,, K. Shibuya,, D. Sullivan,, K. Uchida, and, H. Yamaguchi. 1998. Molecular diagnosis and epidemiology of fungal infections. Med. Mycol. 36(Suppl. 1):249257.
184. Reller, M. E.,, A. B. Mallonee,, N. P. Kwiatkowski, and, W. G. Merz. 2007. Use of peptide nucleic acid fluorescence in situ hybridization for definitive, rapid identification of five common species of Candida. J. Clin. Microbiol. 45:38023803.
185. Rex, J. H.,, M. A. Pfaller,, J. N. Galgiani,, M. S. Bartlett,, A. Espinel-Ingroff,, M. A. Ghannoum,, M. Lancaster,, F. C. Odds,, M. G. Rinaldi,, T. J. Walsh, and, A. L. Barry. 1997. Development of interpretive breakpoints for antifungal susceptibility testing: conceptual framework and analysis of in vitro-in vivo correlation data for fluconazole, itraconazole, and Candida infection. Clin. Infect. Dis. 24:235247.
186. Roboz, J.,, and R. N. Katz. 1992. Diagnosis of disseminated candidiasis based on serum D/L-arabinitol ratios using negative chemical ionization mass spectrometry. J. Chromatogr. 575:281286.
187. Rodriguez-Tudela, J. L.,, and M. Cuenca-Estrella. 2006. Molecular identification of Trichosporon species. Clin. Infect. Dis. 43:1370.
188. Sakai, T.,, K. Ikegami,, E. Yoshinaga,, R. Uesugi-Hayakawa, and, A. Wakizaka. 2000. Rapid, sensitive, and simple detection of Candida deep mycosis by amplification of 18S ribosomal RNA gene; comparison with assay of serum beta-d-glucan level in clinical samples. Tohoku J. Exp. Med. 190:119128.
189. Sandhu, G. S.,, B. C. Kline,, L. Stockman, and, G. D. Roberts. 1995. Molecular probes for diagnosis of fungal infections. J. Clin. Microbiol. 33:29132919.
190. Sanguinetti, M.,, R. Porta,, M. Sali,, M. La Sorda,, G. Pecorini,, G. Fadda, and, B. Posteraro. 2007. Evaluation of Vitek 2 and RapID Yeast Plus systems for yeast species identification: experience at a large clinical microbiology laboratory. J. Clin. Microbiol. 45:13431346.
191. San Millan, R.,, L. Ribacoba,, J. Ponton, and, G. Quindos. 1996. Evaluation of a commercial medium for identification of Candida species. Eur. J. Clin. Microbiol. Infect. Dis. 15:153158.
192. Saunte, D. M.,, L. Klingspor,, S. Jatal,, J. Amau, and, M. C. Arendrup. 2005. Four cases of Candida albicans infections with isolates developing pink colonies on CHROMagar Candida plates. Mycoses 48:378381.
193. Schabereiter-Gurtner, C.,, B. Selitsch,, M. L. Rotter,, A. M. Hirschl, and, B. Willinger. 2007. Development of novel realtime PCR assays for detection and differentiation of eleven medically important Aspergillus and Candida species in clinical specimens. J. Clin. Microbiol. 45:906914.
194. Scorzetti, G.,, J. W. Fell,, A. Fonseca, and, A. Statzell-Tallman. 2002. Systematics of basidiomycetous yeasts: a comparison of large subunit D1/D2 and internal transcribed spacer rDNA regions. FEMS Yeast Res. 2:495517.
195. Selvarangan, R.,, U. Bui,, A. P. Limaye, and, B. T. Cookson. 2003. Rapid identification of commonly encountered Candida species directly from blood culture bottles. J. Clin. Microbiol. 41:56605664.
196. Sendid, B.,, N. Francois,, A. Standaert,, E. Dehecq,, F. Zerimech,, D. Camus, and, D. Poulain. 2007. Prospective evaluation of the new chromogenic medium Candi Select 4 for differentiation and presumptive identification of the major pathogenic Candida species. J. Med. Microbiol. 56:495499.
197. Sendid, B.,, C. Lacroix, and, M. E. Bougnoux. 2006. Is Candida kefyr an emerging pathogen in patients with oncohematological diseases? Clin. Infect. Dis. 43:666667.
198. Sendid, B.,, M. Tabouret,, J. L. Poirot,, D. Mathieu,, J. Fruit, and, D. Poulain. 1999. New enzyme immunoassay for sensitive detection of circulating Candida albicans mannan and antimannan antibodies: useful combined test for diagnosis of systemic candidiasis. J. Clin. Microbiol. 37:15101517.
199. Shepard, J. R.,, R. M. Addison,, B. D. Alexander,, P. Della-Latta,, M. Gherna,, G. Hasse,, G. Hall,, J. K. Johnson,, W. G. Merz,, H. Peltroche-Llacsahuanga,, H. Stender,, R. A. Venezia,, D. Wilson,, G. W. Procop,, F. Wu, and, M. J. Fiandaca. 2008. Multicenter evaluation of the Candida albicans/Candida glabrata peptide nucleic acid fluorescent in situ hybridization method for simultaneous dual color identification of Candida albicans and Candida glabrata directly from blood culture bottles. J. Clin. Microbiol. 46:5055.
200. Shin, J. H.,, F. S. Nolte, and, C. J. Morrison. 1997. Rapid identification of Candida species in blood cultures by a clinically useful PCR method. J. Clin. Microbiol. 35:14541459.
201. Shin, J. H.,, F. S. Nolte,, B. P. Holloway, and, C. J. Morrison. 1999. Rapid identification of up to three Candida species in a single reaction tube by a 5’ exonuclease assay using fluorescent DNA probes. J. Clin. Microbiol. 37:165170.
202. Shin, D. H.,, J. H. Park,, J. H. Shin,, S. P. Suh,, D. W. Ryang, and, S. J. Kim. 2003. Pichia ohmeri fungaemia associated with phlebitis: successful treatment with amphotericin B. J. Infect. Chemother. 9:8889.
203. Shrestha, R. K.,, J. K. Stoller,, G. Honari,, G. W. Procop, and, S. M. Gordon. 2004. Pneumonia due to Cryptococcus neoformans in a patient receiving infliximab: possible zoonotic transmission from a pet cockatiel. Respir. Care 49:606608.
204. Simon, G.,, G. Simon,, M. Erdos, and, M. Laszlo. 2005. Invasive Cryptococcus laurentii disease in a nine-year-old boy with X-linked hyper-immunoglobulin M syndrome. Pediatr. Infect. Dis. J. 24:935937.
205. Smith, M. B.,, D. Dunklee,, H. Vu, and, G. L. Woods. 1999. Comparative performance of the RapID Yeast Plus system and the API 20C AUX clinical yeast system. J. Clin. Microbiol. 37:26972698.
206. Spiess, B.,, W. Seifarth,, M. Hummel,, O. Frank,, A. Fabarius,, C. Zheng,, H. Morz,, R. Hehlmann, and, D. Buchheidt. 2007. DNA microarray-based detection and identification of fungal pathogens in clinical samples from neutropenic patients. J. Clin. Microbiol. 45:37433753.
207. Strockbine, N. A.,, M. T. Largen,, S. M. Zweibel, and, H. R. Buckley. 1984. Identification and molecular weight characterization of antigens from Candida albicans that are recognized by human sera. Infect. Immun. 43:715721.
208. Sugita, T.,, M. Tajima,, M. Amaya,, R. Tsuboi, and, A. Nishikawa. 2004. Genotype analysis of Malassezia restricta as the major cutaneous flora in patients with atopic dermatitis and healthy subjects. Microbiol. Immunol. 48:755759.
209. Sugita, T.,, M. Tajima,, M. Takashima,, M. Amaya,, M. Saito,, R. Tsuboi, and, A. Nishikawa. 2004. A new yeast, Malassezia yamatoensis, isolated from a patient with seborrheic dermatitis, and its distribution in patients and healthy subjects. Microbiol. Immunol. 48:579583.
210. Sugita, T.,, M. Takashima,, M. Kodama,, R. Tsuboi, and, A. Nishikawa. 2003. Description of a new yeast species, Malassezia japonica, and its detection in patients with atopic dermatitis and healthy subjects. J. Clin. Microbiol. 41:46954699.
211. Sugita, T.,, M. Takashima,, T. Skinoda,, H. Suto,, T. Unno,, R. Tsuboi,, H. Ogawa, and, A. Nishikawa. 2002. A new yeast species, Malassezia dermatis, isolated from patients with atopic dermatitis. J. Clin. Microbiol. 40:13631367.
212. Sullivan, D. J.,, T. J. Westereng,, K. A. Haynes,, D. E. Bennett, and, D. C. Coleman. 1995. Candida dubliniensis sp. nov.: phenotypic and molecular characterization of a novel species associated with oral candidosis in HIV-infected individuals. Microbiology 141:15071521.
213. Tavanti, A.,, A. D. Davidson,, N. A. Gow,, M. C. Maiden, and, F. C. Odds. 2005. Candida orthopsilosis and Candida metapsilosis sp. nov. to replace Candida parapsilosis groups II and III. J. Clin. Microbiol. 43:284292.
214. Thuler, L. C.,, S. Faivichenco,, E. Velasco,, C. A. Martins,, C. R. Nascimento, and, I. A. Castilho. 1997. Fungemia caused by Hansenula anomala: an outbreak in a cancer hospital. Mycoses 40:193196.
215. Trick, W. E.,, S. K. Fridkin,, J. R. Edwards,, R. A. Hajjeh,, R. P. Gaynes, andNational Nosocomial Infections Surveillance System Hospitals. 2002. Secular trend of hospital-acquired candidemia among intensive care unit patients in the United States during 1989–1999. Clin. Infect. Dis. 35:627630.
216. Turenne, C. Y.,, S. E. Sanche,, D. J. Hoban,, J. A. Karlowsky, and, A. M. Kabani. 1999. Rapid identification of fungi by using the ITS2 genetic region and an automated fluorescent capillary electrophoresis system. J. Clin. Microbiol. 37:18461851.
217. Upton, A.,, J. A. Faser,, S. E. Kidd,, C. Bretz,, K. H. Bartlett,, J. Heitman, and, K. A. Marr. 2007. First contemporary case of human infection with Cryptococcus gattii in Puget Sound: evidence for spread of the Vancouver Island outbreak. J. Clin. Microbiol. 45:30863088.
218. Verweij, P. E.,, I. M. Breuker,, A. J. Rijs, and, J. F. Meis. 1999. Comparative study of seven commercial yeast identification systems. J. Clin. Pathol. 52:271273.
219. Vilchez, R. A.,, J. Fung, and, S. Kusne. 2002. Cryptococcosis in organ transplant recipients: an overview. Am. J. Transplant. 2:575580.
220. Walsh, T. J.,, and S. J. Chanock. 1998. Diagnosis of invasive fungal infections: advances in nonculture systems. Curr. Clin. Top. Infect. Dis. 18:101153.
221. Walsh, T. J.,, A. Fracesconi,, M. Kasai, and, S. J. Chanock. 1995. PCR and single-strand conformational polymorphism for recognition of medically important opportunistic fungi. J. Clin. Microbiol. 33:32163220.
222. Walsh, T. J.,, J. W. Hathorn,, J. D. Sobel,, W. G. Merz,, V. Sanchez,, S. M. Maret,, H. R. Buckley,, M. A. Pfaller,, R. Schaufele,, C. Sliva,, E. Navarro,, J. Lecciones,, P. Chandrasekar,, J. Lee, and, P. A. Pizzo. 1991. Detection of circulating enolase by immunoassay in patients with cancer and invasive candidiasis. N. Engl. J. Med. 324:10261031.
223. Walsh, T. J.,, W. G. Merz,, J. W. Lee,, R. Schaufele,, T. Sein,, P. O. Whitcomb,, M. Ruddel,, W. Burns,, J. R. Wingard,, A. C. Switchenko,, T. Goodman, and, P. A. Pizzo. 1995. Diagnosis and therapeutic monitoring of invasive candidiasis by rapid enzymatic detection of serum d-arabinitol. Am. J. Med. 99:164172.
224. Wang, C. J. K.,, and J. Schwarz. 1958. The etiology of interstitial pneumonia. Identification as Hansenula anomala of yeast isolated from lung of infants. Mycopathol. Mycol. Appl. 9:299306.
225. Warnock, D. W. 2007. Trends in the epidemiology of invasive fungal infections. Nippon Ishinkin Gakkai Zasshi 48:112.
226. Weiner, M. H.,, and W. J. Yount. 1976. Mannan antigenemia in the diagnosis of invasive Candida infections. J. Clin. Investig. 58:10451053.
227. Wheat, L. J. 2006. Antigen detection, serology and molecular diagnosis of invasive mycoses in the immunocompromised host. Transpl. Infect. Dis. 8:128139.
228. White, P. L.,, A. E. Archer, and, R. A. Barnes. 2005. Comparison of non-culture-based methods for detection of systemic fungal infections, with an emphasis on invasive Candida infections. J. Clin. Microbiol. 43:21812187.