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Chapter 12 : Mycobacteria

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Mycobacteria, Page 1 of 2

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Abstract:

In general terms, the mycobacteria are divided into the complex (MTBC) and the nontuberculous mycobacteria (NTM). NTM immune reconstitution syndrome (IRS), in contrast, may be seen in HIV-infected patients with no previous history of mycobacterial disease, apparently representing an unmasking of subclinical disease in these cases. The most frequently isolated pathogens were rapidly growing mycobacteria, followed by and , for kidney transplant recipients; , complex (MAC), and for heart recipients; MAC, M, and for lung recipients; and MAC for liver transplant recipients. Historically, mycobacteria have been detected and identified by using the conventional methods of acid-fast bacilli (AFB) smear and culture. Specimens are digested and decontaminated using a sodium hydroxide and N-acetyl-L-cysteine method to prepare a concentrated sediment. This sediment can then be used to prepare smears for microscopy and to inoculate media for recovery of mycobacterial growth. The niacin test is one that provides information to separate from other mycobacteria: produces detectable amounts of niacin, while most NTM and do not. Fluorochrome stains are more sensitive than carbol-fuchsin stains, and broth-based culture systems are more sensitive than solid media for isolation of mycobacteria. Clinical equipment (e.g., bronchoscopes) may become contaminated by mycobacteria and then inadequately high-level disinfected or sterilized, causing contamination of specimens from subsequent patients examined with the same instrument or transmission of tuberculosis.

Citation: Warren N, Woods G. 2009. Mycobacteria, p 253-267. In Hayden R, Carroll K, Tang Y, Wolk D (ed), Diagnostic Microbiology of the Immunocompromised Host. ASM Press, Washington, DC. doi: 10.1128/9781555815455.ch12

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Figure 1.

Algorithm for AFB testing.

Citation: Warren N, Woods G. 2009. Mycobacteria, p 253-267. In Hayden R, Carroll K, Tang Y, Wolk D (ed), Diagnostic Microbiology of the Immunocompromised Host. ASM Press, Washington, DC. doi: 10.1128/9781555815455.ch12
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References

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1. Agerton, T.,, S. Valway,, B. Gore,, C. Pozsik,, B. Plikaytis,, C. Woodley, and, I. Ororato. 1997. Transmission of a highly drug-resistant strain (strain W1) of Mycobacterium tuberculosis: community outbreak and nosocomial transmission via a contaminated bronchoscope. JAMA 278:10731077.
2. Askling, J.,, C. M. Fored,, L. Brandt,, E. Baecklund,, L. Bertilsson,, L. Cöster,, P. Geborek,, L. T. Jacobsson,, S. Lindblad,, J. Lysholm,, S. Rantapää-Dahlqvist,, T. Saxne,, V. Romanus,, L. Klareskog, and, N. Feltelius. 2006. Risk and case characteristics of tuberculosis in rheumatoid arthritis associated with tumor necrosis factor antagonists in Sweden. Arthritis Rheum. 52:19861992.
3. Barbar, T. W.,, D. E. Craven, and, H. W. Farber. 1991. Mycobacterium gordonae: a possible opportunistic respiratory tract pathogen in patients with advanced human immunodeficiency virus, type 1 infection. Chest 100:716720.
4. Bashar, M.,, P. Alcabes,, W. N. Rom, and, R. Condos. 2001. Increased incidence of multi-drug resistant tuberculosis in diabetic patients on the Bellevue chest service, 1987 to 1997. Chest 120:15141519.
5. Bhattacharya, M.,, S. Dietrich,, L. Mosher,, F. Saddiqui,, B. E. Reisberg,, W. S. Paul, and, J. R. Warren. 1998. Cross-contamination of specimens with Mycobacterium tuberculosis: clinical significance, causes, and prevention. Am. J. Clin. Pathol. 109:324330.
6. Bloch, K. C.,, L. Zwerling,, M. J. Pletcher,, J. A. Hahn,, J. L. Gerberding,, S. M. Ostroff,, D. J. Vugia, and, A. I. Reingold. 1998. Incidence and clinical implications of isolation of Mycobacterium kansasii: results of a 5 year, population-based study. Ann. Intern. Med. 129:698704.
7. Bouza, E.,, J. G. Moya, and, P. Munñoz. 2001. Infections in systemic lupus erythematosus and rheumatoid arthritis. Infect. Dis. Clin. N. Am. 15:335361.
8. Brassard, P.,, A. Kezouh, and, S. Suissa. 2006. Antirheumatic drugs and the risk of tuberculosis. Clin. Infect. Dis. 43:717722.
9. Brown, N. M.,, E. A. Hellyar,, J. E. Harvey, and, D. S. Reeves. 1993. Mycobacterial contamination of fibreoptic bronchoscopes. Thorax 48:12831285.
10. Brown-Elliott, B. A.,, and R. J. Wallace, Jr. 2002. Clinical and taxonomic status of pathogenic nonpigmented or late-pigmenting rapidly growing mycobacteria. Clin. Microbiol. Rev. 15:716746.
11. Brown-Elliot, B. A.,, and R. J. Wallace, Jr. 2005. Infections caused by nontuberculous mycobacteria, p. 2909–2916. In G. L. Mandell,, R. G. Douglass, Jr., and, J. E. Bennett (ed.), Principles and Practice of Infectious Diseases, 6th ed. Elsevier Churchill Livingstone, Philadelphia, PA.
12. Burman, W. J.,, and R. R. Reves. 2000. Review of false-positive cultures for Mycobacterium tuberculosis and recommendations for avoiding unnecessary treatment. Clin. Infect. Dis. 31:13901395.
13. Butler, W. R.,, and L. S. Guthertz. 2001. Mycolic acid analysis by high-performance liquid chromatography for identification of Mycobacterium species. Clin. Microbiol. Rev. 14:704726.
14. Carmona, L.,, C. Hernández-García,, C. Vadillo,, E. Pato,, A. Balsa,, I. González-álvaro,, M. A. Belmonte,, X. Tena,, R. Sanmartí, and the EMECAR Study Group. 2003. Increased risk of tuberculosis in patients with rheumatoid arthritis. J. Rheumatol. 30:14361439.
15. Centers for Disease Control and Prevention. 2000. Update: nucleic acid amplification tests for tuberculosis. MMWR Morb. Mortal. Wkly. Rep. 49:593594.
16. Clinical and Laboratory Standards Institute. 2006. Laboratory detection and identification of mycobacteria; proposed guideline. CLSI document M48-P. Clinical and Laboratory Standards Institute, Wayne, PA.
17. Clinical and Laboratory Standards Institute. 2003. Susceptibility testing of Mycobacteria, Nocardiae, and other aerobic actinomycetes; approved standard. CSLI document M24-A. Clinical and Laboratory Standards Institute, Wayne, PA.
18. Corbett, E. L,, G. J. Churchyard,, M. Hay,, P. Herselman,, T. Clayton,, B. Williams,, R. Hayes,, D. Mulder, and, K. M. De Cock. 1999. The impact of HIV infection of Mycobacterium kansasii disease in South African gold miners. Am. J. Respir. Crit. Care Med. 160:1014.
19. Crum, N. F.,, E. R. Lederman, and, M. R. Wallace. 2005. Infections associated with tumor necrosis factor-α antagonists. Medicine 84:291302.
20. Doucet-Populaire, F.,, V. Lalande,, E. Carpentier,, A. Bourgoin,, M. Dailloux,, C. Bollet,, A. Vachee,, D. Moinard,, J. Texier-Maugein,, B. Carbonelle, and, J. Grosset. 1996. A blind study of the polymerase chain reaction for the detection of Mycobacterium tuberculosis DNA. Tuber. Lung Dis. 77:358362.
21. Doucette, K.,, and J. A. Fishman. 2004. Nontuberculous mycobacterial infection in hematopoietic stem cell and solid organ transplant recipients. Clin. Infect. Dis. 38:14281439.
22. Eckburg, P. B.,, E. O. Buadu,, P. Stark,, P. S. A. Sarinas,, R. K. Chitkara, and, W. G. Kuschner. 2000. Clinical and chest radiographic findings among persons with sputum culture positive for Mycobacterium gordonae. Chest 117:96102.
23. Falkinham, J. O., III. 1996. Epidemiology of infection by nontuberculous mycobacteria. Clin. Microbiol. Rev. 9:177215.
24. Field, S. K.,, and R. L. Cowie. 2006. Lung disease due to the more common nontuberculous mycobacteria. Chest 129:16531672.
25. Fournier, S.,, G. Piaious, and, V. Vincent. 1998. Mycobacterium genavense and cutaneous disease in AIDS. Ann. Int. Med. 128:409410.
26. Gómez-Reino, J. J.,, L. Carmona,, V. R. Valverde,, E. M. Mola, and M. D. Montero on behalf of the BIOBADASER Group. 2003. Treatment of rheumatoid arthritis with tumor necrosis factor inhibitors may predispose to significant increase in tuberculosis risk. Arthritis Rheum. 48:21222127.
27. Gordin, F. M.,, and R. C. Horsburgh. 2005. Mycobacterium avium complex, p. 2897–2909. In G. L. Mandell,, R. G. Douglass, and, J. E. Bennett (ed.), Principles and Practice of Infectious Disease, 6th ed. Elsevier Churchill Livingstone, Philadelphia, PA.
28. Gubler, J. G. H.,, M. Salfinger, and, A. Graevenitz. 1992. Pseudoepidemic of nontuberculous mycobacteria due to a contaminated bronchoscope cleaning machine: report of an outbreak and review of the literature. Chest 101:12451251.
29. Jie, T.,, A. J. Matas,, K. J. Gillingham,, D. E. R. Sutherland,, D. L. Dunn, and, A. Humar. 2005. Mycobacterial infections after kidney transplant. Transplant. Proc. 37:937939.
30. Juffermans, N. P.,, A. Verbon,, S. A. Danner,, E. J. Kuijper, and, P. Speelman. 1998. Mycobacterium xenopi in HIV-infected patients: an emerging pathogen. AIDS 12:16611666.
31. Karakousis, P. C.,, R. D. Moore, and, R. E. Chaisson. 2004. Mycobacterium avium complex in patients with HIV infection in the era of highly active antiretroviral therapy. Lancet Infect. Dis. 4:557565.
32. Keane, J.,, S. Gershon,, R. P. Wise,, E. Mirabile-Levens,, J. Kasznica,, W. D. Schwieterman,, J. N. Siegel, and, M. M. Braun. 2001. Tuberculosis associated with infliximab, a tumor necrosis factor α-neutralizing agent. N. Engl. J. Med. 345:10981104.
33. Koya, M. P.,, M. A. Simon, and, M. S. Soloway. 2006. Complications of intravesical therapy for urothelial cancer of the bladder. J. Urol. 175:20042010.
34. Lamm, D. L.,, A. P. M. Van Der Meijden,, A. Morales,, S. A. Brosman,, W. J. Catalona,, H. W. Herr,, M. S. Soloway,, A. Steg, and, F. M. J. Debruyne. 1992. Incidence and treatment of complications of bacillus Calmette-Guerin intravesical therapy in superficial bladder cancer. J. Urol. 147:596600.
35. Lan, N. T. N.,, C. D. Wells,, N. J. Binkin,, J. E. Becerra,, P. D. Linh, and, N. V. Co. 1999. Quality control of smear microscopy for acid-fast bacilli: the case for blinded re-reading. Int. J. Tuberc. Lung Dis. 3:5561.
36. Lipsky, B. A.,, J. Gates,, F. C. Tenover, and, J. J. Plorde. 1984. Factors affecting the clinical value of microscopy for acid-fast bacilli. Rev. Infect. Dis. 6:214222.
37. Ludvigsson, J. F.,, J. Wahlstrom,, J. Grunewald,, A. Ekbom, and, S. M. Montgomery. 2006. Coeliac disease and risk of tuberculosis: a population based cohort study. Thorax 62:2328.
38. Maini, R.,, E. W. St. Clair,, F. Breedveld,, D. Furst,, J. Kalden,, M. Weisman,, J. Smolen,, P. Emery,, G. Harriman,, M. Feld-mann, and P. Lipsky for the ATTRACT Study Group. 1999. Infliximab (chimeric anti-tumor necrosis factor α monoclonal antibody) versus placebo in rheumatoid arthritis patients receiving concomitant methotrexate: a randomized phase III trial. Lancet 354:19321939.
39. Mazurek, G. H.,, J. Jereb,, P. LoBue,, M. F. Iademarco,, B. Metchock, and, A. Vernon. 2005. Guidelines for using the QuantiFERON-TB Gold test for detecting Mycobacterium tuberculosis infection, United States. MMWR Morb. Mortal. Wkly. Rep. 54:4955.
40. McNabb, S. J. N.,, C. R. Braden, and, T. R. Navin. 2002. DNA fingerprinting of Mycobacterium tuberculosis: lessons learned and implications for the future. Emerg. Infect. Dis. 8:13141319.
41. Miguez-Burbano, M. J.,, M. Flores,, D. Ashkin,, A. Rodriguez,, A. M. Granada,, N. Quintero, and, A. Pitchenik. 2006. Nontuberculous mycobacteria disease as a cause of hospitalization in HIV-infected subjects. Int. J. Infect Dis. 10:4755.
42. Mori, T.,, M. Sakatani,, F. Yamagishi,, T. Takashima,, Y. Kawabe,, K. Nagao,, E. Shigeto,, N. Harada,, S. Mitarai,, M. Okada,, K. Suzuki,, Y. Inoue,, K. Tsuyuguchi,, Y. Sasaki,, G. H. Mazurek, and, I. Tusyuguchi. 2004. Specific detection of tuberculosis infection: an interferon-γ-based assay using new antigens. Am. J. Respir. Crit. Care Med. 170:5964.
43. Munoåz, P.,, C. Rodríquez, and, E. Bouza. 2005. Mycobacterium tuberculosis infection in recipients of solid organ transplants. Clin. Infect. Dis. 40:581587.
44. Pablos-Méndez, A.,, J. Blustein, and, C. A. Knirsch. 1997. The role of diabetes mellitus in the higher prevalence of tuberculosis among Hispanics. Am. J. Public Health 87:574579.
45. Pérez-Guzmán, C.,, A. Torres-Cruz,, H. Villarreal-Velarde,, M. A. Salazar-Lezama, and, M. H. Vargas. 2001. Atypical radiological images of pulmonary tuberculosis in 192 diabetic patients: a comparative study. Int. J. Tuberc. Lung Dis. 5:455461.
46. Philips, P.,, S. Bonner,, N. Gataric,, T. Bai,, P. Wilcox,, R. Hogg,, M. O’Shaughnessy, and, J. Montaner. 2005. Nontuberculous mycobacterial immune reconstitution syndrome in the HIV infected patients: spectrum of disease and long-term follow-up. Clin. Infect. Dis. 41:14831497.
47. Ponce-De-Leon, A.,, M. L. Garcia-Garcia,, M. C. Garcia-Sancho,, F. J. Gomez-Perez,, J. L. Valdespino-Gomez,, G. Olaiz-Fernandez,, R. Rojas,, L. Ferreyra-Reyes,, B. Cano-Arellano,, M. Bobadilla,, P. M. Small, and, J. Sifuentes-Osornio. 2004. Tuberculosis and diabetes in southern Mexico. Diabetes Care 27:15841590.
48. Queipo, J. A.,, E. Broseta,, M. Santos,, J. Sánchez-Plumed,, A. Budía, and, F. Jiménez-Cruz. 2003. Mycobacterial infection in a series of 1261 renal transplant recipients. Clin. Microbiol. Infect. 9:518525.
49. Ramos, M. C.,, H. Soini,, G. C. Roscanni,, M. Jacques,, M. C. Villares, and, J. M. Musser. 1999. Extensive cross-contamination of specimens with Mycobacterium tuberculosis in a reference laboratory. J. Clin. Microbiol. 37:916919.
50. Rusch-Gerdes, S.,, G. E. Pfyffer,, M. Casal,, M. Chadwick, and, S. Siddiqi. 2006. Multicenter laboratory validation of the BACTEC MGIT 960 technique for testing susceptibilities of Mycobacterium tuberculosis to classical second-line drugs and newer antimicrobials. J. Clin. Microbiol. 44:688692.
51. Saubolle, M. A.,, T. E. Kiehn,, M. H. White,, M. F. Rudinsky and, D. Armstrong. 1996. Mycobacterium haemophilum: microbiology and expanding clinical and geographic spectra of disease in humans. Clin. Microbiol. Rev. 9:435447.
52. Schneider, E.,, M. Moore, and, K. G. Castro. 2005. Epidemiology of tuberculosis in the United States. Clin. Chest Med. 26:183-195.
53. Segal-Maurer, S.,, B. N. Kreisworth,, J. M. Burns,, S. Lavie,, M. Lim,, C. Urban, and, J. J. Rahal. 1998. Mycobacterium tuberculosis specimen contamination revisited: the role of laboratory environmental control in a pseudo-outbreak. Infect. Control Hosp. Epidemiol. 19:101105.
54. Sepkowitz, K. A.,, J. Raffalli,, L. Riley,, T. E. Kiehn, and, D. Armstrong. 1995. Tuberculosis in the AIDS era. Clin. Microbiol. Rev. 8:180199.
55. Singh, N.,, and D. L. Paterson. 1998. Mycobacterium tuberculosis infection in solid organ transplant recipients: impact and implications for management. Clin. Infect. Dis. 27:12661277.
56. Singla, R.,, N. Khan,, N. Al-Sharif,, M. O. Al-Sayegh,, M. A. Shaikh, and, M. M. Osman. 2006. Influence of diabetes on manifestations and treatment outcome of pulmonary TB patients. Int. J. Tuberc. Lung Dis. 10:7479.
57. Small, P. M.,, N. B. McClenny,, S. P. Singh,, G. K. Schoolnik,, L. S. Tompkins, and, P. A. Mickelsen. 1993. Molecular strain typing of Mycobacterium tuberculosis to confirm cross-contamination in the mycobacteriology laboratory and modification of procedure to minimize occurrence of false-positive cultures. J. Clin. Microbiol. 31:16771682.
58. Suffys, P. N.,, A. da Silva Rocha,, M. de Oliveira,, C. E. D. Campos,, A. M. W. Barreto,, F. Portaels,, L. Rigouts,, G. Wouteers,, G. Jannes,, G. van Reybroeck,, W. Mijs, and, R. Vanderborght. 2003. Rapid identification of mycobacteria to the species level using INNO-LiPA mycobacteria, a reverse hybridization assay. J. Clin. Microbiol. 39:44774482.
59. Tenover, F.,, J. Crawford,, R. Huebner,, L. Getter,, C. R. Horsburgh, Jr., and, R. C. Good. 1993. The resurgence of tuberculosis: is your laboratory ready? J. Clin. Microbiol. 32:767770.
60. Thwaites, G. E.,, D. B. Nguyen,, H. D. Nguyen,, T. Q. Hoang,, T. T. O. Do,, T. C. T. Nguyen,, Q. H. Nguyen,, T. T. Nguyen,, N. H. Nguyen,, T. N. L. Nguyen,, N. L. Nguyen,, H. D. Nguyen,, N. T. Vu,, H. H. Cao,, T. H. C. Tran,, P. M. Pham,, T. D. Nguyen,, S. Kasia,, C. P. Simmons,, N. J. White,, T. H. Tran, and, J. J. Farrar. 2005. The influence of HIV infection on clinical presentation, response to treatment, and outcome in adults with tuberculous meningitis. J. Infect. Dis. 192:21342141.
61. Tjhie, J. H. T.,, A. F. van Belle,, M. Dessens-Droon, and, D. van Soolingen. 2001. Misidentification and diagnostic delay caused by a false-positive amplified Mycobacterium tuberculosis direct test in an immunocompetent patient with a Mycobacterium celatum infection. J. Clin. Microbiol. 39:23112312.
62. Tortoli, E. 2003. Impact of genotypic studies on mycobacterial taxonomy: the new mycobacteria of the 1990s. Clin. Microbiol. Rev. 16:319354.
63. Vincent, V.,, B. A. Brown-Elliot,, K. C. Jost, Jr., and, R. J. Wallace, Jr. 2003. Mycobacterium: phenotypic and genotypic identification, p. 560–584. In P. R. Murray,, E. J. Baron,, J. H. Jorgensen,, M. A. Pfaller, and, R. H. Yolken (ed.), Manual of Clinical Microbiology, 8th ed. ASM Press, Washington, DC.
64. Wallace, R. J., Jr.,, J. Glassroth,, D. E. Griffith,, K. N. Oliver,, J. L. Cook, and, F. Gordin. 1997. Diagnosis and treatment of disease caused by nontuberculous mycobacteria. Am. J. Respir. Crit. Care Med. 156:S1S25.
65. Weinberger, M.,, S. L. Berg,, I. M. Feuerstein,, P. A. Pizzo, and, F. G. Witebsky. 1992. Disseminated infection with Mycobacterium gordonae: report of a case and critical review of the literature. Clin. Infect. Dis. 14:12291239.
66. Wright, P. W.,, R. J. Wallace, Jr.,, N. W. Wright,, B. A. Brown, and, D. E. Griffith. 1998. Sensitivity of fluorochrome microscopy for detection of Mycobacterium tuberculosis versus nontuberculous mycobacteria. J. Clin. Microbiol. 36:10461049.

Tables

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Table 1.

Phenotypic characteristics of selected mycobacteria

Citation: Warren N, Woods G. 2009. Mycobacteria, p 253-267. In Hayden R, Carroll K, Tang Y, Wolk D (ed), Diagnostic Microbiology of the Immunocompromised Host. ASM Press, Washington, DC. doi: 10.1128/9781555815455.ch12
Generic image for table
Table 2.

Phenotypic groupings of mycobacteria

Citation: Warren N, Woods G. 2009. Mycobacteria, p 253-267. In Hayden R, Carroll K, Tang Y, Wolk D (ed), Diagnostic Microbiology of the Immunocompromised Host. ASM Press, Washington, DC. doi: 10.1128/9781555815455.ch12
Generic image for table
Table 3.

Comparison of conventional and newer mycobacterial test methods

Citation: Warren N, Woods G. 2009. Mycobacteria, p 253-267. In Hayden R, Carroll K, Tang Y, Wolk D (ed), Diagnostic Microbiology of the Immunocompromised Host. ASM Press, Washington, DC. doi: 10.1128/9781555815455.ch12
Generic image for table
Table 4.

Suggested turnaround times for mycobacteriology laboratory tests

Citation: Warren N, Woods G. 2009. Mycobacteria, p 253-267. In Hayden R, Carroll K, Tang Y, Wolk D (ed), Diagnostic Microbiology of the Immunocompromised Host. ASM Press, Washington, DC. doi: 10.1128/9781555815455.ch12
Generic image for table
Table 5.

Primary and secondary drugs for susceptibility testing of mycobacteria

Citation: Warren N, Woods G. 2009. Mycobacteria, p 253-267. In Hayden R, Carroll K, Tang Y, Wolk D (ed), Diagnostic Microbiology of the Immunocompromised Host. ASM Press, Washington, DC. doi: 10.1128/9781555815455.ch12

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