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Chapter 17 : subsp. : an Unconventional Pathogen?

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Abstract:

The complex includes the closely related subsp. , subsp. , and , as well as the wood pigeon . In recent years, complex strains have assumed greater importance in human medicine, largely because of intractable complex infections in AIDS patients and also because of the possible association of subsp. with Crohn’s disease. subsp. is the causative agent of Johne’s disease (or paratuberculosis), a debilitating chronic enteritis in ruminants. Current research based on understanding of the genomic diversity among subsp. strains is now enabling elucidation of mechanisms of survival in the environment, host specificity, and the association of specific genotypes with overt disease versus subclinical states. The infected macrophages play a critical role in the pathogenesis of the disease and dictate the disease outcome. In this chapter the authors have investigated the nature of macrophage subsp. interactions. Contaminated domestic water, pasteurized milk, contaminated meat or other food, environmental sources, and direct animal exposures have all been suggested as possible mechanisms of human exposure to subsp. . Comprehensive analysis of these survival mechanisms at the transcriptome and proteome levels is expected to improve one's understanding of host-pathogen and pathogen-environment interactions of subsp. .

Citation: Sreevatsan S, Cernicchiaro N, Kaushik R. 2009. subsp. : an Unconventional Pathogen?, p 311-321. In Jaykus L, Wang H, Schlesinger L (ed), Food-Borne Microbes. ASM Press, Washington, DC. doi: 10.1128/9781555815479.ch17

Key Concept Ranking

Crohn's Disease
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Chemicals
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Mycobacterium intracellulare
0.54670143
Mycobacterium tuberculosis
0.54670143
Mycobacterium intracellulare
0.54670143
Mycobacterium tuberculosis
0.54670143
Mycobacterium intracellulare
0.54670143
Mycobacterium tuberculosis
0.54670143
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References

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