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Recent taxonomic analysis using the 16S and 23S rRNA genes have found that the order contains at least four distinct groups at the family level and that within the order are two distinct lineages. Chlamydiae also share a group-specific lipopolysaccharide (LPS) antigen and utilize host adenosine triphosphate for the synthesis of chlamydial protein. Beatty and coworkers demonstrated that the addition of 0.2 ng/ml of IFN-γ inhibited intracellular growth of in HeLa cells by induction of the indoleamine 2,3- dioxygenase, leading to a persistent state. The development of large aberrant reticulate body (RB) forms combined with the absence of elementary bodies (EBs) was characteristic of persistent infection. is a common human respiratory pathogen, affecting all ages with a worldwide distribution. While appears to be clearly associated with asthma exacerbations, it has also been hypothesized to have a role in asthma pathogenesis. The presence of anti- immunoglobulin (Ig)A antibodies or IgG titer has been correlated, but not consistently, with markers of asthma severity and/or wheezing. It has been hypothesized that an inadequate or delayed clearance of the pathogen may lead to the establishment of a latent or persistent infection, which fuels a low-grade chronic immune response that causes tissue damage. Recognition of chlamydial antigens by the cytosolic NOD1 receptor appeared to be of limited biological significance in a mouse study using and , which could be explained by insufficient peptidoglycan (PGN) production by .

Citation: Hammerschlag M, Kohlhoff S, Darville T. 2009. and , p 27-52. In Fratamico P, Smith J, Brogden K (ed), Sequelae and Long-Term Consequences of Infectious Diseases. ASM Press, Washington, DC. doi: 10.1128/9781555815486.ch3

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Lower Respiratory Tract Infections
Tumor Necrosis Factor alpha
Transforming Growth Factor beta
Restriction Fragment Length Polymorphism
Transforming Growth Factor beta
Restriction Fragment Length Polymorphism
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Figure 1.

Life cycle of chlamydiae in epithelial cells.

Citation: Hammerschlag M, Kohlhoff S, Darville T. 2009. and , p 27-52. In Fratamico P, Smith J, Brogden K (ed), Sequelae and Long-Term Consequences of Infectious Diseases. ASM Press, Washington, DC. doi: 10.1128/9781555815486.ch3
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1. Airenne, S.,, A. Kinnunen,, M. Leinonen,, P. Saikku, and, H. M. Surcel. 2002. Secretion of IL-10 and IL-12 in Chlamydia pneumoniae infected human monocytes, p. 77–80. Proceedings of the Tenth International Symposium on Human Chlamydial Infections. International Chlamydia Symposium, San Francisco, CA.
2. Allegra, L.,, F. Blasi,, S. Centanni,, R. Cosentini,, F. Denti,, R. Raccanelli,, P. Tarsia, and, V. Valenti. 1994. Acute exacerbations of asthma in adults: role of Chlamydia pneumoniae. Eur. Respir. J. 7:21652168.
3. Alonso, A.,, S. S. Jick,, H. Jick, and, M. A. Hernan. 2006. Antibiotic use and risk of multiple sclerosis. Am. J. Epidemiol. 163:9971002.
4. Andraws, R.,, J. S. Berger, and, D. L. Brown. 2005. Effects of antibiotic therapy on outcomes of patients with coronary artery disease. A meta-analysis of randomized controlled trials. JAMA 293:26412647.
5. Apfalter, P.,, F. Blasi,, J. Boman,, C. A. Gaydos,, M. Kundi,, M. Maass,, A. Makristathis,, A. Meijer,, R. Nadrchal,, K. Persson,, M. L. Rotter., C. Y. W. Tong,, G. Stanek, and, A. M. Hirschl. 2001. Multicenter comparison trial of DNA extraction methods and PCR assays for detection of Chlamydia pneumoniae in endarterectomy specimens. J. Clin. Microbiol. 39:519524.
6. Apfalter, P.,, O. Assadian,, F. Blasi,, C. A. Gaydos,, M. Kundi,, M. Maass,, A. Makristathis,, M. Nehr,, M. L. Rotter, and, A. M. Hirschl. 2002. Reliability of nested PCR for the detection of Chlamydia pneumoniae DNA in atheromas: results from a multicenter study applying standardized protocols. J. Clin. Microbiol. 40:44284434.
7. Arno, J. N.,, B. P. Katz,, R. McBride,, G. A. Carty,, B. E. Batteiger,, V. A. Caine, and, R. B. Jones. 1994. Age and clinical immunity to infections with Chlamydia trachomatis. Sex. Transm. Dis. 21:4752.
8. Bailey, R. L.,, M. J. Holland,, H. C. Whittle, and, D. C. W. Mabey. 1995. Subjects recovering from human ocular chlamydial infection have enhanced lymphoproliferative responses to chlamydial antigens compared with those of persistently diseased controls. Infect. Immun. 63:389392.
9. Bailey, R. L.,, M. Kajbaf,, H. C. Whittle,, M. E. Ward, and, D. C. Mabey. 1993. The influence of local antichlamydial antibody on the acquisition and persistence of human ocular chlamydial infection: IgG antibodies are not protective. Epidem. Infect. 111:315324.
10. Bailey, R.,, T. Duong,, R. Carpenter,, H. Whittle, and, D. Mabey. 1999. The duration of human ocular Chlamydia trachomatis infection is age dependent. Epidemiol. Infect. 123:479486.
11. Baker, W. L.,, and K. A. Couch. 2007. Azithromycin for secondary prevention of coronary artery disease: a meta-analysis. Am. J. Health Syst. Pharm. 64:830836.
12. Baltch, A. L.,, R. P. Smioth,, W. J. Ritz,, A. N. Carpenter,, L. H. Bopp,, P. B. Michelsen,, C. J. Carlyn, and, J. R. Hibbs. 2004. Effect of levofloxacin on the viability of intracellular Chlamydia pneumoniae and modulation of proinflammatory cytokine production by human monocytes. Diagn. Microbiol. Infect. Dis. 50:205212.
13. Barnes, P. J. 1994. Cytokines as mediators of chronic asthma. Am. J. Respir. Crit. Care Med. 150:S42S49.
14. Beatty, W. L.,, R. P. Morrison, and, G. L. Byrne. 1994. Persistent chlamydiae: from cell culture to a paradigm form chlamydial pathogenesis. Microbiol. Rev. 58:689694.
15. Beatty, W. L. 2007. Lysosome repair enables host cell survival and bacterial persistence following Chlamydia trachomatis infection. Cell Microbiol. 9:21412152.
16. Beatty, W. L.,, R. P. Morrison, and, G. L. Byrne. 1995. Reactivation of persistent Chlamydia trachomatis infection in cell culture. Infect. Immun. 63:199205.
17. Biscardi, S.,, M. Lorrot,, E. Marc,, F. Moulin,, B. Boutonnat-Faucher,, C. Heilbronner,, J. L. Iniguez,, M. Chaussain,, E. Nicand,, J. Raymond, and, D. Gendrel. 2004. Mycoplasma pneumoniae and asthma in children. Clin. Infect. Dis. 38:13411346.
18. Biscione, G. L.,, J. Corne,, A. J. Chauhan, and, S. L. Johnston. 2004. Increased frequency of detection of Chlamydophila pneumoniae in asthma. Eur. Resp. J. 24:745749.
19. Bjoernsson, E.,, E. Hjelm,, C. Janson,, E. Fridell, and, G. Boman. 1996. Serology of Chlamydia in relation to asthma and bronchial hyperresponsiveness. Scand. J. Infect. Dis. 28:6369.
20. Black, P. N.,, C. R. Jenkins,, R. Scicchitano,, L. Allegra,, F. Blasi,, J. Wlodarzyck, and, B. C. Cooper. 2000. Serological evidence of infection with Chlamydia pneumoniae is related to the severity of asthma. Eur. Resp. J. 15:254259.
21. Black, P. N.,, F. Blasi,, C. R. Jenkins,, R. Scicchitano,, G. D. Mills,, A. R. Rubinfeld,, R. E. Ruffin,, P. R. Mullins,, J. Dangain,, B. C. Cooper,, D. B. David, and, L. Allegra. 2001. Trial of roxithromycin in subjects with asthma and serological evidence of infection with Chlamydia pneumoniae. Am. J. Respir. Crit. Care Med. 164:536541.
22. Blasi, F.,, S. Aliberti,, L. Allegra,, G. Piatti,, P. Tarsia,, J. M. Ossewaarde,, V. Verweij,, F. P. Nijkamp, and, G. Folkerts. 2007. Chlamydophila pneumoniae induces a sustained airway hyperresponsiveness and inflammation in mice. Resp. Res. 8:83.
23. Blythe, M. J.,, B. P. Katz,, D. P. Orr,, V. A. Caine, and, R. B. Jones. 1988. Historical and clinical factors associated with Chlamydia trachomatis genitourinary infection in female adolescents. J. Pediatr. 112:10001004.
24. Bobo, L.,, N. Novak,, H. Mkocha,, S. Vitale,, S. West, and, T. C. Quinn. 1996. Evidence for a predominant proinflammatory conjunctival cytokine response in individuals with trachoma. Infect. Immun. 64:32733279.
25. Boman, J.,, and M. R. Hammerschlag. 2002. Chlamydia pneumoniae and atherosclerosis—a critical assessment of diagnostic methods and the relevance to treatment studies. Clin. Microbiol. Rev. 15:120.
26. Brunham, R. C.,, B. Binns,, J. McDowell, and, M. Paraskevas. 1986. Chlamydia trachomatis infection in women with ectopic pregnancy. Obstet. Gynecol. 67:722726.
27. Brunham, R. C.,, B. Pourbohloul,, S. Mak,, R. White, and, M. L. Rekart. 2005. The unexpected impact of a Chlamydia trachomatis infection control program on susceptibility to reinfection. J. Infect. Dis. 192:18361844.
28. Brunham, R. C.,, C. C. Kuo,, L. Cles, and, K. K. Holmes. 1983. Correlation of host immune response with quantitative recovery of Chlamydia trachomatis from the human endocervix. Infect. Immun. 39:14911494.
29. Brunham, R. C.,, J. Kimani,, J. Bwayo,, G. Maitha,, I. Maclean,, C. Yang,, C. Shen,, S. Roman,, N. J. Nagelkerke,, M. Cheang, and, F. A. Plummer. 1996. The epidemiology of Chlamydia trachomatis within a sexually transmitted diseases core group. J. Infect. Dis. 173:950956.
30. Brunham, R. C.,, R. Peeling,, I. Maclean,, J. McDowell,, K. Persson, and, S. Osser. 1987. Postabortal Chlamydia trachomatis salpingitis: correlating risk with antigen-specific serological responses and with neutralization. J. Infect. Dis. 155:749755.
31. Bulut, Y.,, E. Faure,, L. Thomas,, H. Karahashi,, K. S. Michelsen,, O. Equils,, S. G. Morrison,, R. P. Morrison, and, M. Arditi. 2002. Chlamydial heat shock protein 60 activates macrophages and endothelial cells through Toll-like receptor 4 and MD2 in a MyD88-dependent pathway. J. Immunol. 168:14351440.
32. Burstein, G. R.,, C. A. Gaydos,, M. Diener-West,, M. R. Howell,, J. M. Zenilman, and, T. C. Quinn. 1998. Incident Chlamydia trachomatis infections among inner-city adolescent females. JAMA 280:521526.
33. Byrne, G. I.,, S. I. Skarlotos,, C. Grunfeld,, M. V. Kalayoglu,, P. Libby,, P. Saikku,, J. T. Summersgill, and, P. Wyrick. 2000. Collaborative multidisciplinary workshop report: interface of lipid metabolism, atherosclerosis and Chlamydia infection. J. Infect. Dis. 181(Suppl. 3):S490S491.
34. Campbell, L. A.,, D. L. Patton,, D. E. Moore,, A. L. Cappuccio,, B. A. Mueller, and, S. P. Wang. 1993. Detection of Chlamydia trachomatis deoxyribonucleic acid in women with tubal infertility. Fertil. Steril. 59:4550.
35. Carratelli, C. R.,, A. Rizzo,, R. Paolillo,, M. R. Catania,, P. Catalanotti, and, F. Rossano. 2005. Effect of nitric oxide on the growth of Chlamydophila pneumoniae. Can. J. Microbiol. 51:941947.
36. Caspar-Bauguil, S.,, B. Puissant,, D. Nazzal,, J. C. Lefevre,, M. Thomsen,, R. Salvayre, and, H. Benoist. 2000. Chlamydia pneumoniae induces interleukin-10 production that downregulates major histocompatibility complex class I expression. J. Infect. Dis. 182:13941401.
37. Centers for Disease Control and Prevention. 2002. Sexually transmitted disease treatment guidelines 2002. MMWR Recommend. Rep. 51(RR-6):184.
38. Chirgwin, K.,, P. M. Roblin,, M. Gelling,, M. R. Hammerschlag, and, J. Schachter. 1991. Infection with Chlamydia pneumoniae in Brooklyn. J. Infect. Dis. 163:757761.
39. Cho, Y. S.,, T. B. Kim,, T. H. Lee,, K. A. Moon,, J. Lee,, Y. K. Kim,, K. Y. Lee, and, H. B. Moon. 2005. Chlamydia pneumoniae infection enhances cellular proliferation and reduces steroid responsiveness of human peripheral blood mononuclear cells via a tumor necrosis factor-a-dependent pathway. Clin. Exp. Allergy 35:16251631.
40. Choi, J. H.,, M. J. Song,, S. H. Kim,, S. M. Choi,, D. G. Lee,, J. H. Yoo, and, W. S. Shin. 2003. Effect of moxifloxacin on production of proinflammatory cytokines from human peripheral blood mononuclear cells. Antimicrob. Agents Chemother. 47:37043707.
41. Chopra, I.,, C. Storey,, T. J. Falla, and, J. H. Pearce. 1998. Antibiotics, peptidoglycan synthesis and genomics: the chlamydial anomaly revisited. Microbiology 144:26732678.
42. Cohen, C. R.,, K. M. Koochesfahani,, A. S. Meier,, C. Shen,, K. Karunakaran,, B. Ondondo,, T. Kinyari,, N. R. Mugo,, R. Nguti, and, R. C. Brunham. 2005. Immunoepidemiologic profile of Chlamydia trachomatis infection: importance of heat-shock protein 60 and interferon-gamma. J. Infect. Dis. 192:591599.
43. Conway, D. J.,, M. J. Holland,, R. L. Bailey,, A. E. Campbell,, O. S. Mahdi,, R. Jennings,, E. Mbena, and, D. C. Mabey. 1997. Scarring trachoma is associated with polymorphism in the tumor necrosis factor alpha (TNF-α) gene promoter and with elevated TNF-α levels in tear fluid. Infect. Immun. 65:10031006.
44. Cook, P. J.,, P. Davies,, W. Tunnicliffe,, J. G. Ayres,, D. Honeybourne, and, R. Wise. 1998. Chlamydia pneumoniae and asthma. Thorax 53:254259.
45. Cunningham, A. F.,, S. L. Johnston,, S. A. Julious,, F. C. Lampe, and, M. E. Ward. 1998. Chronic Chlamydia pneumoniae infection and asthma exacerbations in children. Eur. Respir. J. 11:345349.
46. Danesh, J.,, P. Whincup,, M. Walker,, L. Lennon,, A. Thomson,, P. Appleby,, Y. Wong,, M. Bernardes-Silva, and, M. Ward. 2000. Chlamydia pneumoniae IgG titres and coronary heart disease: prospective study and meta-analysis. Br. Med. J. 321:208213.
47. Daoud, A.,, C. J. Gloria,, G. Taningco,, M. R. Hammerschlag,, S. Weiss,, M. Gelling,, P. M. Roblin, and, R. Joks. 2008. Minocycline treatment results in reduced oral steroid requirements in adult asthma. Allergy Asthma Proc. 29:286294.
48. Darville, T.,, J. M. O’Neill,, C. W. Andrews, Jr.,, U. M. Nagarajan,, L. Stahl, and, D. M. Ojcius. 2003. Toll-like receptor-2, but not toll-like receptor-4, is essential for development of oviduct pathology in chlamydial genital tract infection. J. Immunol. 171:61876197.
49. Datta, P.,, E. Frost,, R. Peeling,, S. Masinde,, S. Deslandes,, C. Echelu,, I. Wamola, and, R. C. Brunham. 1994. Ophthalmia neonatorum in a trachoma endemic area. Sex. Transm. Dis. 21:14.
50. Dawson, C. R.,, T. Daghfous,, I. Hoshiwara,, K. Ramdhane,, M. Kamoun,, C. Yoneda, and, J. Schachter. 1982. Trachoma therapy with topical tetracycline and oral erythromycin: a comparative trial. Bull. W. H. O. 60:347355.
51. Reference deleted.
52. Dean, D.,, P. Roblin,, L. Mandel,, J. Schachter, and, M. Hammerschlag. 1998. Molecular evaluation of serial isolates from patients with persistent Chlamydia pneumoniae infections, p. 219–222. In R. S. Stephens,, G. I. Byrne,, G. Christiansen,, I. N. Clarke,, J. T. Grayston,, R. G. Rank,, G. L. Ridgway,, P. Saikku,, J. Schachter, and, W. E. Stamm (ed). Chlamydial Infections. Proceedings of the Ninth International Symposium on Human Chlamydia Infections. International Chlamydia Symposium, San Francisco, CA.
53. Dean, D.,, and V. C. Powers. 2001. Persistent Chlamydia trachomatis infections resist apoptotic stimuli. Infect. Immun. 69:24422447.
54. Debattista, J.,, P. Timms,, J. Allan, and, J. Allan. 2002. Reduced levels of gamma-interferon secretion in response to chlamydial 60 kDa heat shock protein amongst women with pelvic inflammatory disease and a history of repeated Chlamydia trachomatis infections. Immunol. Lett. 81:205210.
55. de Kruif, M. D.,, E. C. van Gorp,, T. T. Keller,, J. M. Ossewaarde, and, H. ten Cate. 2005. Chlamydia pneumoniae infections in mouse models: relevance for atherosclerosis research. Cardiovasc. Res. 65:317327.
56. Dill, D. D.,, and J. E. Raulston. 2007. Examination of an inducible expression system for limiting iron availability during Chlamydia trachomatis infection. Microbes Infect. 9:947953.
57. Dowell, S. F.,, J. Boman,, G. M. Carlone,, B. S. Fields,, J. Guarner,, M. R. Hammerschlag,, L. A. Jackson,, C. C. Kuo,, M. Maass,, T. O. Messmer,, R. W. Peeling,, D. Talkington,, M. L. Tondella,, S. R. Zaki, and the C. pneumoniae workshop participants. 2000. Standardizing Chlamydia pneumoniae assays: recommendations from the Centers for Disease Control and Prevention (USA), and the Laboratory Centre for Disease Control (Canada). Clin. Infect. Dis. 33:492503.
58. Dreses-Werringloer, U.,, I. Padubrin,, B. Jürgens-Saathoff,, A. P. Hudson,, H. Zeidler, and, L. Köhler. 2000. Persistence of Chlamydia trachomatis is induced by ciprofloxacin and ofloxacin in vitro. Antimicrob. Agents Chemother. 44:32883297.
59. Durkin, H. G.,, S. M. Chice,, E. Gaetjens,, H. Bazin,, L. Tarcsay, and, P. Dukor. 1989. Origin and fate of IgE-bearing lymphocytes. II. Modulation of IgE isotype expression on Peyer’s patch cells by feeding with certain bacteria and bacterial cell wall components or by thymectomy. J. Immunol. 143:17771783.
60. Eickhoff, M.,, J. Thalmann,, S. Hess,, M. Martin,, T. Laue,, J. Kruppa,, G. Brandes, and, A. Klos. 2007. Host cell responses to Chlamydia pneumoniae in gamma interferon-induced persistence overlap those of productive infection and are linked to genes involved in apoptosis, cell cycle, and metabolism. Infect. Immun. 75:28532863.
61. Emre, U.,, P. M. Roblin,, M. Gelling,, W. Dumornay,, M. Rao,, M. R. Hammerschlag, and, J. Schachter. 1994. The association of Chlamydia pneumoniae infection and reactive airway disease in children. Arch. Pediatr. Adolesc. Med. 148:727731.
62. Emre, U.,, N. Sokolovskaya,, P. M. Roblin,, J. Schachter, and, M. R. Hammerschlag. 1995. Detection of anti-Chlamydia pneumoniae IgE in children with reactive airway disease. J. Infect. Dis. 172:265267.
63. Entrican, G.,, S. Wattegedera,, M. Rocchi,, D. C. Fleming,, R. W. Kelly,, G. Wathne,, V. Magdalenic, and, S. E. M. Howie. 2004. Induction of inflammatory host immune responses by organisms belonging to the genera Chlamydia/Chlamydophila. Vet. Immunol. Immunopathol. 100:179186.
64. Eschenbach, D. A.,, P. Wolner-Hanssen,, S. E. Hawes,, A. Pavletic,, J. Paavonen, and, K. K. Holmes. 1997. Acute pelvic inflammatory disease: associations of clinical and laboratory findings with laparoscopic findings. Obstet. Gynecol. 89:184192.
65. Esposito, S.,, F. Blasi,, C. Arosio,, L. Fiovavanti,, L. Fagetti,, R. Droghetti,, P. Tarsia,, N. Pincipi, and, L. Allegra. 2000. Importance of acute Mycoplasma pneumoniae and Chlamydia pneumoniae infection in children with wheezing. Eur. Resp. J. 16:11421146.
66. Everett, K. D. E.,, R. M. Bush, and, A. A. Anderson. 1999. Emended description of the order Chlamydiales, proposal of Parachlamydiaceae fam. nov. and Simkaniaceae fam. nov., each containing one monotypic genus, revised taxonomy of the family Chlamydiaceae, including a new genus and five new species, and standards for identification of organisms. Int. J. Syst. Bacteriol. 49:425440.
67. Faal, N.,, R. L. Bailey,, I. Sarr,, H. Joof,, D. C. Mabey, and, M. J. Holland. 2005. Temporal cytokine gene expression patterns in subjects with trachoma identify distinct conjunctival responses associated with infection. Clin. Exp. Immunol. 142:347353.
68. Fan, T.,, H. Lu,, H. Hu,, L. Shi,, G. A. McClarty,, D. M. Nance,, A. H. Greenberg, and, G. Zhong. 1998. Inhibition of apoptosis in chlamydia-infected cells: blockade of mitochondrial cytochrome c release and caspase activation. J. Exp. Med. 187:487496.
69. Fenton, K. A.,, and J. Imrie. 2005. Increasing rates of sexually transmitted diseases in homosexual men in Western Europe and the United States: why? Infect. Dis. Clin. North Am. 19:311331.
70. Fonseca-Aten, M.,, P. J. Okada,, K. L. Bowlware,, S. Chavez-Buena,, A. Mejias,, A. M. Rios,, K. Katz,, K. Olsen,, S. Ng,, H. S. Jafri,, G. H. McCracken,, O. Ramilo, and, R. D. Hardy. 2006. Effect of clarithromycin on cytokines and chemokines in children with an acute exacerbation of recurrent wheezing: a double-blind, randomized, placebo-controlled trial. Ann. Allergy Asthma Immunol. 97:457463.
71. Ford, C. A.,, B. W. Pence,, W. C. Miller,, M. D. Resnick,, L. H. Bearinger,, S. Pettingell, and, M. Cohen. 2005. Predicting adolescents’ longitudinal risk for sexually transmitted infection: results from the National Longitudinal Study of Adolescent Health. Arch. Pediatr. Adolesc. Med. 159:657664.
72. Gaydos, C. A.,, J. T. Summersgill,, N. N. Sahney,, J. A. Ramirez, and, T. C. Quinn. 1996. Replication of Chlamydia pneumoniae in vitro in human macrophages, endothelial cells, and aortic artery smooth muscle cells. Infect. Immun. 64:16141620.
73. Gaydos, C. A.,, M. R. Howell,, T. C. Quinn,, K. T. McKee, Jr., and, J. C. Gaydos. 2003. Sustained high prevalence of Chlamydia trachomatis infections in female army recruits. Sex. Transm. Dis. 30:539544.
74. Ghuysen, J. M.,, and C. Goffin. 1999. Lack of cell wall peptidoglycan versus penicillin sensitivity: new insights into the chlamydial anomaly. Antimicrob. Agents Chemother. 43:23392344.
75. Girardin, S. E.,, M. Jehanno,, D. Mengin-Lecreulx,, P. J. Sansonetti,, P. M. Alzari, and, D. J. Philpott. 2005. Identification of the critical residues involved in peptidoglycan detection by Nod 1. J. Biol. Chem. 280:3864838656.
76. Grayston, J. T.,, S. P. Wang,, L. J. Yeh, and, C. C. Kuo. 1985. Importance of reinfection in the pathogenesis of trachoma. Rev. Infect. Dis. 7:717725.
77. Greene, W.,, Y. Xiao,, Y. Huang,, G. McClarty, and, G. Zhong. 2004. Chlamydia-infected cells continue to undergo mitosis and resist induction of apoptosis. Infect. Immun. 72:45160.
78. Gupta, S.,, E. W. Leatham,, D. Carrington,, M. A. Mendall,, J. C. Kaski, and, A. J. Camm. 1997. Elevated Chlamydia pneumoniae antibodies, cardiovascular events, and azithromycin in male survivors of myocardial infarction. Circulation 96:404407.
79. Guymer, R.,, and L. Robman. 2007. Chlamydia pneumoniae and age-related macular degeneration: a role in pathogenesis or merely a chance association? Clin. Exper. Ophthalmol. 35:8993.
80. Hahn, D. L.,, M. B. Plane,, O. S. Mahdi, and, G. I. Byrne. 2006. Secondary outcomes of a pilot randomized trial of azithromycin treatment for asthma. PLOS Clin. Trials 1:e11.
81. Hahn, D. L.,, R. W. Dodge, and, R. Golubjatnikov. 1991. Association of Chlamydia pneumoniae (strain TWAR) infection with wheezing, asthmatic bronchitis, and adult-onset asthma. JAMA 266:225230.
82. Hahn, D. L.,, T. Anttila,, P. Saikku. 1996. Association of Chlamydia pnuemoniae IgA antibodies with recently symptomatic asthma. Epidemiol. Infect. 117:513517.
83. Halme, S.,, and H. M. Surcel. 1997. Cell mediated immunity to Chlamydia pneumoniae. Scand. J. Infect. Dis. 104(Suppl.):1821.
84. Halme, S.,, J. Latvala,, R. Karttunen,, I. Palatsi,, P. Saikku, and, H. M. Surcel. 2000. Cell-mediated immune response during primary Chlamydia pneumoniae infection. Infect. Immun. 68:71567158.
85. Halme, S.,, P. Saikku, and, H. M. Surcel. 1997. Characterization of Chlamydia pneumoniae antigens using human T cell clones. Scand. J. Immunol. 45:378384.
86. Hammerschlag, M. R.,, K. Chirgwin,, P. M. Roblin,, M. Gelling,, W. Dumornay,, L. Mandel,, P. Smith, and, J. Schachter. 1992. Persistent infection with Chlamydia pneumoniae following acute respiratory illness. Clin. Infect. Dis. 14:178182.
87. Hammerschlag, M. R.,, and G. A. Gaydos. 2006. Chlamydia pneumoniae and multiple sclerosis: fact or fiction. Lancet Neurol. 5:892893.
88. Harju, T. H.,, M. Leinonen,, J. Nokso-Koivisto,, T. Korhonen,, R. Räty,, Q. He,, T. Hovi,, J. Mertsola,, A. Bloigu,, P. Rytilä, and, P. Saikku. 2006. Pathogenic bacteria and viruses in induced sputum or pharyngeal secretions of adults with stable asthma. Thorax 61:579584.
89. Harper, A.,, C. I. Pogson,, M. L. Jones, and, J. H. Pearce. 2000. Chlamydial development is adversely affected by minor changes in amino acid supply, blood plasma amino acids levels, and glucose deprivation. Infect. Immun. 68:14571464.
90. Hawkins, R. A.,, R. G. Rank, and, K. A. Kelly. 2002. A Chlamydia trachomatis specific Th2 clone does not provide protection against a genital infection and displays reduced trafficking to the infected genital mucosa. Infect. Immun. 70:51325139.
91. Heinemann, M.,, M. Susa,, U. Simnacher,, R. Marre, and, A. Essig. 1996. Growth of Chlamydia pneumoniae induces cytokine production and expression of CD14 in a human monocytic cell line. Infect. Immun. 64:48724875.
92. Hess, S.,, J. Peters,, G. Bartling,, C. Rheinheimer,, P. Hegde,, M. Magid-Slav,, R. Singer, and, A. Klos. 2003. More than just innate immunity: comparative analysis of Chlamydophila pneumoniae and Chlamydia trachomatis effects on host-cell gene regulation. Cell. Microbiol. 5:785795.
93. Hoffjan, S.,, I. Ostrovnaja,, D. Nicolae,, D. L. Newman,, R. Nicolae,, R. Gangnon,, L. Steiner,, K. Walker,, R. Reynolds,, D. Greene,, D. Mirel,, J. E. Gern,, R. F. Lemanske, and, C. Ober. 2004. Genetic variation in immunoregulatory pathways and atopic phenotypes in infancy. J. Allergy Clin. Immunol. 113:511518.
94. Hogan, R. J.,, S. A. Mathews,, S. Mukhopadhyay,, J. T. Summersgill, and, P. Timms. 2004. Chlamydial persistence: beyond the biphasic paradigm. Infect. Immun. 72:18431855.
95. Holland, M. J.,, R. L. Bailey,, D. J. Conway,, F. Culley,, G. Miranpuri,, G. I. Byrne,, H. C. Whittle, and, D. C. Mabey. 1996. T-helper type 1 (Th1)/Th2 profiles of peripheral blood mononuclear cells (PBMC); responses to antigens of Chlamydia trachomatis in subjects with severe trachomatous scarring. Clin. Exp. Immunol. 105:429435.
96. Holland, M. J.,, R. L. Bailey,, L. J. Hayes,, H. C. Whittle, and, D. C. Mabey. 1993. Conjunctival scarring in trachoma is associated with depressed cell-mediated immune responses to chlamydial antigens. J. Infect. Dis. 168:15281531.
97. Holm, S. O.,, H. C. Jha,, R. C. Bhatta,, J. S. Chaudhary,, B. B. Thapa,, D. Davis,, R. P. Pokhrel,, M. Yinghui,, M. Zegans,, J. Schachter,, K. D. Frick,, L. Tapert, and, T. M. Lietman. 2001. Comparison of two azithromycin distribution strategies for controlling trachoma in Nepal. Bull. W. H. O. 79:194200.
98. Horvat, J. C.,, K. W. Beagley,, M. A. Wade,, J. A. Preston,, N. G. Hansbro,, D. K. Hickey,, G. E. Kaiko,, P. G. Gibson,, P. S. Foster, and, P. M. Hansbro. 2007. Neonatal chlamydial infection induces mixed T-cell responses that drive allergic airway disease. Am. J. Respir. Crit. Care Med. 176:556564.
99. Hoymans, V. Y.,, J. M. Bosmans,, D. Ursi,, W. Martinet,, F. L. Wuyts,, E. V. Marck,, M. Altwegg,, C. J. Vrints, and, M. M. Ieven. 2004. Immunohistostaining assays for detection of Chlamydia pneumoniae in atherosclerotic arteries indicate cross-reactions with nonchlamydial plaque constituents. J. Clin. Microbiol. 42:32193224.
100. Hoymans, V. Y.,, J. M. Bosmans,, M. M. Ieven, and, C. J. Vrints. 2007. Chlamydia pneumoniae-based atherosclerosis: a smoking gun. Acta Cardiol. 63:565571.
101. Hyman, C. L.,, M. H. Augenbraun,, P. Roblin,, J. Schachter, and, M. R. Hammerschlag. 1991. Asymptomatic respiratory tract infection with Chlamydia pneumoniae TWAR. J. Clin. Microbiol. 29:20822083.
102. Hyman, C. L.,, P. M. Roblin,, C. A. Gaydos,, T. C. Quinn,, J. Schachter, and, M. R. Hammerschlag. 1995. The prevalence of asymptomatic nasopharyngeal carriage of Chlamydia pneumoniae in subjectively healthy adults: assessment by polymerase chain reaction-enzyme immunoassay and culture. Clin. Infect. Dis. 20:11741178.
103. Ieven, M. M.,, and V. Y. Hoymans. 2005. Involvement of Chlamydia pneumoniae in atherosclerosis: more evidence for lack of evidence. J. Clin. Microbiol. 43:1924.
104. Igietseme, J. U.,, K. H. Ramsey,, D. M. Magee,, D. M. Williams,, T. J. Kincy, and, R. G. Rank. 1993. Resolution of murine chlamydial genital infection by the adoptive transfer of a biovar-specific, TH1 lymphocyte clone. Reg. Immunol. 5:317324.
105. Ikezawa, S. 2001. Prevalence of Chlamydia pneumoniae in acute respiratory tract infection and detection of anti-Chlamydia pneumoniae-specific IgE in Japanese children with reactive airway disease. Kurume Med. J. 48:165170.
106. Johnston, S. L.,, F. Blasi,, P. N. Black,, R. J. Martin,, D. J. Farrell,, R. B. Nieman, et al. 2006. The effect of telithromycin in acute exacerbations of asthma. N. Engl. J. Med. 354:15891600.
107. Kaiko, G. E.,, S. Phipps,, D. K. Hickey,, C. E. Lam,, P. M. Hansbro,, P. S. Foster, and, K. W. Beagley. 2008. Chlamydia muridarum infection subverts dendritic cell function to promote Th2 immunity and airways hyperreactivity. J. Immunol. 180:22252232.
108. Kalayoglu, M. V.,, and G. I. Byrne. 1998. A Chlamydia pneumoniae component that induces macrophage foam cell formation is chlamydial lipopolysaccharide. Infect. Immun. 66:50675072.
109. Kalayoglu, M. V.,, C. Galavan,, O. S. Mahdi,, G. I. Byrne, and, S. Mansour. 2003. Serological association between Chlamydia pneumoniae infection and age-related macular degeneration. Arch. Ophthalmol. 121:478482.
110. Kalayoglu, M. V.,, D. Bula,, J. Arroyo,, E. S. Gragoudas,, D. D’Amico, and, J. W. Miller. 2005. Identification of Chlamydia pneumoniae within human choroidal neovascular membranes secondary to age-related macular degeneration. Graefes Arch. Clin. Exp. Ophthalmol. 243:10801090.
111. Kalayoglu, M. V.,, P. Libby, and, G. I. Byrne. 2002. Chlamydia pneumoniae as an emerging risk factor in cardiovascular disease. JAMA 288:27242731.
112. Katz, B. P.,, M. J. Blythe,, P. B. Van Der, and, R. B. Jones. 1996. Declining prevalence of chlamydial infection among adolescent girls. Sex. Transm. Dis. 23:226229.
113. Kaufman, M.,, C. A. Gaydos,, S. Sriram,, J. Boman,, M. L. Tondella, and, H. J. Norton. 2002. Is Chlamydia pneumoniae found in spinal fluid samples from multiple sclerosis patients? Conflicting results. Mult. Scler. 8:289294.
114. Kaukoranta-Tolvanen, S. S.,, A. M. Teppo,, K. Laitinen,, P. Saikku,, K. Linnavuori, and, M. Leinonen. 1996. Growth of Chlamydia pneumoniae in cultured human peripheral blood mononuclear cells and induction of a cytokine response. Microb. Pathogen. 21:215221.
115. Keat, A.,, B. J. Thomas, and, D. Taylor Robinson. 1983. Chlamydial infection in the aetiology of arthritis. Br. Med. Bull. 39:168174.
116. Kellock, D. J.,, R. Barlow,, S. K. Suvarna,, S. Green,, A. Eley, and, K. E. Rogstad. 1997. Lymphogranuloma venereum: biopsy, serology, and molecular biology. Genitourin. Med. 73:399401.
117. Kessler, W.,, C. A. Jantos,, J. Dreier, and, S. Pavlovic. 2006. Chlamydia pneumoniae is not detectable in subretinal neovascular membranes in the exudative stage of age-related macular degeneration. Acta Ophthalmol. Scand. 84:333337.
118. Khan, M. A.,, and C. W. Potter. 1996. The nPCR detection of Chlamydia pneumoniae and Chlamydia trachomatis in children hospitalized for bronchiolitis. J. Infect. 33:173175.
119. Kim, C. K.,, S. W. Kim,, C. S. Park,, B. I. Kim,, H. Kang, and, Y. Y. Koh. 2003. Bronchoalveolar lavage cytokine profiles in acute asthma and acute bronchiolitis. J. Allergy Clin. Immunol. 112:6471.
120. Kimani, J.,, I. W. Maclean,, J. J. Bwayo,, K. MacDonald,, J. Oyugi,, G. M. Maitha,, R. W. Peeling,, M. Cheang,, N. J. Nagelkerke,, F. A. Plummer, and, R. C. Brunham. 1996. Risk factors for Chlamydia trachomatis pelvic inflammatory disease among sex workers in Nairobi, Kenya. J. Infect. Dis. 173:14371444.
121. Kinnunen, A. H.,, H. M. Surcel,, M. Lehtinen,, J. Karhukorpi,, A. Tiitinen,, M. Halttunen,, A. Bloigu,, R. P. Morrison,, R. Karttunen, and, J. Paavonen. 2002. HLA DQ alleles and interleukin-10 polymorphism associated with Chlamydia trachomatis-related tubal factor infertility: a case-control study. Hum. Reprod. 17:20732078.
122. Kitamura, N.,, O. Kaminuma,, A. Mori,, T. Hashimoto,, F. Kitamura,, M. Miyagishi,, K. Taira, and, S. Miyatake. 2005. Correlation between mRNA expression of Th1/Th2 cytokines and their specific transcription factors in human helper T-cell clones. Immunol. Cell Biol. 83:536541.
123. Kiviat, N. B.,, P. Wolner-Hanssen,, D. A. Eschenbach,, J. N. Wasserheit,, J. A. Paavonen,, T. A. Bell,, C. W. Critchlow,, W. E. Stamm,, D. E. Moore, and, K. K. Holmes. 1990. Endometrial histopathology in patients with culture-proved upper genital tract infection and laparoscopically diagnosed acute salpingitis. Am. J. Surg. Pathol. 14:167175.
124. Kiviat, N. B.,, P. Wolner-Hanssen,, M. Peterson,, J. Wasserheit,, W. E. Stamm,, D. A. Eschenbach,, J. Paavonen,, J. Lingenfelter,, T. Bell,, V. Zabriskie,, B. Kirby, and, K. K. Holmes. 1986. Localization of Chlamydia trachomatis infection by direct immunofluorescence and culture in pelvic inflammatory disease. Am. J. Obstet. Gynecol. 154:865873.
125. Klein, R.,, B. E. K. Klein,, M. D. Knudtson,, T. Y. Wong,, A. Shankar, and, M. Y. Tsai. 2005. Systemic markers of inflammation, endothelial dysfunction, and age related maculopathy. Am. J. Ophthalmol. 140:3544.
126. Kohlhepp, S. J.,, J. Hardick, and, C. Gaydos. 2005. Chlamydia pneumoniae in peripheral blood mononuclear cells from individuals younger than 20 years and older than 60 years. J. Clin. Microbiol. 43:3030.
127. Kohlhoff, S.,, P. Roblin,, A. Kutlin,, S. Strigl,, M. Nowakowski,, R. Joks, and, M. R. Hammerschlag. 2005. Effect of Chlamydia pneumoniae infection on cytokine profiles of PBMC from asthmatics and healthy subjects. J. Allergy Clin. Immunol. 115:15.
128. Kohlhoff, S. A.,, A. Kutlin,, P. Riska,, P. M. Roblin,, C. Roman, and, M. R. Hammerschlag. 2008. In vitro models of acute and long term continuous infection of human respiratory epithelial cells with Chlamydophila pneumoniae have opposing effects on host cell apoptosis. Microb. Pathogen. 44:3442.
129. Komura, H.,, H. Matsushima,, K. Ouchi,, M. Shirai,, T. Nakazawa, and, S. Furukawa. 2003. Effect of antiasthma drugs on the growth of Chlamydophila pneumoniae in HEp-2 cells. J. Infect. Chemother. 9:160164.
130. Kraft, M.,, G. H. Cassell,, J. E. Henson,, H. Watson,, J. Williamson,, B. P. Marmion,, C. A. Gaydos, and, R. J. Martin. 1998. Detection of Mycoplasma pneumoniae in the airways of adults with chronic asthma. Am. J. Resp. Crit. Care Med. 158:9981001.
131. Kraft, M.,, G. H. Cassell,, J. Pak, and, R. J. Martin. 2002. Mycoplasma pneumoniae and Chlamydia pneumoniae in asthma: effect of clarithromycin. Chest 121:17821788.
132. Kumar, S.,, and M. R. Hammerschlag. 2007. Acute respiratory infection due to Chlamydia pneumoniae: current status of diagnostic methods. Clin. Infect. Dis. 44:568576.
133. Kumar, S.,, S. A. Kohlhoff,, M. Gelling,, P. M. Roblin,, A. Kutlin,, S. Kahane,, M. G. Friedman, and, M. R. Hammerschlag. 2005. Infection with Simkania negevensis in Brooklyn, New York. Pediatr. Infect. Dis. J. 24:989992.
134. Kutlin, A.,, P. M. Roblin, and, M. R. Hammerschlag. 1998. Antibody response to Chlamydia pneumoniae infection in children with respiratory illness. J. Infect. Dis. 177:720724.
135. Kutlin, A.,, C. Flegg,, D. Stenzel,, T. Reznik,, P. M. Roblin,, S. Mathews,, P. Timms, and, M. R. Hammerschlag. 2001. Ultrastructural study of Chlamydia pneumoniae in a continuous infection model. J. Clin. Microbiol. 39:37213723.
136. Kutlin, A.,, P. M. Roblin, and, M. R. Hammerschlag. 2002. Effect of prolonged treatment with azithromycin, clarithromycin and levofloxacin on Chlamydia pneumoniae in a continuous infection model. Antimicrob. Agents Chemother. 46:409412.
137. LaMontagne, D. S.,, K. A. Fenton,, S. Randall,, S. Anderson, and, P. Carter. 2004. Establishing the National Chlamydia Screening Programme in England: results from the first full year of screening. Sex. Transm. Infect. 80:335341.
138. Larsen, F. O.,, S. Norn,, C. H. Mordhorst,, S. P. Stahl,, N. Milman, and, P. Clementsen. 1998. Chlamydia pneumoniae and possible relationship to asthma. APMIS 106:928934.
139. LaVerda, D.,, L. N. Albanese,, P. E. Ruther,, S. G. Morrison,, R. P. Morrison,, K. A. Ault, and, G. I. Byrne. 2000. Seroreactivity to Chlamydia trachomatis Hsp10 correlates with severity of human genital tract disease. Infect. Immun. 68:303309.
140. Littman, A. J.,, L. A. Jackson,, E. White,, M. D. Thornquist,, C. A. Gaydos, and, T. L. Vaughn. 2004. Interlaboratory reliability of microimmunofluorescence test for measurement of Chlamydia pneumoniae-specific immunoglobulin A and G antibody titers. J. Clin. Microbiol. 11:615617.
141. Liu, C.,, and D. D. Waters. 2005. Chlamydia pneumoniae and atherosclerosis: from Koch’s postulates to clinical trials. Prog. Cardiovasc. Dis. 47:230239.
142. MacDowell, A. L.,, and L. B. Bacharier. 2005. Infectious triggers of asthma. Immunol. Allergy Clin. N. Am. 25:4566.
143. Martin, R. J.,, M. Kraft,, H. W. Chu,, E. A. Berns, and, G. H. Cassell. 2001. A link between chronic asthma and chronic infection. J. Allergy Clin. Immunol. 107:595601.
144. Martinez, F. D. 2003. Respiratory syncytial virus bronchiolitis and the pathogenesis of childhood asthma. Pediatr. Infect. Dis. J. 22:S76S82.
145. McCoy, A. J.,, and A. T. Maurelli. 2006. Building the invisible wall: updating the chlamydial peptidoglycan anomaly. Trends Microbiol. 14:7077.
146. Melese, M.,, W. Alemayehu,, T. Lakew,, E. Yi,, J. House,, J. D. Chidambaram,, Z. Zhou,, V. Cevallos,, K. Ray,, K. C. Hong,, T. C. Porco,, I. Phan,, A. Zaidi,, B. D. Gaynor,, J. P. Whitcher, and, T. M. Lietman. 2008. Comparison of annual and biannual mass antibiotic administration for elimination of infectious trachoma. JAMA 299:778784.
147. Miller, W. C.,, C. A. Ford,, M. Morris,, M. S. Handcock,, J. L. Schmitz,, M. M. Hobbs,, M. S. Cohen,, K. M. Harris, and, J. R. Udry. 2004. Prevalence of chlamydial and gonococcal infections among young adults in the United States. JAMA 291:22292236.
148. Mills, G. D.,, J. A. Lindeman,, J. P Fawcett,, G. P. Herbison, and, M. R. Sears. 2000. Chlamydia pneumoniae serological status is not associated with asthma in children or young adults. Int. J. Epidemiol. 29:280284.
149. Moazed, T. C.,, C. C. Kuo,, J. T. Grayston, and, L. A. Campbell. 1998. Evidence of systemic dissemination of Chlamydia pneumoniae via macrophages in the mouse. J. Infect. Dis. 177:13221325.
150. Molano, M.,, C. J. Meijer,, E. Weiderpass,, A. Arslan,, H. Posso,, S. Franceschi,, M. Ronderos,, N. Munoz, and, A. J. van den Brule. 2005. The natural course of Chlamydia trachomatis infection in asymptomatic Colombian women: a 5-year follow-up study. J. Infect. Dis. 191:907916.
151. Molestina, R. E.,, R. D. Miller,, J. A. Ramirez, and, J. T. Summersgill. 1999. Infection of human endothelial cells with Chlamydia pneumoniae stimulates transendotehlial migration of neutrophils and monocytes. Infect. Immun. 67:13231330.
152. Moulder, J. W. 1993. Why is Chlamydia sensitive to penicillin in the absence of peptidoglycan? Infect. Agents Dis. 2:8799.
153. Mozzato-Chamay, N.,, O. S. Mahdi,, O. Jallow,, D. C. Mabey,, R. L. Bailey, and, D. J. Conway. 2000. Polymorphisms in candidate genes and risk of scarring trachoma in a Chlamydia trachomatis-endemic population. J. Infect. Dis. 182:15451548.
154. Mpiga, P.,, and M. Ravaoarinoro. 2006. Chlamydia trachomatis persistence: an update. Microbiol. Res. 161:919.
155. Mukhopadhyay, S.,, R. D. Miller,, E. D. Sullivan,, C. Theodoropoulos,, S. A. Mathews,, P. Timms, and, J. T. Summersgill. 2006. Protein expression profiles of Chlamydia pneumoniae in models of persistence versus those of heat shock stress response. Infect. Immun. 74:38533863.
156. Myashita, N.,, Y. Kubota,, M. Nakajima,, Y. Niki,, H. Kawane, and, T. Matushima. 1998. Chlamydia pneumoniae and exacerbations of asthma in adults. Ann. Allergy Asthma Immunol. 80:405409.
157. Nagy, A.,, G. T. Kozma,, M. Keszei,, A. Treszl,, A. Falus, and, C. Szalai. 2003. The development of asthma in children with Chlamydia pneumoniae is dependent on the modifying effect of mannose-binding lectin. J. Allergy Clin. Immunol. 112:729734.
158. Nagy, A.,, M. Keszei,, Z. Kis,, I. Budai,, G. Tolgyesi,, I. Ungvari,, A. Falus, and, C. Szalai. 2007. Chlamydophila pneumoniae infection status is dependent on the subtypes of asthma and allergy. Allergy Asthma Proc. 28:5863.
159. Naiki, Y.,, K. S. Michelsen,, N. W. J. Schröder,, R. Alsabeh,, A. Slepenkin,, W. Zhang,, S. Chen,, B. Wei,, Y. Bulut,, M. H. Wong,, E. M. Peterson, and, M. Arditi. 2005. Myd88 is pivotal for the early inflammatory response and subsequent bacterial clearance and survival in a mouse model of Chlamydia pneumoniae pneumonia. J. Biol. Chem. 280:2924229249.
160. Nakajo, M. N.,, P. M. Roblin,, M. R. Hammerschlag,, P. Smith, and, M. Nowakowski. 1990. Chlamydicidal activity of human alveolar macrophages. Infect. Immun. 58:36403644.
161. Natividad, A.,, G. Cooke,, M. J. Holland,, M. J. Burton,, H. M. Joof,, K. Rockett,, D. P. Kwiatkowski,, D. C. Mabey, and, R. L. Bailey. 2006. A coding polymorphism in matrix metalloproteinase 9 reduces risk of scarring sequelae of ocular Chlamydia trachomatis infection. BMC Med. Genet. 7:40.
162. Natividad, A.,, J. Wilson,, O. Koch,, M. J. Holland,, K. Rockett,, N. Faal,, O. Jallow,, H. M. Joof,, M. J. Burton,, N. D. Alexander,, D. P. Kwiatkowski,, D. C. Mabey, and, R. L. Bailey. 2005. Risk of trachomatous scarring and trichiasis in Gambians varies with SNP haplotypes at the interferon-gamma and interleukin-10 loci. Genes Immun. 6:332340.
163. Natividad, A.,, M. J. Holland,, K. A. Rockett,, J. Forton,, N. Faal,, H. M. Joof,, D. C. Mabey,, R. L. Bailey, and, D. P. Kwiatkowski. 2008. Susceptibility to sequelae of human ocular chlamydial infection associated with allelic variation in IL10 cis-regulation. Hum. Mol. Genet. 17:323329.
164. Natividad, A.,, N. Hanchard,, M. J. Holland,, O. S. Mahdi,, M. Diakite,, K. Rockett,, O. Jallow,, H. M. Joof,, D. P. Kwiatkowski,, D. C. Mabey, and, R. L. Bailey. 2007. Genetic variation at the TNF locus and the risk of severe sequelae of ocular Chlamydia trachomatis infection in Gambians. Genes Immun. 8:288295.
165. Netea, M. G.,, B. J. Kullberg,, J. M. Galama,, A. F. Stalenhoef,, C. A. Dinarello, and, J. W. Van der Meer. 2002. Non-LPS components of Chlamydia pneumoniae stimulate cytokine production through Toll-like receptor 2-dependent pathways. Eur. J. Immunol. 32:11881195.
166. Niccolai, L. M.,, K. A. Ethier,, T. S. Kershaw,, J. B. Lewis, and, J. R. Ickovics. 2003. Pregnant adolescents at risk: sexual behaviors and sexually transmitted disease prevalence. Am. J. Obstet. Gynecol. 188:6370.
167. Nieuwenhuis, R. F.,, J. M. Ossewaarde,, H. M. Gotz,, J. Dees,, H. B. Thio,, M. G. Thomeer,, J. C. den Hollander,, M. H. Neumann, and, W. I. van der Meijden. 2004. Resurgence of lymphogranuloma venereum in Western Europe: an outbreak of Chlamydia trachomatis serovar L2 proctitis in The Netherlands among men who have sex with men. Clin. Infect. Dis. 39:9961003.
168. Ossewaarde, J. M.,, M. Rieffe,, G. J. van Doornum,, C. J. Henquet, and, A. M. van Loon. 1994. Detection of amplified Chlamydia trachomatis DNA using a microtiter plate-based enzyme immunoassay. Eur. J. Clin. Microbiol. Infect. Dis. 13:732740.
169. Paavonen, J.,, and M. Lehtinen. 1996. Chlamydial pelvic inflammatory disease. Hum. Reprod. Update 2:519529.
170. Paavonen, J.,, K. Teisala,, P. K. Heinonen,, R. Aine,, S. Laine,, M. Lehtinen,, A. Miettinen,, R. Punnonen, and, P. Gronroos. 1987. Microbiological and histopathological findings in acute pelvic inflammatory disease. Br. J. Obstet. Gynaecol. 94:454460.
171. Pasternack, R.,, H. Huhtala, and, J. Karjalainen. 2005. Chlamydophila (Chlamydia) pneumoniae serology and asthma in adults: a longitudinal analysis. J. Allergy Clin. Immunol. 116:11231128.
172. Patton, D. L.,, M. Askienazy-Elbhar,, J. Henry-Suchet,, L. A. Campbell,, A. Cappuccio,, W. Tannous,, S. P. Wang, and, C. C. Kuo. 1994. Detection of Chlamydia trachomatis in fallopian tube tissue in women with postinfectious tubal infertility. Am. J. Obstet. Gynecol. 171:95101.
173. Paukku, M.,, M. Puolakkainen,, T. Paavonen, and, J. Paavonen. 1999. Plasma cell endometritis is associated with Chlamydia trachomatis infection. Am. J. Clin. Pathol. 112:211215.
174. Polkinghorne, A.,, R. J. Hogan,, L. Vaughn,, J. T. Summersgill, and, P. Timms. 2006. Differential expression of chlamydial signal transduction genes in normal and interferon gamma-induced persistent Chlamydophila pneumoniae infections. Microb. Infect. 8:6172.
175. Prebeck, S.,, C. Kirschning,, S. Durr,, C. da Costa,, B. Donath,, K. Brand,, V. Redecke,, H. Wagner, and, T. Miethke. 2001. Predominant role of toll-like receptor 2 versus 4 in Chlamydia pneumoniae-induced activation of dendritic cells. J. Immunol. 167:33163323.
176. Principi, N.,, S. Esposito,, F. Blasi,, L. Allegra, and the Mowgli Study Group. 2001. Role of Mycoplasma pneumoniae and Chlamydia pneumoniae in children with community-aquired lower respiratory tract infection. Clin. Infect. Dis. 32:12811289.
177. Rahm, V.-A.,, H. Gnarpe, and, V. Odlind. 1988. Chlamydia trachomatis among sexually active teenage girls. Lack of correlation between chlamydial infection, history of the patient and clinical signs of infection. Br. J. Obstet. Gynaecol. 95:916919.
178. Rahman, M. U.,, R. Cantwell,, C. C. Johnson,, R. L. Hodinka,, H. R. Schumacher, and, A. P. Hudson. 1992. Inapparent genital infection with Chlamydia trachomatis and its potential role in the genesis of Reiters syndrome. DNA Cell Biol. 11:215219.
179. Rasmussen, S. J.,, L. Eckmann,, A. J. Quayle,, L. Shen,, Y. X. Zhang,, D. J. Anderson,, J. Flerer,, R. S. Stephens, and, M. F. Kagnoff. 1997. Secretion of proinflammatory cytokines by epithelial cells in response to Chlamydia infection suggests a central role for epithelial cells in chlamydial pathogenesis. J. Clin. Investig. 99:7787.
180. Richardson, D.,, and D. Goldmeier. 2007. Lymphogranuloma venereum: an emerging cause of proctitis in men who have sex with men. Int. J. STD AIDS 18:1114.
181. Richeldi, L.,, G. Ferrara,, T. Lasserson, and, P. Gibson. 2005. Macrolides for chronic asthma (Cochrane Review). Cochrane Database Syst. Rev. CD002997. doi: 10.1002/14651858.CD002997.pub3.
182. Risser, W. L.,, and J. M. Risser. 2007. The incidence of pelvic inflammatory disease in untreated women infected with Chlamydia trachomatis: a structured review. Int. J. STD AIDS 18:727731.
183. Roblin, P. M.,, and M. R. Hammerschlag. 1998. Microbiologic efficacy of azithromycin and susceptibility to azithromycin of isolates of Chlamydia pneumoniae from adults and children with community acquired pneumonia. Antimicrob. Agents Chemother. 42:194196.
184. Robman, L.,, O. S. Mahdi,, J. J. Wang,, G. Burlutsky,, P. Mitchell,, G. Byrne,, R. Guymer, and, H. Taylor, 2007. Exposure to Chlamydia pneumoniae infection and age-related macular degeneration: the Blue Mountain Eye Study. Invest. Ophthalmol. Vis. Sci. 48:40074011.
185. Rockey, D. D.,, J. Lenart, and, R. S. Stephens. 2000. Genome sequencing and our understanding of chlamydiae. Infect. Immun. 68:54735479.
186. Rodel, J.,, M. Woytas,, A. Groh,, K. H. Schmidt,, M. Hartmann,, M. Lehmann, and, E. Straube. 2000. Production of basic fibroblast growth factor and interleukin 6 by human smooth muscle cells following infection with Chlamydia pneumoniae. Infect. Immun. 68:36353641.
187. Saikku, P.,, M. Leinonen,, K. Mattila,, M. R. Ekman,, M. S. Nieminen,, P. H. Makela,, J. K. Huttunen, and, V. Valtonen. 1988. Serological evidence of an association of a novel Chlamydia, TWAR, with chronic coronary heart disease and acute myocardial infarction. Lancet ii:983986.
188. Saiman, L.,, B. C. Marshall,, N. Mayer-Hamblett,, J. L. Burns,, A. L. Quittner,, D. A. Cibene,, S. Coquilette,, A. Y. Fieberg,, F. J. Accurso,, P. W. Campbell III, and the Macrolide Study Group. 2003. Azithromycin in patients with cystic fibrosis chronically infected with Pseudomonas aeruginosa: a randomized controlled trial. JAMA 290:17491756.
189. Reference deleted.
190. Scholes, D.,, A. Stergachis,, F. E. Heidrich,, H. Andrilla,, K. K. Holmes, and, W. E. Stamm. 1996. Prevention of pelvic inflammatory disease by screening for cervical chlamydial infection. N. Engl. J. Med. 334:13621366.
191. Schultz, M. J. 2004. Macrolide activities beyond their antimicrobial effects: macrolides in diffuse panbronchiolitis and cystic fibrosis. J. Antimicrob. Chemother. 54:2128.
192. Senn, L.,, M. R. Hammerschlag, and, G. Greub. 2005 Therapeutic approaches to Chlamydia infections. Expert Opin. Pharmacother. 6:110.
193. Shor, A.,, C. C. Kuo, and, D. L. Patton. 1992. Detection of Chlamydia pneumoniae in coronary arterial fatty streaks and atheromatous plaques. S. Afr. Med. J. 82:158161.
194. Smieja, M.,, J. Mahoney,, A. Petrich,, J. Boman, and, M. Chernesky. 2002. Association of circulating Chlamydia pneumoniae DNA with cardiovascular disease: a systematic review. BMC Infect. Dis. 2:21.
195. Smieja, M.,, J. Gnarpe,, E. Lonn,, H. Gnarpe,, G. Olsson,, Q. Yi,, V. Dzavik,, M. Mcqueen,, S. Yusuf, and Heart Outcomes Prevention and Evaluation Study (HOPE) Investigators. 2003. Multiple infections and subsequent cardiovascular events in the Heart Outcomes Prevention and Evaluation Study (HOPE) study. Circulation 107:251257.
196. Smith-Norowitz, T. A.,, M. H. Bluth,, H. Drew,, K. B. Norowitz,, S. Chice,, V. N. Shah,, M. Nowakowski,, A. S. Josephson,, H. G. Durkin, and, R. Joks. 2002. Effect of minocycline and doxycycline on IgE responses. Ann. Allergy Asthma Immunol. 89:172179.
197. Solomon, A. W.,, M. J. Holland,, M. J. Burton,, S. K. West,, N. D. Alexander,, A. Aguirre,, P. A. Massae,, H. Mkocha,, B. Munoz,, G. J. Johnson,, R. W. Peeling,, R. L. Bailey,, A. Foster, and, D. C. Mabey. 2003. Strategies for control of trachoma: observational study with quantitative PCR. Lancet 362:198204.
198. Soong, Y. K.,, S.-M. Kao,, C.-H. Lee,, P. S. Lee, and, C. C. Pao. 1990. Endocervical chlamydial deoxyribonucleic acid in infertile women. Fertil. Steril. 54:815818.
199. Sriram, S.,, W. Mitchell, and, C. Stratton. 1998. Multiple sclerosis associated with Chlamydia pneumoniae infection of the CNS. Neurology 50:571572.
200. Stamm, W. E.,, M. E. Guinan,, C. Johnson,, T. Starcher,, K. K. Holmes, and, W. M. McCormack. 1984. Effect of treatment regimens for Neisseria gonorrhoeae on simultaneous infection with Chlamydia trachomatis. N. Engl. J. Med. 310:545549.
201. Strachan, D.,, P. D. Carrington,, M. Mendall,, B. K. Butland,, J. W. Yarnell, and, P. Elwood. 2000. Chlamydia pneumoniae serology, lung function decline, and treatment for respiratory disease. Am. J. Respir. Crit. Care Med. 161:493497.
202. Sutton, B. J.,, and H. J. Gould. 1993. The human IgE network. Nature 366:421428.
203. Reference deleted.
204. Svensson, L.,, L. Westrom,, K. T. Ripa, and, P. A. Mardh. 1980. Differences in some clinical and laboratory parameters in acute salpingitis related to culture and serologic findings. Am. J. Obstet. Gynecol. 138:10171021.
205. Swanborg, R. H.,, J. A. Whittum-Hudson, and, A. P. Hudson. 2003. Infectious agents and multiple sclerosis—are Chlamydia pneumoniae and human herpes virus 6 involved? J. Neuroimmunol. 135:18.
206. Taylor, H. R.,, J. A. Siler,, H. A. Mkocha,, B. Munoz, and, S. West. 1992. The natural history of endemic trachoma: a longitudinal study. Am. J. Trop. Med. Hyg. 46:552559.
207. Thorsteinsson, S. B. 1982. Lymphogranuloma venereum: review of clinical manifestations, epidemiology, diagnosis, and treatment. Scand. J. Infect. Dis. 32(Suppl.):127131.
208. Tondella, M. L. C.,, G. Galagoda,, C. A. Gaydos, and, J. Boman. 2003. Is Chlamydia pneumoniae present in cerebrospinal fluid samples of multiple sclerosis patients? Clin. Diag. Lab. Immunol. 10:977978.
209. Tramper-Stranders, G. A.,, T. F. Wolfs,, A. Fleer,, J. L. Kimpen, and, C. K. van der Ent. 2007. Maintenance azithromycin treatment in pediatric patients with cystic fibrosis: long-term outcomes related to macrolide resistance and pulmonary function. Pediatr. Infect. Dis. J. 26:812.
210. Tsumura, N.,, U. Emre,, P. Roblin, and, M. R. Hammerschlag. 1996. The effect of hydrocortisone succinate on the growth of Chlamydia pneumoniae in vitro. J. Clin. Microbiol. 34:23792381.
211. Van Strien, R. T.,, R. Engel,, O. Holst,, A. Bufe,, W. Eder,, M. Waser,, C. Braun-Fahrlaender,, J. Riedler,, D. Nowak,, E. von Mutius, and the LAEX Study Team. 2004. Microbial exposure of rural school children, as assessed by levels on N-acetyl-muramic acid in mattress dust, and its association with respiratory health. J. Allergy Clin. Immunol. 113:860867.
212. Velasco, G.,, M. Campo,, O. J. Manrique,, A. Bellou,, R. S. Arestides,, B. Schaub,, D. L. Perkins, and, P. W. Finn. 2005. Toll-like receptor 4 or 2 agonists decrease allergic inflammation. Am. J. Respir. Cell. Mol. Biol. 32:218224.
213. Von Hertzen, L. C. 2002. Role of persistent infection in the control and severity of asthma: focus on Chlamydia pneumoniae. Eur. Respir. J. 19:546556.
214. Wark, P. A. B.,, S. L. Johnston,, J. L. Simpson,, M. J. Hensley, and, P. G. Gibson. 2002. Chlamydia pneumoniae immunoglobulin A reactivation and airway inflammation in acute asthma. Eur. Respir. J. 20:834840.
215. Welter-Stahl, L.,, D. M. Ojcius,, J. Viala,, S. Girardin,, W. Liu,, C. Delarbre,, D. Philpott,, K. A. Kelly, and, T. Darville. 2006. Stimulation of the cytosolic receptor, Nod1, by infection with Chlamydia trachomatis or Chlamydia muridarum. Cell. Microbiol. 8:10471057.
216. Westrom, L.,, R. Joesoef,, G. Reynolds,, A. Hagdu, and, S. E. Thompson. 1992. Pelvic inflammatory disease and fertility. A cohort study of 1,844 women with laparoscopically verified disease and 657 control women with normal laparoscopic results. Sex. Transm. Dis. 19:185192.
217. Williams, A. C.,, H. F. Galley,, A. M. Watt, and, N. R. Webster. 2005. Differential effects of three antibiotics on T helper cell cytokine expression. J. Antimicrob. Chemother. 56:502506.
218. Williams, D. M.,, B. G. Grubbs,, T. Darville,, K. Kelly, and, R. R. Rank. 1998. A role for interleukin-6 in host defense against murine Chlamydia trachomatis infection. Infect. Immun. 66:45644567.
219. Woessner, R.,, T. Grauer,, A. Frese,, F. Bethke,, T. Ginger,, A. Hans, and, J. Treib. 2006. Long-term antibiotic treatment with roxithromycin in patients with multiple sclerosis. Infection 34:342344.
220. Workowski, K. A.,, M. F. Lampe,, K. G. Wong,, M. B. Watts, and, W. E. Stamm. 1993. Long-term eradication of Chlamydia trachomatis genital infection after antimicrobial therapy. Evidence against persistent infection. JAMA 270:20712075.