Chapter 5 : : Enteric and Extraintestinal Infections

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Among the microbial flora that naturally inhabit the human gastrointestinal tract, is the most abundant facultative anaerobe. While members of the family are natural inhabitants of the gastrointestinal tract and are abundant in the environment, there are particular predisposing factors and circumstances that allow both intestinal and extraintestinal infections to occur in community and nosocomial settings. In developing countries of Asia, Latin America, and Africa, where diarrhea is one of the most lethal threats to children under the age of five, enteropathogenic (EPEC) is a major cause of infantile diarrhea. A study describing early predictors of adverse outcomes following neonatal bacterial meningitis found that elevated total protein in the initial cerebrospinal fluid (CSF) analysis, as well as a CSF-to-blood glucose ratio of < 0.5, corresponded with an adverse outcome. The current definition of postinfectious irritable bowel syndrome (IBS) according to the Rome II criteria, which most studies follow, is the new onset of symptoms developing acutely after an illness characterized by two or more of the following: fever, vomiting, acute diarrhea, or positive stool culture. There are two main types of Shiga toxins, and Shiga toxin-producing (STEC) (O157 and non-O157 alike) that produce both Stx2 and Stx1, or Stx2 alone, are more likely to be associated with HUS than those that produce Stx1 only. Prebiotic oligosaccharides may also have similar applications for EPEC. Clearly, new and innovative approaches will be required to reduce the burden of infections and their sequelae.

Citation: Lorenz B, Donnenberg M. 2009. : Enteric and Extraintestinal Infections, p 69-85. In Fratamico P, Smith J, Brogden K (ed), Sequelae and Long-Term Consequences of Infectious Diseases. ASM Press, Washington, DC. doi: 10.1128/9781555815486.ch5

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Traveler's Diarrhea
Immune Systems
Outer Membrane Protein A
Outer Membrane Protein C
Outer Membrane Protein A
Outer Membrane Protein C
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Image of Figure 1.
Figure 1.

A transmission electron micrograph demonstrating the typical attaching and effacing effect on polarized human intestinal epithelial cells infected with EPEC. Bar, 1 μm. (Reprinted from the [ ] with permission from the publisher.)

Citation: Lorenz B, Donnenberg M. 2009. : Enteric and Extraintestinal Infections, p 69-85. In Fratamico P, Smith J, Brogden K (ed), Sequelae and Long-Term Consequences of Infectious Diseases. ASM Press, Washington, DC. doi: 10.1128/9781555815486.ch5
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1. Aberra, F. N.,, C. M. Brensinger,, W. B. Bilker,, G. R. Lichtenstein, and, J. D. Lewis. 2005. Antibiotic use and the risk of flare of inflammatory bowel disease. Clin. Gastroenterol. Hepatol. 3:459465.
2. Adachi, J. A.,, L. Ostrosky-Zeichner,, H. L. DuPont, and, C. D. Ericsson. 2000. Empirical antimicrobial therapy for traveler’s diarrhea. Clin. Infect. Dis. 31:10791083.
3. Altekruse, S. F.,, M. L. Cohen, and, D. L. Swerdlow. 1997. Emerging foodborne diseases. Emerg. Infect. Dis. 3:285293.
4. Alteri, C. J.,, and H. L. Mobley. 2007. Quantitative profile of the uropathogenic Escherichia coli outer membrane proteome during growth in human urine. Infect. Immun. 75:26792688.
5. Assis, A. M.,, M. L. Barreto,, L. M. Santos,, R. Fiaccone, and, G. S. da Silva Gomes. 2005. Growth faltering in childhood related to diarrhea: a longitudinal community based study. Eur. J. Clin. Nutr. 59:13171323.
6. Baltimore, R. S.,, S. M. Huie,, J. I. Meek,, A. Schuchat, and, K. L. O’Brien. 2001. Early-onset neonatal sepsis in the era of group B streptococcal prevention. Pediatrics 108:10941098.
7. Banatvala, N.,, P. M. Griffin,, K. D. Greene,, T. J. Barrett,, W. F. Bibb,, J. H. Green,, J. G. Wells, and Hemolytic Uremic Syndrome Study Collaborators. 2001. The United States National Prospective Hemolytic Uremic Syndrome Study: microbiologic, serologic, clinical, and epidemiologic findings. J. Infect. Dis. 183:10631070.
8. Barnich, N.,, and A. Darfeuille-Michaud. 2007. Adherentinvasive Escherichia coli and Crohn’s disease. Curr. Opin. Gastroenterol. 23:1620.
9. Barry, E. M.,, Z. Altboum,, G. Losonsky, and, M. M. Levine. 2003. Immune responses elicited against multiple enterotoxigenic Escherichia coli fimbriae and mutant LT expressed in attenuated Shigella vaccine strains. Vaccine 21:333340.
10. Bedford, H.,, J. de Louvois,, S. Halket,, C. Peckham,, R. Hurley, and, D. Harvey. 2001. Meningitis in infancy in England and Wales: follow up at age 5 years. BMJ 323:533536.
11. Bhan, M. K.,, N. Bhandari,, S. Sazawal,, J. Clemens,, P. Raj,, M. M. Levine, and, J. B. Kaper. 1989. Descriptive epidemiology of persistent diarrhoea among young children in rural northern India. Bull. W. H. O. 67:281288.
12. Bhatnagar, S.,, M. K. Bhan,, C. George,, U. Gupta,, R. Kumar,, D. Bright, and, S. Saini. 1992. Is small bowel bacterial overgrowth of pathogenic significance in persistent diarrhea? Acta Paediatr. Suppl. 381:108113.
13. Brenner, B. M. 1983. Hemodynamically mediated glomerular injury and the progressive nature of kidney disease. Kidney Int. 23:647655.
14. Burke, D. A.,, and A. T. Axon. 1988. Hydrophobic adhesin of E. coli in ulcerative colitis. Gut 29:4143.
15. Burke, D. A.,, and A. T. Axon. 1988. Adhesive Escherichia coli in inflammatory bowel disease and infective diarrhoea. BMJ 297:102104.
16. Butterton, J. R.,, E. T. Ryan,, D. W. Acheson, and, S. B. Calderwood. 1997. Coexpression of the B subunit of Shiga toxin 1 and EaeA from enterohemorrhagic Escherichia coli in Vibrio cholerae vaccine strains. Infect. Immun. 65:21272135.
17. Centers for Disease Control and Prevention (CDC). 2005. Outbreaks of Escherichia coli O157:H7 associated with petting zoos—North Carolina, Florida, and Arizona, 2004 and 2005. MMWR Morb. Mortal. Wkly. Rep. 54:12771280.
18. Chang, C. J.,, W. N. Chang,, L. T. Huang,, S. C. Huang,, Y. C. Chang,, P. L. Hung,, C. H. Lu,, C. S. Chang,, B. C. Cheng,, P. Y. Lee,, K. W. Wang, and, H. W. Chang. 2004. Bacterial meningitis in infants: the epidemiology, clinical features, and prognostic factors. Brain Dev. 26:168175.
19. Chang, Y. C.,, C. C. Huang,, S. T. Wang, and, C. C. Chio. 1997. Risk factor of complications requiring neurosurgical intervention in infants with bacterial meningitis. Pediatr. Neurol. 17:144149.
20. Conlan, J. W.,, A. D. Cox,, R. KuoLee,, A. Webb, and, M. B. Perry. 1999. Parenteral immunization with a glycoconjugate vaccine containing the O157 antigen of Escherichia coli O157:H7 elicits a systemic humoral immune response in mice, but fails to prevent colonization by the pathogen. Can. J. Microbiol. 45:279286.
21. Conlan, J. W.,, R. KuoLee,, A. Webb, and, M. B. Perry. 1999. Salmonella landau as a live vaccine against Escherichia coli O157:H7 investigated in a mouse model of intestinal colonization. Can. J. Microbiol. 45:723731.
22. Cotran, R. S.,, V. Kumar, and, T. Collins. 1999. Robbins Pathologic Basis of Disease, p. 930–996. W. B. Saunders Company, Philadelphia, PA.
23. Crane, J. K.,, B. P. McNamara, and, M. S. Donnenberg. 2001. Role of EspF in host cell death induced by enteropathogenic Escherichia coli. Cell. Microbiol. 3:197211.
24. Cravioto, A.,, A. Tello,, H. Villafan,, J. Ruiz,, S. del Vedovo, and, J. R. Neeser. 1991. Inhibition of localized adhesion of enteropathogenic Escherichia coli to HEp-2 cells by immunoglobulin and oligosaccharide fractions of human colostrum and breast milk. J. Infect. Dis. 163:12471255.
25. Creydt, V. P.,, C. Silberstein,, E. Zotta, and, C. Ibarra. 2006. Cytotoxic effect of Shiga toxin-2 holotoxin and its B subunit on human renal tubular epithelial cells. Microbes Infect. 8:410419.
26. da Costa, L. B.,, H. Ahn,, W. Montanera, and, H. Ginsberg. 2007. Repeated meningitis as a delayed complication of scoliosis surgery. J. Spinal Disord. Tech. 20:333336.
27. Dalton, C. B.,, E. D. Mintz,, J. G. Wells,, C. A. Bopp, and, R. V. Tauxe. 1999. Outbreaks of enterotoxigenic Escherichia coli infection in American adults: a clinical and epidemiologic profile. Epidemiol. Infect. 123:916.
28. Day, W. A.,, and A. T. Maurelli. 2002. Shigella and enteroinvasive Escherichia coli: paradigms for pathogen evolution and host-parasite interactions, p. 209–237. In M. S. Donnenberg (ed.), Escherichia coli: Virulence Mechanisms of a Versatile Pathogen. Academic Press, San Diego, CA.
29. de Goede, C. G.,, P. E. Jardine,, P. Eunson,, S. Renowden,, P. Sharples, and, R. W. Newton. 2006. Severe progressive late onset myelopathy and arachnoiditis following neonatal meningitis. Eur. J. Paediatr. Neurol. 10:3136.
30. Donnenberg, M. S. 2005. Enterobacteriaceae, p. 2567–2586. In G. L. Mandell,, J. E. Bennett, and, R. Dolin (ed.), Mandell, Douglas, and Bennett’s Principles and Practice of Infectious Diseases. Elsevier, Philadelphia, PA.
31. Donnenberg, M. S. 1999. Interactions between enteropathogenic Escherichia coli and epithelial cells. Clin. Infect. Dis. 28:451455.
32. Donnenberg, M. S.,, and R. A. Welch. 1996. Virulence determinants of uropathogenic Escherichia coli, p. 135–174. In H. L. T. Mobley and, J. W. Warren (ed.), Urinary Tract Infections: Molecular Pathogenesis and Clinical Management. ASM Press, Washington, DC.
33. Dunlop, S. P.,, J. Hebden,, E. Campbell,, J. Naesdal,, L. Olbe,, A. C. Perkins, and, R. C. Spiller. 2006. Abnormal intestinal permeability in subgroups of diarrhea-predominant irritable bowel syndromes. Am. J. Gastroenterol. 101:12881294.
34. DuPont, H. L. 2007. Therapy for and prevention of traveler’s diarrhea. Clin. Infect. Dis. 45(Suppl. 1):S78S84.
35. DuPont, H. L. 2007. The growing threat of foodborne bacterial enteropathogens of animal origin. Clin. Infect. Dis. 45:13531361.
36. DuPont, H. L.,, S. B. Formal,, R. B. Hornick,, M. J. Snyder,, J. P. Libonati,, D. G. Sheahan,, E. H. LaBrec, and, J. P. Kalas. 1971. Pathogenesis of Escherichia coli diarrhea. N. Engl. J. Med. 285:19.
37. DuPont, H. L.,, Z. D. Jiang,, C. D. Ericsson,, J. A. Adachi,, J. J. Mathewson,, M. W. DuPont,, E. Palazzini,, L. M. Riopel,, D. Ashley, and, F. Martinez-Sandoval. 2001. Rifaximin versus ciprofloxacin for the treatment of traveler’s diarrhea: a randomized, double-blind clinical trial. Clin. Infect. Dis. 33:18071815.
38. Eastmond, C. J. 1983. Gram-negative bacteria and B27 disease. Br. J. Rheumatol. 22:6774.
39. Escherich, T. 1885. Die Darmbakterien des naugenborenen und sauglings. Fortschr. Med. 3:515547.
40. Fagundes-Neto, U.,, and J. A. de Andrade. 1999. Acute diarrhea and malnutrition: lethality risk in hospitalized infants. J. Am. Coll. Nutr. 18:303308.
41. Fagundes-Neto, U.,, E. Freymüller,, S. L. Gandolfi, and, I. C. Scaletsky. 1996. Nutritional impact and ultrastructural intestinal alterations in severe infections due to enteropathogenic Escherichia coli strains in infants. J. Am. Coll. Nutr. 15:180185.
42. Fagundes-Neto, U.,, and I. C. Scaletsky. 2000. The gut at war: the consequences of enteropathogenic Escherichia coli infection as a factor of diarrhea and malnutrition. Sao Paulo Med. J. 118:2129.
43. Fagundes-Neto, U.,, L. G. Schmitz, and, I. C. Scaletsky. 1996. Acute diarrhea due to enteropathogenic Escherichia coli: epidemiological and clinical features in Brasilia, Brazil. Int. J. Infect. Dis. 1:6569.
44. Farmer, J. J.,, III, G. R. Fanning,, B. R. Davis,, C. M. O’Hara,, C. Riddle,, F. W. Hickman-Brenner,, M. A. Asbury,, V. A. Lowery III, and, D. J. Brenner. 1985. Escherichia fergusonii and Enterobacter taylorae, two new species of Enterobacteriaceae isolated from clinical specimens. J. Clin. Microbiol. 21:7781.
45. Finne, J.,, M. Leinonen, and, P. H. Mäkelä. 1983. Antigenic similarities between brain components and bacteria causing meningitis. Implications for vaccine development and pathogenesis. Lancet ii:355357.
46. Foxman, B. 2002. Epidemiology of urinary tract infections: incidence, morbidity, and economic costs. Am. J. Med. 113(Suppl. 1A):5S13S.
47. Gagnadoux, M. F.,, R. Habib,, M. C. Gubler,, J. L. Bacri, and, M. Broyer. 1996. Long-term (15–25 years) outcome of childhood hemolytic-uremic syndrome. Clin. Nephrol. 46:3941.
48. Garg, A. X.,, J. E. Pope,, H. Thiessen-Philbrook,, W. F. Clark, and, J. Ouimet. 2008. Arthritis risk after acute bacterial gastroenteritis. Rheumatology (Oxford) 47:200204.
49. Garg, A. X.,, R. S. Suri,, N. Barrowman,, F. Rehman,, D. Matsell,, M. P. Rosas-Arellano,, M. Salvadori,, R. B. Haynes, and, W. F. Clark. 2003. Long-term renal prognosis of diarrhea-associated hemolytic uremic syndrome: a systematic review, meta-analysis, and meta-regression. JAMA 290:13601370.
50. Giaffer, M. H.,, C. D. Holdsworth, and, B. I. Duerden. 1992. Virulence properties of Escherichia coli strains isolated from patients with inflammatory bowel disease. Gut 33:646650.
51. Gill, C. J.,, D. H. Hamer,, J. Lau,, C. S. Wong,, J. R. Brandt,, P. I. Tarr,, S. L. Watkins,, M. A. Neill,, D. G. Maki, and, N. Safdar. 2002. Risk of hemolytic uremic syndrome from antibiotic treatment of Escherichia coli O157:H7 colitis. JAMA 288:31103112.
52. Glandt, M.,, J. A. Adachi,, J. J. Mathewson,, Z. D. Jiang,, D. DiCesare,, D. Ashley,, C. D. Ericsson, and, H. L. DuPont. 1999. Enteroaggregative Escherichia coli as a cause of traveler’s diarrhea: clinical response to ciprofloxacin. Clin. Infect. Dis. 29:335338.
53. Gomes, T. A.,, V. Rassi,, K. L. MacDonald,, S. R. Ramos,, L. R. Trabulsi,, M. A. Vieira,, B. E. Guth,, J. A. Candeias,, C. Ivey,, M. R. Toledo, et al. 1991. Enteropathogens associated with acute diarrheal disease in urban infants in São Paulo, Brazil. J. Infect. Dis. 164:331337.
54. Gomes, T. A.,, M. A. Vieira,, I. K. Wachsmuth,, P. A. Blake, and, L. R. Trabulsi. 1989. Serotype-specific prevalence of Escherichia coli strains with EPEC adherence factor genes in infants with and without diarrhea in São Paulo, Brazil. J. Infect. Dis. 160:131135.
55. Gupta, K.,, M. Y. Chou,, A. Howell,, C. Wobbe,, R. Grady, and, A. E. Stapleton. 2007. Cranberry products inhibit adherence of P-fimbriated Escherichia coli to primary cultured bladder and vaginal epithelial cells. J. Urol. 177:23572360.
56. Gwee, K. A.,, J. C. Graham,, M. W. McKendrick,, S. M. Collins,, J. S. Marshall,, S. J. Walters, and, N. W. Read. 1996. Psychometric scores and persistence of irritable bowel after infectious diarrhoea. Lancet 347:150153.
57. Gwee, K. A.,, Y. L. Leong,, C. Graham,, M. W. McKendrick,, S. M. Collins,, S. J. Walters,, J. E. Underwood, and, N. W. Read. 1999. The role of psychological and biological factors in postinfective gut dysfunction. Gut 44:400406.
58. Harris, J. R.,, J. Mariano,, J. G. Wells,, B. J. Payne,, H. D. Donnell, and, M. L. Cohen. 1985. Person-to-person transmission in an outbreak of enteroinvasive Escherichia coli. Am. J. Epidemiol. 122:245252.
59. Harvey, D.,, D. E. Holt, and, H. Bedford. 1999. Bacterial meningitis in the newborn: a prospective study of mortality and morbidity. Semin. Perinatol. 23:218225.
60. Heath, P. T.,, N. K. Nik Yusoff, and, C. J. Baker. 2003. Neonatal meningitis. Arch. Dis. Child Fetal Neonatal Ed. 88:F173F178.
61. Henderson, I. R.,, S. Hicks,, F. Navarro-Garcia,, W. P. Elias,, A. D. Philips, and, J. P. Nataro. 1999. Involvement of the enteroaggregative Escherichia coli plasmid-encoded toxin in causing human intestinal damage. Infect. Immun. 67:53385344.
62. Hooton, T. M.,, P. L. Roberts, and, W. E. Stamm. 1994. Effects of recent sexual activity and use of a diaphragm on the vaginal microflora. Clin. Infect. Dis. 19:274278.
63. Hooton, T. M.,, A. E. Stapleton,, P. L. Roberts,, C. Winter,, D. Scholes,, T. Bavendam, and, W. E. Stamm. 1999. Perineal anatomy and urine-voiding characteristics of young women with and without recurrent urinary tract infections. Clin. Infect. Dis. 29:16001601.
64. Howell, A. B.,, N. Vorsa,, M. A. Der, and, L. Y. Foo. 1998. Inhibition of the adherence of P-fimbriated Escherichia coli to uroepithelial-cell surfaces by proanthocyanidin extracts from cranberries. N. Engl. J Med. 339:10851086.
65. Huang, D. B.,, J. P. Nataro,, H. L. DuPont,, P. P. Kamat,, A. D. Mhatre,, P. C. Okhuysen, and, T. Chiang. 2006. Enteroaggregative Escherichia coli is a cause of acute diarrheal illness: a meta-analysis. Clin. Infect. Dis. 43:556563.
66. Huang, S. H.,, C. Wass,, Q. Fu,, N. V. Prasadarao,, M. Stins, and, K. S. Kim. 1995. Escherichia coli invasion of brain microvascular endothelial cells in vitro and in vivo: molecular cloning and characterization of invasion gene ibe10. Infect. Immun. 63:44704475.
67. Huppertz, H. I.,, S. Rutkowski,, S. Aleksic, and, H. Karch. 1997. Acute and chronic diarrhoea and abdominal colic associated with enteroaggregative Escherichia coli in young children living in western Europe. Lancet 349:16601662.
68. Huys, G.,, M. Cnockaert,, J. M. Janda, and, J. Swings. 2003. Escherichia albertii sp. nov., a diarrhoeagenic species isolated from stool specimens of Bangladeshi children. Int. J. Syst. Evol. Microbiol. 53:807810.
69. Ikäheimo, R.,, A. Siitonen,, T. Heiskanen,, U. Kärkkäinen,, P. Kuosmanen,, P. Lipponen, and, P. H. Mäkelä. 1996. Recurrence of urinary tract infection in a primary care setting: analysis of a 1-year follow-up of 179 women. Clin. Infect. Dis. 22:9199.
70. Islam, M.,, M. P. Doyle,, S. C. Phatak,, P. Millner, and, X. Jiang. 2004. Persistence of enterohemorrhagic Escherichia coli O157:H7 in soil and on leaf lettuce and parsley grown in fields treated with contaminated manure composts or irrigation water. J. Food Prot. 67:13651370.
71. Jacobson, S. H. 1986. P-fimbriated Escherichia coli in adults with renal scarring and pyelonephritis. Acta Med. Scand. Suppl. 713:164.
72. Jacobson, S. H.,, O. Eklöf,, L. E. Lins,, I. Wikstad, and, J. Winberg. 1992. Long-term prognosis of post-infectious renal scarring in relation to radiological findings in childhood—a 27-year follow-up. Pediatr. Nephrol. 6:1924.
73. Jakobsson, B.,, U. Berg, and, L. Svensson. 1994. Renal scarring after acute pyelonephritis. Arch. Dis. Child 70:111115.
74. Jay, M. T.,, M. Cooley,, D. Carychao,, G. W. Wiscomb,, R. A. Sweitzer,, L. Crawford-Miksza,, J. A. Farrar,, D. K. Lau,, J. O’Connell,, A. Millington,, R. V. Asmundson,, E. R. Atwill, and, R. E. Mandrell. 2007. Escherichia coli O157:H7 in feral swine near spinach fields and cattle, central California coast. Emerg. Infect. Dis. 13:19081911.
75. Jertborn, M.,, C. Ahrén,, J. Holmgren, and, A. M. Svennerholm. 1998. Safety and immunogenicity of an oral inactivated enterotoxigenic Escherichia coli vaccine. Vaccine 16:255260.
76. Jiang, Z. D.,, P. C. Okhuysen,, D. C. Guo,, R. He,, T. M. King,, H. L. DuPont, and, D. M. Milewicz. 2003. Genetic susceptibility to enteroaggregative Escherichia coli diarrhea: polymorphism in the interleukin-8 promotor region. J. Infect. Dis. 188:506511.
77. Johanson, W. G.,, A. K. Pierce, and, J. P. Sanford. 1969. Changing pharyngeal bacterial flora of hospitalized patients. Emergence of gram-negative bacilli. N. Engl. J. Med. 281:11371140.
78. Johnson, J. R.,, P. L. Roberts, and, W. E. Stamm. 1987. P fimbriae and other virulence factors in Escherichia coli urosepsis: association with patients’ characteristics. J. Infect. Dis. 156:225229.
79. Johnson, K. E.,, C. M. Thorpe, and, C. L. Sears. 2006. The emerging clinical importance of non-O157 Shiga toxin-producing Escherichia coli. Clin. Infect. Dis. 43:15871595.
80. Jones, T. F.,, and F. J. Angulo. 2006. Eating in restaurants: a risk factor for foodborne disease? Clin. Infect. Dis. 43:13241328.
81. Kang, G.,, S. Sheela,, M. M. Mathan, and, V. I. Mathan. 1999. Prevalence of enteroaggregative and other HEp-2 cell adherent Escherichia coli in asymptomatic rural south Indians by longitudinal sampling. Microbios 100:5766.
82. Kant, A. K.,, and B. I. Graubard. 2004. Eating out in America, 1987–2000: trends and nutritional correlates. Prev. Med. 38:243249.
83. Kapasi, K.,, and R. D. Inman. 1992. HLA-B27 expression modulates gram-negative bacterial invasion into transfected L cells. J. Immunol. 148:35543559.
84. Karmali, M. A.,, M. Petric,, C. Lim,, P. C. Fleming,, G. S. Arbus, and, H. Lior. 1985. The association between idiopathic hemolytic uremic syndrome and infection by verotoxin-producing Escherichia coli. J. Infect. Dis. 151:775782.
85. Kenny, B.,, R. DeVinney,, M. Stein,, D. J. Reinscheid,, E. A. Frey, and, B. B. Finlay. 1997. Enteropathogenic E. coli (EPEC) transfers its receptor for intimate adherence into mammalian cells. Cell 91:511520.
86. Keusch, G. T.,, D. W. Acheson,, C. Marchant, and, J. McIver. 1998. Toxioid-based active and passive immunization to prevent and/or modulate hemolytic-uremic syndrome due to Shiga-producing Escherichia coli, p. 409–418. In J. B. Kaper and, A. D. O’Brien (ed.), Escherichia coli O157:H7 and Other Shiga Toxin-Producing E. coli Strains. American Society for Microbiology, Washington, DC.
87. Khan, N. A.,, Y. Wang,, K. J. Kim,, J. W. Chung,, C. A. Wass, and, K. S. Kim. 2002. Cytotoxic necrotizing factor-1 contributes to Escherichia coli K1 invasion of the central nervous system. J. Biol. Chem. 277:1560715612.
88. Klinger, G.,, C. N. Chin,, J. Beyene, and, M. Perlman. 2000. Predicting the outcome of neonatal bacterial meningitis. Pediatrics 106:477482.
89. Kontiokari, T.,, K. Sundqvist,, M. Nuutinen,, T. Pokka,, M. Koskela, and, M. Uhari. 2001. Randomised trial of cranberry-lingonberry juice and Lactobacillus GG drink for the prevention of urinary tract infections in women. BMJ 322:1571.
90. Korczak, B.,, J. Frey,, J. Schrenzel,, G. Pluschke,, R. Pfister,, R. Ehricht, and, P. Kuhnert. 2005. Use of diagnostic microarrays for determination of virulence gene patterns of Escherichia coli K1, a major cause of neonatal meningitis. J. Clin. Microbiol. 43:10241031.
91. Korhonen, T. K.,, M. V. Valtonen,, J. Parkkinen,, V. Väisänen-Rhen,, L. Wang,, J. Finne,, F. Ørskov,, I. Ørskov,, S. B. Svenson, and, P. H. Mäkelä. 1985. Serotypes, hemolysin production, and receptor recognition of Escherichia coli strains associated with neonatal sepsis and meningitis. Infect. Immun. 48:486491.
92. Lama, G.,, M. E. Salsano,, M. Pedulla,, C. Grassia, and, G. Ruocco. 1997. Angiotensin converting enzyme inhibitors and reflux nephropathy: 2-year follow-up. Pediatr. Nephrol. 11:714718.
93. Langermann, S.,, and W. R. Ballou, Jr. 2001. Vaccination utilizing the FimCH complex as a strategy to prevent Escherichia coli urinary tract infections. J. Infect. Dis. 183(Suppl. 1):S84S86.
94. Lehnardt, S.,, L. Massillon,, P. Follett,, F. E. Jensen,, R. Ratan,, P. A. Rosenberg,, J. J. Volpe, and, T. Vartanian. 2003. Activation of innate immunity in the CNS triggers neurodegeneration through a Toll-like receptor 4-dependent pathway. Proc. Natl. Acad. Sci. USA 100:85148519.
95. Levine, M. M.,, D. R. Nalin,, D. L. Hoover,, E. J. Bergquist,, R. B. Hornick, and, C. R. Young. 1979. Immunity to enterotoxigenic Escherichia coli. Infect. Immun. 23:729736.
96. Litwin, M. S.,, C. S. Saigal,, E. M. Yano,, C. Avila,, S. A. Geschwind,, J. M. Hanley,, G. F. Joyce,, R. Madison,, J. Pace,, S. M. Polich, and, M. Wang. 2005. Urologic diseases in America Project: analytical methods and principal findings. J. Urol. 173:933937.
97. Lomberg, H.,, P. de Man, and, C. Svanborg Edén. 1989. Bacterial and host determinants of renal scarring. APMIS 97:193199.
98. Long, K. Z.,, J. I. Santos,, J. L. Rosado,, C. Lopez-Saucedo,, R. Thompson-Bonilla,, M. Abonce,, H. L. DuPont,, E. Hertzmark, and, T. Estrada-Garcia. 2006. Impact of vitamin A on selected gastrointestinal pathogen infections and associated diarrheal episodes among children in Mexico City, Mexico. J. Infect. Dis. 194:12171225.
99. Lund, B.,, F. Lindberg, and, S. Normark. 1988. Structure and antigenic properties of the tip-located P pilus proteins of uropathogenic Escherichia coli. J. Bacteriol. 170:18871894.
100. Mackowiak, P. A.,, R. M. Martin,, S. R. Jones, and, J. W. Smith. 1978. Pharyngeal colonization by gram-negative bacilli in aspiration-prone persons. Arch. Intern. Med. 138:12241227.
101. Marcato, P.,, G. Mulvey, and, G. D. Armstrong. 2002. Cloned Shiga toxin 2 B subunit induces apoptosis in Ramos Burkitt’s lymphoma B cells. Infect. Immun. 70:12791286.
102. Marcato, P.,, G. Mulvey,, R. J. Read,, H. K. Vander,, P. N. Nation, and, G. D. Armstrong. 2001. Immunoprophylactic potential of cloned Shiga toxin 2 B subunit. J. Infect. Dis. 183:435443.
103. Marshall, J. K.,, M. Thabane,, M. R. Borgaonkar, and, C. James. 2007. Postinfectious irritable bowel syndrome after a food-borne outbreak of acute gastroenteritis attributed to a viral pathogen. Clin. Gastroenterol. Hepatol. 5:457460.
104. Mathewson, J. J.,, P. C. Johnson,, H. L. DuPont,, D. R. Morgan,, S. A. Thornton,, L. V. Wood, and, C. D. Ericsson. 1985. A newly recognized cause of travelers’ diarrhea: enteroadherent Escherichia coli. J. Infect. Dis. 151:471475.
105. Mathewson, J. J.,, R. A. Oberhelman,, H. L. DuPont,, F. Javier de la Cabada, and, E. V. Garibay. 1987. Enteroadherent Escherichia coli as a cause of diarrhea among children in Mexico. J. Clin. Microbiol. 25:19171919.
106. Mayer, H. B.,, and C. A. Wanke. 1995. Enteroaggregative Escherichia coli as a possible cause of diarrhea in an HIV-infected patient. N. Engl. J. Med. 332:273274.
107. McCracken, G. H., Jr.,, L. D. Sarff,, M. P. Glode,, S. G. Mize,, M. S. Schiffer,, J. B. Robbins,, E. C. Gotschlich,, I. Ørskov, and, F. Ørskov. 1974. Relation between Escherichia coli K1 capsular polysaccharide antigen and clinical outcome in neonatal meningitis. Lancet ii:246250.
108. McDermott, S.,, V. Daguise,, H. Mann,, L. Szwejbka, and, W. Callaghan. 2001. Perinatal risk for mortality and mental retardation associated with maternal urinary-tract infections. J. Fam. Pract. 50:433437.
109. McKendrick, M. W.,, and N. W. Read. 1994. Irritable bowel syndrome-post Salmonella infection. J. Infect. 29:13.
110. McLorie, G. A.,, P. H. McKenna,, B. M. Jumper,, B. M. Churchill,, R. F. Gilmour, and, A. E. Khoury. 1990. High grade vesicoureteral reflux: analysis of observational therapy. J. Urol. 144:537540.
111. McNamara, B. P.,, A. Koutsouris,, C. B. O’Connell,, J. P. Nougayrede,, M. S. Donnenberg, and, G. Hecht. 2001. Translocated EspF protein from enteropathogenic Escherichia coli disrupts host intestinal barrier function. J. Clin. Investig. 107:621629.
112. Mead, P. S.,, L. Slutsker,, V. Dietz,, L. F. McCaig,, J. S. Bresee,, C. Shapiro,, P. M. Griffin, and, R. V. Tauxe. 1999. Food-related illness and death in the United States. Emerg. Infect. Dis. 5:607625.
113. Mofredj, A.,, J. M. Guerin,, F. Leibinger, and, R. Mamoudi. 2000. Spontaneous Escherichia coli meningitis in an adult. Scand. J. Infect. Dis. 32:699700.
114. Nataro, J. P. 2004. Vaccines against diarrheal diseases. Semin. Pediatr. Infect. Dis. 15:272279.
115. Nataro, J. P.,, C. A. Bopp,, P. I. Fields,, J. B. Kaper, and, N. A. Strockbine. 2007. Escherichia, Shigella, and Salmonella, p. 670–687. In P. R. Murray,, E. J. Baron,, J. H. Jorgensen,, M. L. Landry, and, M. A. Pfaller (ed.), Manual of Clinical Microbiology, 9th ed. vol. 1. ASM Press, Washington, DC.
116. Nataro, J. P.,, Y. Deng,, D. R. Maneval,, A. L. German,, W. C. Martin, and, M. M. Levine. 1992. Aggregative adherence fimbriae I of enteroaggregative Escherichia coli mediate adherence to HEp-2 cells and hemagglutination of human erythrocytes. Infect. Immun. 60:22972304.
117. Nataro, J. P.,, and J. B. Kaper. 1998. Diarrheagenic Escherichia coli. Clin. Microbiol. Rev. 11:142201.
118. Nataro, J. P.,, J. B. Kaper,, R. Robins-Browne,, V. Prado,, P. Vial, and, M. M. Levine. 1987. Patterns of adherence of diarrheagenic Escherichia coli to HEp-2 cells. Pediatr. Infect. Dis. J. 6:829831.
119. Neal, K. R.,, J. Hebden, and, R. Spiller. 1997. Prevalence of gastrointestinal symptoms six months after bacterial gastroenteritis and risk factors for development of the irritable bowel syndrome: postal survey of patients. Br. Med. J. 314:779782.
120. O’Brien, A. D.,, J. W. Newland,, S. F. Miller,, R. K. Holmes,, H. W. Smith, and, S. B. Formal. 1984. Shiga-like toxin-converting phages from Escherichia coli strains that cause hemorrhagic colitis or infantile diarrhea. Science 226:694696.
121. O’Hanley, P. 1996. Prospects for urinary tract infection vaccines, p. 405–425. In H. L. T. Mobley and, J. W. Warren (ed.), Urinary Tract Infections: Molecular Pathogenesis and Clinical Management. ASM Press, Washington, DC.
122. Okhuysen, P. C.,, Z. D. Jiang,, L. Carlin,, C. Forbes, and, H. L. DuPont. 2004. Post-diarrhea chronic intestinal symptoms and irritable bowel syndrome in North American travelers to Mexico. Am. J. Gastroenterol. 99:17741778.
123. Ørskov, I.,, F. Ørskov,, B. Jann, and, K. Jann. 1977. Serology, chemistry, and genetics of O and K antigens of Escherichia coli. Bacteriol. Rev. 41:667710.
124. Ostroff, S. M.,, P. I. Tarr,, M. A. Neill,, J. H. Lewis,, N. Hargrett-Bean, and, J. M. Kobayashi. 1989. Toxin genotypes and plasmid profiles as determinants of systemic sequelae in Escherichia coli O157:H7 infections. J. Infect. Dis. 160:994998.
125. Passeron, A.,, L. Capron, and, G. Grateau. 2004. Recurrent Escherichia coli meningitis associated with aspergillar sphenoidal sinusitis. Scand. J. Infect. Dis. 36:492493.
126. Paton, A. W.,, R. Morona, and, J. C. Paton. 2006. Designer probiotics for prevention of enteric infections. Nat. Rev. Microbiol. 4:193200.
127. Patterson, J. E.,, and V. T. Andriole. 1997. Bacterial urinary tract infections in diabetes. Infect. Dis. Clin. North Am. 11:735750.
128. Polivka, B. J.,, J. T. Nickel, and, J. R. Wilkins III. 1997. Urinary tract infection during pregnancy: a risk factor for cerebral palsy? J. Obstet. Gynecol. Neonatal Nurs. 26:405413.
129. Pupo, G. M.,, D. K. Karaolis,, R. Lan, and, P. R. Reeves. 1997. Evolutionary relationships among pathogenic and nonpathogenic Escherichia coli strains inferred from multilocus enzyme electrophoresis and mdh sequence studies. Infect. Immun. 65:26852692.
130. Pupo, G. M.,, R. Lan, and, P. R. Reeves. 2000. Multiple independent origins of Shigella clones of Escherichia coli and convergent evolution of many of their characteristics. Proc. Natl. Acad. Sci. USA 97:1056710572.
131. Pylkkänen, J.,, J. Vilska, and, O. Koskimies. 1981. The value of level diagnosis of childhood urinary tract infection in predicting renal injury. Acta Paediatr. Scand. 70:879883.
132. Qadri, F.,, A. M. Svennerholm,, A. S. Faruque, and, R. B. Sack. 2005. Enterotoxigenic Escherichia coli in developing countries: epidemiology, microbiology, clinical features, treatment, and prevention. Clin. Microbiol. Rev. 18:465483.
133. Rangel, J. M.,, P. H. Sparling,, C. Crowe,, P. M. Griffin, and, D. L. Swerdlow. 2005. Epidemiology of Escherichia coli O157:H7 outbreaks, United States, 1982–2002. Emerg. Infect. Dis. 11:603609.
134. Ray, P. E.,, and X. H. Liu. 2001. Pathogenesis of Shiga toxin-induced hemolytic uremic syndrome. Pediatr. Nephrol. 16:823839.
135. Raz, R.,, B. Chazan, and, M. Dan. 2004. Cranberry juice and urinary tract infection. Clin. Infect. Dis. 38:14131419.
136. Raz, R.,, and W. E. Stamm. 1993. A controlled trial of intravaginal estriol in postmenopausal women with recurrent urinary tract infections. N. Engl. J. Med. 329:753756.
137. Reisbig, R.,, S. Olsnes, and, K. Eiklid. 1981. The cytotoxic activity of Shigella toxin. Evidence for catalytic inactivation of the 60 S ribosomal subunit. J. Biol. Chem. 256:87398744.
138. Repetto, H. A. 2005. Long-term course and mechanisms of progression of renal disease in hemolytic uremic syndrome. Kidney Int. Suppl. 97:S102S106.
139. Resta-Lenert, S.,, and K. E. Barrett. 2003. Live probiotics protect intestinal epithelial cells from the effects of infection with enteroinvasive Escherichia coli (EIEC). Gut 52:988997.
140. Richardson, S. E.,, M. A. Karmali,, L. E. Becker, and, C. R. Smith. 1988. The histopathology of the hemolytic uremic syndrome associated with verocytotoxin-producing Escherichia coli infections. Hum. Pathol. 19:11021108.
141. Roberts, J. A. 1991. Etiology and pathophysiology of pyelonephritis. Am. J. Kidney Dis. 17:19.
142. Robins-Browne, R. M. 1987. Traditional enteropathogenic Escherichia coli of infantile diarrhea. Rev. Infect. Dis. 9:2853.
143. Rothbaum, R.,, A. J. McAdams,, R. Giannella, and, J. C. Partin. 1982. A clinicopathologic study of enterocyte-adherent Escherichia coli: a cause of protracted diarrhea in infants. Gastroenterology 83:441454.
144. Russo, T. A.,, and J. R. Johnson. 2006. Extraintestinal isolates of Escherichia coli: identification and prospects for vaccine development. Expert. Rev. Vaccines 5:4554.
145. Russo, T. A.,, A. Stapleton,, S. Wenderoth,, T. M. Hooton, and, W. E. Stamm. 1995. Chromosomal restriction fragment length polymorphism analysis of Escherichia coli strains causing recurrent urinary tract infections in young women. J. Infect. Dis. 172:440445.
146. Safdar, N.,, A. Said,, R. E. Gangnon, and, D. G. Maki. 2002. Risk of hemolytic uremic syndrome after antibiotic treatment of Escherichia coli O157:H7 enteritis: a meta-analysis. JAMA 288:9961001.
147. Sartor, R. B. 2008. Microbial influences in inflammatory bowel diseases. Gastroenterology 134:577594.
148. Savarino, S. J.,, A. Fasano,, J. Watson,, B. M. Martin,, M. M. Levine,, S. Guandalini, and, P. Guerry. 1993. Enteroaggregative Escherichia coli heat-stable enterotoxin 1 represents another subfamily of E. coli heat-stable toxin. Proc. Natl. Acad. Sci. USA 90:30933097.
149. Scheutz, F.,, T. Cheasty,, D. Woodward, and, H. R. Smith. 2004. Designation of O174 and O175 to temporary O groups OX3 and OX7, and six new E. coli O groups that include Verocytotoxin-producing E. coli (VTEC): O176, O177, O178, O179, O180 and O181. APMIS 112:569584.
150. Schnurrenberger, L. W.,, R. Beck, and, J. Pate. 1971. Gastroenteritis attributed to imported French cheese. MMWR Morb. Mortal. Wkly. Rpt. 20:427428.
151. Scholes, D.,, T. M. Hooton,, P. L. Roberts,, A. E. Stapleton,, K. Gupta, and, W. E. Stamm. 2000. Risk factors for recurrent urinary tract infection in young women. J. Infect. Dis. 182:11771182.
152. Schrag, S. J.,, S. Zywicki,, M. M. Farley,, A. L. Reingold,, L. H. Harrison,, L. B. Lefkowitz,, J. L. Hadler,, R. Danila,, P. R. Cieslak, and, A. Schuchat. 2000. Group B streptococcal disease in the era of intrapartum antibiotic prophylaxis. N. Engl. J. Med. 342:1520.
153. Schultsz, C.,, M. Moussa,, R. van Ketel,, G. N. Tytgat, and, J. Dankert. 1997. Frequency of pathogenic and enteroadherent Escherichia coli in patients with inflammatory bowel disease and controls. J. Clin. Pathol. 50:573579.
154. Serény, B. 1955. Experimental Shigella keratoconjunctivitis: a preliminary report. Acta Microbiol. Acad. Sci. Hung. 2:293296.
155. Shah, D. K.,, A. J. Daley,, R. W. Hunt,, J. J. Volpe, and, T. E. Inder. 2005. Cerebral white matter injury in the newborn following Escherichia coli meningitis. Eur. J. Paediatr. Neurol. 9:1317.
156. Sheikh, J.,, J. R. Czeczulin,, S. Harrington,, S. Hicks,, I. R. Henderson,, B. C. Le,, P. Gounon,, A. Phillips, and, J. P. Nataro. 2002. A novel dispersin protein in enteroaggregative Escherichia coli. J. Clin. Investig. 110:13291337.
157. Shen, W.,, H. Steinrück, and, Å. Ljungh. 1995. Expression of binding of plasminogen, thrombospondin, vitronectin, and fibrinogen, and adhesive properties by Escherichia coli strains isolated from patients with colonic diseases. Gut 36:401406.
158. Shin, S.,, G. Lu,, M. Cai, and, K. S. Kim. 2005. Escherichia coli outer membrane protein A adheres to human brain microvascular endothelial cells. Biochem. Biophys. Res. Commun. 330:11991204.
159. Shoaf, K.,, G. L. Mulvey,, G. D. Armstrong, and, R. W. Hutkins. 2006. Prebiotic galactooligosaccharides reduce adherence of enteropathogenic Escherichia coli to tissue culture cells. Infect. Immun. 74:69206928.
160. Siitonen, A.,, A. Takala,, Y. A. Ratiner,, A. Pere, and, P. H. Mäkelä. 1993. Invasive Escherichia coli infections in children: bacterial characteristics in different age groups and clinical entities. Pediatr. Infect. Dis. J. 12:606612.
161. Sobel, J. D. 1997. Pathogenesis of urinary tract infection. Role of host defenses. Infect. Dis. Clin. North Am. 11:531549.
162. Sobieszczanska, B. M.,, J. Osek,, D. Wasko-Czopnik,, E. Dworniczek, and, K. Jermakow. 2007. Association of enteroaggregative Escherichia coli with irritable bowel syndrome. Clin. Microbiol. Infect. 13:404407.
163. Soyturk, M.,, H. Akpinar,, O. Gurler,, E. Pozio,, I. Sari,, S. Akar,, M. Akarsu,, M. Birlik,, F. Onen, and, N. Akkoc. 2007. Irritable bowel syndrome in persons who acquired trichinellosis. Am. J. Gastroenterol. 102:10641069.
164. Spangler, B. D. 1992. Structure and function of cholera toxin and the related Escherichia coli heat-labile enterotoxin. Microbiol. Rev. 56:622647.
165. Spiller, R. C. 2007. Role of infection in irritable bowel syndrome. J. Gastroenterol. 42(Suppl. 17):4147.
166. Spiller, R. C.,, D. Jenkins,, J. P. Thornley,, J. M. Hebden,, T. Wright,, M. Skinner, and, K. R. Neal. 2000. Increased rectal mucosal enteroendocrine cells, T lymphocytes, and increased gut permeability following acute Campylobacter enteritis and in post-dysenteric irritable bowel syndrome. Gut 47:804811.
167. Steiner, T. S.,, A. A. Lima,, J. P. Nataro, and, R. L. Guerrant. 1998. Enteroaggregative Escherichia coli produce intestinal inflammation and growth impairment and cause interleukin-8 release from intestinal epithelial cells. J. Infect. Dis. 177:8896.
168. Steiner, T. S.,, J. P. Nataro,, C. E. Poteet-Smith,, J. A. Smith, and, R. L. Guerrant. 2000. Enteroaggregative Escherichia coli expresses a novel flagellin that causes IL-8 release from intestinal epithelial cells. J. Clin. Investig. 105:17691777.
169. Steinlin, M.,, B. Knecht,, D. Konu,, E. Martin, and, E. Boltshauser. 1999. Neonatal Escherichia coli meningitis: spinal adhesions as a late complication. Eur. J. Pediatr. 158:968970.
170. Stevens, J. P.,, M. Eames,, A. Kent,, S. Halket,, D. Holt, and, D. Harvey. 2003. Long term outcome of neonatal meningitis. Arch. Dis. Child Fetal Neonatal Ed. 88:F179F184.
171. Stewart, G. T. 1950. Post-dysenteric colitis. Br. Med. J. 1:405409.
172. Stothers, L. 2002. A randomized trial to evaluate effectiveness and cost effectiveness of naturopathic cranberry products as prophylaxis against urinary tract infection in women. Can. J. Urol. 9:15581562.
173. Sukumaran, S. K.,, H. Shimada, and, N. V. Prasadarao. 2003. Entry and intracellular replication of Escherichia coli K1 in macrophages require expression of outer membrane protein A. Infect. Immun. 71:59515961.
174. Tacket, C. O.,, R. H. Reid,, E. C. Boedeker,, G. Losonsky,, J. P. Nataro,, H. Bhagat, and, R. Edelman. 1994. Enteral immunization and challenge of volunteers given enterotoxigenic E. coli CFA/II encapsulated in biodegradable microspheres. Vaccine 12:12701274.
175. Tauxe, R. V. 1997. Emerging foodborne diseases: an evolving public health challenge. Emerg. Infect. Dis. 3:425434.
176. Teng, C. H.,, M. Cai,, S. Shin,, Y. Xie,, K. J. Kim,, N. A. Khan,, C. F. Di, and, K. S. Kim. 2005. Escherichia coli K1 RS218 interacts with human brain microvascular endothelial cells via type 1 fimbria bacteria in the fimbriated state. Infect. Immun. 73:29232931.
177. Ternhag, A.,, A. Törner,, A. Svensson,, K. Ekdahl, and, J. Giesecke. 2008. Short- and long-term effects of bacterial gastrointestinal infections. Emerg. Infect. Dis. 14:143148.
178. Thabane, M.,, D. T. Kottachchi, and, J. K. Marshall. 2007. Systematic review and meta-analysis: the incidence and prognosis of post-infectious irritable bowel syndrome. Aliment. Pharmacol. Ther. 26:535544.
179. Tilden, J., Jr.,, W. Young,, A. M. McNamara,, C. Custer,, B. Boesel,, M. A. Lambert-Fair,, J. Majkowski,, D. Vugia,, S. B. Werner,, J. Hollingsworth, and, J. G. Morris, Jr. 1996. A new route of transmission for Escherichia coli: infection from dry fermented salami. Am. J. Public Health 86:11421145.
180. Tomson, F. L.,, V. K. Viswanathan,, K. J. Kanack,, R. P. Kanteti,, K. V. Straub,, M. Menet,, J. B. Kaper, and, G. Hecht. 2005. Enteropathogenic Escherichia coli EspG disrupts microtubules and in conjunction with Orf3 enhances perturbation of the tight junction barrier. Mol. Microbiol. 56:447464.
181. Tönshoff, B.,, A. Sammet,, I. Sanden,, O. Mehls,, R. Waldherr, and, K. Schärer. 1994. Outcome and prognostic determinants in the hemolytic uremic syndrome of children. Nephron 68:6370.
182. Trabulsi, L. R.,, R. Keller, and, T. A. Tardelli Gomes. 2002. Typical and atypical enteropathogenic Escherichia coli. Emerg. Infect. Dis. 8:508513.
183. Trachtman, H.,, A. Cnaan,, E. Christen,, K. Gibbs,, S. Zhao,, D. W. Acheson,, R. Weiss,, F. J. Kaskel,, A. Spitzer, and, G. H. Hirschman. 2003. Effect of an oral Shiga toxin-binding agent on diarrhea-associated hemolytic uremic syndrome in children: a randomized controlled trial. JAMA 290:13371344.
184. Tulloch, E. F., Jr.,, K. J. Ryan,, S. B. Formal, and, F. A. Franklin. 1973. Invasive enteropathic Escherichia coli dysentery. An outbreak in 28 adults. Ann. Intern. Med. 79:1317.
185. Unhanand, M.,, M. M. Mustafa,, G. H. McCracken, Jr., and, J. D. Nelson. 1993. Gram-negative enteric bacillary meningitis: a twenty-one-year experience. J. Pediatr. 122:1521.
186. Vachvanichsanong, P. 2007. Urinary tract infection: one lingering effect of childhood kidney diseases—review of the literature. J. Nephrol. 20:2128.
187. Venkat, K. K. 2004. Proteinuria and microalbuminuria in adults: significance, evaluation, and treatment. South. Med. J. 97:969979.
188. Vieira, N.,, S. J. Bates,, O. D. Solberg,, K. Ponce,, R. Howsmon,, W. Cevallos,, G. Trueba,, L. Riley, and, J. N. Eisenberg. 2007. High prevalence of enteroinvasive Escherichia coli isolated in a remote region of northern coastal Ecuador. Am. J. Trop. Med. Hyg. 76:528533.
189. Vila, J.,, M. Vargas,, C. Casals,, H. Urassa,, H. Mshinda,, D. Schellemberg, and, J. Gascon. 1999. Antimicrobial resistance of diarrheagenic Escherichia coli isolated from children under the age of 5 years from Ifakara, Tanzania. Antimicrob. Agents Chemother. 43:30223024.
190. von Wulffen, H.,, H. Rüssmann,, H. Karch,, T. Meyer,, M. Bitzan,, T. C. Kohrt, and, S. Aleksic. 1989. Verocytotoxin-producing Escherichia coli O2:H5 isolated from patients with ulcerative colitis. Lancet i:14491450.
191. Walker-Smith, J. A. 1984. Food allergy and bowel disease in childhood. Midwife Health Visitor Community Nurse 20:308316.
192. Walterspiel, J. N.,, S. Ashkenazi,, A. L. Morrow, and, T. G. Cleary. 1992. Effect of subinhibitory concentrations of antibiotics on extracellular Shiga-like toxin I. Infection 20:2529.
193. Wang, H. S.,, M. F. Kuo, and, S. C. Huang. 2005. Diagnostic approach to recurrent bacterial meningitis in children. Chang Gung. Med. J. 28:441452.
194. Wang, L.,, D. Rothemund,, H. Curd, and, P. R. Reeves. 2003. Species-wide variation in the Escherichia coli flagellin (Hantigen) gene. J. Bacteriol. 185:29362943.
195. Wang, L. H.,, X. C. Fang, and, G. Z. Pan. 2004. Bacillary dysentery as a causative factor of irritable bowel syndrome and its pathogenesis. Gut 53:10961101.
196. Warren, J. W. 1996. Clinical presentations and epidemiology of urinary tract infections, p. 3–27. In H. L. T. Mobley and, J. W. Warren (ed.), Urinary Tract Infections: Molecular Pathogenesis and Clinical Management. ASM Press, Washington, DC.
197. Wong, C. S.,, S. Jelacic,, R. L. Habeeb,, S. L. Watkins, and, P. I. Tarr. 2000. The risk of the hemolytic-uremic syndrome after antibiotic treatment of Escherichia coli O157:H7 infections. N. Engl. J. Med. 342:19301936.
198. World Health Organization. 1999. New frontiers in the development of vaccines against enterotoxinogenic (ETEC) and enterohaemorrhagic (EHEC) E. coli infections. Part I. Wkly. Epidemiol. Rec. 74:98101.
199. Wu, S. X.,, and R. Q. Peng. 1992. Studies on an outbreak of neonatal diarrhea caused by EPEC 0127:H6 with plasmid analysis restriction analysis and outer membrane protein determination. Acta Paediatr. 81:217221.
200. Yamamoto, T.,, P. Echeverria, and, T. Yokota. 1992. Drug resistance and adherence to human intestines of enteroaggregative Escherichia coli. J. Infect. Dis. 165:744749.
201. Yamamoto, T.,, S. Endo,, T. Yokota, and, P. Echeverria. 1991. Characteristics of adherence of enteroaggregative Escherichia coli to human and animal mucosa. Infect. Immun. 59:37223739.
202. Yatsuyanagi, J.,, Y. Kinouchi,, S. Saito,, H. Sato, and, M. Morita. 1996. Enteropathogenic Escherichia coli strains harboring enteroaggregative Escherichia coli (EAggEC) heat-stable enterotoxin-1 gene isolated from a food-borne like outbreak. Kansenshogaku Zasshi 70:7379. (In Japanese.)
203. Yoder, P. S.,, and R. C. Hornik. 1994. Perceptions of severity of diarrhoea and treatment choice: a comparative study of HealthCom sites. J. Trop. Med. Hyg. 97:112.

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