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Abstract:

was first described in 1983 by Barry Marshall and Robin Warren, who were awarded a Nobel prize for this work in 2005. infections are extremely common, and approximately half the world’s population have the bacteria in their stomachs. The virulence determinant which confers the most significant increases in the risk of peptic ulcer disease and gastric cancer is the cytotoxin-associated gene pathogenicity island (cag PaI). Gastric mucosa-associated lymphoid tissue (MALT) lymphoma is an uncommon disease, with an incidence of approximately 0.8 per 100,000 per year. Iron deficiency anemia (IDA), the most common form of anemia, is highly prevalent in developing countries, where infection is virtually ubiquitous. Several researchers have reported an association between infection and vitamin B deficiency and malabsorption, even when gastric corpus atrophy is minimal. Chronic infection with has been reported as a possible causal factor in several extragastric diseases, including idiopathic thrombocytopenic purpura (ITP), ischemic heart disease, hepatobiliary disease, pulmonary disease, growth retardation, and Parkinson’s disease. A number of researchers have reported that abrogates the severity of gastroesophageal reflux disease (GERD) and its sequelae, and more recently there has been great interest in the possibility that the infection may help to prevent the development of allergy, asthma, and some autoimmune diseases. From an evolutionary viewpoint, one could consider that when colonization is absent, as is increasingly the case in developed countries, our immunity and gastroesophageal physiology are impaired.

Citation: Robinson K, Atherton J. 2009. , p 107-133. In Fratamico P, Smith J, Brogden K (ed), Sequelae and Long-Term Consequences of Infectious Diseases. ASM Press, Washington, DC. doi: 10.1128/9781555815486.ch7

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Tumor Necrosis Factor alpha
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Type IV Secretion Systems
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Figures

Image of Figure 1.
Figure 1.

Host cell signalling events induced by the pathogenicity island. The PaI-encoded type IV secretion system delivers CagA into epithelial cells. CagA is phosphorylated by Scr kinases prior to its interaction with SHP-2, a protein phosphatase. Subsequent activation of MAP kinase pathways results in a number of cellular effects, including actin rearrangements, cellular proliferation and cell scattering, increased apoptosis, disruption of the cell cycle, and the expression of proinflammatory genes. In addition, when the type IV secretion system connects bacterial and epithelial cell cytoplasm, bacterial cell wall components enter the epithelial cell and activate other cell signaling pathways. Peptidoglycan components bind to and activate the intracellular pattern recognition receptor Nod1, leading to activation of NF-κB ( ). This transcription factor stimulates expression of genes encoding factors which attract inflammatory cells (such as IL-8) and genes encoding antibacterial peptides ( ).

Citation: Robinson K, Atherton J. 2009. , p 107-133. In Fratamico P, Smith J, Brogden K (ed), Sequelae and Long-Term Consequences of Infectious Diseases. ASM Press, Washington, DC. doi: 10.1128/9781555815486.ch7
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Image of Figure 2.
Figure 2.

Effects of VacA polymorphisms on cytotoxic activity and associations with disease. The gene varies most in the signal region (which determines cytotoxic activity and may be type s1 or s2), the intermediate region located within the p37 subunit (which determines cytotoxic activity and may be type i1 or i2), and the mid-region within the p58 subunit (which determines binding to host cells and may be type m1 or m2). Only the combinations of regions shown occur commonly.

Citation: Robinson K, Atherton J. 2009. , p 107-133. In Fratamico P, Smith J, Brogden K (ed), Sequelae and Long-Term Consequences of Infectious Diseases. ASM Press, Washington, DC. doi: 10.1128/9781555815486.ch7
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Image of Figure 3.
Figure 3.

CD4 T-cell subsets and their associations with -induced inflammation and disease.

Citation: Robinson K, Atherton J. 2009. , p 107-133. In Fratamico P, Smith J, Brogden K (ed), Sequelae and Long-Term Consequences of Infectious Diseases. ASM Press, Washington, DC. doi: 10.1128/9781555815486.ch7
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Image of Figure 4.
Figure 4.

Colonization and gastritis patterns in the stomach: their effects on gastric acid production and their associations with duodenal and gastric ulceration.

Citation: Robinson K, Atherton J. 2009. , p 107-133. In Fratamico P, Smith J, Brogden K (ed), Sequelae and Long-Term Consequences of Infectious Diseases. ASM Press, Washington, DC. doi: 10.1128/9781555815486.ch7
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References

/content/book/10.1128/9781555815486.ch07
1. Adams, B. L.,, T. C. Bates, and, J. D. Oliver. 2003. Survival of Helicobacter pylori in a natural freshwater environment. Appl. Environ. Microbiol. 69:74627466.
2. Akhiani, A. A.,, J. Pappo,, Z. Kabok,, K. Schon,, W. Gao,, L. E. Franzen, and, N. Lycke. 2002. Protection against Helicobacter pylori infection following immunization is IL-12-dependent and mediated by Th1 cells. J. Immunol. 169:69776984.
3. Amedei, A.,, M. P. Bergman,, B. J. Appelmelk,, A. Azzurri,, M. Benagiano,, C. Tamburini,, R. van der Zee,, J. L. Telford,, C. M. Vandenbroucke-Grauls,, M. M. D’Elios, and, G. Del Prete. 2003. Molecular mimicry between Helicobacter pylori antigens and H+, K+–adenosine triphosphatase in human gastric autoimmunity. J. Exp. Med. 198:11471156.
4. Amedei, A.,, A. Cappon,, G. Codolo,, A. Cabrelle,, A. Polenghi,, M. Benagiano,, E. Tasca,, A. Azzurri,, M. M. D’Elios,, G. Del Prete, and, M. de Bernard. 2006. The neutrophil-activating protein of Helicobacter pylori promotes Th1 immune responses. J. Clin. Investig. 116:10921101.
5. Ameriso, S. F.,, E. A. Fridman,, R. C. Leiguarda, and, G. E. Sevlever. 2001. Detection of Helicobacter pylori in human carotid atherosclerotic plaques. Stroke 32:385391.
6. Ananieva, O.,, I. Nilsson,, T. Vorobjova,, R. Uibo, and, T. Wadstrom. 2002. Immune responses to bile-tolerant Helicobacter species in patients with chronic liver diseases, a randomized population group, and healthy blood donors. Clin. Diagn. Lab. Immunol. 9:11601164.
7. Anderson, L. A.,, S. J. Murphy,, B. T. Johnston,, P. Watson,, H. Ferguson,, K. B. Bamford,, A. Ghazy,, P. McCarron,, J. Mc Guigan,, J. V. Reynolds,, H. Comber, and, L. J. Murray. 2008. Relationship between Helicobacter pylori infection and gastric atrophy and the stages of the oesophageal inflammation, metaplasia, adenocarcinoma sequence: results from the FINBAR case-control study. Gut 57:7349.
8. Annibale, B.,, G. Capurso,, E. Lahner,, S. Passi,, R. Ricci,, F. Maggio, and, G. Delle Fave. 2003. Concomitant alterations in intragastric pH and ascorbic acid concentration in patients with Helicobacter pylori gastritis and associated iron deficiency anaemia. Gut 52:496501.
9. Annibale, B.,, G. Capurso,, G. Martino,, C. Grossi, and, G. Delle Fave. 2000. Iron deficiency anaemia and Helicobacter pylori infection. Int. J. Antimicrob. Agents 16:515519.
10. Annibale, B.,, M. Marignani,, B. Monarca,, G. Antonelli,, A. Marcheggiano,, G. Martino,, F. Mandelli,, R. Caprilli, and, G. Delle Fave. 1999. Reversal of iron deficiency anemia after Helicobacter pylori eradication in patients with asymptomatic gastritis. Ann. Intern. Med. 131:668672.
11. Anonymous. 2001. Gastric cancer and Helicobacter pylori: a combined analysis of 12 case control studies nested within prospective cohorts. Gut 49:347353.
12. Anonymous. 1994. Schistosomes, liver flukes and Helicobacter pylori. IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. Lyon, 7–14 June 1994. IARC Monogr. Eval. Carcinog. Risks Hum. 61:1241.
13. Arachchi, H. S.,, V. Kalra,, B. Lal,, V. Bhatia,, C. S. Baba,, S. Chakravarthy,, S. Rohatgi,, P. M. Sarma,, V. Mishra,, B. Das, and, V. Ahuja. 2007. Prevalence of duodenal ulcer-promoting gene (dupA) of Helicobacter pylori in patients with duodenal ulcer in North Indian population. Helicobacter 12:591597.
14. Araujo, M. I.,, B. S. Hoppe,, M. Medeiros, Jr., and, E. M. Carvalho. 2004. Schistosoma mansoni infection modulates the immune response against allergic and auto-immune diseases. Mem. Inst. Oswaldo Cruz 99:2732.
15. Arents, N. L.,, A. A. van Zwet,, J. C. Thijs,, A. M. Kooistra-Smid,, K. R. van Slochteren,, J. E. Degener,, J. H. Kleibeuker, and, L. J. van Doorn. 2001. The importance of vacA, cagA, and iceA genotypes of Helicobacter pylori infection in peptic ulcer disease and gastroesophageal reflux disease. Am. J. Gastroenterol. 96:26032608.
16. Argent, R. H.,, A. Burette,, V. Y. Miendje Deyi, and, J. C. Atherton. 2007. The presence of dupA in Helicobacter pylori is not significantly associated with duodenal ulceration in Belgium, South Africa, China, or North America. Clin. Infect. Dis. 45:12041206.
17. Argent, R. H.,, M. Kidd,, R. J. Owen,, R. J. Thomas,, M. C. Limb, and, J. C. Atherton. 2004. Determinants and consequences of different levels of CagA phosphorylation for clinical isolates of Helicobacter pylori. Gastroenterology 127:514523.
18. Argent, R. H.,, R. J. Thomas,, F. Aviles-Jimenez,, D. P. Letley,, M. C. Limb,, E. M. El-Omar, and, J. C. Atherton. 2008. Toxigenic Helicobacter pylori infection precedes gastric hypochlorhydria in cancer relatives, and H. pylori virulence evolves in these families. Clin. Cancer Res. 14:22272235.
19. Argent, R. H.,, R. J. Thomas,, F. Aviles-Jimenez,, D. P. Letley,, M. C. Limb,, E. M. El-Omar, and, J. C. Atherton. 2008. Toxigenic Helicobacter pylori infection precedes gastric hypochlorhydria in cancer relatives, and H. pylori virulence evolves in these families. Clin. Cancer Res. 14:22272235.
20. Arias, E.,, H. Martinetto,, M. Schultz,, S. Ameriso,, S. Rivera,, O. Lossetti, and, G. Sevlever. 2006. Seminested polymerase chain reaction (PCR) for detecting Helicobacter pylori DNA in carotid atheromas. Diagn. Mol. Pathol. 15:174179.
21. Arora, O. P.,, C. P. Kapoor, and, P. Sobti. 1968. Study of gastroduodenal abnormalities in chronic bronchitis and emphysema. Am J. Gastroenterol. 50:289296.
22. Asghar, R. J.,, and J. Parsonnet. 2001. Helicobacter pylori and risk for gastric adenocarcinoma. Semin. Gastrointest. Dis. 12:203208.
23. Ashorn, M.,, T. Ruuska, and, A. Makipernaa. 2001. Helicobacter pylori and iron deficiency anaemia in children. Scand. J. Gastroenterol. 36:701705.
24. Atherton, J. C. 2006. The pathogenesis of Helicobacter pylori-induced gastro-duodenal diseases. Ann. Rev. Pathol. 1:6396.
25. Atherton, J. C.,, P. Cao,, R. M. Peek, Jr.,, M. K. Tummuru,, M. J. Blaser, and, T. L. Cover. 1995. Mosaicism in vacuolating cytotoxin alleles of Helicobacter pylori. Association of specific vacA types with cytotoxin production and peptic ulceration. J. Biol. Chem. 270:1777117777.
26. Auer, I. A.,, R. D. Gascoyne,, J. M. Connors,, F. E. Cotter,, T. C. Greiner,, W. G. Sanger, and, D. E. Horsman. 1997. t(11;18)(q21;q21) is the most common translocation in MALT lymphomas. Ann. Oncol. 8:979985.
27. Austin, J. B.,, B. Kaur,, H. R. Anderson,, M. Burr,, L. S. Harkins,, D. P. Strachan, and, J. O. Warner. 1999. Hay fever, eczema, and wheeze: a nationwide UK study (ISAAC, international study of asthma and allergies in childhood). Arch. Dis. Child 81:225230.
28. Baens, M.,, B. Maes,, A. Steyls,, K. Geboes,, P. Marynen, and, C. De Wolf-Peeters. 2000. The product of the t(11;18), an API2-MLT fusion, marks nearly half of gastric MALT type lymphomas without large cell proliferation. Am. J. Pathol. 156:14331439.
29. Bamford, K. B.,, X. Fan,, S. E. Crowe,, J. F. Leary,, W. K. Gourley,, G. K. Luthra,, E. G. Brooks,, D. Y. Graham,, V. E. Reyes, and, P. B. Ernst. 1998. Lymphocytes in the human gastric mucosa during Helicobacter pylori have a T helper cell 1 phenotype. Gastroenterology 114:482492.
30. Bauditz, J.,, M. Ortner,, M. Bierbaum,, G. Niedobitek,, H. Lochs, and, S. Schreiber. 1999. Production of IL-12 in gastritis relates to infection with Helicobacter pylori. Clin. Exp. Immunol. 117:316323.
31. Bauerfeind, P.,, R. Garner,, B. E. Dunn, and, H. L. Mobley. 1997. Synthesis and activity of Helicobacter pylori urease and catalase at low pH. Gut 40:2530.
32. Bayraktaroglu, T.,, A. S. Aras,, S. Aydemir,, C. Davutoglu,, Y. Ustundag,, H. Atmaca, and, A. Borazan. 2004. Serum levels of tumor necrosis factor-alpha, interleukin-6 and interleukin-8 are not increased in dyspeptic patients with Helicobacter pylori-associated gastritis. Mediators Inflamm. 13:2528.
33. Beachy, P. A.,, S. S. Karhadkar, and, D. M. Berman. 2004. Tissue repair and stem cell renewal in carcinogenesis. Nature 432:324331.
34. Bebb, J. R.,, D. P. Letley,, R. J. Thomas,, F. Aviles,, H. M. Collins,, S. A. Watson,, N. M. Hand,, A. Zaitoun, and, J. C. Atherton. 2003. Helicobacter pylori upregulates matrilysin (MMP-7) in epithelial cells in vivo and in vitro in a Cag dependent manner. Gut 52:14081413.
35. Bell, G. D.,, K. Powell,, J. Weil,, G. Harrison,, S. Brookes, and, S. Prosser. 1991. 13C-urea breath test for Helicobacter pylori infection. Gut 32:551552.
36. Bergman, M. P.,, A. Amedei,, M. M. D’Elios,, A. Azzurri,, M. Benagiano,, C. Tamburini,, R. van der Zee,, C. M. Vandenbroucke-Grauls,, B. J. Appelmelk, and, G. Del Prete. 2003. Characterization of H+, K+-ATPase T cell epitopes in human autoimmune gastritis. Eur. J. Immunol. 33:539545.
37. Bjarnason, I. T.,, A. Charlett,, R. J. Dobbs,, S. M. Dobbs,, M. A. Ibrahim,, R. W. Kerwin,, R. F. Mahler,, N. L. Oxlade,, D. W. Peterson,, J. M. Plant,, A. B. Price, and, C. Weller. 2005. Role of chronic infection and inflammation in the gastrointestinal tract in the etiology and pathogenesis of idiopathic parkinsonism. Part 2: response of facets of clinical idiopathic parkinsonism to Helicobacter pylori eradication. A randomized, double-blind, placebo-controlled efficacy study. Helicobacter 10:276287.
38. Blaser, M. J. 1999. Hypothesis: the changing relationships of Helicobacter pylori and humans: implications for health and disease. J. Infect. Dis. 179:15231530.
39. Blaser, M. J.,, and J. C. Atherton. 2004. Helicobacter pylori persistence: biology and disease. J. Clin. Investig. 113:321333.
40. Blaser, M. J.,, Y. Chen, and, J. Reibman. 2008. Does Helicobacter pylori protect against asthma and allergy? Gut 57:561567.
41. Blaser, M. J.,, G. I. Perez-Perez,, H. Kleanthous,, T. L. Cover,, R. M. Peek,, P. H. Chyou,, G. N. Stemmermann, and, A. Nomura. 1995. Infection with Helicobacter pylori strains possessing cagA is associated with an increased risk of developing adenocarcinoma of the stomach. Cancer Res. 55:21112115.
42. Blasi, F.,, F. Denti,, M. Erba,, R. Cosentini,, R. Raccanelli,, A. Rinaldi,, L. Fagetti,, G. Esposito,, U. Ruberti, and, L. Allegra. 1996. Detection of Chlamydia pneumoniae but not Helicobacter pylori in atherosclerotic plaques of aortic aneurysms. J. Clin. Microbiol. 34:27662769.
43. Bloomfield, S. F.,, R. Stanwell-Smith,, R. W. Crevel, and, J. Pickup. 2006. Too clean, or not too clean: the hygiene hypothesis and home hygiene. Clin. Exp. Allergy 36:402425.
44. Bohr, U. R.,, B. Annibale,, F. Franceschi,, D. Roccarina, and, A. Gasbarrini. 2007. Extragastric manifestations of Helicobacter pylori infection—other Helicobacters. Helicobacter 12(Suppl. 1):4553.
45. Boomkens, S. Y.,, J. G. Kusters,, G. Hoffmann,, R. G. Pot,, B. Spee,, L. C. Penning,, H. F. Egberink,, T. S. van den Ingh, and, J. Rothuizen. 2004. Detection of Helicobacter pylori in bile of cats. FEMS Immunol. Med. Microbiol. 42:307311.
46. Bouzourene, H.,, T. Haefliger,, F. Delacretaz, and, E. Saraga. 1999. The role of Helicobacter pylori in primary gastric MALT lymphoma. Histopathology 34:118123.
47. Bravo, L. E.,, R. Mera,, J. C. Reina,, A. Pradilla,, A. Alzate,, E. Fontham, and, P. Correa. 2003. Impact of Helicobacter pylori infection on growth of children: a prospective cohort study. J. Pediatr. Gastroenterol. Nutr. 37:614619.
48. Brown, L. M.,, T. L. Thomas,, J. L. Ma,, Y. S. Chang,, W. C. You,, W. D. Liu,, L. Zhang, and, M. H. Gail. 2001. Helicobacter pylori infection in rural China: exposure to domestic animals during childhood and adulthood. Scand. J. Infect. Dis. 33:686691.
49. Bunch, T. J.,, J. D. Day,, J. L. Anderson,, B. D. Horne,, J. B. Muhlestein,, B. G. Crandall,, J. P. Weiss,, D. L. Lappe, and, S. J. Asirvatham. 2008. Frequency of Helicobacter pylori seropositivity and C-reactive protein increase in atrial fibrillation in patients undergoing coronary angiography. Am. J. Cardiol. 101:848851.
50. Buyukgebiz, A.,, B. Dundar,, E. Bober, and, B. Buyukgebiz. 2001. Helicobacter pylori infection in children with constitutional delay of growth and puberty. J. Pediatr. Endocrinol. Metab. 14:549551.
51. Byrne, M. F.,, S. W. Kerrigan,, P. A. Corcoran,, J. C. Atherton,, F. E. Murray,, D. J. Fitzgerald, and, D. M. Cox. 2003. Helicobacter pylori binds von Willebrand factor and interacts with GPIb to induce platelet aggregation. Gastroenterology 124:18461854.
52. Cai, X.,, J. Carlson,, C. Stoicov,, H. Li,, T. C. Wang, and, J. Houghton. 2005. Helicobacter felis eradication restores normal architecture and inhibits gastric cancer progression in C57BL/6 mice. Gastroenterology 128:19371952.
53. Carmel, R.,, G. I. Perez-Perez, and, M. J. Blaser. 1994. Helicobacter pylori infection and food-cobalamin malabsorption. Dig. Dis. Sci. 39:309314.
54. Caruso, R.,, F. Pallone, and, G. Monteleone. 2007. Emerging role of IL-23/IL-17 axis in H. pylori-associated pathology. World J. Gastroenterol. 13:55475551.
55. Chang, F.,, L. S. Steelman,, J. G. Shelton,, J. T. Lee,, P. M. Navolanic,, W. L. Blalock,, R. Franklin, and, J. A. McCubrey. 2003. Regulation of cell cycle progression and apoptosis by the Ras/Raf/MEK/ERK pathway. Int. J. Oncol. 22:469480.
56. Chen, L. H.,, and H. S. Luo. 2007. Effects of H. pylori therapy on erythrocytic and iron parameters in iron deficiency anemia patients with H. pylori-positive chronic gastristis. World J. Gastroenterol. 13:53805383.
57. Chen, W.,, D. Shu, and, V. S. Chadwick. 2001. Helicobacter pylori infection: mechanism of colonization and functional dyspepsia. Reduced colonization of gastric mucosa by Helicobacter pylori in mice deficient in interleukin-10. J. Gastroenterol. Hepatol. 16:377383.
58. Chen, Y.,, and M. J. Blaser. 2007. Inverse associations of Helicobacter pylori with asthma and allergy. Arch. Intern. Med. 167:821827.
59. Choe, Y. H.,, S. K. Kim, and, Y. C. Hong. 2000. Helicobacter pylori infection with iron deficiency anaemia and subnormal growth at puberty. Arch. Dis. Child 82:136140.
60. Choe, Y. H.,, Y. J. Oh,, N. G. Lee,, I. Imoto,, Y. Adachi,, N. Toyoda, and, E. C. Gabazza. 2003. Lactoferrin sequestration and its contribution to iron-deficiency anemia in Helicobacter pylori-infected gastric mucosa. J. Gastroenterol. Hepatol. 18:980985.
61. Chow, T. K.,, J. R. Lambert,, M. L. Wahlqvist, and, B. H. Hsu-Hage. 1995. Helicobacter pylori in Melbourne Chinese immigrants: evidence for oral-oral transmission via chopsticks. J. Gastroenterol. Hepatol. 10:562569.
62. Claeys, D.,, G. Faller,, B. J. Appelmelk,, R. Negrini, and, T. Kirchner. 1998. The gastric H+, K+-ATPase is a major autoantigen in chronic Helicobacter pylori gastritis with body mucosa atrophy. Gastroenterology 115:340347.
63. Clyne, M.,, A. Labigne, and, B. Drumm. 1995. Helicobacter pylori requires an acidic environment to survive in the presence of urea. Infect. Immun. 63:16691673.
64. Colbeck, J. C.,, L. M. Hansen,, J. M. Fong, and, J. V. Solnick. 2006. Genotypic profile of the outer membrane proteins BabA and BabB in clinical isolates of Helicobacter pylori. Infect. Immun. 74:43754378.
65. Conrad, M. E.,, and S. G. Schade. 1968. Ascorbic acid chelates in iron absorption: a role for hydrochloric acid and bile. Gastroenterology 55:3545.
66. Corcoran, P. A.,, J. C. Atherton,, S. W. Kerrigan,, T. Wadstrom,, F. E. Murray,, R. M. Peek,, D. J. Fitzgerald,, D. M. Cox, and, M. F. Byrne. 2007. The effect of different strains of Helicobacter pylori on platelet aggregation. Can. J. Gastroenterol. 21:367370.
67. Correa, P.,, E. T. Fontham,, J. C. Bravo,, L. E. Bravo,, B. Ruiz,, G. Zarama,, J. L. Realpe,, G. T. Malcom,, D. Li,, W. D. Johnson, and, R. Mera. 2000. Chemoprevention of gastric dysplasia: randomized trial of antioxidant supplements and anti-Helicobacter pylori therapy. J. Natl. Cancer Inst. 92:18811888.
68. Correa, P.,, W. Haenszel,, C. Cuello,, S. Tannenbaum, and, M. Archer. 1975. A model for gastric cancer epidemiology. Lancet ii:5860.
69. Cover, T. L.,, and S. R. Blanke. 2005. Helicobacter pylori VacA, a paradigm for toxin multifunctionality. Nat. Rev. Microbiol. 3:320332.
70. Cover, T. L.,, and M. J. Blaser. 1992. Purification and characterization of the vacuolating toxin from Helicobacter pylori. J. Biol. Chem. 267:1057010575.
71. Crew, K. D.,, and A. I. Neugut. 2006. Epidemiology of gastric cancer. World J. Gastroenterol. 12:354362.
72. Cui, G.,, J. Houghton,, N. Finkel,, J. Carlson, and, T. Wang. 2003. IFN-gamma infusion induces gastric atrophy, metaplasia and dysplasia in the absence of Helicobacter pylori infection: a role for the immune response in Helicobacter disease. Gastroenterology 124(Suppl. 1):A19.
73. D’Elios, M. M.,, M. P. Bergman,, A. Amedei,, B. J. Appelmelk, and, G. Del Prete. 2004. Helicobacter pylori and gastric autoimmunity. Microbes Infect. 6:13951401.
74. Danesh, J.,, S. Kaptoge,, A. G. Mann,, N. Sarwar,, A. Wood,, S. B. Angleman,, F. Wensley,, J. P. Higgins,, L. Lennon,, G. Eiriksdottir,, A. Rumley,, P. H. Whincup,, G. D. Lowe, and, V. Gudnason. 2008. Long-term interleukin-6 levels and subsequent risk of coronary heart disease: two new prospective studies and a systematic review. PLoS Med. 5:e78.
75. Danesh, J.,, and R. Peto. 1998. Risk factors for coronary heart disease and infection with Helicobacter pylori: metaanalysis of 18 studies. BMJ 316:11301132.
76. Das, U. N. 1998. Hypothesis: cis-unsaturated fatty acids as potential anti-peptic ulcer drugs. Prostaglandins Leukot. Essent. Fatty Acids 58:377380.
77. de Jonge, R.,, R. G. Pot,, R. J. Loffeld,, A. H. van Vliet,, E. J. Kuipers, and, J. G. Kusters. 2004. The functional status of the Helicobacter pylori sabB adhesin gene as a putative marker for disease outcome. Helicobacter 9:158164.
78. Delamore, I. W.,, and D. J. Shearman. 1965. Chronic iron-deficiency anaemia and atrophic gastritis. Lancet i:889891.
79. Di Bonaventura, G.,, R. Piccolomini,, A. Pompilio,, R. Zappacosta,, M. Piccolomini, and, M. Neri. 2007. Serum and mucosal cytokine profiles in patients with active Helicobacter pylori and ischemic heart disease: is there a relationship? Int. J. Immunopathol. Pharmacol. 20:163172.
80. Dickson, J. H.,, A. Grabowska,, M. El-Zaatari,, J. Atherton, and, S. A. Watson. 2006. Helicobacter pylori can induce heparin-binding epidermal growth factor expression via gastrin and its receptor. Cancer Res. 66:75247531.
81. Dimola, S.,, and M. L. Caruso. 1999. Helicobacter pylori in animals affecting the human habitat through the food chain. Anticancer Res. 19:38893894.
82. Dobbs, R. J.,, A. Charlett,, A. G. Purkiss,, S. M. Dobbs,, C. Weller, and, D. W. Peterson. 1999. Association of circulating TNF-alpha and IL-6 with ageing and parkinsonism. Acta Neurol. Scand. 100:3441.
83. Dore, M. P.,, G. Realdi,, A. R. Sepulveda, and, D. Y. Graham. 2003. Detection of genomic Helicobacter pylori DNA in the blood of patients positive for the infection. Dig. Liver Dis. 35:839840.
84. Dore, M. P.,, A. R. Sepulveda,, H. El-Zimaity,, Y. Yamaoka,, M. S. Osato,, K. Mototsugu,, A. M. Nieddu,, G. Realdi, and, D. Y. Graham. 2001. Isolation of Helicobacter pylori from sheep-implications for transmission to humans. Am. J. Gastroenterol. 96:13961401.
85. Doscherholmen, A.,, D. Ripley,, S. Chang, and, S. E. Silvis. 1977. Influence of age and stomach function on serum vitamin B12 concentration. Scand. J. Gastroenterol. 12:313319.
86. Dowsett, S. A.,, and M. J. Kowolik. 2003. Oral Helicobacter pylori: can we stomach it? Crit. Rev. Oral Biol. Med. 14:226233.
87. Du, M. Q.,, and J. C. Atherton. 2006. Molecular subtyping of gastric MALT lymphomas: implications for prognosis and management. Gut 55:886893.
88. Du, M. Q.,, C. F. Xu,, T. C. Diss,, H. Z. Peng,, A. C. Wotherspoon,, P. G. Isaacson, and, L. X. Pan. 1996. Intestinal dissemination of gastric mucosa-associated lymphoid tissue lymphoma. Blood 88:44454451.
89. Du, Y.,, A. Agnew,, X. P. Ye,, P. A. Robinson,, D. Forman, and, J. E. Crabtree. 2006. Helicobacter pylori and Schistosoma japonicum co-infection in a Chinese population: helminth infection alters humoral responses to H. pylori and serum pepsinogen I/II ratio. Microbes Infect. 8:5260.
90. Dunn, B. E.,, H. Cohen, and, M. J. Blaser. 1997. Helicobacter pylori. Clin. Microbiol. Rev. 10:720741.
91. Dzierzanowska-Fangrat, K.,, J. Michalkiewicz,, J. Cielecka-Kuszyk,, M. Nowak,, D. Celinska-Cedro,, E. Rozynek,, D. Dzierzanowska, and, J. E. Crabtree. 2008. Enhanced gastric IL-18 mRNA expression in Helicobacter pylori-infected children is associated with macrophage infiltration, IL-8, and IL-1 beta mRNA expression. Eur. J. Gastroenterol. Hepatol. 20:314319.
92. Eaton, K. A.,, and S. Krakowka. 1994. Effect of gastric pH on urease-dependent colonization of gnotobiotic piglets by Helicobacter pylori. Infect. Immun. 62:36043607.
93. Eaton, K. A.,, M. Mefford, and, T. Thevenot. 2001. The role of T cell subsets and cytokines in the pathogenesis of Helicobacter pylori gastritis in mice. J. Immunol. 166:74567461.
94. Eaton, K. A.,, D. R. Morgan, and, S. Krakowka. 1992. Motility as a factor in the colonisation of gnotobiotic piglets by Helicobacter pylori. J. Med. Microbiol. 37:123127.
95. Ece, F.,, Hataby, N. F.,, N. Erdal,, C. Gedik,, C. Guney, and, F. Aksoy. 2005. Does Helicobacter pylori infection play a role in lung cancer? Respir. Med. 99:12581262.
96. Eck, M.,, B. Schmausser,, R. Haas,, A. Greiner,, S. Czub, and, H. K. Muller-Hermelink. 1997. MALT-type lymphoma of the stomach is associated with Helicobacter pylori strains expressing the CagA protein. Gastroenterology 112:14821486.
97. El-Omar, E. M.,, M. Carrington,, W. H. Chow,, K. E. Mc-Coll,, J. H. Bream,, H. A. Young,, J. Herrera,, J. Lissowska,, C. C. Yuan,, N. Rothman,, G. Lanyon,, M. Martin,, J. F. Fraumeni, Jr., and, C. S. Rabkin. 2000. Interleukin-1 polymorphisms associated with increased risk of gastric cancer. Nature 404:398402.
98. El-Omar, E. M.,, C. S. Rabkin,, M. D. Gammon,, T. L. Vaughan,, H. A. Risch,, J. B. Schoenberg,, J. L. Stanford,, S. T. Mayne,, J. Goedert,, W. J. Blot,, J. F. Fraumeni, Jr., and, W. H. Chow. 2003. Increased risk of noncardia gastric cancer associated with proinflammatory cytokine gene polymorphisms. Gastroenterology 124:11931201.
99. Elizalde, J. I.,, J. M. Pique,, V. Moreno,, J. D. Morillas,, I. Elizalde,, L. Bujanda,, C. M. De Argila,, A. Cosme,, A. Castiella, and, E. Ros. 2002. Influence of Helicobacter pylori infection and eradication on blood lipids and fibrinogen. Aliment. Pharmacol. Ther. 16:577586.
100. Emilia, G.,, M. Luppi,, P. Zucchini,, M. Morselli,, L. Potenza,, F. Forghieri,, F. Volzone,, G. Jovic,, G. Leonardi,, A. Donelli, and, G. Torelli. 2007. Helicobacter pylori infection and chronic immune thrombocytopenic purpura: long-term results of bacterium eradication and association with bacterium virulence profiles. Blood 110:38333841.
101. Enarsson, K.,, A. Lundgren,, B. Kindlund,, M. Hermansson,, G. Roncador,, A. H. Banham,, B. S. Lundin, and, M. Quiding-Jarbrink. 2006. Function and recruitment of mucosal regulatory T cells in human chronic Helicobacter pylori infection and gastric adenocarcinoma. Clin. Immunol. 121:358368.
102. Erdman, S. E.,, T. Poutahidis,, M. Tomczak,, A. B. Rogers,, K. Cormier,, B. Plank,, B. H. Horwitz, and, J. G. Fox. 2003. CD4+ CD25+ regulatory T lymphocytes inhibit microbially induced colon cancer in Rag2-deficient mice. Am. J. Pathol. 162:691702.
103. Everhart, J. E. 2000. Recent developments in the epidemiology of Helicobacter pylori. Gastroenterol. Clin. North. Am. 29:559578.
104. Fallone, C. A.,, A. N. Barkun,, G. Friedman,, S. Mayrand,, V. Loo,, R. Beech,, L. Best, and, L. Joseph. 2000. Is Helicobacter pylori eradication associated with gastroesophageal reflux disease? Am. J. Gastroenterol. 95:914920.
105. Farinha, P.,, and R. D. Gascoyne. 2005. Helicobacter pylori and MALT lymphoma. Gastroenterology 128:15791605.
106. Farsak, B.,, A. Yildirir,, Y. Akyon,, A. Pinar,, M. Oc,, E. Boke,, S. Kes, and, L. Tokgozoglu. 2000. Detection of Chlamydia pneumoniae and Helicobacter pylori DNA in human atherosclerotic plaques by PCR. J. Clin. Microbiol. 38:44084411.
107. Ferreira-Chagas, B.,, G. Lasne,, S. Dupouy,, A. Gallois,, A. Morgner,, A. Menard,, F. Megraud, and, P. Lehours. 2007. In vitro proinflammatory properties of Helicobacter pylori strains causing low-grade gastric MALT lymphoma. Helicobacter 12:616617.
108. Figueiredo, C.,, J. C. Machado,, P. Pharoah,, R. Seruca,, S. Sousa,, R. Carvalho,, A. F. Capelinha,, W. Quint,, C. Caldas,, L. J. van Doorn,, F. Carneiro, and, M. Sobrinho-Simoes. 2002. Helicobacter pylori and interleukin 1 genotyping: an opportunity to identify high-risk individuals for gastric carcinoma. J. Natl. Cancer Inst. 94:16801687.
109. Figueiredo, C.,, W. Quint,, N. Nouhan,, H. van den Munckhof,, P. Herbrink,, J. Scherpenisse,, W. de Boer,, P. Schneeberger,, G. Perez-Perez,, M. J. Blaser, and, L. J. van Doorn. 2001. Assessment of Helicobacter pylori vacA and cagA genotypes and host serological response. J. Clin. Microbiol. 39:13391344.
110. Figura, N.,, F. Cetta,, M. Angelico,, G. Montalto,, D. Cetta,, L. Pacenti,, C. Vindigni,, D. Vaira,, F. Festuccia,, A. De Santis,, G. Rattan,, R. Giannace,, S. Campagna, and, C. Gennari. 1998. Most Helicobacter pylori-infected patients have specific antibodies, and some also have H. pylori antigens and genomic material in bile: is it a risk factor for gallstone formation? Dig. Dis. Sci. 43:854862.
111. Fox, J. G.,, P. Beck,, C. A. Dangler,, M. T. Whary,, T. C. Wang,, H. N. Shi, and, C. Nagler-Anderson. 2000. Concurrent enteric helminth infection modulates inflammation and gastric immune responses and reduces Helicobacter-induced gastric atrophy. Nat. Med. 6:536542.
112. Fox, J. G.,, F. E. Dewhirst,, Z. Shen,, Y. Feng,, N. S. Taylor,, B. J. Paster,, R. L. Ericson,, C. N. Lau,, P. Correa,, J. C. Araya, and, I. Roa. 1998. Hepatic Helicobacter species identified in bile and gallbladder tissue from Chileans with chronic cholecystitis. Gastroenterology 114:755763.
113. Fox, J. G.,, A. B. Rogers,, M. Ihrig,, N. S. Taylor,, M. T. Whary,, G. Dockray,, A. Varro, and, T. C. Wang. 2003. Helicobacter pylori-associated gastric cancer in INS-GAS mice is gender specific. Cancer Res. 63:942950.
114. Fox, J. G.,, T. C. Wang,, A. B. Rogers,, T. Poutahidis,, Z. Ge,, N. Taylor,, C. A. Dangler,, D. A. Israel,, U. Krishna,, K. Gaus, and, R. M. Peek, Jr. 2003. Host and microbial constituents influence Helicobacter pylori-induced cancer in a murine model of hypergastrinemia. Gastroenterology 124:18791890.
115. Franceschi, F.,, N. Christodoulides,, M. H. Kroll, and, R. M. Genta. 2004. Helicobacter pylori and idiopathic thrombocytopenic purpura. Ann. Intern. Med. 140:766767.
116. Franchini, M.,, M. Cruciani,, C. Mengoli,, G. Pizzolo, and, D. Veneri. 2007. Effect of Helicobacter pylori eradication on platelet count in idiopathic thrombocytopenic purpura: a systematic review and meta-analysis. J. Antimicrob. Chemother. 60:237246.
117. Franchini, M.,, and D. Veneri. 2004. Helicobacter pylori infection and immune thrombocytopenic purpura: an update. Helicobacter 9:342346.
118. Furuta, T.,, N. Shirai,, F. Xiao,, M. Takashima, and, H. Hanai. 2002. Effect of Helicobacter pylori infection and its eradication on nutrition. Aliment. Pharmacol. Ther. 16:799806.
119. Gebert, B.,, W. Fischer,, E. Weiss,, R. Hoffmann, and, R. Haas. 2003. Helicobacter pylori vacuolating cytotoxin inhibits T lymphocyte activation. Science 301:10991102.
120. Genta, R. M.,, H. W. Hamner, and, D. Y. Graham. 1993. Gastric lymphoid follicles in Helicobacter pylori infection: frequency, distribution, and response to triple therapy. Hum. Pathol. 24:577583.
121. Gessner, B. D.,, H. C. Baggett,, P. T. Muth,, E. Dunaway,, B. D. Gold,, Z. Feng, and, A. J. Parkinson. 2006. A controlled, household-randomized, open-label trial of the effect that treatment of Helicobacter pylori infection has on iron deficiency in children in rural Alaska. J. Infect. Dis. 193:537546.
122. Go, M. F.,, and D. T. Smoot. 2000. Helicobacter pylori, gastric MALT lymphoma, and adenocarcinoma of the stomach. Semin. Gastrointest. Dis. 11:134141.
123. Gobel, R.,, E. L. Symonds,, R. N. Butler, and, C. D. Tran. 2007. Association between Helicobacter pylori infection in mothers and birth weight. Dig. Dis. Sci. 52:30493053.
124. Goll, R.,, F. Gruber,, T. Olsen,, G. Cui,, G. Raschpichler,, M. Buset,, A. M. Asfeldt,, A. Husebekk, and, J. Florholmen. 2007. Helicobacter pylori stimulates a mixed adaptive immune response with a strong T-regulatory component in human gastric mucosa. Helicobacter 12:185192.
125. Goodman, K. J.,, and P. Correa. 1995. The transmission of Helicobacter pylori. A critical review of the evidence. Int. J. Epidemiol. 24:875887.
126. Graham, D. Y.,, H. M. Malaty,, D. G. Evans,, D. J. Evans, Jr.,, P. D. Klein, and, E. Adam. 1991. Epidemiology of Helicobacter pylori in an asymptomatic population in the United States. Effect of age, race, and socioeconomic status. Gastroenterology 100:14951501.
127. Graham, D. Y.,, A. R. Opekun,, M. S. Osato,, H. M. El-Zimaity,, C. K. Lee,, Y. Yamaoka,, W. A. Qureshi,, M. Cadoz, and, T. P. Monath. 2004. Challenge model for Helicobacter pylori infection in human volunteers. Gut 53:12351243.
128. Gumurdulu, Y.,, E. Serin,, B. Ozer,, F. Kayaselcuk,, K. Kul,, C. Pata,, M. Guclu,, G. Gur, and, S. Boyacioglu. 2003. Predictors of vitamin B12 deficiency: age and Helicobacter pylori load of antral mucosa. Turk. J. Gastroenterol. 14:4449.
129. Guo, Y. S.,, J. Z. Cheng,, G. F. Jin,, J. S. Gutkind,, M. R. Hellmich, and, C. M. Townsend, Jr. 2002. Gastrin stimulates cyclooxygenase-2 expression in intestinal epithelial cells through multiple signaling pathways. Evidence for involvement of ERK5 kinase and transactivation of the epidermal growth factor receptor. J. Biol. Chem. 277:4875548763.
130. Gyulai, Z.,, G. Klausz,, A. Tiszai,, Z. Lenart,, I. T. Kasa,, J. Lonovics, and, Y. Mandi. 2004. Genetic polymorphism of interleukin-8 (IL-8) is associated with Helicobacter pylori-induced duodenal ulcer. Eur. Cytokine Netw. 15:353358.
131. Hahm, K. B.,, H. Y. Lim,, S. Sohn,, H. J. Kwon,, K. M. Lee,, J. S. Lee,, Y. J. Surh,, Y. B. Kim,, H. J. Joo,, W. S. Kim, and, S. W. Cho. 2002. In vitro evidence of the role of COX-2 in attenuating gastric inflammation and promoting gastric carcinogenesis. J. Environ. Pathol. Toxicol. Oncol. 21:165176.
132. Hamada, H.,, K. Haruma,, M. Mihara,, T. Kamada,, M. Yoshihara,, K. Sumii,, G. Kajiyama, and, M. Kawanishi. 2000. High incidence of reflux oesophagitis after eradication therapy for Helicobacter pylori: impacts of hiatal hernia and corpus gastritis. Aliment. Pharmacol. Ther. 14:729735.
133. Han, S. R.,, H. C. Zschausch,, H. G. Meyer,, T. Schneider,, M. Loos,, S. Bhakdi, and, M. J. Maeurer. 2000. Helicobacter pylori: clonal population structure and restricted transmission within families revealed by molecular typing. J. Clin. Microbiol. 38:36463651.
134. Hanninen, M. L. 1991. Sensitivity of Helicobacter pylori to different bile salts. Eur. J. Clin. Microbiol. Infect. Dis. 10:515518.
135. Hansson, L. E.,, L. Engstrand,, O. Nyren,, D. J. Evans, Jr.,, A. Lindgren,, R. Bergstrom,, B. Andersson,, L. Athlin,, O. Bendtsen, and, P. Tracz. 1993. Helicobacter pylori infection: independent risk indicator of gastric adenocarcinoma. Gastroenterology 105:10981103.
136. Hardaker, E. L.,, A. M. Bacon,, K. Carlson,, A. K. Roshak,, J. J. Foley,, D. B. Schmidt,, P. T. Buckley,, M. Comegys,, R. A. Panettieri, Jr.,, H. M. Sarau, and, K. E. Belmonte. 2004. Regulation of TNF-alpha- and IFN-gamma-induced CXCL10 expression: participation of the airway smooth muscle in the pulmonary inflammatory response in chronic obstructive pulmonary disease. FASEB J. 18:191193.
137. Harford, W. V.,, C. Barnett,, E. Lee,, G. Perez-Perez,, M. J. Blaser, and, W. L. Peterson. 2000. Acute gastritis with hypochlorhydria: report of 35 cases with long term follow up. Gut 47:467472.
138. Harris, P. R.,, S. W. Wright,, C. Serrano,, F. Riera,, I. Duarte,, J. Torres,, A. Pena,, A. Rollan,, P. Viviani,, E. Guiraldes,, J. M. Schmitz,, R. G. Lorenz,, L. Novak,, L. E. Smythies, and, P. D. Smith. 2008. Helicobacter pylori gastritis in children is associated with a regulatory T-cell response. Gastroenterology 134:491499.
139. Haruma, K.,, M. Mihara,, E. Okamoto,, H. Kusunoki,, M. Hananoki,, S. Tanaka,, M. Yoshihara,, K. Sumii, and, G. Kajiyama. 1999. Eradication of Helicobacter pylori increases gastric acidity in patients with atrophic gastritis of the corpus-evaluation of 24-h pH monitoring. Aliment. Pharmacol. Ther. 13:155162.
140. Hida, N.,, T. Shimoyama, Jr.,, P. Neville,, M. F. Dixon,, A. T. Axon,, T. Shimoyama, Sr., and, J. E. Crabtree. 1999. Increased expression of IL-10 and IL-12 (p40) mRNA in Helicobacter pylori infected gastric mucosa: relation to bacterial cag status and peptic ulceration. J. Clin. Pathol. 52:658664.
141. Higashi, H.,, A. Nakaya,, R. Tsutsumi,, K. Yokoyama,, Y. Fujii,, S. Ishikawa,, M. Higuchi,, A. Takahashi,, Y. Kurashima,, Y. Teishikata,, S. Tanaka,, T. Azuma, and, M. Hatakeyama. 2004. Helicobacter pylori CagA induces Ras-independent morphogenetic response through SHP-2 recruitment and activation. J. Biol. Chem. 279:1720517216.
142. Higashi, H.,, R. Tsutsumi,, A. Fujita,, S. Yamazaki,, M. Asaka,, T. Azuma, and, M. Hatakeyama. 2002. Biological activity of the Helicobacter pylori virulence factor CagA is determined by variation in the tyrosine phosphorylation sites. Proc. Natl. Acad. Sci. USA 99:1442814433.
143. Higashi, H.,, R. Tsutsumi,, S. Muto,, T. Sugiyama,, T. Azuma,, M. Asaka, and, M. Hatakeyama. 2002. SHP-2 tyrosine phosphatase as an intracellular target of Helicobacter pylori CagA protein. Science 295:683686.
144. Hirata, I.,, M. Murano,, T. Ishiguro,, K. Toshina,, F. Y. Wang, and, K. Katsu. 2007. HLA genotype and development of gastric cancer in patients with Helicobacter pylori infection. Hepatogastroenterology 54:990994.
145. Hirata, Y.,, T. Ohmae,, W. Shibata,, S. Maeda,, K. Ogura,, H. Yoshida,, T. Kawabe, and, M. Omata. 2006. MyD88 and TNF receptor-associated factor 6 are critical signal transducers in Helicobacter pylori-infected human epithelial cells. J. Immunol. 176:37963803.
146. Ho, L.,, R. E. Davis,, B. Conne,, R. Chappuis,, M. Berczy,, P. Mhawech,, L. M. Staudt, and, J. Schwaller. 2005. MALT1 and the API2-MALT1 fusion act between CD40 and IKK and confer NF-kappa B-dependent proliferative advantage and resistance against FAS-induced cell death in B cells. Blood 105:28912899.
147. Hoffmeister, A.,, D. Rothenbacher,, G. Bode,, K. Persson,, W. Marz,, M. A. Nauck,, H. Brenner,, V. Hombach, and, W. Koenig. 2001. Current infection with Helicobacter pylori, but not seropositivity to Chlamydia pneumoniae or cytomegalovirus, is associated with an atherogenic, modified lipid profile. Arterioscler. Thromb. Vasc. Biol. 21:427432.
148. Hold, G. L.,, C. S. Rabkin,, W. H. Chow,, M. G. Smith,, M. D. Gammon,, H. A. Risch,, T. L. Vaughan,, K. E. McColl,, J. Lissowska,, W. Zatonski,, J. B. Schoenberg,, W. J. Blot,, N. A. Mowat,, J. F. Fraumeni, Jr., and, E. M. El-Omar. 2007. A functional polymorphism of toll-like receptor 4 gene increases risk of gastric carcinoma and its precursors. Gastroenterology 132:905912.
149. Hoshi, H.,, I. Ohno,, M. Honma,, Y. Tanno,, K. Yamauchi,, G. Tamura, and, K. Shirato. 1995. IL-5, IL-8 and GM-CSF immunostaining of sputum cells in bronchial asthma and chronic bronchitis. Clin. Exp. Allergy 25:720728.
150. Houghton, J.,, C. Stoicov,, S. Nomura,, A. B. Rogers,, J. Carlson,, H. Li,, X. Cai,, J. G. Fox,, J. R. Goldenring, and, T. C. Wang. 2004. Gastric cancer originating from bone marrow-derived cells. Science 306:15681571.
151. Hsu, J. Y.,, S. L. King,, B. I. Kuo, and, C. D. Chiang. 2004. Age of onset and the characteristics of asthma. Respirology 9:369372.
152. Hsu, P. I.,, C. N. Li,, H. H. Tseng,, K. H. Lai,, P. N. Hsu,, G. H. Lo,, C. C. Lo,, J. J. Yeh,, L. P. Ger,, M. Hsiao,, Y. Yamaoka,, I. R. Hwang, and, A. Chen. 2004. The interleukin-1 RN polymorphism and Helicobacter pylori infection in the development of duodenal ulcer. Helicobacter 9:605613.
153. Hsu, P. I.,, P. J. Lu,, E. M. Wang,, L. P. Ger,, G. H. Lo,, F. W. Tsay,, T. A. Chen,, H. B. Yang,, H. C. Chen,, W. S. Lin, and, K. H. Lai. 2008. Polymorphisms of death pathway genes FAS and FASL and risk of premalignant gastric lesions. Anticancer Res. 28:97103.
154. Hu, L. T.,, and H. L. Mobley. 1990. Purification and N-terminal analysis of urease from Helicobacter pylori. Infect. Immun. 58:992998.
155. Hu, P. J.,, H. M. Mitchell,, Y. Y. Li,, M. H. Zhou, and, S. L. Hazell. 1994. Association of Helicobacter pylori with gastric cancer and observations on the detection of this bacterium in gastric cancer cases. Am. J. Gastroenterol. 89:18061810.
156. Huang, Y.,, X. G. Fan,, Z. S. Tang,, L. Liu,, X. F. Tian, and, N. Li. 2006. Detection of Helicobacter pylori DNA in peripheral blood from patients with peptic ulcer or gastritis. APMIS 114:851856.
157. Hunt, R. H.,, K. Sumanac, and, J. Q. Huang. 2001. Review article: should we kill or should we save Helicobacter pylori? Aliment. Pharmacol. Ther. 15(Suppl. 1):5159.
158. Hussell, T.,, P. G. Isaacson,, J. E. Crabtree, and, J. Spencer. 1993. The response of cells from low-grade B-cell gastric lymphomas of mucosa-associated lymphoid tissue to Helicobacter pylori. Lancet 342:571574.
159. Ikkala, E.,, H. J. Salmi, and, M. Siurala. 1970. Gastric mucosa in iron deficiency anaemia. Results of follow-up examinations. Acta Haematol. 43:228231.
160. Itoh, T.,, Y. Wakatsuki,, M. Yoshida,, T. Usui,, Y. Matsunaga,, S. Kaneko,, T. Chiba, and, T. Kita. 1999. The vast majority of gastric T cells are polarized to produce T helper 1 type cytokines upon antigenic stimulation despite the absence of Helicobacter pylori infection. J. Gastroenterol. 34:560570.
161. Jackson, L. A.,, L. A. Campbell,, C. C. Kuo,, D. I. Rodriguez,, A. Lee, and, J. T. Grayston. 1997. Isolation of Chlamydia pneumoniae from a carotid endarterectomy specimen. J. Infect. Dis. 176:292295.
162. Jackson, S.,, P. L. Beck,, G. F. Pineo, and, M. C. Poon. 2005. Helicobacter pylori eradication: novel therapy for immune thrombocytopenic purpura? A review of the literature. Am. J. Hematol. 78:142150.
163. Jaiswal, M.,, N. F. LaRusso, and, G. J. Gores. 2001. Nitric oxide in gastrointestinal epithelial cell carcinogenesis: linking inflammation to oncogenesis. Am. J. Physiol. Gastrointest. Liver Physiol. 281:G626G634.
164. Jeon, B. H.,, Y. J. Oh,, N. G. Lee, and, Y. H. Choe. 2004. Polymorphism of the Helicobacter pylori feoB gene in Korea: a possible relation with iron-deficiency anemia? Helicobacter 9:330334.
165. Jones, D. M.,, and A. Curry. 1992. The ultrastructure of Helicobacter pylori, p. 29–41. In B. J. Rathbone and, R. V. Heatley (ed.), Helicobacter pylori and Gastroduodenal Disease, 2nd ed. Blackwell Scientific Publications, Oxford, United Kingdom.
166. Kabir, S. 2001. Detection of Helicobacter pylori in faeces by culture, PCR and enzyme immunoassay. J. Med. Microbiol. 50:10211029.
167. Kaiser, V.,, and G. Diamond. 2000. Expression of mammalian defensin genes. J. Leukoc. Biol. 68:779784.
168. Kalach, N.,, F. Briet,, J. Raymond,, P. H. Benhamou,, P. Barbet,, M. Bergeret,, L. Senouci,, M. Maurel,, B. Flourie, and, C. Dupont. 1998. The 13carbon urea breath test for the noninvasive detection of Helicobacter pylori in children: comparison with culture and determination of minimum analysis requirements. J. Pediatr. Gastroenterol. Nutr. 26:291296.
169. Kanbay, M.,, G. Gur,, S. Akcay, and, U. Yilmaz. 2005. Helicobacter pylori seroprevalence in patients with chronic bronchitis. Respir. Med. 99:12131216.
170. Kanbay, M.,, G. Gur,, M. Yucel,, U. Yilmaz, and, S. Boyacioglu. 2005. Does eradication of Helicobacter pylori infection help normalize serum lipid and CRP levels? Dig. Dis. Sci. 50:12281231.
171. Kao, J. Y.,, A. Pierzchala,, S. Rathinavelu,, Y. Zavros,, A. Tessier, and, J. L. Merchant. 2006. Somatostatin inhibits dendritic cell responsiveness to Helicobacter pylori. Regul. Pept. 134:2329.
172. Kaparakis, M.,, K. L. Laurie,, O. Wijburg,, J. Pedersen,, M. Pearse,, I. R. van Driel,, P. A. Gleeson, and, R. A. Strugnell. 2006. CD4+ CD25+ regulatory T cells modulate the T-cell and antibody responses in Helicobacter-infected BALB/c mice. Infect. Immun. 74:35193529.
173. Kaptan, K.,, C. Beyan, and, A. Ifran. 2006. Helicobacter pylori and vitamin B12 deficiency. Haematologica 91:ELT10.
174. Kaptan, K.,, C. Beyan,, A. U. Ural,, T. Cetin,, F. Avcu,, M. Gulsen,, R. Finci, and, A. Yalcin. 2000. Helicobacter pylori—is it a novel causative agent in Vitamin B12 deficiency? Arch. Intern. Med. 160:13491353.
175. Karin, M. 2006. Nuclear factor-kappaB in cancer development and progression. Nature 441:431436.
176. Kenefeck, R. M. W.,, J. C. Atherton, and, K. Robinson. 2007. Human Helicobacter pylori infection induces CD4+ CD25hi IL-10+ regulatory T-cells in the peripheral blood. Zoonoses Public Health 54(Suppl. 1):150.
177. Khan, Z. E.,, T. C. Wang,, G. Cui,, A. L. Chi, and, R. Dimaline. 2003. Transcriptional regulation of the human trefoil factor, TFF1, by gastrin. Gastroenterology 125:510521.
178. Kidd, M.,, A. J. Lastovica,, J. C. Atherton, and, J. A. Louw. 1999. Heterogeneity in the Helicobacter pylori vacA and cagA genes: association with gastroduodenal disease in South Africa? Gut 45:499502.
179. Kidd, M.,, R. M. Peek,, A. J. Lastovica,, D. A. Israel,, A. F. Kummer, and, J. A. Louw. 2001. Analysis of iceA genotypes in South African Helicobacter pylori strains and relationship to clinically significant disease. Gut 49:629635.
180. Kiltz, U.,, B. Pfaffenbach,, W. E. Schmidt, and, R. J. Adamek. 2002. The lack of influence of CagA positive Helicobacter pylori strains on gastro-oesophageal reflux disease. Eur. J. Gastroenterol. Hepatol. 14:979984.
181. Kim, H.,, J. W. Lim, and, K. H. Kim. 2001. Helicobacter pylori-induced expression of interleukin-8 and cyclooxygenase-2 in AGS gastric epithelial cells: mediation by nuclear factor-kappaB. Scand. J. Gastroenterol. 36:706716.
182. King, C. E.,, J. Leibach, and, P. P. Toskes. 1979. Clinically significant vitamin B12 deficiency secondary to malabsorption of protein-bound vitamin B12. Dig. Dis. Sci. 24:397402.
183. Kitadai, Y.,, A. Sasaki,, M. Ito,, S. Tanaka,, N. Oue,, W. Yasui,, M. Aihara,, K. Imagawa,, K. Haruma, and, K. Chayama. 2003. Helicobacter pylori infection influences expression of genes related to angiogenesis and invasion in human gastric carcinoma cells. Biochem. Biophys. Res. Commun. 311:809814.
184. Kivi, M.,, and Y. Tindberg. 2006. Helicobacter pylori occurrence and transmission: a family affair? Scand. J. Infect. Dis. 38:407417.
185. Ko, Y. H.,, J. J. Han,, J. H. Noh, and, H. J. Ree. 2002. Lymph nodes in gastric B-cell lymphoma: pattern of involvement and early histological changes. Histopathology 40:497504.
186. Kodama, M.,, Y. Kitadai,, M. Ito,, H. Kai,, H. Masuda,, S. Tanaka,, M. Yoshihara,, K. Fujimura, and, K. Chayama. 2007. Immune response to CagA protein is associated with improved platelet count after Helicobacter pylori eradication in patients with idiopathic thrombocytopenic purpura. Helicobacter 12:3642.
187. Koehler, C. I.,, M. B. Mues,, H. P. Dienes,, J. Kriegsmann,, P. Schirmacher, and, M. Odenthal. 2003. Helicobacter pylori genotyping in gastric adenocarcinoma and MALT lymphoma by multiplex PCR analyses of paraffin wax embedded tissues. Mol. Pathol. 56:3642.
188. Koenig,