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Antiviral Research: Strategies in Antiviral Drug Discovery

Editor: Robert L. LaFemina, Ph. D.
Content Type: Monograph
Format: Hardcover, Electronic
Publication Year: 2009

Category: Viruses and Viral Pathogenesis; Clinical Microbiology

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This book captures the state of the science with twenty reviews that examine the latest in today’s antiviral drug discovery efforts. The introduction of nucleoside analogs and investigations of novel antiviral targets have brought significant new possibilities to the field. These reviews range from in-depth analyses of a specific viral target, to examination of multiple targets in medically important viruses. All chapters include the authors’ thoughts regarding future developments in their specific topic, and the book concludes with an Afterword in which several experts consider the general future of antiviral drug discovery.

With its coverage of many different types of viruses including influenza virus, herpesvirus, the SARS coronavirus, orthopox- and flaviviruses, hepatitis C virus, and a wide range of topics in HIV-1, offers investigators a broad view of the current state of nucleoside analogs and other antiviral strategies. This book is certain to help stimulate new ideas and approaches for virologists, biochemists, pharmaceutical chemists, and other investigators.

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Microbiology Today

03 March 2013

Our ever-increasing understanding of viral replication, not only in terms of the functions of viral proteins, but also those of cellular ones, has allowed the development of antiviral agents that have proved a real success in the treatment of diseases caused by herpes viruses, human immunodeficiency virus and influenza virus, and it probably will not be long before hepatitis C virus can be added to the list. This book describes the efforts that are being made to identify and validate antiviral targets and evaluate their efficacy in animal models and in the clinic. The critical issue of drug resistance is discussed, as is the possibility of using microbicides to prevent infection. The book contains a wealth of information and I can recommend it to all students, research scientists and clinicians interested in human viral disease and its management. The book's hefty price tag, however, is likely to limit its purchase to institutions.

Society for General Microbiology: Microbiology Today

Reviewer: Christopher Ring, Middlesex University

Review Date: Feb 2009

Doody Enterprises

19 December 2012

At A Glance

After fifty years of work on antiviral agents we still have far fewer than are needed. This volume describes antiviral drug discovery from a target-based approach.

Description

This book reviews the biochemical mechanisms of current antiviral agents and examines the approach taken to discover new antiviral agents. It also provides details on the techniques used to discover and test these new compounds.

Purpose

It is designed to bring together research on antiviral agents in a single place and compare the methods used to discover new therapeutic antiviral agents. The compilation of this information in one book will aid other scientist in developing new antiviral agents.

Audience

This will appeal to scientists working on new compounds that act to interrupt the viral pathogenesis pathways. It also might be of interest to those involved in the study of cell processes. It is written by accomplished scientists who work in this area of antiviral drug discovery and would be of interest to more advanced scientists.

Features

The book begins with a review of the first successful antiviral agent used as effective therapy against herpes simplex virus. This sets the stage for the rest of the book. It is clear that the current antiviral agents have had a tremendous impact on the clinical outcome of several well-known viral infections such as human immunodeficiency virus and herpesvirus infection. However, viruses are very fluid and have begun to develop resistance to the current agents, thus new drugs are needed to continue to control these devastating diseases. The discovery of new antiviral agents begins with an understanding of the cellular pathway required for viral replication. New agents can then be designed to block the viral replication without damaging uninfected cells. The remaining chapters describe this discovery process and the potential for new antiviral agents. They also describe the methods used in this endeavor.

Assessment

This book details information on viral pathways in the cell and the mechanism of antiviral action and would be very useful to scientists working on antiviral agents. Most of the chapters address drugs that target HIV and herpesviruses, and there is no data on antiviral agents used to treat hepatitis B, a major viral pathogen.

Doody Enterprises

Reviewer: Rebecca Horvat, PhD, D(ABMM) (University of Kansas Medical Center)

Date Reviewed: May 2009

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