Chapter 18 : Innate Defense against : the Phagocyte

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Macrophages and neutrophils are essential components of the innate immune response of the host to infection by microorganisms. Macrophages have three main functions: (i) to take up and kill pathogens by phagocytosis; (ii) to generate a large array of biologically active molecules, including cytokines, chemokines, and lipid mediators, that orchestrate the recruitment of other phagocytes, such as monocytes and neutrophils; and (iii) to present antigens to lymphocytes. The innate immune system is the first line of host defense against pathogens. Macrophages and neutrophils constitute the bulwark of the innate immune system. The macrophages internalize microorganisms via different types of receptors expressed on their surface. These receptors bind pathogen-associated molecular patterns (PAMP) directly or via opsonins. is recognized directly, via its carbohydrates, by DC-SIGN and dectin-1. Alveolar macrophages are important for the host defense against , as demonstrated in a murine model of invasive pulmonary aspergillosis (IPA). As for alveolar macrophages, pathogen recognition is the first important step. Neutrophils express various toll-like receptors (TLRs) but have no TLR3. Alveolar macrophages and neutrophils are clearly of prime importance for combating inhaled . Indeed, if for any reason these cells are absent or incapacitated, the fungus grows and causes a life threatening infection.

Citation: Chignard M. 2009. Innate Defense against : the Phagocyte, p 229-238. In Latgé J, Steinbach W (ed), and Aspergillosis. ASM Press, Washington, DC. doi: 10.1128/9781555815523.ch18

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Innate Immune System
Tumor Necrosis Factor alpha
Murine Invasive Pulmonary Aspergillosis
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Image of Figure 1.
Figure 1.

Role of neutrophils and alveolar macrophages in experimental IPA. Mice were infected intratracheally with 10 (A) or 10 (B) conidia of . Mice were depleted of neutrophils and macrophages by treatment with vinblastine ( ) and chlodronate ( ), respectively. (From with permission of the publisher.)

Citation: Chignard M. 2009. Innate Defense against : the Phagocyte, p 229-238. In Latgé J, Steinbach W (ed), and Aspergillosis. ASM Press, Washington, DC. doi: 10.1128/9781555815523.ch18
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Image of Figure 2.
Figure 2.

Neutrophil recruitment and chitin concentration in the lung in experimental IPA. Mice were infected intratracheally with 10 conidia of and BAL was obtained at various time points. Neutrophils were counted and chitin quantified. (Images courtesy of V. Balloy et al. [unpublished data].)

Citation: Chignard M. 2009. Innate Defense against : the Phagocyte, p 229-238. In Latgé J, Steinbach W (ed), and Aspergillosis. ASM Press, Washington, DC. doi: 10.1128/9781555815523.ch18
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