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Cellular Signaling and Innate Immune Responses to RNA Virus Infections

Editors: Allan R. Brasier1, Adolfo García-Sastre2, Stanley M. Lemon3
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Affiliations: 1: University of Texas Medical Branch, Galveston, Texas; 2: Mount Sinai School of Medicine, New York, New York; 3: University of Texas Medical Branch, Galveston, Texas
Content Type: Monograph
Format: Electronic, Hardcover
Publication Year: 2009

Category: Viruses and Viral Pathogenesis; Microbial Genetics and Molecular Biology

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Infections by RNA viruses represent a significant cause of illness and death in vertebrates. Specifically in humans, RNA virus infections are responsible for a spectrum of significant acute, chronic, and emerging infections. This volume provides a comprehensive survey of the most recent discoveries in this field, suggests important areas of future research, and highlights issues in need of further investigation. With chapters written by many of the world’s leading investigators, this volume represents a landmark publication in this field for researchers and clinicians.

This volume is arranged around the belief that a careful examination of the early host responses to these RNA virus infections, as well as of the mechanisms adopted by these viruses to evade host antiviral responses, will provide a platform of knowledge that will lead to the development of more effective methods for controlling the spread of RNA viruses or modifying their disease course.

Divided into two major sections, this volume synthesizes recent findings in this fast-moving field while also reviewing accepted knowledge. The first part focuses on the antiviral signaling pathways in the host, including specific pattern recognition receptors (PRRs) and how these cellular alarms signal the innate immune response. The second section examines the ways in which specific major RNA virus families interact with, activate, and elude these signaling pathways and responses. Taken together, this volume provides a timely summary of the latest knowledge and points to areas for further research.

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Microbiology Today

03 March 2013

This is an excellent and authoritative collection of detailed chapters from some of the world's leading scientists working on the nature of RNA virus interactions with the host innate immune system. Usefully, the book is organized both by topic area and then separately by RNA virus family, providing a systematic and cross-referenced approach invaluable to those who are interested in specific viruses as well as those interested in the detailed biochemistry of host response to virus infection. Each chapter provides a stand-alone review; inevitably, this approach does lead to some repetition, but this is a minor criticism for what is overall a very timely state-of-the-art specialist review text book suited to a postgraduate and professional virology and cell biology audience.

The cost of the book indicates that it is unlikely to be a personal purchase, but is highly recommended for laboratories and institutes working on viral pathogenesis, and innate immune responses. It should also have a place in university biological science libraries for reference purposes during those final year essay crises. Highly recommended.

Society for General Microbiology: Microbiology Today

Reviewer: Maria Zambon, Health Protection Agency

Review Date: 2008

Doody Enterprises

26 January 2013

At A Glance

Infections with RNA viruses represent a significant cause of morbidity and mortality in vertebrates. This volume is written with the belief that a careful examination of the early host responses to these RNA virus infections, as well as of the mechanisms adopted by these viruses to evade early host antiviral responses, will provide a platform of knowledge on which we will be able to develop new and more effective methods for controlling the spread of RNA viruses or modifying their disease course.

Description

This book takes a unique look at the pathogenesis of RNA viruses by showing the evidence that the ability to cause disease is linked to the disruption of innate immune responses in the host. These mechanisms vary with specific viral pathogens, but they all result in the survival and replication of the virus.

Purpose

The overall purpose is to describe the molecular basis of the mammalian innate immune response and then to demonstrate how these responses are disrupted during viral infections. This is a new area of rapidly developing investigation that has significantly advanced our understanding of viral disease.

Audience

This book is directed to scientists and students interested in viral diseases in humans and animals. It also would be useful to investigators designing vaccines for viral agents. The authors, well established scientists who work in this area, contribute valuable insights into new discoveries in viral diseases.

Features

The first section of the book describes the molecular pathways that activate and control the innate immune response to invading pathogens. These chapters discuss detailed intracellular pathways that are activated by cell surface receptors. This innate response of the mammalian host has redundancy which allows the host to respond when one pathway is inactivated. Detailed figures that show the activation pathways are well designed and allow readers to follow the complex responses that occur upon activation of various cell surface receptors. The second section of the book focuses on various specific viral pathogens and gives a description of mechanisms used to subvert the innate response of the mammalian host. These chapters provide some interesting insight into potential new therapeutic agents or vaccines that would address these viral invasions.

Assessment

This unique book likely will lead to future strategies for vaccines and therapy directed at deadly viral infections. I found myself going back to the detailed figures of intracellular activation in the first section as I reviewed the action of specific viral pathogens. These are exciting developments that may lead to discoveries in other fields such as autoimmune and allergy problems.

Doody Enterprises

Reviewer: Rebecca Horvat, PhD, D(ABMM) (University of Kansas Medical Center)

Review Date: Unknown

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