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Chapter 12 : Human Genetic Factors Involved in Viral Pathogenesis

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Human Genetic Factors Involved in Viral Pathogenesis, Page 1 of 2

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Abstract:

This chapter reviews genetic traits associated with susceptibility and resistance to several RNA viruses. HIV is an enveloped retrovirus that has caused more than 25 million deaths worldwide. is a duplicated variant of (), and this chemokine is the most potent chemokine receptor 5 (CCR5) agonist and hence the most effective competitive inhibitor of R5 HIV-1 entry. Volunteer challenge studies have concluded that (i) nonsecretors are resistant to infection, (ii) susceptibility occurs despite repeated challenge with identical virus, and (iii) short-term protective immunity can develop. Studies from authentic outbreaks show that protection from symptomatic norovirus infection is strongly associated with the G428A nonsense mutation in . There are four different dengue virus serotypes circulating (1 to 4), each being able to cause both asymptomatic and severe disease. A study that compared the genotypes of 87 unrelated Thai children who had been hospitalized because of dengue hemorrhagic fever (DHF) or dengue shock syndrome (DSS) was followed and reviewed by others, of which several found associations with HLA class I genotypes and some also with an HLA class II antigen. There is limited information regarding human genetic susceptibility factors associated with tick-borne encephalitis virus (TBEV). An interesting example comes from the pharmacokinetics of an HIV medicine, in which abacavir, a nucleoside reverse transcriptase inhibitor, can induce hypersensitivity that limits its use. Investigators identified a particular HLA haplotype that greatly increases the risk of abacavir hypersensitivity.

Citation: Svensson L, Kindberg E. 2009. Human Genetic Factors Involved in Viral Pathogenesis, p 177-193. In Brasier A, García-Sastre A, Lemon S (ed), Cellular Signaling and Innate Immune Responses to RNA Virus Infections. ASM Press, Washington, DC. doi: 10.1128/9781555815561.ch12

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Figure 1

Secretor status, the ability to express histo-blood group antigens on mucosa and in secretions, is determined by the gene. Individuals lacking a functional allele are so-called nonsecretors, and carriers of at least one functional allele are termed secretors. Secretor status also indirectly determines the Lewis phenotype. Nonsecretors with a functional FUT3 enzyme are Lewis a (Le a) positive and secretors are Lewis b (Le b) positive. Individuals lacking the FUT3 enzyme are so-called Lewis negative.

Citation: Svensson L, Kindberg E. 2009. Human Genetic Factors Involved in Viral Pathogenesis, p 177-193. In Brasier A, García-Sastre A, Lemon S (ed), Cellular Signaling and Innate Immune Responses to RNA Virus Infections. ASM Press, Washington, DC. doi: 10.1128/9781555815561.ch12
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Image of Figure 2
Figure 2

Electron micrograph of human norovirus in a clinical specimen.

Citation: Svensson L, Kindberg E. 2009. Human Genetic Factors Involved in Viral Pathogenesis, p 177-193. In Brasier A, García-Sastre A, Lemon S (ed), Cellular Signaling and Innate Immune Responses to RNA Virus Infections. ASM Press, Washington, DC. doi: 10.1128/9781555815561.ch12
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References

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1. Ali, S.,, M. A. Niang,, I. N’Doye,, C. W. Critchlow,, S. E. Hawes,, A. V. Hill, and, N. B. Kiviat. 2000. Secretor polymorphism and human immunodeficiency virus infection in Senegalese women. J. Infect. Dis. 181:737739.
2. Alkhatib, G.,, C. Combadiere,, C. C. Broder,, Y. Feng,, P. E. Kennedy,, P. M. Murphy, and, E. A. Berger. 1996. CC CKR5: a RANTES, MIP-1alpha, MIP-1beta receptor as a fusion cofactor for macrophage-tropic HIV-1. Science 272:19551958.
3. Arenzana-Seisdedos, F., and, M. Parmentier. 2006. Genetics of resistance to HIV infection: role of co-receptors and co-receptor ligands. Semin. Immunol. 18:387403.
4. Asindi, A. A.,, E. J. Bell,, M. J. Browning, and, J. B. Stephenson. 1988. Vaccine-induced polioencephalomyelitis in Scotland. Scott. Med. J. 33:306307.
5. Barrett, S.,, E. Ryan, and, J. Crowe. 1999. Association of the HLA-DRB1*01 allele with spontaneous viral clearance in an Irish cohort infected with hepatitis C virus via contaminated anti-D immunoglobulin. J. Hepatol. 30:979983.
6. Blackwell, C. C.,, V. S. James,, S. Davidson,, R. Wyld,, R. P. Brettle,, R. J. Robertson, and, D. M. Weir. 1991. Secretor status and heterosexual transmission of HIV. BMJ 303:825826.
7. Boyton, R. J., and, D. M. Altmann. 2007. Natural killer cells, killer immunoglobulin-like receptors and human leucocyte antigen class I in disease. Clin. Exp. Immunol. 149:18.
8. Brown, K. E.,, J. R. Hibbs,, G. Gallinella,, S. M. Anderson,, E. D. Lehman,, P. McCarthy, and, N. S. Young. 1994. Resistance to parvovirus B19 infection due to lack of virus receptor (erythrocyte P antigen). N. Engl. J. Med. 330:11921196.
9. Burke, D. S., and, T. P. Monath. 2001. Flaviviruses, p. 1043–1125. In D. M. Knipe and, P. M. Howley (ed.), Fields Virology, 4th ed., vol. 1. Lippincott Williams & Wilkins, Philadelphia, PA.
10. Buttinelli, G.,, V. Donati,, S. Fiore,, J. Marturano,, A. Plebani,, P. Balestri,, A. R. Soresina,, R. Vivarelli,, F. Delpeyroux,, J. Martin, and, L. Fiore. 2003. Nucleotide variation in Sabin type 2 poliovirus from an immunodeficient patient with poliomyelitis. J. Gen. Virol. 84:12151221.
11. Casrouge, A.,, S. Y. Zhang,, C. Eidenschenk,, E. Jouanguy,, A. Puel,, K. Yang,, A. Alcais,, C. Picard,, N. Mahfoufi,, N. Nicolas,, L. Lorenzo,, S. Plancoulaine,, B. Senechal,, F. Geissmann,, K. Tabeta,, K. Hoebe,, X. Du,, R. L. Miller,, B. Heron,, C. Mignot,, T. B. de Villemeur,, P. Lebon,, O. Dulac,, F. Rozenberg,, B. Beutler,, M. Tardieu,, L. Abel, and, J. L. Casanova. 2006. Herpes simplex virus encephalitis in human UNC-93B deficiency. Science 314:308312.
12. Cerundolo, V., and, H. de la Salle. 2006. Description of HLA class I- and CD8-deficient patients: insights into the function of cytotoxic T lymphocytes and NK cells in host defense. Semin. Immunol. 18:330336.
13. Chen, T. Y.,, Y. S. Hsieh,, T. T. Wu,, S. F. Yang,, C. J. Wu,, G. J. Tsay, and, H. L. Chiou. 2007. Impact of serum levels and gene polymorphism of cytokines on chronic hepatitis C infection. Transl. Res. 150:116121.
14. Chiewsilp, P.,, R. M. Scott, and, N. Bhamarapravati. 1981. Histocompatibility antigens and dengue hemorrhagic fever. Am. J. Trop. Med. Hyg. 30:11001105.
15. Chitsike, I., and, R. van Furth. 1999. Paralytic poliomyelitis associated with live oral poliomyelitis vaccine in child with HIV infection in Zimbabwe: case report. BMJ 318:841843.
16. Choe, H.,, M. Farzan,, Y. Sun,, N. Sullivan,, B. Rollins,, P. D. Ponath,, L. Wu,, C. R. Mackay,, G. LaRosa,, W. Newman,, N. Gerard,, C. Gerard, and, J. Sodroski. 1996. The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates. Cell 85:11351148.
17. Christie, J. M.,, C. J. Healey,, J. Watson,, V. S. Wong,, M. Duddridge,, N. Snowden,, W. M. Rosenberg,, K. A. Fleming,, H. Chapel, and, R. W. Chapman. 1997. Clinical outcome of hypogammaglobulinaemic patients following outbreak of acute hepatitis C: 2 year follow up. Clin. Exp. Immunol. 110:48.
18. Cocchi, F.,, A. L. DeVico,, A. Garzino-Demo,, S. K. Arya,, R. C. Gallo, and, P. Lusso. 1995. Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells. Science 270:18111815.
19. Cooke, G. S.,, K. Tosh,, P. A. Ramaley,, P. Kaleebu,, J. Zhuang,, J. S. Nakiyingi,, C. Watera,, C. F. Gilks,, N. French,, J. A. Whitworth, and, A. V. Hill. 2006. A polymorphism that reduces RANTES expression is associated with protection from death in HIV-seropositive Ugandans with advanced disease. J. Infect. Dis. 194:666669.
20. Dean, M.,, M. Carrington,, C. Winkler,, G. A. Huttley,, M. W. Smith,, R. Allikmets,, J. J. Goedert,, S. P. Buchbinder,, E. Vittinghoff,, E. Gomperts,, S. Donfield,, D. Vlahov,, R. Kaslow,, A. Saah,, C. Rinaldo,, R. Detels, and, S. J. O’Brien. 1996. Genetic restriction of HIV-1 infection and progression to AIDS by a deletion allele of the CKR5 structural gene. Hemophilia Growth and Development Study, Multicenter AIDS Cohort Study, Multicenter Hemophilia Cohort Study, San Francisco City Cohort, ALIVE Study. Science 273:18561862.
21. Dolin, R.,, N. R. Blacklow,, H. DuPont,, S. Formal,, R. M. Buscho,, J. A. Kasel,, R. F. Chames,, R. Hornick, and, R. M. Chanock. 1971. Transmission of acute infectious non-bacterial gastroenteritis to volunteers by oral administration of stool filtrates. J. Infect. Dis. 123:307312.
22. Ermolovich, M. A.,, E. V. Fel’dman,, E. O. Samoilovich,, N. A. Kuzovkova, and, V. I. Levin. 2002. [Characterization of the immune status of patients with vaccine-associated poliomyelitis]. Zh. Mikrobiol. Epidemiol. Immunobiol. 2:4250.
23. Fanning, L. J.,, J. Levis,, E. Kenny-Walsh,, F. Wynne,, M. Whelton, and, F. Shanahan. 2000. Viral clearance in hepatitis C (1b) infection: relationship with human leukocyte antigen class II in a homogeneous population. Hepatology 31:13341337.
24. Feng, Y.,, C. C. Broder,, P. E. Kennedy, and, E. A. Berger. 1996. HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor. Science 272:872877.
25. Flores-Villanueva, P. O.,, E. E. Yunis,, J. C. Delgado,, E. Vittinghoff,, S. Buchbinder,, J. J. Leung,, A. M. Uglialoro,, O. P. Clavijo,, E. S. Rosenberg,, S. A. Kalams,, J. D. Braun,, S. L. Boswell,, B. D. Walker, and, A. E. Goldfeld. 2001. Control of HIV-1 viremia and protection from AIDS are associated with HLA-Bw4 homozygosity. Proc. Natl. Acad. Sci. USA 98:51405145.
26. Fowke, K. R.,, N. J. Nagelkerke,, J. Kimani,, J. N. Simonsen,, A. O. Anzala,, J. J. Bwayo,, K. S. MacDonald,, E. N. Ngugi, and, F. A. Plummer. 1996. Resistance to HIV-1 infection among persistently seronegative prostitutes in Nairobi, Kenya. Lancet 348:13471351.
27. Garbi, N.,, S. Tanaka,, M. van den Broek,, F. Momburg, and, G. J. Hammerling. 2005. Accessory molecules in the assembly of major histocompatibility complex class I/peptide complexes: how essential are they for CD8+ T-cell immune responses? Immunol. Rev. 207:7788.
28. Garred, P.,, H. O. Madsen,, U. Balslev,, B. Hofmann,, C. Pedersen,, J. Gerstoft, and, A. Svejgaard. 1997. Susceptibility to HIV infection and progression of AIDS in relation to variant alleles of mannose-binding lectin. Lancet 349:236240.
29. Geijtenbeek, T. B.,, D. S. Kwon,, R. Torensma,, S. J. van Vliet,, G. C. van Duijnhoven,, J. Middel,, I. L. Cornelissen,, H. S. Nottet,, V. N. KewalRamani,, D. R. Littman,, C. C. Figdor, and, Y. van Kooyk. 2000. DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells. Cell 100:587597.
30. Glass, W. G.,, J. K. Lim,, R. Cholera,, A. A. Pletnev,, J. L. Gao, and, P. M. Murphy. 2005. Chemokine receptor CCR5 promotes leukocyte trafficking to the brain and survival in West Nile virus infection. J. Exp. Med. 202:10871098.
31. Glass, W. G.,, D. D. McDermott,, J. K. Lim,, S. Lekhong,, S. F. Yu,, W. A. Frank,, J. Pape,, R. R. Cheshier, and, P. M. Murphy. 2006. CCR5 deficiency increases risk of symptomatic West Nile virus infection. J. Exp. Med. 203:3540.
32. Gonzalez, E.,, H. Kulkarni,, H. Bolivar,, A. Mangano,, R. Sanchez,, G. Catano,, R. P. Nibbs,, B. I. Freedman,, M. M. Quinones,, M. J. Bamshad,, K. K. Murthy,, B. H. Rovin,, W. Bradley,, R. C. Clark,, S. A. Anderson,, R. J. O’Connell,, B. K. Agan,, S. S. Ahuja,, R. Bologna,, L. Sen,, M. M. Dolan, and, S. K. Ahuja. 2005. The influence of CCL3L1 gene-containing segmental duplications on HIV-1/AIDS susceptibility. Science 307:14341440.
33. Gritsun, T. S.,, V. A. Lashkevich, and, E. A. Gould. 2003. Tick-borne encephalitis. Antiviral Res. 57:129146.
34. Grygorczuk, S.,, J. Zajkowska,, R. Swierzbinska,, S. Pancewicz,, M. Kondrusik, and, T. Hermanowska-Szpakowicz. 2006. [Concentration of the beta-chemokine CCL5 (RANTES) in cerebrospinal fluid in patients with tick-borne encephalitis]. Neurol. Neurochir. Pol. 40:106111.
35. Grygorczuk, S.,, J. Zajkowska,, R. Swierzbinska,, S. Pancewicz,, M. Kondrusik, and, T. Hermanowska-Szpakowicz. 2006. Elevated concentration of the chemokine CCL3 (MIP-1alpha) in cerebrospinal fluid and serum of patients with tick borne encephalitis. Adv. Med. Sci. 51:340344.
36. Guzman, M. G., and, G. Kouri. 2003. Dengue and dengue hemorrhagic fever in the Americas: lessons and challenges. J. Clin. Virol. 27:113.
37. Haller, O.,, M. Frese, and, G. Kochs. 1998. Mx proteins: mediators of innate resistance to RNA viruses. Rev. Sci. Tech. 17:220230.
38. Halstead, S. B. 1988. Pathogenesis of dengue: challenges to molecular biology. Science 239:476481.
39. Hennig, B. J.,, A. J. Frodsham,, S. Hellier,, S. Knapp,, L. J. Yee,, M. Wright,, L. Zhang,, H. C. Thomas,, M. Thursz, and, A. V. Hill. 2007. Influence of IL-10RA and IL-22 polymorphisms on outcome of hepatitis C virus infection. Liver Int. 27:11341143.
40. Henry, S.,, R. Mollicone,, J. B. Lowe,, B. Samuelsson, and, G. Larson. 1996. A second nonsecretor allele of the blood group alpha(1,2)fucosyl-transferase gene (FUT2). Vox Sang. 70:2125.
41. Hidalgo, S.,, M. Garcia Erro,, D. Cisterna, and, M. C. Freire. 2003. Paralytic poliomyelitis caused by a vaccine-derived polio virus in an antibody-deficient Argentinean child. Pediatr. Infect. Dis. J. 22:570572.
42. Hijikata, M.,, Y. Ohta, and, S. Mishiro. 2000. Identification of a single nucleotide polymorphism in the MxA gene promoter (G/T at nt -88) correlated with the response of hepatitis C patients to interferon. Intervirology 43:124127.
43. Holmes, K. V., and, G. S. Dveksler. 1994. Specificity of coronavirus/receptor interactions, p. 403–443. In E. Wimmer (ed.), Cellular Receptors for Animal Viruses. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
44. Horisberger, M. A.,, P. Staeheli, and, O. Haller. 1983. Interferon induces a unique protein in mouse cells bearing a gene for resistance to influenza virus. Proc. Natl. Acad. Sci. USA 80:19101914.
45. Hutson, A. M.,, F. Airaud,, J. LePendu,, M. M. Estes, and, R. L. Atmar. 2005. Norwalk virus infection associates with secretor status genotyped from sera. J. Med. Virol. 77:116120.
46. Johnson, P. C.,, J. J. Mathewson,, H. L. DuPont, and, H. B. Greenberg. 1990. Multiple-challenge study of host susceptibility to Norwalk gastroenteritis in US adults. J. Infect. Dis. 161:1821.
47. Kalayanarooj, S.,, R. J. Gibbons,, D. Vaughn,, S. Green,, A. Nisalak,, R. R. Jarman,, M. P. Mammen, Jr., and, G. C. Perng. 2007. Blood group AB is associated with increased risk for severe dengue disease in secondary infections. J. Infect. Dis. 195:10141017.
48. Kelly, R. J.,, S. Rouquier,, D. Giorgi,, G. G. Lennon, and, J. B. Lowe. 1995. Sequence and expression of a candidate for the human Secretor blood group α(1,2)fucosyltransferase gene (FUT2). Homozygosity for an enzyme-inactivating nonsense mutation commonly correlates with the non-secretor phenotype. J. Biol. Chem. 270:46404649.
49. Kenny-Walsh, E. 1999. Clinical outcomes after hepatitis C infection from contaminated anti-D immune globulin. Irish Hepatology Research Group. N. Engl. J. Med. 340:12281233.
50. Khakoo, S. I.,, C. L. Thio,, M. P. Martin,, C. L. Brooks,, X. Gao,, J. Astemborski,, J. Cheng,, J. K. Goedert,, D. Vlahov,, M. Hilgartner,, S. Cox,, A. G. Little,, G. J. Alexander,, M. E. Cramp,, S. J. O’Brien,, W. M. Rosenberg,, D. L. Thomas, and, M. Carrington. 2004. HLA and NK cell inhibitory receptor genes in resolving hepatitis C virus infection. Science 305:872874.
51. Kilpatrick, D. C.,, T. E. Delahooke,, C. Koch,, M. L. Turner, and, P. C. Hayes. 2003. Mannan-binding lectin and hepatitis C infection. Clin. Exp. Immunol. 132:9295.
52. Kindberg, E.,, B. Akerlind,, C. Johnsen,, J. D. Knudsen,, O. Heltberg,, G. Larson,, B. Bottiger, and, L. Svensson. 2007. Host genetic resistance to symptomatic norovirus (GGII.4) infections in Denmark. J. Clin. Microbiol. 45:27202722.
53. Kindberg, E.,, B. Hejdeman,, G. Bratt,, B. Wahren,, B. Lindblom,, J. Hinkula, and, L. Svensson. 2006. A nonsense mutation (428G→A) in the fucosyltransferase FUT2 gene affects the progression of HIV-1 infection. AIDS 20:685689.
54. Kindberg, E.,, A. Mickiene,, C. Ax, B. Åkerlind,, S. Vene,, L. Lindquist,, A. Lundkvist, and, L. Svensson. 2008. A deletion in the chemokine receptor 5 (CCR5) gene is associated with tick-borne encephalitis. J. Infect. Dis. 197:266269.
55. Kinnunen, E.,, T. Hovi, and, S. Koskimies. 1986. Outbreak of poliomyelitis in Finland: no distinct HLA association. Tissue Antigens 28:190191.
56. Koda, Y.,, M. Soejima, and, H. Kimura. 2001. The polymorphisms of fucosyltransferases. Leg. Med. (Tokyo) 3:214.
57. Koike, S.,, H. Horie,, I. Ise,, A. Okitsu,, M. Yoshida,, N. Iizuka,, K. Takeuchi,, T. Takegami, and, A. Nomoto. 1990. The poliovirus receptor protein is produced both as membrane-bound and secreted forms. EMBO J. 9:32173224.
58. Larsson, M. P.,, G. E. Rydell,, A. Grahn,, J. Rodriguez-Diaz,, B. Akerlind,, A. M. Hutson,, M. K. Estes,, G. Larson, and, L. Svensson. 2006. Antibody prevalence and titer to norovirus (genogroup II) correlate with secretor (FUT2) but not with ABO phenotype or Lewis (FUT3) genotype. J. Infect. Dis. 194:14221427.
59. Lasch, E. O.,, H. Joshua,, E. Gazit,, M. El-Massri,, O. Marcus, and, R. Zamir. 1979. Study of the HLA antigen in Arab children with paralytic poliomyelitis. Isr. J. Med. Sci. 15:1213.
60. Le Pendu, J.,, N. Ruvoen-Clouet,, E. Kindberg, and, L. Svensson. 2006. Mendelian resistance to human norovirus infections. Semin. Immunol. 18:375386.
61. Lindesmith, L.,, C. Moe,, J. Lependu,, J. A. Frelinger,, J. Treanor, and, R. S. Baric. 2005. Cellular and humoral immunity following Snow Mountain virus challenge. J. Virol. 79:29002909.
62. Lindesmith, L.,, C. Moe,, S. Marionneau,, N. Ruvoen,, X. Jiang,, L. Lindblad,, P. Stewart,, J. LePendu, and, R. Baric. 2003. Human susceptibility and resistance to Norwalk virus infection. Nat. Med. 9:548553.
63. Liu, H.,, Y. Hwangbo,, S. Holte,, J. Lee,, C. Wang,, N. Kaupp,, H. Zhu,, C. Celum,, L. Corey,, M. M. McElrath, and, T. Zhu. 2004. Analysis of genetic polymorphisms in CCR5, CCR2, stromal cell-derived factor-1, RANTES, and dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin in seronegative individuals repeatedly exposed to HIV-1. J. Infect. Dis. 190:10551058.
64. Liu, R.,, W. A. Paxton,, S. Choe,, D. Ceradini,, S. R. Martin,, R. Horuk,, M. K. MacDonald,, H. Stuhlmann,, R. R. Koup, and, N. R. Landau. 1996. Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection. Cell 86:367377.
65. Liu, Y.,, Y. Koda,, M. Soejima,, H. Pang,, T. Schlaphoff,, E. D. du Toit, and, H. Kimura. 1998. Extensive polymorphism of the FUT2 gene in an African (Xhosa) population of South Africa. Hum. Genet. 103:204210.
66. Loke, H.,, D. Bethell,, C. X. Phuong,, N. Day,, N. White,, J. Farrar, and, A. Hill. 2002. Susceptibility to dengue hemorrhagic fever in Vietnam: evidence of an association with variation in the vitamin D receptor and Fc gamma receptor IIa genes. Am. J. Trop. Med. Hyg. 67:102106.
67. Lopez-Vazquez, A.,, A. Mina-Blanco,, J. Martinez-Borra,, P. D. Njobvu,, B. Suarez-Alvarez,, M. A. Blanco-Gelaz,, S. Gonzalez,, L. Rodrigo, and, C. Lopez-Larrea. 2005. Interaction between KIR3DL1 and HLA-B*57 supertype alleles influences the progression of HIV-1 infection in a Zambian population. Hum. Immunol. 66:285289.
68. Martin, M. P.,, M. Dean,, M. L. Smith,, C. Winkler,, B. Gerrard,, N. L. Michael,, B. Lee,, R. A. Doms,, J. Margolick,, S. Buchbinder,, J. D. Goedert,, T. R. O’Brien,, M. J. Hilgartner,, D. Vlahov,, S. J. O’Brien, and, M. Carrington. 1998. Genetic acceleration of AIDS progression by a promoter variant of CCR5. Science 282:19071911.
69. Martin, M. P.,, X. Gao,, J. H. Lee,, G. W. Nelson,, R. Detels,, J. J. Goedert,, S. Buchbinder,, K. Hoots,, D. Vlahov,, J. Trowsdale,, M. Wilson,, S. J. O’Brien, and, M. Carrington. 2002. Epistatic interaction between KIR3DS1 and HLA-B delays the progression to AIDS. Nat. Genet. 31:429434.
70. Mashimo, T.,, M. Lucas,, D. Simon-Chazottes,, M. J. Frenkiel,, X. Montagutelli,, P. D. Ceccaldi,, V. Deubel,, J. L. Guenet, and, P. Despres. 2002. A nonsense mutation in the gene encoding 2′-5′-oligoadenylate synthetase/L1 isoform is associated with West Nile virus susceptibility in laboratory mice. Proc. Natl. Acad. Sci. USA 99:1131111316.
71. Matsushita, M.,, M. Hijikata,, Y. Ohta,, K. Iwata,, M. Matsumoto,, K. Nakao,, K. Kanai,, N. Yoshida,, K. Baba, and, S. Mishiro. 1998. Hepatitis C virus infection and mutations of mannose-binding lectin gene MBL. Arch. Virol. 143:645651.
72. Mellado, M.,, J. M. Rodriguez-Frade,, A. J. Vila-Coro,, A. M. de Ana, and, A. C. Martinez. 1999. Chemokine control of HIV-1 infection. Nature 400:723724.
73. Melnick, J. L. 1996. Current status of poliovirus infections. Clin. Microbiol. Rev. 9:293300.
74. Mendelsohn, C. L.,, E. Wimmer, and, V. R. Racaniello. 1989. Cellular receptor for poliovirus: molecular cloning, nucleotide sequence, and expression of a new member of the immunoglobulin superfamily. Cell 56:855865.
75. Migueles, S. A.,, M. S. Sabbaghian,, W. L. Shupert,, M. P. Bettinotti,, F. M. Marincola,, L. Martino,, C. W. Hallahan,, S. M. Selig,, D. Schwartz,, J. Sullivan, and, M. Connors. 2000. HLA B*5701 is highly associated with restriction of virus replication in a subgroup of HIV-infected long term nonprogressors. Proc. Natl. Acad. Sci. USA 97:27092714.
76. Monath, T. P. 1994. Dengue: the risk to developed and developing countries. Proc. Natl. Acad. Sci. USA 91:23952400.
77. Montes-Cano, M. A.,, J. L. Caro-Oleas,, M. Romero-Gomez,, M. Diago,, R. Andrade,, I. Carmona,, J. Aguilar Reina,, A. Nunez-Roldan, and, M. F. Gonzalez-Escribano. 2005. HLA-C and KIR genes in hepatitis C virus infection. Hum. Immunol. 66:11061109.
78. Morra, M.,, D. Howie,, M. S. Grande,, J. Sayos,, N. Wang,, C. Wu,, P. Engel, and, C. Terhorst. 2001. X-linked lymphoproliferative disease: a progressive immunodeficiency. Annu. Rev. Immunol. 19:657682.
79. Morris, P. J., and, M. C. Pietsch. 1973. Letter: a possible association between paralytic poliomyelitis and multiple sclerosis. Lancet 2:847848.
80. Mueller, S.,, E. Wimmer, and, J. Cello. 2005. Poliovirus and poliomyelitis: a tale of guts, brains, and an accidental event. Virus Res. 111:175193.
81. Navarro-Sanchez, E.,, R. Altmeyer,, A. Amara,, O. Schwartz,, F. Fieschi,, J. L. Virelizier,, F. Arenzana-Seisdedos, and, P. Despres. 2003. Dendritic-cell-specific ICAM3-grabbing non-integrin is essential for the productive infection of human dendritic cells by mosquito-cell-derived dengue viruses. EMBO Rep. 4:723728.
82. O’Brien, S. J., and, G. W. Nelson. 2004. Human genes that limit AIDS. Nat. Genet. 36:565574.
83. O’Brien, T. R.,, C. Winkler,, M. Dean,, J. A. Nelson,, M. Carrington,, N. L. Michael, and, G. C. White, II. 1997. HIV-1 infection in a man homozygous for CCR5 delta 32. Lancet 349:1219.
84. Pallansch, M. A., and, R. P. Roos. 2001. Enteroviruses: polioviruses, coxsackieviruses, echoviruses, and newer enteroviruses, p. 723–775. In H. P. Knipe et al. (ed.), Fields Virology, vol. 1. Lippincott Williams & Wilkins, Philadelphia, PA.
85. Parrino, T. A.,, D. S. Schreiber,, J. S. Trier,, A. Z. Kapikian, and, N. R. Blacklow. 1977. Clinical immunity in acute gastroenteritis caused by Norwalk agent. N. Engl. J. Med. 297:8689.
86. Pavio, N.,, T. Couderc,, S. Girard,, J. Y. Sgro,, B. Blondel, and, F. Colbere-Garapin. 2000. Expression of mutated poliovirus receptors in human neuroblastoma cells persistently infected with poliovirus. Virology 274:331342.
87. Perelygin, A. M.,, S. V. Scherbik,, I. B. Zhulin,, B. M. Stockman,, Y. Li, and, M. A. Brinton. 2002. Positional cloning of the murine flavivirus resistance gene. Proc. Natl. Acad. Sci. USA 99:93229327.
88. Petersen, L. R.,, A. A. Marfin, and, D. J. Gubler. 2003. West Nile virus. JAMA 290:524528.
89. Picard, C.,, J. L. Casanova, and, L. Abel. 2006. Mendelian traits that confer predisposition or resistance to specific infections in humans. Curr. Opin. Immunol. 18:383390.
90. Pohlmann, S.,, J. Zhang,, F. Baribaud,, Z. Chen,, G. J. Leslie,, G. Lin,, A. Granelli-Piperno,, R. W. Doms,, C. M. Rice, and, J. A. McKeating. 2003. Hepatitis C virus glycoproteins interact with DC-SIGN and DC-SIGNR. J. Virol. 77:40704080.
91. Poljak, M.,, K. Seme,, I. J. Marin,, D. Z. Babic,, M. Matcic, and, J. Meglic. 2003. Frequency of the 32-base pair deletion in the chemokine receptor CCR5 gene is not increased in hepatitis C patients. Gastroenterology 124:15581560; author reply 1560–1561.
92. Power, J. P.,, E. Lawlor,, F. Davidson,, E. C. Holmes,, P. L. Yap, and, P. Simmonds. 1995. Molecular epidemiology of an outbreak of infection with hepatitis C virus in recipients of anti-D immunoglobulin. Lancet 345:12111213.
93. Poynard, T.,, P. Marcellin,, S. S. Lee,, C. Niederau,, G. S. Minuk,, G. Ideo,, V. Bain,, J. Heathcote,, S. Zeuzem,, C. Trepo, and, J. Albrecht. 1998. Randomised trial of interferon alpha2b plus ribavirin for 48 weeks or for 24 weeks versus interferon alpha2b plus placebo for 48 weeks for treatment of chronic infection with hepatitis C virus. International Hepatitis Interventional Therapy Group (IHIT). Lancet 352:14261432.
94. Promrat, K.,, D. H. McDermott,, C. M. Gonzalez,, D. E. Kleiner,, D. E. Koziol,, M. Lessie,, M. Merrell,, A. Soza,, T. Heller,, M. Ghany,, Y. Park,, H. J. Alter,, J. H. Hoofnagle,, P. M. Murphy, and, T. J. Liang. 2003. Associations of chemokine system polymorphisms with clinical outcomes and treatment responses of chronic hepatitis C. Gastroenterology 124:352360.
95. Ramoz, N.,, L. A. Rueda,, B. Bouadjar,, L. S. Montoya,, G. Orth, and, M. Favre. 2002. Mutations in two adjacent novel genes are associated with epidermodysplasia verruciformis. Nat. Genet. 32:579581.
96. Sakuntabhai, A.,, C. Turbpaiboon,, I. Casademont,, A. Chuansumrit,, T. Lowhnoo,, A. Kajaste-Rudnitski,, S. M. Kalayanarooj,, K. Tangnararatchakit,, N. Tangthawornchaikul,, S. Vasanawathana,, W. Chaiyaratana,, P. T. Yenchitsomanus,, P. Suriyaphol,, P. Avirutnan,, K. Chokephaibulkit,, F. Matsuda,, S. Yoksan,, Y. Jacob,, G. M. Lathrop,, P. Malasit,, P. Despres, and, C. Julier. 2005. A variant in the CD209 promoter is associated with severity of dengue disease. Nat. Genet. 37:507513.
97. Samson, M.,, F. Libert,, B. J. Doranz,, J. Rucker,, C. Liesnard,, C. M. Farber,, S. Saragosti,, C. Lapoumeroulie,, J. Cognaux,, C. Forceille,, G. Muyldermans,, C. Verhofstede,, G. Burtonboy,, M. Georges,, T. Imai,, S. Rana,, Y. Yi,, R. J. Smyth,, R. G. Collman,, R. W. Doms,, G. Vassart, and, M. Parmentier. 1996. Resistance to HIV-1 infection in Caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene. Nature 382:722725.
98. Samuel, M. A., and, M. S. Diamond. 2006. Pathogenesis of West Nile virus infection: a balance between virulence, innate and adaptive immunity, and viral evasion. J. Virol. 80:93499360.
99. Saulsbury, F. T.,, J. A. Winkelstein,, L. E. Davis,, S. H. Hsu,, B. J. D’Souza,, G. R. Gutcher, and, I. J. Butler. 1975. Combined immunodeficiency and vaccine-related poliomyelitis in a child with cartilage-hair hypoplasia. J. Pediatr. 86:868872.
100. Saunderson, R.,, B. Yu,, R. J. Trent, and, R. Pamphlett. 2004. A polymorphism in the poliovirus receptor gene differs in motor neuron disease. Neuroreport 15:383386.
101. Schreiber, D. S.,, N. R. Blacklow, and, J. S. Trier. 1973. The mucosal lesion of the proximal small intestine in acute infectious nonbacterial gastroenteritis. N. Engl. J. Med. 288:13181323.
102. Schreiber, D. S.,, N. R. Blacklow, and, J. S. Trier. 1974. The small intestinal lesion induced by Hawaii agent acute infectious nonbacterial gastroenteritis. J. Infect. Dis. 129:705708.
103. Segat, L.,, L. R. Silva Vasconcelos,, F. Montenegro de Melo,, B. Santos Silva,, L. C. Arraes,, P. Moura, and, S. Crovella. 2007. Association of polymorphisms in the first exon of mannose binding lectin gene (MBL2) in Brazilian patients with HCV infection. Clin. Immunol. 124:1317.
104. Sierra, B.,, R. Alegre,, A. B. Perez,, G. Garcia,, K. Sturn-Ramirez,, O. Obasanjo,, E. Aguirre,, M. Alvarez,, R. Rodriguez-Roche,, L. Valdes,, P. Kanki, and, M. G. Guzman. 2007. HLA-A, -B, -C, and -DRB1 allele frequencies in Cuban individuals with antecedents of dengue 2 disease: advantages of the Cuban population for HLA studies of dengue virus infection. Hum. Immunol. 68:531540.
105. Singh, K. K.,, C. F. Barroga,, M. D. Hughes,, J. Chen,, C. Raskino,, R. E. McKinney, and, S. A. Spector. 2003. Genetic influence of CCR5, CCR2, and SDF1 variants on human immunodeficiency virus 1 (HIV-1)-related disease progression and neurological impairment, in children with symptomatic HIV-1 infection. J. Infect. Dis. 188:14611472.
106. Smith, M. W.,, M. Dean,, M. Carrington,, C. Winkler,, G. A. Huttley,, D. A. Lomb,, J. J. Goedert,, T. R. O’Brien,, L. P. Jacobson,, R. Kaslow,, S. Buchbinder,, E. Vittinghoff,, D. Vlahov,, K. Hoots,, M. W. Hilgartner, and, S. J. O’Brien. 1997. Contrasting genetic influence of CCR2 and CCR5 variants on HIV-1 infection and disease progression. Hemophilia Growth and Development Study (HGDS), Multicenter AIDS Cohort Study (MACS), Multicenter Hemophilia Cohort Study (MHCS), San Francisco City Cohort (SFCC), ALIVE Study. Science 277:959965.
107. Sun, X. K.,, J. F. Chen, and, A. E. Xu. 2005. A homozygous nonsense mutation in the EVER2 gene leads to epidermodysplasia verruciformis. Clin. Exp. Dermatol. 30:573574.
108. Suzuki, F.,, Y. Arase,, Y. Suzuki,, A. Tsubota,, N. Akuta,, T. Hosaka,, T. Someya,, M. Kobayashi,, S. Saitoh,, K. Ikeda,, M. Kobayashi,, M. Matsuda,, K. Takagi,, J. Satoh, and, H. Kumada. 2004. Single nucleotide polymorphism of the MxA gene promoter influences the response to interferon monotherapy in patients with hepatitis C viral infection. J. Viral Hepat. 11:271276.
109. Tate, G.,, T. Suzuki,, K. Kishimoto, and, T. Mitsuya. 2004. Novel mutations of EVER1/TMC6 gene in a Japanese patient with epidermodysplasia verruciformis. J. Hum. Genet. 49:223225.
110. Thio, C. L.,, D. L. Thomas,, J. J. Goedert,, D. Vlahov,, K. E. Nelson,, M. W. Hilgartner,, S. J. O’Brien,, P. Karacki,, D. Marti,, J. Astemborski, and, M. Carrington. 2001. Racial differences in HLA class II associations with hepatitis C virus outcomes. J. Infect. Dis. 184:1621.
111. Thomas, D. L.,, J. Astemborski,, R. M. Rai,, F. A. Anania,, M. Schaeffer,, N. Galai,, K. Nolt,, K. E. Nelson,, S. A. Strathdee,, L. Johnson,, O. Laeyendecker,, J. Boitnott,, L. E. Wilson, and, D. Vlahov. 2000. The natural history of hepatitis C virus infection: host, viral, and environmental factors. JAMA 284:450456.
112. Thorven, M.,, A. Grahn,, K. O. Hedlund,, H. Johansson,, C. Wahlfrid,, G. Larson, and, L. Svensson. 2005. A homozygous nonsense mutation (428G→A) in the human secretor (FUT2) gene provides resistance to symptomatic norovirus (GGII) infections. J. Virol. 79:1535115355.
113. Trachtenberg, E.,, B. Korber,, C. Sollars,, T. B. Kepler,, P. T. Hraber,, E. Hayes,, R. Funkhouser,, M. Fugate,, J. Theiler,, Y. S. Hsu,, K. Kunstman,, S. Wu,, J. Phair,, H. Erlich, and, S. Wolinsky. 2003. Advantage of rare HLA supertype in HIV disease progression. Nat. Med. 9:928935.
114. van Eden, W.,, G. G. Persijn,, H. Bijkerk,, R. R. de Vries,, R. K. Schuurman, and, J. J. van Rood. 1983. Differential resistance to paralytic poliomyelitis controlled by histocompatibility leukocyte antigens. J. Infect. Dis. 147:422426.
115. van Rij, R. P.,, A. M. de Roda Husman,, M. Brouwer,, J. Goudsmit,, R. A. Coutinho, and, H. Schuitemaker. 1998. Role of CCR2 genotype in the clinical course of syncytium-inducing (SI) or non-SI human immunodeficiency virus type 1 infection and in the time to conversion to SI virus variants. J. Infect. Dis. 178:18061811.
116. Villano, S. A.,, D. Vlahov,, K. E. Nelson,, S. Cohn, and, D. L. Thomas. 1999. Persistence of viremia and the importance of long-term follow-up after acute hepatitis C infection. Hepatology 29:908914.
117. Winkler, C.,, W. Modi,, M. E. Smith,, G. W. Nelson,, X. Wu,, M. Carrington,, M. Dean,, T. Honjo,, K. Tashiro,, D. Yabe,, S. Buchbinder,, E. Vittinghoff,, J. J. Goedert,, T. R. O’Brien,, L. P. Jacobson,, R. Detels,, S. Donfield,, A. Willoughby,, E. Gomperts,, D. Vlahov,, J. Phair, and, S. J. O’Brien. 1998. Genetic restriction of AIDS pathogenesis by an SDF-1 chemokine gene variant. ALIVE Study, Hemophilia Growth and Development Study (HGDS), Multicenter AIDS Cohort Study (MACS), Multicenter Hemophilia Cohort Study (MHCS), San Francisco City Cohort (SFCC). Science 279:389393.
118. Woitas, R. P.,, G. Ahlenstiel,, A. Iwan,, J. K. Rockstroh,, H. H. Brackmann,, B. Kupfer,, B. Matz,, R. Offergeld,, T. Sauerbruch, and, U. Spengler. 2002. Frequency of the HIV-protective CC chemokine receptor 5-Delta32/Delta32 genotype is increased in hepatitis C. Gastroenterology 122:17211728.
119. World Health Organization. 1997. Dengue Hemorrhagic Fever. Diagnosis, Treatment, Prevention and Control, 2nd ed. World Health Organization, Geneva, Switzerland.
120. Wright, P. F.,, M. H. Hatch,, A. G. Kasselberg,, S. P. Lowry,, W. B. Wadlington, and, D. T. Karzon. 1977. Vaccine-associated poliomyelitis in a child with sex-linked agammaglobulinemia. J. Pediatr. 91:408412.
121. Wyatt, R. G.,, R. Dolin,, N. R. Blacklow,, H. L. DuPont,, R. F. Buscho,, T. S. Thornhill,, A. Z. Kapikian, and, R. M. Chanock. 1974. Comparison of three agents of acute infectious nonbacterial gastroenteritis by cross-challenge in volunteers. J. Infect. Dis. 129:709714.
122. Yakub, I.,, K. M. Lillibridge,, A. Moran,, O. Y. Gonzalez,, J. Belmont,, R. A. Gibbs, and, D. J. Tweardy. 2005. Single nucleotide polymorphisms in genes for 2′-5′-oligoadenylate synthetase and RNase L in patients hospitalized with West Nile virus infection. J. Infect. Dis. 192:17411748.
123. Yawata, M.,, N. Yawata,, M. Draghi,, A. M. Little,, F. Partheniou, and, P. Parham. 2006. Roles for HLA and KIR polymorphisms in natural killer cell repertoire selection and modulation of effector function. J. Exp. Med. 203:633645.
124. Yee, L. J. 2004. Host genetic determinants in hepatitis C virus infection. Genes Immun. 5:237245.
125. Zhang, S. Y.,, E. Jouanguy,, S. Ugolini,, A. Smahi,, G. Elain,, P. Romero,, D. Segal,, V. Sancho-Shimizu,, L. Lorenzo,, A. Puel,, C. Picard,, A. Chapgier,, S. Plancoulaine,, M. Titeux,, C. Cognet,, H. von Bernuth,, C. L. Ku,, A. Casrouge,, X. X. Zhang,, L. Barreiro,, J. Leonard,, C. Hamilton,, P. Lebon,, B. Heron,, L. Vallee,, L. Quintana-Murci,, A. Hovnanian,, F. Rozenberg,, E. Vivier,, F. Geissmann,, M. Tardieu,, L. Abel, and, J. L. Casanova. 2007. TLR3 deficiency in patients with herpes simplex encephalitis. Science 317:15221527.

Tables

Generic image for table
Table 1

Genetic factors associated with resistance or predisposition to specific viral infections

Citation: Svensson L, Kindberg E. 2009. Human Genetic Factors Involved in Viral Pathogenesis, p 177-193. In Brasier A, García-Sastre A, Lemon S (ed), Cellular Signaling and Innate Immune Responses to RNA Virus Infections. ASM Press, Washington, DC. doi: 10.1128/9781555815561.ch12
Generic image for table
Table 2

Influence of genetic variability on susceptibility to HIV infection and AIDS

Citation: Svensson L, Kindberg E. 2009. Human Genetic Factors Involved in Viral Pathogenesis, p 177-193. In Brasier A, García-Sastre A, Lemon S (ed), Cellular Signaling and Innate Immune Responses to RNA Virus Infections. ASM Press, Washington, DC. doi: 10.1128/9781555815561.ch12

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