Chapter 30 : “Quorum Sensing” in Honeybees: Pheromone Regulation of Division of Labor

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This chapter focuses on the understanding of the regulation of division of labor in honeybee colonies from the perspective of quorum sensing. A flexible system of division of labor presumably is very important to colony fitness because a bee colony must develop and produce reproductive individuals despite constant changes in external and colony conditions. Three pheromones have been identified that regulate honeybee division of labor: a worker inhibitory pheromone, queen mandibular pheromone, and brood pheromone. These pheromones act directly or indirectly on physiological factors including juvenile hormone and molecular pathways associated with the foraging, malvolio, and vitellogenin genes. Ethyl oleate (EO), a substance produced by adult forager honeybees, was recently identified as a chemical inhibitory factor, delaying the age of onset of foraging in field experiments. Bees detect molecules (pheromones) that reflect the abundance of a particularly relevant category of conspecifics and respond accordingly. With the identification of these pheromones and the ability to detect their effects on brain gene expression, it should be possible to trace the flow of information from the environment ultimately to neurons in the brain to determine whether quorum sensing in bacteria and pheromone regulation of division of labor in the honey bee share any features at the molecular level.

Citation: Conte Y, Huang Z, Robinson G. 2008. “Quorum Sensing” in Honeybees: Pheromone Regulation of Division of Labor, p 463-468. In Winans S, Bassler B (ed), Chemical Communication among Bacteria. ASM Press, Washington, DC. doi: 10.1128/9781555815578.ch30

Key Concept Ranking

Quorum Sensing
Gene Expression
Fatty Acids
Natural Selection
Oleic Acid
Palmitic Acid
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1. Amdam, G. V.,, and S. W. Omholt. 2003. The hive bee to forager transition in honeybee colonies: the double repressor hypothesis. J. Theor. Biol. 223:451464.
2. Beshers, S. N.,, and J. H. Fewell. 2001. Models of division of labor in social insects. Annu. Rev. Entomol. 46:413440.
3. Beshers, S. N.,, Z. Y. Huang,, Y. Oono,, and G. E. Robinson. 2001. Social inhibition and the regulation of temporal polyethism in honey bees. J. Theor. Biol. 213:461479.
4. Camazine, S. 1991. Self-organizing pattern formation on the combs of honey bee colonies. Behav. Ecol. Sociobiol. 28:6176.
5. Detrain, C.,, J. L. Deneubourg,, and J. M. Pasteels. 1999. Decision-making in foraging by social insects, p. 331–354. In C. Detrain,, J. L. Deneubourg,, and J. M. Pasteels (ed.), Information Processing in Social Insects. Birkhauser Verlag, Basel, Switzerland.
6. Fahrbach, S. E.,, T. Giray,, and G. E. Robinson. 1995. Volume changes in the mushroom bodies of adult honey bee queens. Neurobiol. Learn. Memory 63:181191.
7. Foster, K. R.,, K. Parkinson,, and C. R. L. Thompson. 2007. What can microbial genetics teach sociobiology? Trends Genet. 23:7480.
8. Fukuda, H. 1983. The relationship between work efficiency and population size in a honeybee colony. Res. Popul. Ecol. 25:249263.
9. Grozinger, C. M.,, N. M. Sharabash,, C. W. Whitfield,, and G. E. Robinson. 2003. Pheromone-mediated gene expression in the honey bee brain. Proc. Natl. Acad. Sci. USA 100:1451914525.
10. Huang, Z. Y.,, E. Plettner,, and G. E. Robinson. 1998. Effects of social environment and worker mandibular glands on endocrine-mediated behavioral development in honey bees. J. Comp. Physiol. A-Sens. Neural Behav. Physiol. 183:143152.
11. Huang, Z. Y.,, and G. E. Robinson. 1992. Honeybee colony integration: worker-worker interactions mediate hormonally regulated plasticity in division of labor. Proc. Natl. Acad. Sci. USA 89:11726117269.
12. Huang, Z. Y.,, and G. E. Robinson. 1996. Regulation of honey bee division of labor by colony age demography. Behav. Ecol. Sociobiol. 39:147158.
13. Le Conte, Y.,, G. Arnold,, J. Trouiller,, C. Masson,, and B. Chappe. 1990. Identification of a brood pheromone in honeybees. Natur wissenschaften 77:334336.
14. Le Conte, Y.,, G. Arnold,, J. Trouiller,, C. Masson,, B. Chappe,, and G. Ourisson. 1989. Attraction of the parasitic mite Varroa to the drone larvae of honey bees by simple aliphatic esters. Science 245:638639.
15. Le Conte, Y.,, J. M. Bécard,, G. Costagliola,, G. de Vaublanc,, M. El Maataoui,, D. Crauser,, E. Plettner,, and K. N. Slessor. 2006. Larval salivary glands are a source of primer and releaser pheromone in honey bee (Apis mellifera L.). Naturwissenschaften 93:237241.
16. Le Conte, Y.,, A. Mohammedi,, and G. E. Robinson. 2001. Primer effects of a brood pheromone on honeybee behavioural development. Proc. R. Soc. Lond. Ser. B-Biol. Sci. 268:163168.
17. Le Conte, Y.,, L. Sreng,, and S. H. Poitout. 1995. Brood pheromone can modulate the feeding behavior of Apis mellifera workers (Hymenoptera: Apidae). J. Econ. Entomol. 88:798804.
18. Le Conte, Y.,, L. Sreng,, N. Sacher,, J. Trouiller,, G. Dusticier,, and S. H. Poitout. 1995. Chemical recognition of queen cells by honey bee workers Apis mellifera (Hymenoptera: Apidae). Chemoecology 5/6:612.
19. Le Conte, Y.,, L. Sreng,, and J. Trouiller. 1994. The recognition of larvae by worker honeybees. Naturwissenschaften 81:462465.
20. Leoncini, I.,, D. Crauser,, G. E. Robinson,, and Y. Le Conte. 2004. Worker-worker inhibition of honey bee behavioural development independent of queen and brood. Insect. Soc. 51:392394.
21. Leoncini, I.,, Y. Le Conte,, G. Costagliola,, E. Plettner,, A. L. Toth,, M. Wang,, Z. Huang,, J. M. Bécard,, D. Crauser,, K. N. Slessor,, and G. E. Robinson. 2004. Regulation of behavioral maturation by a primer pheromone produced by adult worker honey bees. Proc. Natl. Acad. Sci. USA 101:1755917564.
22. Menzel, R.,, and M. Giurfa. 2006. Dimensions of cognition in an insect, the honeybee. Behav. Cogn. Neurosci. Rev. 5:2440.
23. Naug, D.,, and R. Gadagkar. 1999. Flexible division of labor mediated by social interactions in an insect colony—a simulation model. J. Theor. Biol. 197:123133.
24. Nelson, C. M.,, K. E. Ihle,, M. K. Fondrk,, J. R. E. Page,, and G. V. Amdam. 2007. The gene vitellogenin has multiple coordinating effects on social organization. PLoS Biol. 5:e62.
25. Oster, G. F.,, and E. O. Wilson. 1978. Caste and Ecology in the Social Insects. Princeton University Press, Princeton, NJ.
26. Pankiw, T. 2004. Worker honey bee pheromone regulation of foraging ontogeny. Naturwissenschaften 91:178181.
27. Pankiw, T.,, Z. Y. Huang,, M. L. Winston,, and G. E. Robinson. 1998. Queen mandibular gland pheromone influences worker honey bee (Apis mellifera L.) foraging ontogeny and juvenile hormone titers. J. Insect Physiol. 44:685692.
28. Robinson, G. E. 1992. Regulation of division of labor in insect societies. Annu. Rev. Entomol. 37:637665.
29. Robinson, G. E.,, C. M. Grozinger,, and C. W. Whitfield. 2005. Sociogenomics: social life in molecular terms. Nat. Rev. Genet. 6:257270.
30. Robinson, G. E.,, R. E. Page,, C. Strambi,, and A. Strambi. 1992. Colony integration in honey bees: mechanisms of behavioral reversion. Ethology 90:336348.
31. Robinson, G. E.,, R. E. J. Page,, C. Strambi,, and A. Strambi. 1989. Hormonal and genetic control of behavioral integration in honey bee colonies. Science 246:109112.
32. Seeley, T. D. 1995. The Wisdom of the Hive. Harvard University Press, Cambridge, MA.
33. Seeley, T. D.,, P. K. Visscher,, and K. M. Passino. 2006. Group decision making in honeybee swarms. Am. Sci. 94:220230.
34. Slessor, K. N.,, M. L. Winston,, and Y. Le Conte. 2005. Pheromone communication in the honeybee (Apis mellifera L.). J. Chem. Ecol. 31:27312745.
35. West-Eberhard, M. J. 1986. Alternative adaptations, speciation, and phylogeny. Proc. Natl. Acad. Sci. USA 83:13881392.
36. Whitfield, C. W.,, Y. Ben-Shahar,, C. Brillet,, I. Leoncini,, D. Crauser,, Y. LeConte,, S. Rodriguez-Zas,, and G. E. Robinson. 2006. Genomic dissection of behavioral maturation in the honey bee. Proc. Natl. Acad. Sci. USA 1033:1606816075.
37. Whitfield, C. W.,, A. M. Cziko,, and G. E. Robinson. 2003. Gene expression profiles in the brain predict behavior in individual honey bees. Science 302:296299.
38. Wilson, E. O. 1971. The Insect Societies. Harvard University Press, Cambridge, MA.
39. Winston, M. L. 1987. The Biology of the Honey Bee. Harvard University Press, Cambridge, MA.
40. Winston, M. L.,, and K. N. Slessor. 1992. The essence of royalty—honey bee queen pheromone. Am. Sci. 80:374385.

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