1 : Avian Influenza A (H5N1) Virus

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Avian Influenza A (H5N1) Virus, Page 1 of 2

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Since 1997, highly pathogenic avian influenza A (H5N1) viruses have caused unprecedented widespread poultry outbreaks with high mortality in a number of Asian, European, Middle Eastern, and African countries; have infected other animal species; and have caused sporadic, severe, and fatal human infections. Influenza viruses are single-stranded, negative-sense RNA viruses with eight gene segments that encode 10 proteins and belong to the family . It is now known that H5N1 virus emerged in southern China in 1996 and that outbreaks of highly pathogenic avian influenza (HPAI) H5N1 among poultry have occurred in southern China for several years. Epidemiological studies conducted in Hong Kong during the 1997 H5N1 outbreak implicated avian-to-human transmission of H5N1 virus. Clinical case reports of H5N1 infection reflect surveillance for severe respiratory illness in hospitals. There are few descriptions of the clinical features of mild or atypical disease. Detection of H5N1 RNA by conventional or real-time PCR testing of respiratory specimens using H5-specific primers under biosafety level 2 (BSL2) laboratory conditions is the most common method of H5N1 diagnosis. The key to preventing human infections with H5N1 virus is to avoid unprotected direct contact with diseased and dead poultry, materials contaminated by poultry feces, and uncooked or inadequately cooked poultry or poultry products. There are several challenges to producing a pandemic influenza vaccine. Aside from the problems with production capacity and distribution, three additional challenges to creating an H5N1 vaccine are antigenic drift, immunogenicity, and vaccine pathogenicity to embryonated chicken eggs.

Citation: Ortiz J, Uyeki T. 2007. Avian Influenza A (H5N1) Virus, p 1-22. In Scheld W, Hooper D, Hughes J (ed), Emerging Infections 7. ASM Press, Washington, DC. doi: 10.1128/9781555815585.ch1
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Figure 1.

Confirmed human H5N1 cases in Eurasia reported from January 2004 to February 2006. (Source: World Health Organization [http://www.who.int/csr/disease/avian_influenza/updates/en/index.html]. Map by Margaret McCarron.)

Citation: Ortiz J, Uyeki T. 2007. Avian Influenza A (H5N1) Virus, p 1-22. In Scheld W, Hooper D, Hughes J (ed), Emerging Infections 7. ASM Press, Washington, DC. doi: 10.1128/9781555815585.ch1
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Image of Figure 2.
Figure 2.

WHO confirmed H5N1 cases as of 4 July 2006. Eleven of 12 Turkish cases are represented. (Source: World Health Organization [http://www.who.int/csr/disease/avian_influenza/country/cases_table_2006_02_06/en/index.html].)

Citation: Ortiz J, Uyeki T. 2007. Avian Influenza A (H5N1) Virus, p 1-22. In Scheld W, Hooper D, Hughes J (ed), Emerging Infections 7. ASM Press, Washington, DC. doi: 10.1128/9781555815585.ch1
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Figure 3.

WHO H5N1 case definitions used in Vietnam, 2004 (source: reference ).

Citation: Ortiz J, Uyeki T. 2007. Avian Influenza A (H5N1) Virus, p 1-22. In Scheld W, Hooper D, Hughes J (ed), Emerging Infections 7. ASM Press, Washington, DC. doi: 10.1128/9781555815585.ch1
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1. Apisarnthanarak, A.,, R. Kitphati,, K. Thongphubeth,, P. Patoomanunt,, P. Anthanont,, W. Auwanit,, P. Thawatsupha,, M. Chittaganpitch,, S. Saeng-Aroon,, S. Waicharoen,, P. Apisarnthanarak,, G. A. Storch,, L. M. Mundy, and, V. J. Fraser. 2004. Atypical avian influenza (H5N1). Emerg. Infect. Dis. 10:13211324.
2. Beigel, J. H.,, J. Farrar,, A. M. Han,, F. G. Hayden,, R. Hyer,, M. D. de Jong,, S. Lochindarat,, T. K. Nguyen,, T. H. Nguyen,, T. H. Tran,, A. Nicoll,, S. Touch, and, K. Y. Yuen. 2005. Avian influenza A (H5N1) infection in humans. N. Engl. J. Med. 353:13741385.
3. Bridges, C. B.,, M. J. Kuehnert, and, C. B. Hall. 2003. Transmission of influenza: implications for control in health care settings. Clin. Infect. Dis. 37:10941101.
4. Bridges, C. B.,, W. Lim,, J. Hu-Primmer,, L. Sims,, K. Fukuda,, K. H. Mak,, T. Rowe,, W. W. Thompson,, L. Conn,, X. Lu,, N. J. Cox, and, J. M. Katz. 2002. Risk of influenza A (H5N1) infection among poultry workers, Hong Kong, 1997–1998. J. Infect. Dis. 185:1005–1010.
5. Butt, K. M.,, G. J. Smith,, H. Chen,, L. J. Zhang,, Y. H. Leung,, K. M. Xu,, W. Lim,, R. G. Webster,, K. Y. Yuen,, J. S. Peiris, and, Y. Guan. 2005. Human infection with an avian H9N2 influenza A virus in Hong Kong in 2003. J. Clin. Microbiol. 43:57605767.
6. Buxton Bridges, C.,, J. M. Katz,, W. H. Seto,, P. K. Chan,, D. Tsang,, W. Ho,, K. H. Mak,, W. Lim,, J. S. Tam,, M. Clarke,, S. G. Williams,, A. W. Mounts,, J. S. Bresee,, L. A. Conn,, T. Rowe,, J. Hu-Primmer,, R. A. Abernathy,, X. Lu,, N. J. Cox, and, K. Fukuda. 2000. Risk of influenza A (H5N1) infection among health care workers exposed to patients with influenza A (H5N1), Hong Kong. J. Infect. Dis. 181:344348.
7. Centers for Disease Control and Prevention. 2004. Interim recommendations for infection control in health-care facilities caring for patients with known or suspected avian influenza. [Online.] http://www.cdc.gov/flu/avian/professional/infect-control.htm.
8. Centers for Disease Control and Prevention. 1997. Isolation of avian influenza A(H5N1) viruses from humans—Hong Kong, May–December 1997. Morb. Mortal. Wkly. Rep. 46:12041207.
9. Centers for Disease Control and Prevention. 2004. Overview of biosecurity and avian influenza. [Online.] http://www.cdc.gov/flu/pp/biosecurity_on_farm_11_2004.pdf.
10. Centers for Disease Control and Prevention. 2004. Update: influenza activity—United States and worldwide, 2003–04 season, and composition of the 2004–05 influenza vaccine. Morb. Mortal. Wkly. Rep. 53:547552.
11. Centers for Disease Control and Prevention. 1998. Update: isolation of avian influenza A(H5N1) viruses from humans—Hong Kong, 1997–1998. Morb. Mortal. Wkly. Rep. 46:12451247.
12. Chan, M. C.,, C. Y. Cheung,, W. H. Chui,, G. S. Tsao,, J. M. Nicholls,, Y. O. Chan,, R. W. Chan,, H. T. Long,, L. L. Poon,, Y. Guan, and, J. S. Peiris. 2005. Proinflammatory cytokine responses induced by influenza A (H5N1) viruses in primary human alveolar and bronchial epithelial cells. Respir. Res. 6:135.
13. Chan, P. K., 2002. Outbreak of avian influenza A(H5N1) virus infection in Hong Kong in 1997. Clin. Infect. Dis. 34(Suppl. 2):S58S64.
14. Chen, H.,, G. J. Smith,, S. Y. Zhang,, K. Qin,, J. Wang,, K. S. Li,, R. G. Webster,, J. S. Peiris, and, Y. Guan. 2005. Avian flu: H5N1 virus outbreak in migratory waterfowl. Nature 436:191192.
15. Chen, H.,, G. J. D. Smith,, K. S. Li,, J. Wang,, X. F. Fan,, J. M. Rayner,, D. Vijaykrishna,, J. X. Zhang,, C. T. Guo,, C. L. Cheung,, K. M. Xu,, L. Duan,, K. Huang,, K. Qin,, Y. H. C. Leung,, W. L. Wu,, H. R. Lu,, Y. Chen,, N. S. Xia,, S. P. Naipospos,, K. Y. Yuen,, S. S. Hassan,, S. Bahri,, T. D. Nguyen,, R. G. Webster,, J. S. M. Peiris, and, Y. Guan. 2006. Establishment of multiple sub-lineages of H5N1 influenza virus in Asia—implications for pandemic control. Proc. Natl. Acad. Sci. USA 103:28452850.
16. Cheung, C. Y.,, L. L. Poon,, A. S. Lau,, W. Luk,, Y. L. Lau,, K. F. Shortridge,, S. Gordon,, Y. Guan, and, J. S. Peiris. 2002. Induction of proinflammatory cytokines in human macrophages by influenza A (H5N1) viruses: a mechanism for the unusual severity of human disease? Lancet 360:18311837.
17. Choi, Y. K.,, T. D. Nguyen,, H. Ozaki,, R. J. Webby,, P. Puthavathana,, C. Buranathal,, A. Chaisingh,, P. Auewarakul,, N. T. Hanh,, S. K. Ma,, P. Y. Hui,, Y. Guan,, J. S. Peiris, and, R. G. Webster. 2005. Studies of H5N1 influenza virus infection of pigs by using viruses isolated in Vietnam and Thailand in 2004. J. Virol. 79:1082110825.
18. Chokephaibulkit, K.,, M. Uiprasertkul,, P. Puthavathana,, P. Chearskul,, P. Auewarakul,, S. F. Dowell, and, N. Vanprapar. 2005. A child with avian influenza A (H5N1) infection. Pediatr. Infect. Dis. J. 24:162166.
19. Chotpitayasunondh, T.,, K. Ungchusak,, W. Hanshaoworakul,, S. Chunsuthiwat,, P. Sawanpanyalert,, R. Kijphati,, S. Lochindarat,, P. Srisan,, P. Suwan,, Y. Osotthanakorn,, T. Anantasetagoon,, S. Kanjanawasri,, S. Tanupattarachai,, J. Weerakul,, R. Chaiwirattana,, M. Maneerattanaporn,, R. Poolsavathitikool,, K. Chokephaibulkit,, A. Apisarnthanarak, and, S. F. Dowell. 2005. Human disease from influenza A (H5N1), Thailand, 2004. Emerg. Infect. Dis. 11:201209.
20. Chutinimitkul, S.,, P. Bhattarakosol,, S. Srisuratanon,, A. Eiamudomkan,, K. Kongsomboon,, S. Damrongwatanapokin,, A. Chaisingh,, K. Suwannakarn,, T. Chieochansin,, A. Theamboonlers, and, Y. Poovorawan. 2006. H5N1 influenza A virus and infected human plasma. Emerg. Infect. Dis. 12:10411043.
21. Cox, N. J., and, K. Subbarao. 1999. Influenza. Lancet 354:12771282.
22. Crawford, P. C.,, E. J. Dubovi,, W. L. Castleman,, I. Stephenson,, E. P. Gibbs,, L. Chen,, C. Smith,, R. C. Hill,, P. Ferro,, J. Pompey,, R. A. Bright,, M. J. Medina,, C. M. Johnson,, C. W. Olsen,, N. J. Cox,, A. I. Klimov,, J. M. Katz, and, R. O. Donis. 2005. Transmission of equine influenza virus to dogs. Science 310:482485.
23. Cyranoski, D., 2004. Bird flu data languish in Chinese journals. Nature 430:955.
24. Cyranoski, D., 2005. Bird flu spreads among Java’s pigs. Nature 435:390391.
25. de Jong, M. D.,, V. C. Bach,, T. Q. Phan,, M. H. Vo,, T. T. Tran,, B. H. Nguyen,, M. Beld,, T. P. Le,, H. K. Truong,, V. V. Nguyen,, T. H. Tran,, Q. H. Do, and, J. Farrar. 2005. Fatal avian influenza A (H5N1) in a child presenting with diarrhea followed by coma. N. Engl. J. Med. 352:686691.
26. de Jong, M. D.,, T. T. Thanh,, T. H. Khanh,, V. M. Hien,, G. J. D. Smith,, N. V. Chau,, B. V. Cam,, P. T. Qui,, D. Q. Ha,, Y. Guan,, J. S. M. Peiris,, T. T. Hien, and, J. Farrar. 2005. Oseltamivir resistance during treatment of influenza A (H5N1) infection. N. Engl. J. Med. 353:26672672.
27. Fouchier, R. A.,, V. Munster,, A. Wallensten,, T. M. Bestebroer,, S. Herfst,, D. Smith,, G. F. Rimmelzwaan,, B. Olsen, and, A. D. Osterhaus. 2005. Characterization of a novel influenza A virus hemagglutinin subtype (H16) obtained from black-headed gulls. J. Virol. 79:28142822.
28. Govorkova, E. A.,, I. A. Leneva,, O. G. Goloubeva,, K. Bush, and, R. G. Webster. 2001. Comparison of efficacies of RWJ-270201, zanamivir, and oseltamivir against H5N1, H9N2, and other avian influenza viruses. Antimicrob. Agents Chemother. 45:27232732.
29. Grose, C., and, K. Chokephaibulkit. 2004. Avian influenza virus infection of children in Vietnam and Thailand. Pediatr. Infect. Dis. J. 23:793794.
30. Harper, S.,, A. Klimov,, T. Uyeki, and, K. Fukuda. 2002. Influenza. Clin. Lab. Med. 22:863882, vi.
31. Harper, S. A.,, K. Fukuda,, T. M. Uyeki,, N. J. Cox, and, C. B. Bridges. 2005. Prevention and control of influenza. Recommendations of the Advisory Committee on Immunization Practices (ACIP). Morb. Mortal. Wkly. Rep. Recomm. Rep. 54:140.
32. Hien, T. T.,, M. de Jong, and, J. Farrar. 2004. Avian influenza—a challenge to global health care structures. N. Engl. J. Med. 351:23632365.
33. Hinshaw, V. S.,, R. G. Webster, and, B. Turner. 1979. Water-borne transmission of influenza A viruses? In-tervirology 11:6668.
34. Ito, T.,, K. Okazaki,, Y. Kawaoka,, A. Takada,, R. G. Webster, and, H. Kida. 1995. Perpetuation of influenza A viruses in Alaskan waterfowl reservoirs. Arch. Virol. 140:11631172.
35. Johnson, N. P., and, J. Mueller. 2002. Updating the accounts: global mortality of the 1918–1920 “Spanish” influenza pandemic. Bull. Hist. Med. 76:105115.
36. Keawcharoen, J.,, K. Oraveerakul,, T. Kuiken,, R. A. Fouchier,, A. Amonsin,, S. Payungporn,, S. Noppornpanth,, S. Wattanodorn,, A. Theambooniers,, R. Tantilertcharoen,, R. Pattanarangsan,, N. Arya,, P. Ratanakorn,, D. M. Osterhaus, and, Y. Poovorawan. 2004. Avian influenza H5N1 in tigers and leopards. Emerg. Infect. Dis. 10:21892191.
37. Kishida, N.,, Y. Sakoda,, N. Isoda,, K. Matsuda,, M. Eto,, Y. Sunaga,, T. Umemura, and, H. Kida. 2005. Pathogenicity of H5 influenza viruses for ducks. Arch. Virol. 150:13831392.
38. Koopmans, M.,, B. Wilbrink,, M. Conyn,, G. Natrop,, H. van der Nat,, H. Vennema,, A. Meijer,, J. van Steenbergen,, R. Fouchier,, A. Osterhaus, and, A. Bosman. 2004. Transmission of H7N7 avian influenza A virus to human beings during a large outbreak in commercial poultry farms in the Netherlands. Lancet 363:587593.
39. Ku, A. S., and, L. T. Chan. 1999. The first case of H5N1 avian influenza infection in a human with complications of adult respiratory distress syndrome and Reye’s syndrome. J. Paediatr. Child Health 35:207209.
40. Kuiken, T.,, G. Rimmelzwaan,, D. van Riel,, G. van Amerongen,, M. Baars,, R. Fouchier, and, A. Osterhaus. 2004. Avian H5N1 influenza in cats. Science 306:241.
41. Kurtz, J.,, R. J. Manvell, and, J. Banks. 1996. Avian influenza virus isolated from a woman with conjunctivitis. Lancet 348:901902.
42. Le, Q. M.,, M. Kiso,, K. Someya,, Y. T. Sakai,, T. H. Nguyen,, K. H. Nguyen,, N. D. Pham,, H. H. Nguyen S. Yamada,, Y. Muramoto,, T. Horimoto,, A. Takada,, H. Goto,, T. Suzuki,, Y. Suzuki, and, Y. Kawaoka. 2005. Avian flu: isolation of drug-resistant H5N1 virus. Nature 437:1108.
43. Leneva, I. A.,, N. Roberts,, E. A. Govorkova,, O. G. Goloubeva, and, R. G. Webster. 2000. The neuraminidase inhibitor GS4104 (oseltamivir phosphate) is efficacious against A/Hong Kong/156/97 (H5N1) and A/Hong Kong/1074/99 (H9N2) influenza viruses. Antivir. Res. 48:101115.
44. Liem, N. T., and, W. Lim. 2005. Lack of H5N1 avian influenza transmission to hospital employees, Hanoi, 2004. Emerg. Infect. Dis. 11:210215.
45. Matrosovich, M. N, T. Y. Matrosovich, T. Gray, N. A. Roberts, and H. D. Klenk., 2004. Human and avian influenza viruses target different cell types in cultures of human airway epithelium. Proc. Natl. Acad. Sci. USA 101:46204624.
46. Mounts, A. W.,, H. Kwong,, H. S. Izurieta,, Y. Ho,, T. Au,, M. Lee,, C. Buxton Bridges,, S. W. Williams,, K. H. Mak,, J. M. Katz,, W. W. Thompson,, N. J. Cox, and, K. Fukuda. 1999. Case-control study of risk factors for avian influenza A (H5N1) disease, Hong Kong, 1997. J. Infect. Dis. 180:505508.
47. Nicholson, K. G.,, J. M. Wood, and, M. Zambon. 2003. Influenza. Lancet 362:17331745.
48. Ohishi, K.,, A. Ninomiya,, H. Kida,, C. H. Park,, T. Maruyama,, T. Arai,, E. Katsumata,, T. Tobayama,, A. N. Boltunov,, L. S. Khuraskin, and, N. Miyazaki. 2002. Serological evidence of transmission of human influenza A and B viruses to Caspian seals (Phoca caspica). Microbiol. Immunol. 46:639644.
49. Olsen, C. W.,, L. Brammer,, B. C. Easterday,, N. Arden,, E Belay,, I. Baker, and, N. J. Cox. 2002. Serologic evidence of H1 swine influenza virus infection in swine farm residents and employees. Emerg. Infect. Dis. 8:814819.
50. Olsen, S. J.,, K. Ungchusak,, L. Sovann,, T. M. Uyeki,, S. F. Dowell,, N. J. Cox,, W. Aldis, and, S. Chunsuttiwat. 2005. Family clustering of avian influenza A (H5N1). Emerg. Infect. Dis. 11:17991801.
51. Osterhaus, A. D.,, G. F. Rimmelzwaan,, B. E. Martina,, T. M. Bestebroer, and, R. A. Fouchier. 2000. Influenza B virus in seals. Science 288:10511053.
52. Peiris, J. S.,, W. C. Yu,, C. W. Leung,, C. Y. Cheung,, W. F. Ng,, J. M. Nicholls,, T. K. Ng,, K. H. Chan,, S. T. Lai,, W. L. Lim,, K. Y. Yuen, and, Y. Guan. 2004. Re-emergence of fatal human influenza A subtype H5N1 disease. Lancet 363:617619.
53. Rowe, T.,, R. A. Abernathy,, J. Hu-Primmer,, W. W. Thompson,, X. Lu,, W. Lim,, K. Fukuda,, N. J. Cox, and, J. M. Katz. 1999. Detection of antibody to avian influenza A (H5N1) virus in human serum by using a combination of serologic assays. J. Clin. Microbiol. 37:937943.
54. Schultsz, C.,, V. C. Dong,, N. V. V. Chau,, N. T. H. Le,, W. Lim,, T. T. Thanh,, C. Dolecek,, M. D. de Jong,, T. T. Hien, and, J. Farrar. 2005. Avian influenza H5N1 and healthcare workers. Emerg. Infect. Dis. 11:11581159.
55. Shortridge, K. F., 1999. Poultry and the influenza H5N1 outbreak in Hong Kong, 1997: abridged chronology and virus isolation. Vaccine 17(Suppl., 1):S26S29.
56. Sims, L. D.,, J. Domenech,, C. Benigno,, S. Kahn,, A. Kamata,, J. Lubroth,, V. Martin, and, P. Roeder. 2005. Origin and evolution of highly pathogenic H5N1 avian influenza in Asia. Vet. Rec. 157:159164.
57. Stephenson, I.,, J. M. Wood,, K. G. Nicholson,, A. Charlett, and, M. C. Zambon. 2004. Detection of anti-H5 responses in human sera by HI using horse erythrocytes following MF59-adjuvanted influenza A/Duck/Singapore/97 vaccine. Virus Res. 103:9195.
58. Suarez, D. L.,, M. L. Perdue,, N. Cox,, T. Rowe,, C. Bender,, J. Huang, and, D. E. Swayne. 1998. Comparisons of highly virulent H5N1 influenza A viruses isolated from humans and chickens from Hong Kong. J. Virol. 72:66786688.
59. Taubenberger, J. K.,, A. H. Reid,, R. M. Lourens,, R. Wang,, G. Jin, and, T. G. Fanning. 2005. Characterization of the 1918 influenza virus polymerase genes. Nature 437:889893.
60. Thompson, W. W.,, D. K. Shay,, E. Weintraub,, L. Brammer,, C. B. Bridges,, N. J. Cox, and, K. Fukuda. 2004. Influenza-associated hospitalizations in the United States. JAMA 292:13331340.
61. Thompson, W. W.,, D. K. Shay,, E. Weintraub,, L. Brammer,, N. Cox,, L. J. Anderson, and, K. Fukuda. 2003. Mortality associated with influenza and respiratory syncytial virus in the United States. JAMA 289:179186.
62. Tiensin, T.,, P. Chaitaweesub,, T. Songserm,, A. Chaisingh,, W. Hoonsuwan,, C. Buranathai,, T. Parakamawongsa,, S. Premashthira,, A. Amonsin,, M. Gilbert,, M. Nielen, and, A. Stegeman. 2005. Highly pathogenic avian influenza H5N1, Thailand, 2004. Emerg. Infect. Dis. 11:16641672.
63. Treanor, J. J.,, J. D. Campbell,, K. M. Zangwill,, T. Rowe, and, M. Wolff. 2006. Safety and immunogenicity of an inactivated subvirion influenza A (H5N1) vaccine. N. Engl. J. Med. 354:13431351.
64. Tweed, S. A.,, D. M. Skowronski,, S. T. David,, A. Larder,, M. Petric,, W. Lees,, Y. Li,, J. Katz,, M. Krajden,, R. Tellier,, C. Halpert,, M. Hirst,, C. Astell,, D. Lawrence, and, A. Mak. 2004. Human illness from avian influenza H7N3, British Columbia. Emerg. Infect. Dis. 10:21962199.
65. Uiprasertkul, M.,, P. Puthavathana,, K. Sangsiriwut,, P. Pooruk,, K. Srisook,, M. Peiris,, J. M. Nicholls,, K. Chokephaibulkit,, N. Vanprapar, and, P. Auewarakul. 2005. Influenza A H5N1 replication sites in humans. Emerg. Infect. Dis. 11:10361041.
66. Ungchusak, K.,, P. Auewarakul,, S. F. Dowell,, R. Kitphati,, W. Auwanit,, P. Puthavathana,, M. Uiprasertkul,, K. Boonnak,, C. Pittayawonganon,, N. J. Cox,, S. R. Zaki,, P. Thawatsupha,, M. Chittaganpitch,, R. Khontong,, J. M. Simmerman, and, S. Chunsutthiwat. 2005. Probable person-to-person transmission of avian influenza A (H5N1). N. Engl. J. Med. 352:333340.
67. Uyeki, T. M.,, Y. H. Chong,, J. M. Katz,, W. Lim,, Y. Y. Ho,, S. S. Wang,, T. H. Tsang,, W. W. Au,, S. C. Chan,, T. Rowe,, J. Hu-Primmer,, J. C. Bell,, W. W. Thompson,, C. B. Bridges,, N. J. Cox,, K. H. Mak, and, K. Fukuda. 2002. Lack of evidence for human-to-human transmission of avian influenza A (H9N2) viruses in Hong Kong, China 1999. Emerg. Infect. Dis. 8:154159.
68. van Maanen, C., and, A. Cullinane. 2002. Equine influenza virus infections: an update. Vet. Q. 24:7994.
69. van Riel, D.,, V. J. Munster,, E. de Wit,, G. F. Rimmelzwaan,, R. A. Fouchier,, A. D. Osterhaus, and, T. Kuiken. 2006. H5N1 virus attachment to lower respiratory tract. Science 312:399.
70. Webby, R. J.,, D. R. Perez,, J. S. Coleman,, Y. Guan,, J. H. Knight,, E. A. Govorkova,, L. R. McClain-Moss,, J. S. Peiris,, J. E. Rehg,, E. I. Tuomanen, and, R. G. Webster. 2004. Responsiveness to a pandemic alert: use of reverse genetics for rapid development of influenza vaccines. Lancet 363:10991103.
71. Webby, R. J.,, K. Rossow,, G. Erickson,, Y. Sims, and, R. Webster. 2004. Multiple lineages of antigenically and genetically diverse influenza A virus co-circulate in the United States swine population. Virus Res. 103:6773.
72. Webster, R. G. 2004. Wet markets—a continuing source of severe acute respiratory syndrome and influenza? Lancet 363:234236.
73. World Health Organization. 2005. Avian influenza frequently asked questions. [Online.] http://www.who.int/csr/disease/avian_influenza/avian_faqs/en/.
74. World Health Organization. 2005. Clarification. Use of masks by health-care workers in pandemic settings. [Online.] http://www.who.int/csr/resources/publications/influenza/Mask%20Clarification10_11.pdf.
75. World Health Organization. 2004. Influenza A (H5N1): WHO interim infection control guidelines for health care facilities. [Online.] http://www.who.int/csr/disease/avian_influenza/guidelines/Guidelines_for_health_care_facilities.pdf.
76. World Health Organization. 2005. Recommended laboratory tests to identify avian influenza A virus in specimens from humans. [Online.] http://www.who.int/csr/disease/avian_influenza/guidelines/labtests/en/index.html.
77. World Health Organization. 2005. Situation updates—avian influenza. [Online.] http://www.who.int/csr/disease/avian_influenza/updates/en/index.html.
78. World Health Organization. 2003. Summary of probable SARS cases with onset of illness from 1 November 2002 to 31 July 2003. [Online.] http://www.who.int/csr/sars/country/table2004_04_21/en/index.html.
79. World Health Organization. 2005. Vaccine research and development: current status. [Online.] http://www .who.int/csr/disease/avian_influenza/vaccineresearch2005_11_3/en/index.html.
80. World Health Organization. 2005. WHO global influenza preparedness plan. [Online.] http://www.who.int/csr/resources/publications/influenza/GIP_2005_5Eweb.pdf.
81. World Health Organization. 2004. WHO guidelines for global surveillance of influenza A/H5. [Online.] http://www.who.int/csr/disease/avian_influenza/guidelines/globalsurveillance.pdf.
82. World Health Organization. 2005. WHO intercountry-consultation. Influenza A/H5N1 in humans in Asia. Manila, Philippines 6–7 May 2005. [Online.] http://www.who.int/csr/resources/publications/influenza/WHO_CDS_CSR_GIP_2005_7_04.pdf.
83. World Health Organization. 2004. WHO interim recommendations for the protection of persons involved in the mass slaughter of animals potentially infected with highly pathogenic influenza viruses. [Online.] http://www.who.int/csr/disease/avian_influenza/guidelines/Avian%20Influenza.pdf.
84. World Health Organization. 2005. WHO recommendations on the use of rapid testing for influenza diagnosis. [Online.] http://www.who.int/csr/disease/avian_influenza/guidelines/RapidTestInfluenza_web.pdf.
85. World Health Organization. 2006. Epidemiology of WHO-confirmed human cases of avian influenza A (H5N1) infection. Wkly. Epidemiol. Rec. 81:249257.
86. World Health Organization. May 2006. WHO Rapid Advice Guidelines on pharmacological management of humans infected with avian influenza A (H5N1) virus. [Online.] http://www.who.int/medicines/publications/WHO_PSM_PAR_2006.6.pdf.
87. World Health Organization Global Influenza Program Surveillance Network. 2005. Evolution of H5N1 avian influenza viruses in Asia. Emerg. Infect. Dis. 11:15151521.
88. World Organisation for Animal Health. 2005. Highly Pathogenic Avian Influenza in Romania. Follow-up report no. 3. [Online.] http://www.oie.int/eng/info/hebdo/AIS_48.HTM#Sec1.
89. World Organisation for Animal Health. 2005. Manual of Diagnostic Tests and Vaccines for Terrestrial Animals. [Online.] http://www.oie.int/eng/normes/mmanual/A_00037.htm.
90. Yen, H. L.,, A. S. Monto,, R. G. Webster, and, E. A. Govorkova. 2005. Virulence may determine the necessary duration and dosage of oseltamivir treatment for highly pathogenic A/Vietnam/1203/04 influenza virus in mice. J. Infect. Dis. 192:665672.
91. Yuanji, G., 2002. Influenza activity in China: 1998–1999. Vaccine 20(Suppl. 2):S28S35.
92. Yuen, K. Y., and, S. S. Wong. 2005. Human infection by avian influenza A H5N1. Hong Kong Med. J. 11:189199.


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Table 1.

Influenza pandemics of the 20th century

Citation: Ortiz J, Uyeki T. 2007. Avian Influenza A (H5N1) Virus, p 1-22. In Scheld W, Hooper D, Hughes J (ed), Emerging Infections 7. ASM Press, Washington, DC. doi: 10.1128/9781555815585.ch1
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Table 2.

WHO pandemic phases

Citation: Ortiz J, Uyeki T. 2007. Avian Influenza A (H5N1) Virus, p 1-22. In Scheld W, Hooper D, Hughes J (ed), Emerging Infections 7. ASM Press, Washington, DC. doi: 10.1128/9781555815585.ch1
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Table 3.

WHO human influenza A (H5N1) confirmed cases and deaths

Citation: Ortiz J, Uyeki T. 2007. Avian Influenza A (H5N1) Virus, p 1-22. In Scheld W, Hooper D, Hughes J (ed), Emerging Infections 7. ASM Press, Washington, DC. doi: 10.1128/9781555815585.ch1

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