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Chapter 12 : Community-Associated Methicillin-Resistant

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Abstract:

Community-associated methicillin-resistant (CA-MRSA) infections have emerged globally over a relatively short period of time. These infections have become a common reason why patients present to primary care practitioners, urgent care centers, and emergency rooms and are associated with substantial morbidity and mortality. This chapter reviews the current knowledge of the epidemiology, pathogenesis, treatment, and prevention of CA-MRSA infections. The majority of these investigations were performed before the rapid rise in CA-MRSA incidence and represent investigations of severely ill patients or those with multiple medical comorbidities. One study found that six exotoxin genes were significantly more likely to be found among CA-MRSA strains, and seven different genes were significantly more likely to be found among health care-associated MRSA (HA-MRSA) strains. The involvement of virulence determinants in CA-MRSA colonization and infection is only beginning to be understood. The study found that MRSA colonization was associated with MRSA infection, yet over half of the clinical MRSA infections in the soldiers (7 of 11, or 64%) occurred in those who were, retrospectively, not colonized nasally with MRSA. The large number of recurrent CA-MRSA infections and household clusters of CA-MRSA infections have pressed clinicians to try to prevent infections by eradicating MRSA body colonization.

Citation: Miller L, Eells S. 2008. Community-Associated Methicillin-Resistant , p 229-256. In Scheld W, Hammer S, Hughes J (ed), Emerging Infections 8. ASM Press, Washington, DC. doi: 10.1128/9781555815592.ch12

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Tables

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Table 1.

In vitro susceptibilities of CA-MRSA strains to various antimicrobial agents

Citation: Miller L, Eells S. 2008. Community-Associated Methicillin-Resistant , p 229-256. In Scheld W, Hammer S, Hughes J (ed), Emerging Infections 8. ASM Press, Washington, DC. doi: 10.1128/9781555815592.ch12

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