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Chapter 37 : Evolution of Helicobacter and Helicobacter Infections

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Evolution of Helicobacter and Helicobacter Infections, Page 1 of 2

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Abstract:

Skin, ears, eyes, vagina, mouth, and gastrointestinal mucosa are colonized with diverse microbial communities of bacteria, archaea, fungi, protozoa, and helminths. We know little about these colonizers and even less about the indigenous viruses and their ecologic role in microbial communities. Mechanisms that may permit lactic acid bacteria to reduce intestinal infections include lowering the gut pH to inhibit competing pathogens, secretion of natural antibiotics (e.g., lactobacilli and bifidobacteria species), improved immune stimulation, and blocking of adhesion sites in the gut needed by the pathogens. Competition for resources in the face of host responses, population density, and strain dominance surely affect the evolution of Helicobacter pylori as well as the downstream risks of disease. Host physiology allows higher density and more diverse colonization in some parts of the body than in others. A list of Helicobacter species isolated from animals and humans is provided in this chapter. H. pylori has numerous strain-specific restriction-modification (RM) systems that vary in activity and are regulated by mutation and recombination. A list of restriction endonucleases isolated from three H. pylori strains is also provided in the chapter. Transformation and mutation are important sources of variation of H. pylori to provide genetic substrate to respond to selection forces. In total, through endogenous mutation and horizontal gene transfer H. pylori is capable of maintaining great variability that confers the ability to colonize numerous different gastric niches and to survive gastric changes.

Citation: Domínguez-Bello M, Blaser M. 2008. Evolution of Helicobacter and Helicobacter Infections, p 445-454. In Baquero F, Nombela C, Cassell G, Gutiérrez-Fuentes J (ed), Evolutionary Biology of Bacterial and Fungal Pathogens. ASM Press, Washington, DC. doi: 10.1128/9781555815639.ch37
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Figures

Image of Figure 1.
Figure 1.

Ages of life on Earth.

Citation: Domínguez-Bello M, Blaser M. 2008. Evolution of Helicobacter and Helicobacter Infections, p 445-454. In Baquero F, Nombela C, Cassell G, Gutiérrez-Fuentes J (ed), Evolutionary Biology of Bacterial and Fungal Pathogens. ASM Press, Washington, DC. doi: 10.1128/9781555815639.ch37
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Image of Figure 2.
Figure 2.

Schematic representation of host resource utilization by H. pylori populations.

Citation: Domínguez-Bello M, Blaser M. 2008. Evolution of Helicobacter and Helicobacter Infections, p 445-454. In Baquero F, Nombela C, Cassell G, Gutiérrez-Fuentes J (ed), Evolutionary Biology of Bacterial and Fungal Pathogens. ASM Press, Washington, DC. doi: 10.1128/9781555815639.ch37
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Image of Figure 3.
Figure 3.

Biphasic interaction of a coevolved symbiont microbe and its host. In the postproductive period symbiosis involves the microbial-induced demise of the host. Although deleterious for the individual, it is beneficial for the group.

Citation: Domínguez-Bello M, Blaser M. 2008. Evolution of Helicobacter and Helicobacter Infections, p 445-454. In Baquero F, Nombela C, Cassell G, Gutiérrez-Fuentes J (ed), Evolutionary Biology of Bacterial and Fungal Pathogens. ASM Press, Washington, DC. doi: 10.1128/9781555815639.ch37
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References

/content/book/10.1128/9781555815639.ch37
1. al-Agha, R., and, I. Teodorescu. 2000. Intestinal parasites infestation and anemia in primary school children in Gaza Governorates—Palestine. Roum. Arch. Microbiol. Immunol. 59:131143.
2. Alper, J. 1993. New bind for ulcer bacterium. Science 262:1817.
3. Andersen, L. P. 2001. New Helicobacter species in humans. Dig. Dis. 19:112115.
4. Ando, T. et al. 2003. Evolutionary history of hrgA, which replaces the restriction gene hpyIIIR in the hpyIII locus of Helicobacter pylori. J. Bacteriol. 185:295301.
5. Andrutis, K. A. et al. 1995. Inability of an isogenic urease-negative mutant stain of Helicobacter mustelae to colonize the ferret stomach. Infect. Immun. 63:37223725.
6. Apostolopoulos, P. et al. 2002. Helicobacter pylori (H pylori) infection in Greece: the changing prevalence during a ten-year period and its antigenic profile. BMC Gastroenterol. 2:11.
7. Aras, R. A. et al. 2002. Helicobacter pylori interstrain restriction-modification diversity prevents genome subversion by chromosomal DNA from competing strains. Nucleic. Acids Res. 30:53915397.
8. Aras, R. A. et al. 2001. Regulation of the HpyII restriction-modification system of Helicobacter pylori by gene deletion and horizontal reconstitution. Mol. Microbiol. 42:369382.
9. Aspholm-Hurtig, M. et al. 2004. Functional adaptation of BabA, the H. pylori ABO blood group antigen binding adhesin. Science 305:519522.
10. Atherton, J. C. et al. 1995. Mosaicism in vacuolating cytotoxin alleles of Helicobacter pylori. Association of specific vacA types with cytotoxin production and peptic ulceration. J. Biol. Chem. 270:1777117777.
11. Backhed, F. et al. 2005. Host-bacterial mutualism in the human intestine. Science 307:19151920.
12. Bik, E. M.,, P. B. Eckburg,, S. R. Gill,, K. E. Nelson,, E. A. Purdom,, F. Francois,, G. Perez-Perez,, M. J. Blaser, and, D. A. Relman. 2006. Molecular analysis of the bacterial microbiota in the human stomach. Proc. Natl. Acad. Sci. USA 103:732737.
13. Bonatto, S. L., and, F. M. Salzano. 1997a. A single and early migration for the peopling of the Americas supported by mitochondrial DNA sequence data. Proc. Natl. Acad. Sci. USA 94:18661871.
14. Bonatto, S. L., and, F. M. Salzano. 1997b. Diversity and age of the four major mtDNA haplogroups, and their implications for the peopling of the New World. Am. J. Hum. Genet. 61:14131423.
15. Boren, T. et al. 1993. Attachment of Helicobacter pylori to human gastric epithelium mediated by blood group antigens. Science 262:18921895.
16. Bronsdon, M. A. et al. 1991. Helicobacter nemestrinae sp. nov., a spiral bacterium found in the stomach of a pigtailed macaque (Macaca nemestrina) [see comments]. Int. J. Syst. Bacteriol. 41:148153.
17. Bry, L. et al. 1996. A model of host-microbial interactions in an open mammalian ecosystem. Science 273:13801383.
18. Cano, P. G., and, G. Perdigon. 2003. Probiotics induce resistance to enteropathogens in a re-nourished mouse model. J. Dairy Res. 70:433440.
19. Censini, S. et al. 1996. cag, a pathogenicity island of Helicobacter pylori, encodes type I-specific and disease-associated virulence factors. Proc. Natl. Acad. Sci. USA 93:1464814653.
20. Cremonini, F., and, A. Gasbarrini. 2003. Atopy, Helicobacter pylori and the hygiene hypothesis. Eur. J. Gastroenterol. Hepatol. 15:635636.
21. Croinin, T. O.,, M. Clyne, and, B. Drumm. 1998. Molecular mimicry of ferret gastric epithelial blood group antigen A by Helicobacter mustelae [see comments]. Gastroenterology 114:690696.
22. De Groote, D. et al. 1999a. ‘Candidatus Helicobacter suis’, a gastric helicobacter from pigs, and its phylogenetic relatedness to other gastrospirilla. Int. J. Syst. Bacteriol. 49:17691777.
23. De Groote, D. et al. 1999b. Phylogenetic characterization of ‘Candidatus Helicobacter bovis,’ a new gastric helicobacter in cattle. Int. J. Syst. Bacteriol. 49:17071715.
24. Dewhirst, F. E. et al. 1994. Phylogeny of Helicobacter isolates from bird and swine feces and description of Helicobacter pametensis sp. nov. Int. J. Syst. Bacteriol. 44:553560.
25. Dominguez-Bello, M. G. et al. 2005. No evidence of detrimental effect of Helicobacter pylori and intestinal parasites on the nutritional status of Amerindians in Venezuela. In ASM Conference on Beneficial Microbes. Lake Tahoe, NV.
26. Dominguez-Bello, M. G. et al. 2004. Resistance of rumen bacteria murein to bovine gastric lysozyme. BMC Ecol. 4:7.
27. Dominguez-Bello, M. G. et al. 2002. Socioeconomic and seasonal variations of Helicobacter pylori infection in patients in Venezuela. Am. J. Trop. Med. Hyg. 66:4951.
28. Drumm, B. et al. 1990. Intrafamilial clustering of Helicobacter pylori infection. N. Engl. J. Med. 322:359363.
29. Dubois, A. et al. 1996. Transient and persistent experimental infection of nonhuman primates with Helicobacter pylori: implications for human disease. Infect. Immun. 64:28852891.
30. Eaton, K. A. et al. 1993. Helicobacter acinonyx sp. nov., isolated from cheetahs with gastritis. Int. J. Syst. Bacteriol. 43:99106.
31. Eaton, K. A. et al. 1996. Prevalence and varieties of Helicobacter species in dogs from random sources and pet dogs: animal and public health implications. J. Clin. Microbiol. 34:31653170.
32. Eckburg, P. B. et al. 2005. Diversity of the human intestinal microbial flora. Science 308:16351638.
33. Falush, D. et al. 2001. Recombination and mutation during long-term gastric colonization by Helicobacter pylori: estimates of clock rates, recombination size, and minimal age. Proc. Natl. Acad. Sci. USA 98:1505615061.
34. Falush, D. et al. 2003. Traces of human migrations in Helicobacter pylori populations. Science 299:15821585.
35. Figueiredo, C. et al. 2002. Helicobacter pylori and interleukin 1 genotyping: an opportunity to identify high-risk individuals for gastric carcinoma. J. Natl. Cancer Inst. 94:16801687.
36. Figura, N. et al. 1998. cagA positive and negative Helicobacter pylori strains are simultaneously present in the stomach of most patients with non-ulcer dyspepsia: relevance to histological damage. Gut 42:772778.
37. Fox, J. G. et al. 1991. Gastric colonization of the ferret with Helicobacter species: natural and experimental infections. Rev. Infect. Dis. 13(Suppl 8): S671S680.
38. Fox, J. G. et al. 1995. Helicobacter bilis sp. nov., a novel Helicobacter species isolated from bile, livers, and intestines of aged, inbred mice. J. Clin. Microbiol. 33:445454.
39. Fox, J. G. et al. 1996. Helicobacter canis isolated from a dog liver with multifocal necrotizing hepatitis. J. Clin. Microbiol. 34:24792482.
40. Fox, J. G. et al. 1994. Helicobacter hepaticus sp. nov., a microaerophilic bacterium isolated from livers and intestinal mucosal scrapings from mice. J. Clin. Microbiol. 32:12381245.
41. Fox, J. G. et al. 1998. Hepatic Helicobacter species identified in bile and gallbladder tissue from Chileans with chronic cholecystitis. Gastroenterology 114:755763.
42. Fox, J. G. 1997. The expanding genus of Helicobacter: pathogenic and zoonotic potential. Semin. Gastrointest. Dis. 8:124141.
43. Franklin, C. L. et al. 1996. Isolation of a novel Helicobacter species, Helicobacter cholecystus sp. nov., from the gallbladders of Syrian hamsters with cholangiofibrosis and centrilobular pancreatitis. J. Clin. Microbiol. 34:29522958.
44. Fukushima, K. et al. 2003. Non-pathogenic bacteria modulate colonic epithelial gene expression in germ-free mice. Scand. J. Gastroenterol. 38:626634.
45. Garg, P. K. et al. 2006. Concordance of Helicobacter pylori infection among children in extended-family homes. Epidemiol. Infect. 134:450459.
46. Gerhard, M. et al. 1999. Clinical relevance of the Helicobacter pylori gene for blood-group antigen-binding adhesin. Proc. Natl. Acad. Sci. USA 96:1277812783.
47. Ghose, C. et al. 2002. East Asian genotypes of Helicobacter pylori strains in Amerindians provide evidence for its ancient human carriage. Proc. Natl. Acad. Sci. USA 99:1510715111.
48. Ghose, C. et al. 2005. High frequency of gastric colonization with multiple Helicobacter pylori strains in Venezuelan subjects. J. Clin. Microbiol. 43:26352641.
49. Gonzalez-Valencia, G. et al. 2000. Helicobacter pylori vacA and cagA genotypes in Mexican adults and children. J. Infect. Dis. 182:14501454.
50. Goto, K. et al. 1998. Isolation and characterization of Helicobacter species from the stomach of the house musk shrew (Suncus murinus) with chronic gastritis. Curr. Microbiol. 37:4451.
51. Gueneau, P. et al. 2002. Are goats naturally resistant to gastric Helicobacter infection? Vet. Microbiol. 84:115121.
52. Hanninen, M. L. et al. 1996. Culture and characteristics of Helicobacter bizzozeronii, a new canine gastric Helicobacter sp. Int. J. Syst. Bacteriol. 46:160166 [Erratum 46:839].
53. Hansson, L. E. et al. 1993. Helicobacter pylori infection: independent risk indicator of gastric adenocarcinoma. Gastroenterology 105:10981103.
54. Higashi, H. et al. 2002. SHP-2 tyrosine phosphatase as an intracellular target of Helicobacter pylori CagA protein. Science 295:683686.
55. Hooper, L. V., and, J. I. Gordon. 2001. Commensal host-bacterial relationships in the gut. Science 292:11151118.
56. Hooper, L. V. et al. 1999. A molecular sensor that allows a gut commensal to control its nutrient foundation in a competitive ecosystem. Proc. Natl. Acad. Sci. USA 96:98339838.
57. Ilver, D. et al. 1998. Helicobacter pylori adhesin binding fucosylated histo-blood group antigens revealed by retagging. Science 279:373377.
58. Israel, D. A. et al. 2001. Helicobacter pylori genetic diversity within the gastric niche of a single human host. Proc. Natl. Acad. Sci. USA 98:1462514630.
59. Jalava, K. et al. 1997. Helicobacter salomonis sp. nov., a canine gastric Helicobacter sp. related to Helicobacter felis and Helicobacter bizzozeronii. Int. J. Syst. Bacteriol. 47:975982.
60. Kang, G. et al. 1998. Prevalence of intestinal parasites in rural Southern Indians. Trop. Med. Int. Health 3:7075.
61. Karita, M.,, M. Tsuda, and, T. Nakazawa. 1995. Essential role of urease in vitro and in vivo Helicobacter pylori colonization study using a wild-type and isogenic urease mutant strain. J. Clin. Gastroenterol. 21(Suppl 1): S160S163.
62. Kennedy, G. E. 1980. The emergence of modern man. Nature 284:1112.
63. Kersulyte, D. et al. 2000. Differences in genotypes of Helicobacter pylori from different human populations. J. Bacteriol. 182:32103218.
64. Kim, J. J. et al. 2002. Helicobacter pylori impairs DNA mismatch repair in gastric epithelial cells. Gastroenterology 123:542553.
65. Kong, H. et al. 2000. Functional analysis of putative restriction-modification system genes in the Helicobacter pylori J99 genome. Nucleic Acids Res. 28:32163223.
66. Kroes, I.,, P. W. Lepp, and, D. A. Relman. 1999. Bacterial diversity within the human subgingival crevice. Proc. Natl. Acad. Sci. USA 96:1454714552.
67. Kucik, C. J.,, G. L. Martin, and, B. V. Sortor. 2004. Common intestinal parasites. Am. Fam. Physician 69:11611168.
68. Kuipers, E. J. et al. 1998. Evidence for a conjugation-like mechanism of DNA transfer in Helicobacter pylori. J. Bacteriol. 180:29012905.
69. Lee, A., and, J. O’Rourke. 1993. Gastric bacteria other than Helicobacter pylori. Gastroenterol. Clin. North Am. 22:2142.
70. Lee, A. et al. 1992. Helicobacter muridarum sp. nov., a microaerophilic helical bacterium with a novel ultrastructure isolated from the intestinal mucosa of rodents. Int. J. Syst. Bacteriol. 42:2736.
71. Lerman, D.,, E. Barrett-Connor, and, W. Norcross. 1982. Intestinal parasites in asymptomatic adult Southeast Asian immigrants. J. Fam. Pract. 15:443446.
72. Lin, L. F. et al. 2001. Comparative genomics of the restriction-modification systems in Helicobacter pylori. Proc. Natl. Acad. Sci. USA 98:27402745.
73. Linton, A. H., and, M. H. Hinton. 1988. Enterobacteriaceae associated with animals in health and disease. Soc. Appl. Bacteriol. Symp. Ser. 17:71S85S.
74. Linz, B. 2005. The evolutionary history of the cag pathogenicity island from Helicobacter pylori. Paper presented at the CHRO conference, Gold Coast, Queensland, Australia.
75. Maeda, S. et al. 2002. Analysis of apoptotic and antiapoptotic signalling pathways induced by Helicobacter pylori. Mol. Pathol. 55:286293.
76. Majewski, J. 2001. Sexual isolation in bacteria. FEMS Microbiol. Lett. 199:161169.
77. Marshall, B. J., and, J. R. Warren. 1984. Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. Lancet 1:13111315.
78. Martin Sanchez, A. M. et al. 2004. Intestinal parasitosis in the asymptomatic Subsaharian immigrant population. Gran Canaria 2000. Rev. Clin. Esp. 204:1417.
79. Martins, F. S. et al. 2005. Screening of yeasts as probiotic based on capacities to colonize the gastrointestinal tract and to protect against enteropathogen challenge in mice. J. Gen. Appl. Microbiol. 51:8392.
80. Mattapallil, J. J. et al. 2000. A predominant Th1 type of immune response is induced early during acute Helicobacter pylori infection in rhesus macaques. Gastroenterology 118:307315.
81. McCune, A. et al. 2003. Reduced risk of atopic disorders in adults with Helicobacter pylori infection. Eur. J. Gastroenterol. Hepatol. 15:637640.
82. Meining, A.,, G. Kroher, and, M. Stolte. 1998. Animal reservoirs in the transmission of Helicobacter heilmannii. Results of a questionnaire-based study. Scand. J. Gastroenterol. 33:795798.
83. Mendes, E. N. et al. 1996. Helicobacter trogontum sp. nov., isolated from the rat intestine. Int. J. Syst. Bacteriol. 46:916921.
84. Miyaji, H. et al. 2000. Helicobacter pylori infection occurs via close contact with infected individuals in early childhood. J. Gastroenterol. Hepatol. 15:257262.
85. Neiger, R. et al. 1998. Detection and prevalence of Helicobacter infection in pet cats. J. Clin. Microbiol. 36:634637.
86. Norris, C. R. et al. 1999. Healthy cats are commonly colonized with “Helicobacter heilmannii” that is associated with minimal gastritis. J. Clin. Microbiol. 37:189194.
87. Odenbreit, S. et al. 2000. Translocation of Helicobacter pylori CagA into gastric epithelial cells by type IV secretion. Science 287:14971500.
88. Parsonnet, J. et al. 1997. Risk for gastric cancer in people with CagA positive or CagA negative Helicobacter pylori infection. Gut 40:297301.
89. Patterson, M. M. et al. 2000. Helicobacter aurati sp. nov., a urease-positive Helicobacter species cultured from gastrointestinal tissues of Syrian hamsters. J. Clin. Microbiol. 38:37223728.
90. Peek, R. M., and, M. J. Blaser. 2002. Helicobacter pylori and gastrointestinal tract adenocarcinomas. Nat. Rev. Cancer 2:2837.
91. Pei, Z. et al. 2004. Bacterial biota in the human distal esophagus. Proc. Natl. Acad. Sci. USA 101:42504255.
92. Perez-Perez, G. I. et al. 2002. Evidence that cagA(+) Helicobacter pylori strains are disappearing more rapidly than cagA(−) strains. Gut 50:295298.
93. Pride, D. T., and, M. J. Blaser. 2002a. Concerted evolution between duplicated genetic elements in Helicobacter pylori. J. Mol. Biol. 316:629642.
94. Pride, D. T., and, M. J. Blaser. 2002b. Identification of horizontally acquired genetic elements in Helicobacter pylori and other prokaryotes using oligonucleotide difference analysis. Genome Lett. 1:215.
95. Prinz, C. et al. 2001. Key importance of the Helicobacter pylori adherence factor blood group antigen binding adhesin during chronic gastric inflammation. Cancer Res. 61:19031909.
96. Pultz, N. J. et al. 2005. Mechanisms by which anaerobic microbiota inhibit the establishment in mice of intestinal colonization by vancomycin-resistant Enterococcus. J. Infect. Dis. 191:949956.
97. Pyndiah, S., et al. 2005. Evaluation of the homologous recombination in Helicobacter pylori. Helicobacter 10:185192.
98. Rhee, K. J. et al. 2004. Role of commensal bacteria in development of gut-associated lymphoid tissues and preimmune antibody repertoire. J. Immunol. 172:11181124.
99. Robertson, B. R. et al. 2001. Helicobacter ganmani sp. nov., a urease-negative anaerobe isolated from the intestines of laboratory mice. Int. J. Syst. Evol. Microbiol. 51:18811889.
100. Rothenbacher, D. et al. 2000. Inverse relationship between gastric colonization of Helicobacter pylori and diarrheal illnesses in children: results of a population-based cross-sectional study. J. Infect. Dis. 182:14461449.
101. Salzano, F. M., and, S. M. Callegari-Jacques (ed.). 1988. South American Indians. A Case Study in Evolution. Oxford University Press, Oxford, United Kingdom.
102. Segal, E. D. et al. 1999. Altered states: involvement of phosphorylated CagA in the induction of host cellular growth changes by Helicobacter pylori. Proc. Natl. Acad. Sci. USA 96:1455914564.
103. Shen, Z. et al. 1997. Helicobacter rodentium sp. nov., a urease-negative Helicobacter species isolated from laboratory mice. Int. J. Syst. Bacteriol. 47:627634.
104. Solnick, J. V. et al. 1999. Rhesus monkey (Macaca mulatta) model of Helicobacter pylori: noninvasive detection and derivation of specific-pathogen-free monkeys. Lab. Anim. Sci. 49:197201.
105. Sozzi, M. et al. 2001. Heterogeneity of Helicobacter pylori cag genotypes in experimentally infected mice. FEMS Microbiol. Lett. 203:109114.
106. Stanley, J. et al. 1993. Helicobacter canis sp. nov., a new species from dogs: an integrated study of phenotype and genotype. J. Gen. Microbiol. 139:24952504.
107. Stanley, J. et al. 1994. Helicobacter pullorum sp. nov.-genotype and phenotype of a new species isolated from poultry and from human patients with gastroenteritis. Microbiology 140:34413449.
108. Suerbaum, S. et al. 1998. Free recombination within Helicobacter pylori. Proc. Natl. Acad. Sci. USA 95:1261912624.
109. Takata, T. et al. 2002. Phenotypic and genotypic variation in methylases involved in type II restriction-modification systems in Helicobacter pylori. Nucleic. Acids Res. 30:24442452.
110. Templeton, A. 2002. Out of Africa again and again. Nature 416:4551.
111. Thompson, S. A., and, M. J. Blaser. 1995. Isolation of the Helicobacter pylori recA gene and involvement of the recA region in resistance to low pH. Infect. Immun. 63:21852193.
112. Totten, P. A. et al. 1985. Campylobacter cinaedi (sp. nov.) and Campylobacter fennelliae (sp. nov.): two new Campylobacter species associated with enteric disease in homosexual men. J. Infect. Dis. 151:131139.
113. Traub, R. J. et al. 2003. Humans, dogs and parasitic zoonoses—unravelling the relationships in a remote endemic community in northeast India using molecular tools. Parasitol. Res. 90(Suppl 3): S156S157.
114. Tummuru, M. K.,, S. A. Sharma, and, M. J. Blaser. 1995. Helicobacter pylori picB, a homologue of the Bordetella pertussis toxin secretion protein, is required for induction of IL-8 in gastric epithelial cells. Mol. Microbiol. 18:867876.
115. Tummuru, M. K.,, T. L. Cover, and, M. J. Blaser. 1993. Cloning and expression of a high-molecular-mass major antigen of Helicobacter pylori: evidence of linkage to cytotoxin production. Infect. Immun. 61:17991809.
116. van Doorn, L. J. et al. 1999. Distinct variants of Helicobacter pylori cagA are associated with vacA subtypes. J. Clin. Microbiol. 37:23062311.
117. van Doorn, L. J. et al. 1998. Expanding allelic diversity of Helicobacter pylori vacA. J. Clin. Microbiol. 36:25972603.
118. Viala, J. et al. 2004. Nod1 responds to peptidoglycan delivered by the Helicobacter pylori cag pathogenicity island. Nat. Immunol. 5:11661174.
119. Vicari, J. J. et al. 1998. The seroprevalence of cagA-positive Helicobacter pylori strains in the spectrum of gastroesophageal reflux disease. Gastroenterology 115:5057.
120. Webb, P. M. et al. 1994. Relation between infection with Helicobacter pylori and living conditions in childhood: evidence for person to person transmission in early life. Br. Med. J. 308:750753.
121. Wells, C. L. 1990. Relationship between intestinal microecology and the translocation of intestinal bacteria. Antonie Van Leeuwenhoek 58:8793.
122. Williams, R. C. et al. 1985. GM allotypes in Native Americans: evidence for three distinct migrations across the Bering land bridge. Am. J. Phys. Anthropol. 66:119.
123. Wirth, H. P.,, M. Yang,, E. Sanabria-Valentin,, D. E. Berg,, A. Dubois, and, M. J. Blaser. 2006. Host Lewis phenotype-dependent Helicobacter pylori Lewis antigen expression in rhesus monkeys. FASEB J. 20:15341536.
124. Wirth, H. P. et al. 1996. Expression of the human cell surface glycoconjugates Lewis x and Lewis y by Helicobacter pylori isolates is related to cagA status. Infect. Immun. 64:45984605.
125. Wirth, H. P. et al. 1997. Helicobacter pylori Lewis expression is related to the host Lewis phenotype. Gastroenterology 113:10911098.
126. Xu, Q. et al. 2000. Identification of type II restriction and modification systems in Helicobacter pylori reveals their substantial diversity among strains. Proc. Natl. Acad. Sci. USA 97:96719676.
127. Xu, Q. et al. 1997. The Helicobacter pylori genome is modified at CATG by the product of hpyIM. J. Bacteriol. 179:68076815.
128. You, W. C. et al. 2001. Helicobacter pylori prevalence and CagA status among children in two counties of China with high and low risks of gastric cancer. Ann. Epidemiol. 11:543546.

Tables

Generic image for table
Table 1.

Helicobacter species isolated from animals and humans

Citation: Domínguez-Bello M, Blaser M. 2008. Evolution of Helicobacter and Helicobacter Infections, p 445-454. In Baquero F, Nombela C, Cassell G, Gutiérrez-Fuentes J (ed), Evolutionary Biology of Bacterial and Fungal Pathogens. ASM Press, Washington, DC. doi: 10.1128/9781555815639.ch37
Generic image for table
Table 2.

Restriction endonucleases isolated from three H. pylori strains a

Citation: Domínguez-Bello M, Blaser M. 2008. Evolution of Helicobacter and Helicobacter Infections, p 445-454. In Baquero F, Nombela C, Cassell G, Gutiérrez-Fuentes J (ed), Evolutionary Biology of Bacterial and Fungal Pathogens. ASM Press, Washington, DC. doi: 10.1128/9781555815639.ch37

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