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HIV and the Pathogenesis of AIDS, Third Edition

Author: Jay A. Levy1
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Affiliations: 1: Department of Medicine, Laboratory for Tumor and AIDS Virus Research and Cancer Research Institute University of California, School of Medicine San Francisco, California
Content Type: Monograph
Format: Paperback, Electronic
Publication Year: 2007

Category: Viruses and Viral Pathogenesis

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The new edition of provides a state-of-the-art review of the current research, explains the history of the disease, and examines how scientists, clinicians, and public health workers have responded to the challenges presented by HIV/AIDS in the 25 years since its recognition. Many exciting developments in the field have deepened scientific understanding of HIV/AIDS and have provided novel approaches for prevention and treatment. The book explores potential approaches for therapy and a vaccine for the prevention of HIV infection and AIDS is discussed.

Thoroughly updated and revised, the third edition continues to provide a comprehensive analysis of the subject that is unmatched in the field. Figures and tables illustrate and emphasize key points and the text is extensively annotated. Written in an accessible and clear style, the book presents a balanced view of HIV/AIDS and serves as a valuable reference for students, researchers, clinicians, and health care providers

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Microbiology Today

23 June 2013

Ten years on from the 2nd edition, Levy's book remains an invaluable reference of HIV/AIDS. Levy helpfully lists 15 significant advances in his preface, and suggests that HIV research has reached a stage of incremental change rather than significant advance (the 'pioneering' research of times past is celebrated by an eclectic photo gallery of HIV/AIDS alumni, including the current SGM president). Levy's assertion is probably true in respect of research into the virus itself, but the interaction of the virus with its host remains a huge challenge that will require significant advance if, for example, we are to develop an effective vaccine or predict post-infection survival. Either way, HIV/AIDS remains a disease of significant unmet need in the sense that Developed World patients benefit from an armament of treatments that are often not available to Developing World patients, where 90% plus of all HIV-infected persons are resident. In 2006, 3 million people died from AIDS, taking the cumulative total to almost 25 million, and so Levy's book is both a reminder of past success but also a reality check on what remains unfulfilled.

Society for General Microbiology: Microbiology Today

Reviewer: Eddie Blair, Integrated Medicines Ltd

Review Date: Unknown

Doody Enteprises

23 June 2013

At A Glance

The new edition of HIV and the Pathogenesis of AIDS provides a state-of-the-art review of the current research, explains the history of the disease, and examines how scientists, clinicians, and public health workers have responded to the challenges presented by HIV/AIDS in the 25 years since its recognition. Many exciting developments in the field have deepened scientific understanding of HIV/AIDS and have provided novel approaches for prevention and treatment. The book explores potential approaches for therapy and a vaccine for the prevention of HIV infection and AIDS is discussed.

Thoroughly updated and revised, the third edition continues to provide a comprehensive analysis of the subject that is unmatched in the field. Figures and tables illustrate and emphasize key points and the text is extensively annotated. Written in an accessible and clear style, the book presents a balanced view of HIV/AIDS and serves as a valuable reference for students, researchers, clinicians, and health care providers.

Praise for the second edition:

"It is the best single source for students committed to understanding the multiple facets of the HIV epidemic and is equally valuable for experienced investigators to confirm facts, test concepts, and with persistence gain new insights into old ideas."

- Journal of the American Medical Association

"Jay Levy has managed this academic A-Z...of AIDS pathogenesis with considerable aplomb, as befits a scientist who has been at the centre of AIDS research for over one and a half decades."

- The Lancet

Description

The author includes a small history chapter in this third edition, but most of the book concentrates on the cellular biology of HIV, finishing with chapters on treatment and vaccine development. The second edition was published 10 years ago.

Purpose

The purpose "is to provide a resource for clinicians, researchers, health care providers and students." The book is the most comprehensive biological treatise on HIV that I have read, but has less emphasis on the clinical care of people living with HIV/AIDS. Therefore, it appears to be directed more at researchers and students and less at clinicians and HIV care providers.

Audience

This will be of tremendous interest to cellular biologists and researchers, with perhaps less utility to clinicians and HIV care providers. The author is a legend in HIV discovery and care.

Features

The author provides a comprehensive look at HIV transmission, cellular interactions, immune responses, development of malignancy in an HIV-affected immune system, and spends some time on novel therapies and vaccine development. The most interesting reading for me, however, was the end of each chapter, where "Salient Features" provides a summary. The photos and brief biographies of AIDS pioneer researchers in each chapter are very interesting, and provide a humanistic point of view on this subject. From my point of view, the only shortcoming of the book is its very microbiological focus.

Assessment

This is a powerful resource, well referenced, and very up to date. It represents exhaustive work by Dr. Levy and others, and is likely to be found on the bookshelf of serious practitioners and researchers in HIV care.

Doody Enterprises

Reviewer: Mark Goodman, MD (Creighton University Medical Center)

Review Date: Unknown

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