Chapter 5 : Risk Factors for Mortality by Legionnaires’ Disease (1983–2005)

MyBook is a cheap paperback edition of the original book and will be sold at uniform, low price.

Ebook: Choose a downloadable PDF or ePub file. Chapter is a downloadable PDF file. File must be downloaded within 48 hours of purchase

Buy this Chapter
Digital (?) $15.00

Preview this chapter:
Zoom in

Risk Factors for Mortality by Legionnaires’ Disease (1983–2005), Page 1 of 2

| /docserver/preview/fulltext/10.1128/9781555815660/9781555813901_Chap05-1.gif /docserver/preview/fulltext/10.1128/9781555815660/9781555813901_Chap05-2.gif


This chapter determines variables related to mortality of Legionnaire's disease (LD). An observational, comparative study was performed from 1983 to 2005, with 408 cases of pneumonia being diagnosed during this time. The variables studied included demographic characteristics, individual and aspiration risk factors, clinical manifestations, radiological manifestations, diagnostic data, treatment, and outcome. The variables were analyzed using univariate and multivariate logistic regression analysis by SPSS version 12.0. Regarding demographic data and risk factors, patients who died had a higher frequency of underlying diseases than the control group (89.8 versus 66.9%): mainly chronic respiratory disease (42.9 versus 29.6%), chronic heart failure (22.4 versus 10.2%), neoplasm (38.8 versus 15.8%), neurological sequelae (20 versus 7.6%), and inmunosuppressive therapy-mainly corticoids (45.8 versus 14.6%). Despite the improvement in the diagnostic procedures of LD and the use of more efficacious antibiotics against , chronic heart failure, hematological cancer, and corticotherapy are still bad prognostic factors of LD. Recommendations for prevention of LD should focus on settings in which there are persons at greatest risk for illness or serious outcome.

Citation: Sopena N, Pedro-Botet M, Mateu L, Roure S, Casas I, Esteve M, Ragull S, Rey-Joly C, Sabrià M. 2006. Risk Factors for Mortality by Legionnaires’ Disease (1983–2005), p 25-27. In Cianciotto N, Kwaik Y, Edelstein P, Fields B, Geary D, Harrison T, Joseph C, Ratcliff R, Stout J, Swanson M (ed), . ASM Press, Washington, DC. doi: 10.1128/9781555815660.ch05

Key Concept Ranking

Legionella pneumophila
Chronic Respiratory Disease
Highlighted Text: Show | Hide
Loading full text...

Full text loading...


1. Benin, A. L.,, R. F. Benson, and, R. E. Bessser.2002.Trends in Legionnaires’ disease, 1980–1998. Declining mortality and new patterns of diagnosis. Clin. Infect. Dis. 35:10391046.
2. Gacouin, A.,, Y. Le Tulzo,, S. Lavoue,, C. Camus,, H. Hoff,, R. Bassen, C. Arvieux,, C. Heurtin, and R. Thomas. 2002. Severe pneumonia due to Legionella pneumophila: prognostic factors, impact of delayed appropriate antimicrobial therapy. Intensive Care Med. 28:686691.
3. Gupta, S. K., and, G.A. Sarosi. 2001.The role of atypical pathogens in community-acquired pneumonia. Med. Clin. North Am. 85:13491365.
4. Health, C. H.,, D. I. Grove, and, D. F. M. Looke.1996.Delaying appropriate therapy of Legionella pneumonia associated with increased mortality. Eur. J. Clin. Microbiol. Infect. Dis. 15:286290.
5. Marston, B. J., H. B. Lipman, and, R. F. Breiman. 1994. Surveillance for Legionnaires’ disease: risk factors for morbidity and mortality. Arch. Intern. med. 154:24172422.
6. Mykietiuk, A.,, J. Carratala,, N. Fernandez-Sabe,, J. Dorca,, R. Verdaguer,, F. Manresa, and, F. Gudiol. 2005. Clinical outcomes for hospitalized patients with Legionella pneumonia in the antigenuria era: the influenza of levofloxacin therapy. Clin. Infect. Dis. 40:794799.
7. Pedro-Botet, M. L.,, J. E. Stout, and, V. L. Yu.2002. Legionnaires’ disease contracted from patient homes: the coming of the third plague? Eur. J. Clin. Microbiol. Infect. Dis. 21:699705.
8. Pedro-Botet, M. L.,, M. Sabrià,, N. Sopena,, J. M. Manterola,, J. Morera,, R. Blavia,, E. Padilla,, L. Matas, and J. M. Gimeno. 1998. Role of immunosuppression in the evolution of Legionnaries’ disease. Clin. Infect. Dis. 26:1419.
9. Sabrià, M.,, J. M. Modol,, M. Garcia-Núñez,, E. Reynaga,, M. L. Pedro-Bote,, N. Sopena, and, C. Rey-Joly. 2004. Environmental cultures and hospital-acquired Legionnaires’ disease. A five-year prospective study in twenty hospitals in Catalonia. Spain. Infect. Control Hosp. Epidemiol. 25:10721076.
10. Sopena, N.,, M. Sabrià,, M. L. Pedro-Botet,, J. M. Manterola,, L. Matas,, J. Domínguez,, J. M. Mòdol,, P. Tudela,, V. Ausina, and, M. Foz.1999. Prospective study of community-acquired pneumonia of bacterial etiology in adults. Eur. J. Clin. Microbiol. Infect. Dis. 18:852858.

This is a required field
Please enter a valid email address
Please check the format of the address you have entered.
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error