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Chapter 29 : Prevalence of Legionnaires’ Disease and Investigation on Risk Factors: Results of an Italian Multicentric Study

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Prevalence of Legionnaires’ Disease and Investigation on Risk Factors: Results of an Italian Multicentric Study, Page 1 of 2

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Abstract:

This chapter presents the preliminary results of a large multicentric study carried out in Italy to detect Legionnaires’ disease among patients with pneumonia. The general objective was to better evaluate the prevalence of disease within various Italian regions in order to confirm the existing data on the disease frequency and to eventually verify differences related to the geographical area. A case-control study was also designed to investigate behavioral, personal, and environmental risk factors related to the disease. Among studied parameters, the presence of chemokine receptor (CCR) 5D32 and CCR264I mutations was investigated to establish their possible role in susceptibility to Legionnaires’ disease. From 2001 to 2004, an active surveillance has been carried out in six hospitals (between 800 and 1,000 beds) located in the north, center and south of Italy. Both community-acquired and suspected nosocomial pneumonia were considered. A brief questionnaire for collecting personal data and disease characteristics was filled out for each examined patient. In conclusion, to always perform laboratory tests for Legionnaires’ disease appears an effective method to increase the detection of cases. The active clinical surveillance scheme was able to identify 189 cases, contributing to increased reports in Italy, where in total about 600 cases for year are reported. The preliminary results of the case-control study show that cases have peculiar, although not sufficiently studied, alterations in both immune and biochemical parameters, which deserve further investigations. Furthermore, a more extensive study may support a possible involvement of CCR2 in resistance and susceptibility to Legionnaires’ disease.

Citation: Borella P, Boccia S, Leoni E, Zanetti F, Marchesi I, Bargellini A, Teresa Montagna M, Tatò D, Montegrosso S, Pennino F, Romano-Spica V, Stancanelli G, Scaltriti S. 2006. Prevalence of Legionnaires’ Disease and Investigation on Risk Factors: Results of an Italian Multicentric Study, p 110-113. In Cianciotto N, Kwaik Y, Edelstein P, Fields B, Geary D, Harrison T, Joseph C, Ratcliff R, Stout J, Swanson M (ed), . ASM Press, Washington, DC. doi: 10.1128/9781555815660.ch29

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References

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1. Benin, A. L.,, R. F. Benson, and, R. E. Besser. 2002.Trends in Legionnaires’ disease, 1980-1998: declining mortality and new patterns of diagnosis. Clin. Infect. Dis. 35:10391046.
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8. Seenivasan, M. H.,, V. L. Yu, and, R. R. Muder. 2005. Legionnaires’ disease in long-term care facilities: overview and proposed solutions. J. Am. Geriatric. Soc. 53:875880.
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Tables

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TABLE 1

Results of active surveillance: number of pneumonia cases surveyed and number/percentage of detected Legionnaires’ disease cases according to geographic area.

Citation: Borella P, Boccia S, Leoni E, Zanetti F, Marchesi I, Bargellini A, Teresa Montagna M, Tatò D, Montegrosso S, Pennino F, Romano-Spica V, Stancanelli G, Scaltriti S. 2006. Prevalence of Legionnaires’ Disease and Investigation on Risk Factors: Results of an Italian Multicentric Study, p 110-113. In Cianciotto N, Kwaik Y, Edelstein P, Fields B, Geary D, Harrison T, Joseph C, Ratcliff R, Stout J, Swanson M (ed), . ASM Press, Washington, DC. doi: 10.1128/9781555815660.ch29

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