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Chapter 34 : 10 Years of Surveillance: Change of Subtype Preceded Epidemic of Nosocomial Legionnaires’ Disease

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10 Years of Surveillance: Change of Subtype Preceded Epidemic of Nosocomial Legionnaires’ Disease, Page 1 of 2

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Abstract:

This chapter evaluates the changing patterns of strains causing nosocomial infections (nLD) from a university hospital water system during a decade of active surveillance. All bronchoalveolar lavage specimens were routinely screened for . Bronchial secretions and urine probes from patients with suspicious atypical pneumonia were processed by routine culture methods. Isolates of spp. from patients and available corresponding environmental ones were genotyped using an AFLP technique previously described by EWGLI and further subtyped by monoclonal antibody analysis. -positive clinical specimens were reported to the infection control team, and every case was carefully followed up. Detection of was defined as nLD if the patient was admitted to the university hospital at least 10 days before and no other source of infection could be observed. Currently, the majority of infections in Germany are detected by a urine antigen test, and consequently the utilization rate of culture methods to detect has decreased over the past years to 11% in 2004, but only the latter method allows comparison of patient isolates with the ones isolated from the water system.

Citation: Weist K, Brandt C, Christian Lück P, Wagner J, Eckmanns T, Rüden H. 2006. 10 Years of Surveillance: Change of Subtype Preceded Epidemic of Nosocomial Legionnaires’ Disease, p 128-131. In Cianciotto N, Kwaik Y, Edelstein P, Fields B, Geary D, Harrison T, Joseph C, Ratcliff R, Stout J, Swanson M (ed), . ASM Press, Washington, DC. doi: 10.1128/9781555815660.ch34

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Direct Immunofluorescence Assay
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Ground Water
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Figures

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FIGURE 1

AFLP-Patterns of sg 1 isolates from four cases with nLD (Lane numbers correspond with patient no. of Table 1 ) and 1 isolate detected from a tap water outlet where case patients had been treated. M, marker; R, reference strain.

Citation: Weist K, Brandt C, Christian Lück P, Wagner J, Eckmanns T, Rüden H. 2006. 10 Years of Surveillance: Change of Subtype Preceded Epidemic of Nosocomial Legionnaires’ Disease, p 128-131. In Cianciotto N, Kwaik Y, Edelstein P, Fields B, Geary D, Harrison T, Joseph C, Ratcliff R, Stout J, Swanson M (ed), . ASM Press, Washington, DC. doi: 10.1128/9781555815660.ch34
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References

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Tables

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TABLE 1

Confirmed cases of nosocomial pneumonia in a university hospital during 10 years of surveillance

Citation: Weist K, Brandt C, Christian Lück P, Wagner J, Eckmanns T, Rüden H. 2006. 10 Years of Surveillance: Change of Subtype Preceded Epidemic of Nosocomial Legionnaires’ Disease, p 128-131. In Cianciotto N, Kwaik Y, Edelstein P, Fields B, Geary D, Harrison T, Joseph C, Ratcliff R, Stout J, Swanson M (ed), . ASM Press, Washington, DC. doi: 10.1128/9781555815660.ch34

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