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Chapter 62 : Role of -Specific Genes in Pathogenesis

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Role of -Specific Genes in Pathogenesis, Page 1 of 2

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Abstract:

Several studies have compared the virulence traits of different spp., yet little is known about the genetic basis of these phenotypic differences. To investigate genetic differences between and , the authors performed a low stringency genomic subtractive hybridization between a serogroup 1 isolate of and a clinical isolate of . Subtractive hybridization revealed 151 open reading frames (ORFs) present in 02/41 and absent in 02/42. LadC is predicted to be an adenylate cyclase, as it possesses an intact HAMP signal transduction region and the catalytic domain for adenylate cyclases. There are several mechanisms by which LadC, as a putative adenylate cyclase, could influence the invasion of host cells. LadC, through control of cAMP levels within the bacterial cell, may influence the regulation of virulence determinants or it may play a direct role in host-pathogen interactions. This investigation has demonstrated that possesses virulence determinants that are absent in other species.

Citation: J. Newton H, M. Sansom F, Bennett-Wood V, L. Hartland E. 2006. Role of -Specific Genes in Pathogenesis, p 251-254. In Cianciotto N, Kwaik Y, Edelstein P, Fields B, Geary D, Harrison T, Joseph C, Ratcliff R, Stout J, Swanson M (ed), . ASM Press, Washington, DC. doi: 10.1128/9781555815660.ch62

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Type IV Secretion Systems
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Rough Endoplasmic Reticulum
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Figures

Image of FIGURE 1
FIGURE 1

entry into THP-1 and A549 cells 130b (black), (white), and (pMIP:) (stripes) are shown. shows statistically significant reduced entry in comparison to 130b and (pMIP:W), < 0.05.

Citation: J. Newton H, M. Sansom F, Bennett-Wood V, L. Hartland E. 2006. Role of -Specific Genes in Pathogenesis, p 251-254. In Cianciotto N, Kwaik Y, Edelstein P, Fields B, Geary D, Harrison T, Joseph C, Ratcliff R, Stout J, Swanson M (ed), . ASM Press, Washington, DC. doi: 10.1128/9781555815660.ch62
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Image of FIGURE 2
FIGURE 2

entry into THP-1 and A549 cells 130b (black), (white), and (pMIP:) (stripes) are shown. shows statistically significant reduced entry in comparison to 130b and (pMIP:), < 0.05.

Citation: J. Newton H, M. Sansom F, Bennett-Wood V, L. Hartland E. 2006. Role of -Specific Genes in Pathogenesis, p 251-254. In Cianciotto N, Kwaik Y, Edelstein P, Fields B, Geary D, Harrison T, Joseph C, Ratcliff R, Stout J, Swanson M (ed), . ASM Press, Washington, DC. doi: 10.1128/9781555815660.ch62
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Download as Powerpoint

References

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