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Chapter 75 : Locus on Chromosome 13 in Mice Involved in Clearance of from the Lungs

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Locus on Chromosome 13 in Mice Involved in Clearance of from the Lungs, Page 1 of 2

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Abstract:

This chapter focuses on identifying the loci responsible for regulating replication in the lungs, by comparing susceptible B10.A/Niid with other resistant inbred strains. First, the susceptibility of B10.A/Niid mice might be a general response against the species. Second, in order to identify the locus that is responsible for the susceptibility phenotype on the major histocompatibility complex (MHC) region of the H-2 haplotype, the authors analyzed the influence of the MHC haplotypes on infection by using three types of B10.A intra-MHC-congenic mice, i.e., B10.A (2R), B10.A (3R), and B10.A (5R), as well as the parental mice, B10.A/SgSnJ, obtained from the Jackson laboratory. Third, to identify the responsible locus, the authors performed a whole-genome single-point linkage analysis on 280 (AKR/NxB10.A/Niid)F mice using 81 simple sequence-length markers that are polymorphic for B10.A/Niid and AKR/N. On the basis of this analysis, a susceptibility locus with significant linkage was mapped between and (mapped position 54 to 57 cM) on chromosome 13 (P<0.00001); no additional significant linkages were observed. Finally, the authors compared the replication in thioglycolate-elicited macrophages obtained from B10.A/Niid mice and the B10.A/Niid- congenic mouse strain that was constructed by introgressively backcrossing (B10.A/ NiidxA/J) F mice to B10.A/Niid mice.

Citation: Kobayashi S, Kura F, Amemura-Maekawa J, Chang B, Yamamoto N, Watanabe H. 2006. Locus on Chromosome 13 in Mice Involved in Clearance of from the Lungs, p 310-312. In Cianciotto N, Kwaik Y, Edelstein P, Fields B, Geary D, Harrison T, Joseph C, Ratcliff R, Stout J, Swanson M (ed), . ASM Press, Washington, DC. doi: 10.1128/9781555815660.ch75

Key Concept Ranking

Major Histocompatibility Complex
0.52168345
Legionella pneumophila
0.43633994
0.52168345
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Figures

Image of FIGURE 1
FIGURE 1

The mouse strain B10. A/Niid is susceptible to pulmonary infection. B10. A/Niid (striped bar) and C57BL/10 strains (white bar) were infected with 3 × 10 CFU of 80-045 (serogroup 1) per lung by intranasal infection. Data were mean ± standard deviation of 6 to 8 mice. The data shown are the combined data from two experiments. The asterisk (*) indicates a significant difference ( < 0.05) between B10. A/Niid and C57BL/10 strains.

Citation: Kobayashi S, Kura F, Amemura-Maekawa J, Chang B, Yamamoto N, Watanabe H. 2006. Locus on Chromosome 13 in Mice Involved in Clearance of from the Lungs, p 310-312. In Cianciotto N, Kwaik Y, Edelstein P, Fields B, Geary D, Harrison T, Joseph C, Ratcliff R, Stout J, Swanson M (ed), . ASM Press, Washington, DC. doi: 10.1128/9781555815660.ch75
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Image of FIGURE 2
FIGURE 2

Schematic representation of chromosome 13. Markers shown were used to genotype mice of the F cross. Approximate location of the markers was obtained from the mouse genome database. The centromere is indicated by a large circle.

Citation: Kobayashi S, Kura F, Amemura-Maekawa J, Chang B, Yamamoto N, Watanabe H. 2006. Locus on Chromosome 13 in Mice Involved in Clearance of from the Lungs, p 310-312. In Cianciotto N, Kwaik Y, Edelstein P, Fields B, Geary D, Harrison T, Joseph C, Ratcliff R, Stout J, Swanson M (ed), . ASM Press, Washington, DC. doi: 10.1128/9781555815660.ch75
Permissions and Reprints Request Permissions
Download as Powerpoint

References

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1. Diez, E.,, S. H. Lee,, S. Gauthier,, Z. Yaraghi,, M. Tremblay,, S. Vidal, and, P. Gros. 2003. Birc1e is the gene within the Lgn1 locus associated with resistance to Legionella pneumophila. Nat. Genet. 33:5560.
2. Wright, E. K.,, S. A. Goodart,, J. D. Growney,, V. Hadinoto,, M. G. Endrizzi,, E. M. Long,, K. Sadigh,, A. L. Abney,, I. Bernstein-Hanley, and, W. F. Dietrich. 2003. Naip5 affects host susceptibility to the intracellular pathogen Legionella pneumophila. Curr. Biol. 13:2736.

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