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Chapter 77 : A Peptidoglycan-Associated Lipoprotein of Activates Toll-Like Receptor 2 in Murine Macrophages

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A Peptidoglycan-Associated Lipoprotein of Activates Toll-Like Receptor 2 in Murine Macrophages, Page 1 of 2

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Abstract:

The innate immune system has an important function in activation and shaping of the adaptive immune response through the induction of costimulatory molecules and cytokines. The toll-like receptors (TLRs), which have recently been characterized as receptors of innate immunity, are one of the most important pattern recognition receptor families. TLRs recognize various classes of pathogen-associated molecular pattern. A 19-kDa Legionella peptidoglycan-associated lipopro-tein (PAL) is a species-common antigen that successfully induces the PAL-specific immune responses in mice delivered with plasmid DNA3-PAL. The purpose of this study was to determine whether peptidoglycan-associated lipoprotein (PAL) can activate TLRs involved in innate immunity that might be linked to development of specific immune responses. Recombinant-PAL (rPAL) of serogroup 1 was prepared. It also showed that r-PAL-induced cytokine production was inhibited significantly in the presence of TLR2-blocking antibody. These results indicate that the PAL is likely to activate TLR2-mediated signaling in murine macrophages, and they have important implications for the development of immune responses by surface antigens.

Citation: Jeong Kim M, Kyeong Lee I, Yang J, Sim H, Wook Sohn J, Ja Kim M. 2006. A Peptidoglycan-Associated Lipoprotein of Activates Toll-Like Receptor 2 in Murine Macrophages, p 321-322. In Cianciotto N, Kwaik Y, Edelstein P, Fields B, Geary D, Harrison T, Joseph C, Ratcliff R, Stout J, Swanson M (ed), . ASM Press, Washington, DC. doi: 10.1128/9781555815660.ch77

Key Concept Ranking

Tumor Necrosis Factor alpha
0.5625
Innate Immune System
0.49786213
Immune Response
0.49600014
Toll-Like Receptor 2
0.44362247
0.5625
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References

/content/book/10.1128/9781555815660.ch77
1. Akira, S.,, K. Takeda, and, T. Kaisho. 2001. Toll like receptors: critical proteins linking innate and acquired immunity. Nat. Immunol. 675680.
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3. Takeuchi, O.,, K. Hoshino,, T. Kawai,, H. Sanjo,, H. Takada,, T. Ogawa,, K. Takeda, and, S. Akira. 1999. Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components. Immunity 11:443451.
4. Yoon, W. S.,, S. H. Park,, Y. K. Park,, S. C. Park,, J. I. Sin, and, M. J. Kim. 2002. Comparison of responses elicited by immunization with a Legionella species common lipoprotein delivered as naked DNA or recombinant protein. DNA Cell Biol. 21:99107.

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