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Chapter 85 : Genome Rearrangements and Horizontal Gene Transfer in

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Genome Rearrangements and Horizontal Gene Transfer in , Page 1 of 2

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Abstract:

is found in diverse ecological niches such as axenic cultures, biofilms with other microbes, and intracellular vacuoles of protozoa and human cells. This may have provided ample opportunities for the organisms to rearrange their genomes and to accumulate genes that help them survive in these different environments. ability to survive in harsh conditions such as in plumbing systems treated with potent biocides may require additional genes necessary for detoxification. The needed gene pool can be assembled via gene family expansions and horizontal gene transfer from other organisms. Genome comparisons of the Philadelphia 1 strain and those of Paris and Lens, indicating positions of the large-scale genome rearrangements. Phylogenetic and gene composition analysis indicate that different strains display distinct acquisition histories for these gene subsets, suggesting gene rearrangements as well as repeated horizontal gene transfer events. Several dozen eukaryotic gene homologs with distinct phenotypes which appear to be acquired by gene transfer were identified. Overall, the genome of reveals features supporting genome rearrangement events of different scales. Given its intracellular existence, it is not surprising that examination of the genome sequence offers evidence that can be an active participant in horizontal gene transfer. As more strains of are sequenced, along with other species of , much more will be learned about their evolutionary origins, lifestyle, and potential for pathogenicity.

Citation: Morozova I, Morozov P, Pampou S, de Felipe K, Kalachikov S, A. Shuman H, J. Russo J. 2006. Genome Rearrangements and Horizontal Gene Transfer in , p 351-354. In Cianciotto N, Kwaik Y, Edelstein P, Fields B, Geary D, Harrison T, Joseph C, Ratcliff R, Stout J, Swanson M (ed), . ASM Press, Washington, DC. doi: 10.1128/9781555815660.ch85

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Horizontal Gene Transfer
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Figures

Image of FIGURE 1
FIGURE 1

Genome alignments (dot plots) of Philadelphia 1 against Lens and Paris strains show the location of major genome rearrangement and acquisition events.

Citation: Morozova I, Morozov P, Pampou S, de Felipe K, Kalachikov S, A. Shuman H, J. Russo J. 2006. Genome Rearrangements and Horizontal Gene Transfer in , p 351-354. In Cianciotto N, Kwaik Y, Edelstein P, Fields B, Geary D, Harrison T, Joseph C, Ratcliff R, Stout J, Swanson M (ed), . ASM Press, Washington, DC. doi: 10.1128/9781555815660.ch85
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Image of FIGURE 2
FIGURE 2

Gene content of 100-kb efflux regions in three strains. (a) Efflux elements can be in two different locations in the analyzed genomes. In all three genomes the efflux gene cassette is located next to the para-efflux element which constitutes a remnant of a presumably mobile element.(b) Structure comparisons of the four regions shown in panel a. The insertion of the mobile element most likely occured at the tRNA gene site, and the regions are surrounded by numerous IS elements. In two cases, the error-prone DNA repair SOS system operon is found in the vicinity.

Citation: Morozova I, Morozov P, Pampou S, de Felipe K, Kalachikov S, A. Shuman H, J. Russo J. 2006. Genome Rearrangements and Horizontal Gene Transfer in , p 351-354. In Cianciotto N, Kwaik Y, Edelstein P, Fields B, Geary D, Harrison T, Joseph C, Ratcliff R, Stout J, Swanson M (ed), . ASM Press, Washington, DC. doi: 10.1128/9781555815660.ch85
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Download as Powerpoint

References

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