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Chapter 17 : Effects of Estrogen, Chorionic Gonadotropin, and Thyroid Hormones on Tuberculosis

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Effects of Estrogen, Chorionic Gonadotropin, and Thyroid Hormones on Tuberculosis, Page 1 of 2

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Abstract:

Since estrogen increased the hyaluronic acid and water content of the skin, it decreased the spread of intradermally injected virulent bovine-type tubercle bacilli in rabbits. Chorionic gonadotropin had the reverse effect. These two sex hormones had no appreciable effect on the innate or acquired ability of the host to control the progression of tuberculosis, because neither hormone appreciably changed the number of primary pulmonary tubercles generated by aerosols of virulent human-type tubercle bacilli. However, estrogen markedly suppressed the development of amyloid in the spleens of rabbits dying of the more chronic form of tuberculosis caused by bovine-type bacilli. In rabbits, triiodothyronine or thyroxine increased host resistance in that they decreased the number of grossly visible primary pulmonary tubercles produced by the inhalation of virulent human-type tubercle bacilli, whereas thyroidectomy or propylthiouracil treatment increased the number of such primary tubercles. Thyroid hormones were most beneficial in inbred rabbits of intermediate resistance. The resistance of the most susceptible inbred C rabbits and that of the most resistant III(r) rabbits were not appreciably increased by thyroid hormones.

Citation: Dannenberg, Jr. A. 2006. Effects of Estrogen, Chorionic Gonadotropin, and Thyroid Hormones on Tuberculosis, p 285-291. In Pathogenesis of Human Pulmonary Tuberculosis. ASM Press, Washington, DC. doi: 10.1128/9781555815684.ch17
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Figures

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FIGURE 1

Effect of thyroxine on the number of human-type tubercle bacilli (H37Rv) cultured from the lungs of inbred III IIIC rabbits (which are of rather high resistance) at various times after aerosol infection. The points represent the mean number of viable bacilli at weekly intervals divided by the number on the first day. Reproduced from reference 7.

Note that thyroxine treatment of these rabbits inhibited bacillary growth, especially during the first 7 days. Evidently, the pulmonary alveolar macrophages of these hyperthyroid rabbits had an increased ability to destroy or inhibit the inhaled bacilli.

Citation: Dannenberg, Jr. A. 2006. Effects of Estrogen, Chorionic Gonadotropin, and Thyroid Hormones on Tuberculosis, p 285-291. In Pathogenesis of Human Pulmonary Tuberculosis. ASM Press, Washington, DC. doi: 10.1128/9781555815684.ch17
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References

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1. Lurie, M. B.,, S. Abramson, and, M. J. Allison. 1949. Constitutional factors in resistance to infection. I. The effect of estrogen and chorionic gonadotropin on the course of tuberculosis in highly inbred rabbits. Am. Rev. Tuberc. 59:168185.
2. Lurie, M. B.,, T. N. Harris,, S. Abramson, and, M. J. Allison. 1949. Constitutional factors in resistance to infection. II. The effect of estrogen on tuberculin skin sensitivity and on the allergy of the internal tissues. Am. Rev. Tuberc. 59:186197.
3. Lurie, M. B.,, S. Abramson,, A. G. Heppleston, and, M. J. Allison. 1949. Constitutional factors in resistance to infection. III. On the mode of action of estrogen and gonadotropin on the progress of tuberculosis. Am. Rev. Tuberc. 59:198218.
4. Lurie, M. B. 1964. Resistance to Tuberculosis: Experimental Studies in Native and Acquired Defensive Mechanisms, p. 181191. Harvard University Press, Cambridge, Mass.
5. Lurie, M. B. 1955. On the role of hormones in experimental tuberculosis. Adv. Tuberc. Res. 6:1848.
6. Lurie, M. B. 1964. Resistance to Tuberculosis: Experimental Studies in Native and Acquired Defensive Mechanisms, p. 265301. Harvard University Press, Cambridge, Mass.
7. Lurie, M. B.,, P. Zappasodi,, R. S. Levy, and, R. G. Blaker. 1959. On the role of the thyroid in native resistance to tuberculosis. I. The effect of hyperthyroidism. Am. Rev. Tuberc. 79:152179.
8. Lurie, M. B.,, P. Zappasodi,, R. G. Blaker, and, R. S. Levy. 1959. On the role of the thyroid in native resistance to tuberculosis. II. The effect of hypothyroidism: the mode of action of thyroid hormones. Am. Rev. Tuberc. 79:180203.
9. Lurie, M. B.,, P. Zappasodi, and, C. Tickner. 1955. On the nature of genetic resistance to tuberculosis in the light of the host-parasite relationships in natively resistant and susceptible rabbits. Am. Rev. Tuberc. 72:297329.

Tables

Generic image for table
TABLE 1

Effects of estrogen on tuberculosis produced by the inhalation of human-type tubercle bacilli (H37Rv) in female susceptible CaC rabbits a

Citation: Dannenberg, Jr. A. 2006. Effects of Estrogen, Chorionic Gonadotropin, and Thyroid Hormones on Tuberculosis, p 285-291. In Pathogenesis of Human Pulmonary Tuberculosis. ASM Press, Washington, DC. doi: 10.1128/9781555815684.ch17
Generic image for table
TABLE 2

Effects of -triiodothyronine, dinitrophenol (DNP), and -thyroxine on tuberculosis produced by the inhalation of human-type tubercle bacilli (H37Rv) in inbred rabbits a

Citation: Dannenberg, Jr. A. 2006. Effects of Estrogen, Chorionic Gonadotropin, and Thyroid Hormones on Tuberculosis, p 285-291. In Pathogenesis of Human Pulmonary Tuberculosis. ASM Press, Washington, DC. doi: 10.1128/9781555815684.ch17
Generic image for table
TABLE 3

Effect on tuberculosis of triiodothyronine treatment begun 3 weeks after the inhalation of human-type tubercle bacilli (H37Rv) and continued for 7 subsequent weeks in III IIIC rabbits of rather high resistance a

Citation: Dannenberg, Jr. A. 2006. Effects of Estrogen, Chorionic Gonadotropin, and Thyroid Hormones on Tuberculosis, p 285-291. In Pathogenesis of Human Pulmonary Tuberculosis. ASM Press, Washington, DC. doi: 10.1128/9781555815684.ch17
Generic image for table
TABLE 4

Effects of thyroidectomy (Thyx) and propylthiouracil treatment (PtuRx) on tuberculosis produced by the inhalation of human-type tubercle bacilli (H37Rv) a

Citation: Dannenberg, Jr. A. 2006. Effects of Estrogen, Chorionic Gonadotropin, and Thyroid Hormones on Tuberculosis, p 285-291. In Pathogenesis of Human Pulmonary Tuberculosis. ASM Press, Washington, DC. doi: 10.1128/9781555815684.ch17

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