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The Spectrum of Neuro-AIDS Disorders: Pathophysiology, Diagnosis, and Treatment

Editors: Karl Goodkin1, Paul Shapshak2, Ashok Verma3
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Affiliations: 1: Department of Psychiatry and Behavioral, Neurosciences, Cedars-Sinai Medical Center, and Department of Psychiatry and Biobehavioral Sciences, University of California-Los Angeles, Los Angeles, California; 2: Ann Lowerey Murphey Laboratory, Department of Psychiatry and Behavioral Medicine, University of South Florida College of Medicine, Tampa, Florida; 3: Department of Neurology, University of Miami, Miller School of Medicine, Miami, Florida
Content Type: Monograph
Publication Year: 2009

Category: Viruses and Viral Pathogenesis

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In the decade-plus since the introduction of highly active antiretroviral therapy (HAART), clinicians and researchers have come to recognize the implications of the brain as a reservoir for resistant HIV, and the significance of this chronic infection to the patient’s functioning and prognosis. This unique volume covers the full scope of research on the neurological and neurobehavioral implications of HIV/AIDS, or “neuro-AIDS,” including the fields of microbiology and immunology.

In this book, noted researchers from all over the world examine the wide range of HIV-associated neurological and neurobehavioral disorders. Neuro-AIDS can affect the entire neuraxis, resulting in physiological, neurological, and neurobehavioral deficits ranging from distal sensory polyneuropathy and primary CNS lymphoma to HIV-associated neurocognitive impairment and disorders including HIV-associated dementia. Toxicities of the antiretroviral medications themselves are a serious concern

This book presents the wide variety of HIV-associated disorders and comorbidities with a look at the pre-HAART literature as well as the latest findings from the post-HAART era. Pathophysiology and selected neuroimaging techniques for diagnosis and assessment are examined in detail. In addition, this volume stands out for its chapters on specific patient populations such as women, children, minorities, and older persons, as well as special chapters addressing medico-legal and end-of-life concerns. The book concludes with a look at global issues and the future of neuro-AIDS in the HAART era.

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Doody Enterprises

14 July 2013

At A Glance

In the decade-plus since the introduction of highly active antiretroviral therapy (HAART), clinicians and researchers have come to recognize the implications of the brain as a reservoir for resistant HIV, and the significance of this chronic infection to the patient’s functioning and prognosis. This unique volume covers the full scope of research on the neurological and neurobehavioral implications of HIV/AIDS, or “neuro-AIDS,” including the fields of microbiology and immunology.

In this book, noted researchers from all over the world examine the wide range of HIV-associated neurological and neurobehavioral disorders. Neuro-AIDS can affect the entire neuraxis, resulting in physiological, neurological, and neurobehavioral deficits ranging from distal sensory polyneuropathy and primary CNS lymphoma to HIV-associated neurocognitive impairment and disorders including HIV-associated dementia. Toxicities of the antiretroviral medications themselves are a serious concern.

This book presents the wide variety of HIV-associated disorders and comorbidities with a look at the pre-HAART literature as well as the latest findings from the post-HAART era. Pathophysiology and selected neuroimaging techniques for diagnosis and assessment are examined in detail. In addition, this volume stands out for its chapters on specific patient populations such as women, children, minorities, and older persons, as well as special chapters addressing medico-legal and end-of-life concerns. The book concludes with a look at global issues and the future of neuro-AIDS in the HAART era.

Key Features

Considers the broad scope of effects of HIV/AIDS on the brain and peripheral nervous system (“neuro-AIDS”), both pre- and post-HAART era



Links basic pathology and pathophysiology research with clinical findings, diagnostic, and assessment techniques in both the CNS and the periphery



Examines the wide range of HIV-associated comorbidities including fungal, viral, syphilitic,



and Toxoplasma infections



Covers neurological and neurobehavioral syndromes (dementia, delirium, depressive disorders, fatigue, and peripheral nervous and muscular dysfunction), including diagnosis and treatment



Presents specific information on neuro-AIDS in special populations including women, children, minorities, and older persons



Explores medico-legal issues, including end-of-life concerns specific to neuro-AIDS patients



Examines the status of neuro-AIDS conditions at the global level

Description

This book is a comprehensive description of the latest discoveries in neuro-AIDS. It is a thorough and up-to-date overview of the pathophysiology of, diagnostic approaches to, and clinical treatment strategies in neuro-AIDS.

Purpose

It is intended to bridge the gap between research on disease pathophysiology and clinical practice, and ultimately promote translational research. The authors want to integrate the information on the pathophysiological bases of, diagnostic approaches to, and clinical treatment strategies for neuro-AIDS. This book provides a nicely organized reference to all aspects of neuro-AIDS.

Audience

It is intended for a broad audience: infectious disease physicians, internists and other primary care providers, neurologists, neuropsychiatrists, neuropsychologists, neuroradiologists, virologists, immunologists, epidemiologists, biochemists, and pharmacologists. It can appeal to many other professionals involved in the care of patients with neuro-AIDS, including nurses, case managers, and social workers.

Features

The six sections of the book cover disorders due to primary pathogenesis and treatment, pathophysiological issues, neuroimaging in HIV infection, HIV comorbidities including opportunistic infections, special populations with different ethnic backgrounds as well as women and children with HIV, and special healthcare issues and neuro-AIDS involving global issues. Each section nicely summarizes the findings of the pre-HAART (highly active antiretroviral therapy) era and brings readers up-to-date with the latest developments. One of the shortcomings of the book is that few of the illustrations are in color and many, especially those in the neuroimaging section, would have benefited from added color.

Assessment

This comprehensive book is nicely written and provides a spectrum of the latest research in neuro-AIDS disorders from pathophysiology to diagnosis and eventually treatment.

Doody Enterprises

Reviewer: Mary Ricardo-Dukelow, MD (Univ of Hawaii John A. Burns School of Medicine)

Review Date: Unknown

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