Chapter 6 : Distal Sensory Polyneuropathy and Other Selected Neuropathies in HIV Infection

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This chapter discusses the clinical features, diagnosis, and management of HIV distal sensory polyneuropathy (DSP); toxic neuropathies, with emphasis on the antiretroviral (ARV)-associated neuropathies; and other neuropathies found in HIV-infected individuals. Subjects were classified as having asymptomatic DSP if they only had neurologic signs or as having symptomatic DSP if they also had paresthesias or pain in a study by Schifitto and coworkers. The study showed that use of these drugs was not a significant risk factor for incident symptomatic DSP. Such an effect may be related to preservation of immune function, forestalling the potential occurrence of neurotoxicity. This study also addressed the important issue of whether the presence of asymptomatic DSP is a risk factor for incident symptomatic DSP. Thus, it is not surprising that patients with advanced HIV infection and severe immunosuppression remain at the greatest risk of neurotoxicity due to ARV agents. The incidence, severity, progression, and reversibility of peripheral neuropathy from zalcitabine (ddC), as with other toxic neuropathies, are dose dependent. Unlike other toxic neuropathies, dapsone-induced peripheral neuropathy involves primarily motor nerves. Mononeuropathy multiplex (MM) is an infrequent manifestation of HIV infection. A reduced number of oxytocin neurons in the paraventricular nucleus of the hypothalamus have also been described, although the clinical significance of this is unclear. It has been suggested that the pathophysiological mechanism may be due to HIV infection itself as well as an autoimmune mechanism. It may arise from HIV itself or from medications used to treat HIV infection and other concomitant infections.

Citation: Estanislao L, Geraci A, Simpson D. 2009. Distal Sensory Polyneuropathy and Other Selected Neuropathies in HIV Infection, p 75-86. In Goodkin K, Shapshak P, Verma A (ed), The Spectrum of Neuro-AIDS Disorders. ASM Press, Washington, DC. doi: 10.1128/9781555815691.ch6

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Citation: Estanislao L, Geraci A, Simpson D. 2009. Distal Sensory Polyneuropathy and Other Selected Neuropathies in HIV Infection, p 75-86. In Goodkin K, Shapshak P, Verma A (ed), The Spectrum of Neuro-AIDS Disorders. ASM Press, Washington, DC. doi: 10.1128/9781555815691.ch6
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1. Alexander, L.,, and C. Wilcox. 1997. A prospective trial of thalidomide for the treatment of HIV-associated idiopathic esophageal ulcers. AIDS Res. Hum. Retrovir. 13:301304.
2. Anders, H,, and F. Goebel. 1998. Cytomegalovirus polyradiculopathy in patients with AIDS. Clin. Infect. Dis. 27:345352.
3. Anderson, T.,, A. Davidoch,, D. Feldman,, T. Sprinkle,, J. Arezzo,, C. Brosnan,, R. O. Calderon,, L. H. Fossom,, J. DeVries, and, G. DeVries. 1994. Mitochondrial schwannopathy and peripheral myelinopathy in a rabbit model of dideoxycytidine neurotoxicity. Lab. Investig. 70:724739.
4. Anderson, T. D.,, A. Davidovich,, R. Arceo,, C. Brosnan,, J. Arezzo, and, H. Schaumburg. 1992. Peripheral neuropathy induced by 2′,3′-dideoxycytidine. A rabbit model of 2′,3′-dideoxycytidine neurotoxicity. Lab. Investig. 66:6374.
5. Angelucci, L.,, M. Ramacci,, G. Taglialatela,, C. Hulsebosch,, B. Morgan,, K. Werrbach-Perez, and, R. Perez-Polo. 1988. Nerve growth factor binding in aged rat central nervous system: effect of acetyl-l-carnitine. J. Neurosci. Res. 20:491496.
6. Bacellar, H.,, A. Munoz,, E. N. Miller,, B. A. Cohen,, D. Besley,, O. A. Selnes,, J. T. Becker, and, J. C. McArthur. 1994. Temporal trends in the incidence of HIV-1-related neurologic diseases: multicenter AIDS cohort study, 1985–1992. Neurology 44:18921900.
7. Balzarini, J.,, P. Herdewlin, and, E. De Clercq. 1989. Differential patterns of intracellular metabolism of 2′3′-dideoxythymidine and 3′-azido-2′3′-dideoxythymidine, two potent anti-human immunodeficiency virus compounds. J. Biol. Chem. 264:61276133.
8. Batman, P. A.,, A. R. Miller,, P. M. Sedgwick, and, G. E. Griffin. 1991. Autonomic denervation in jejunal mucosa of homosexual men infected with HIV. AIDS 5:12471252.
9. Berger, A. R.,, J. C. Arezzo,, H. H. Schaumburg,, G. Skowron,, T. Merigan,, S. Bozzette,, D. Richman, and, W. Soo. 1993. Dideoxycytidine (ddC) toxic neuropathy: a study of 52 patients. Neurology 43:358362.
10. Berger, A. R.,, H. H. Schaumburg,, C. Schroeder,, S. Apfel, and, R. Reynolds. 1992. Dose response, coasting, and differential fiber vulnerability in human toxic neuropathy: a prospective study of pyridoxine neurotoxicity. Neurology 42:13671370.
11. Berger, J. R.,, M. Flaster,, N. Schatz,, D. Droller,, P. Benedetto,, R. Poblete, and, M. J. Post. 1993. Cranial neuropathy heralding otherwise occult AIDS-related large cell lymphoma. J. Clin. Neurophysiol. 13:113118.
12. Biehl, J.,, and H. Nimitz. 1954. Studies on the use of a high dose of isoniazid. Am. Rev. Tuberc. 70:430444.
13. Biehl, J.,, and J. Skavlem. 1953. Toxicity of isoniazid. Am. Rev. Tuberc. 68:296297.
14. Biehl, J.,, and R. Vilter. 1954. Effect of isonazid on vitamin B12 metabolism, its possible significance in producing isoniazid neuritis. Proc. Soc. Exp. Biol. Med. 85:389395.
15. Blakemore, W. 1980. Isoniazid, p. 476–489. In P. Spencer, and, H. Schaumburg (ed.), Experimental and Clinical Neurotoxicology. Williams & Wilkins, Baltimore, MD.
16. Boyce, E.,, E. Cookson, and, W. Bond. 1990. Persistent metronidazole-induced peripheral neuropathy. Ann. Pharmacother. 24:1921.
17. Bradley, W.,, I. Karlsson, and, C. Rassol. 1977. Metronidazole neuropathy. Br. Med. J. 2:610611.
18. Brew, B.,, S. Tisch, and, M. Law. 2003. Lactate concentrations distinguish between nucleoside neuropathy and HIV neuropathy. AIDS 17:10941096.
19. Browne, M.,, K. Mayer, and, S. Chafee. 1993. Didehydro-3′-deoxythymidine (d4T) in patients with AIDS or AIDS-related complex: a phase I trial. J. Infect. Dis. 167:2129.
20. Calabrese, L.,, and A. Fleischer, Jr. 2000. Thalidomide: current and potential clinical applications. Am. J. Med. 108:487495.
21. Cavanagh, J. 1979. The “dying back” process, a common denominator in many naturally occurring and toxic neuropathies. Arch. Pathol. Lab. Med. 193:659664.
22. Chen, C. H.,, and Y. C. Cheng. 1989. Delayed cytotoxicity and selective loss of mitochondrial DNA in cells treated with the anti-human immunodeficiency virus compound 2′3′-dideoxycytidine. J. Biol. Chem. 264:1193411937.
23. Childs, E. A.,, R. H. Lyles,, O. A. Selnes,, B. Chen,, E. N. Miller,, B. A. Cohen,, J. T. Becker,, J. Mellors, and, J. C. McArthur. 1999. Plasma viral load and CD4 lymphocytes predict HIV-associated peripheral neuropathy. Neurology 52:607613.
24. Chimelli, L.,, and A. R. Martins. 2002. Degenerative and inflammatory lesions in sympathetic ganglia: further morphologic evidence for an autonomic neuropathy in AIDS. J. Neuro-AIDS 2:6782.
25. Chimelli, L.,, and F. Scaravilli. 1991. Morphological changes in the autonomic nervous system of patients with AIDS, p. 89. Proc. Seventh Int. Conf. Neurosci. HIV Infect. Padova, Italy.
26. Cohen, B. A.,, J. C. McArthur,, S. Grohman,, B. Patterson, and, J. D. Glass. 1993. Neurologic prognosis of cytomegalovirus polyradiculomyelopathy in AIDS. Neurology 43:493499.
27. Colucci, W.,, and R. Gandour. 1988. Carnitine acetyltransferase: a review of its biology, enzymology and bioorganic chemistry. Bioorg. Chem. 16:307334.
28. Cooley, T. P.,, L. M. Kunche,, C. A. Saunders,, J. K. Ritter,, C. J. Perkins,, C. McLaren,, R. P. McCaffrey, and, H. A. Liebman. 1990. Once-daily administration of 2′3′didexyinosine (ddI) in patients with the acquired immunodeficiency syndrome or AIDS-related complex. N. Engl. J. Med. 322:13401345.
29. Cooney, D. A.,, M. Dalal,, H. Mitsuya,, J. B. McMahon,, M. Nadkarni,, J. Balzarini,, S. Broder, and, D. G. Johns. 1986. Initial studies on the cellular pharmacology of 2′3′-dideoxycytidine, an inhibitor of HTLV-III infectivity. Biochem. Pharmacol. 35:20652068.
30. Cornblath, D.,, and J. McArthur. 1988. Predominantly sensory neuropathy in patients with AIDS and AIDS-related complex. Neurology 38:794796.
31. Cornblath, D. R.,, J. C. McArthur,, P. G. Kennedy,, A. S. Witte, and, J. W. Griffin. 1987. Inflammatory demyelinating peripheral neuropathies associated with human T-cell lymphotropic virus type III infection. Ann. Neurol. 21:3240.
32. Cote, H.,, B. Brumme,, K. Craib,, M. Math,, C. Alexander,, B. Wynhoven,, L. Ting,, H. Wong,, M. Harris,, R. Harrigan,, M. O’Shaughnessy, and, J. Montaner. 2002. Changes in mitochondrial DNA as a marker of nucleoside toxicity in HIV-infected patients. N. Engl. J. Med. 346:811820.
33. Coxon, A.,, and C. Pallis. 1976. Metronidazole neuropathy. J. Neurol. Neurosurg. Psychiatry 39:403405.
34. Craddock, C.,, G. Pasvol,, R. Bull,, A. Protheroe, and, J. Hopkin. 1987. Cardiorespiratory arrest and autonomic neuropathy in acquired immunodeficiency syndrome. Lancet ii:1618.
35. Cui, L.,, L. Locatelli,, M. Y. Xie, and, J. P. Sommadossi. 1997. Effect of nucleoside analogs on neurite regeneration and mitochondrial DNA synthesis in PC-12 cells. J. Pharmacol. Exp. Ther. 280:12281234.
36. Dalakas, M.,, C. Semino-Mora, and, M. Leon-Monzon. 2001. Mitochondrial alterations with mitochondrial DNA depetion in the nerves of AIDS patients with peripheral neuropathy induced by 2′3′-dideoxycytidine (ddC). Lab. Investig. 81:15371544.
37. de Gans, J.,, P. Portegies,, G. Tiessens,, D. Troost,, S. A. Danner, and, J. M. Lange. 1990. Therapy for cytomegalovirus polyradiculopathy in patients with AIDS: treatment with ganciclovir. AIDS 4:421425.
38. Dreger, L. M.,, P. P. Gleason,, T. K. Chowdhry, and, D. J. Gazzuolo. 1998. Intermittent-dose metronidazole-induced peripheral neuropathy. Ann. Pharmacother. 32:267268.
39. Dube, M. 2000. Disorders of glucose metabolism in patients infected with human immunodeficiency virus. Clin. Infect. Dis. 31:14671475.
40. Dubinsky, R. M.,, R. Yarchoan,, M. Dalakas, and, S. Broder. 1989. Reversible axonal neuropathy from the treatment of AIDS and related disorders with 2′3′-dideoxycytidine (ddC). Muscle Nerve 12:856860.
41. Duffy, L. F.,, F. Daum,, S. E. Fisher,, J. Selman,, S. M. Vishnubhakat,, H. W. Aiges,, J. F. Markowitz, and, M. Silverberg. 1985. Peripheral neuropathy in Crohn’s disease. Patients treated with metronidazole. Gastroenterology 88:681684.
42. Eidelberg, D.,, A. Sotrel,, H. Vogel,, P. Walker,, J. Kleefield, and, C. S. Crumpacker III. 1986. Progressive polyradiculopathy in acquired immune deficiency syndrome. Neurology 36:912916.
43. Engstrom, J.,, E. Lewis, and, D. McGuire. 1991. Cranial neuropathy and the acquired immunodeficiency syndrome. Neurology 41(Suppl. 1):S374.
44. Epstein, F.,, and M. Bohm. 1976. Dapsone-induced peripheral neuropathy. Arch. Dermatol. 112:17611762.
45. Famularo, G.,, S. Moretti,, S. Marcellini,, V. Trinchieri,, S. Tzantzoglou,, G. Santini,, A. Longo, and, C. De Simone. 1997. Acetyl-carnitine deficiency in AIDS patients with neurotoxicity on treatment with antiretroviral nucleoside analogues. AIDS 11:185190.
46. Fichtenbaum, C.,, D. Clifford, and, W. Powderly. 1995. Risk factors for dideoxynucleoside-induced toxic neuropathy in patients with the human immunodeficiency virus infection. J. Acquir. Immune Defic. Syndr. Hum Retrovirol. 10:169174.
47. Fischl, M.,, R. Olson, and, S. Follansbee. 1993. Zalcitabine compared with zidovudine in patients with advanced HIV-1 infection who received previous zidovudine therapy. Ann. Intern. Med. 118:762769.
48. Fredericks, E.,, R. Kugelman, and, N. Kirsch. 1976. Dapsone-induced motor polyneuropathy. Arch. Dermatol. 112:11581160.
49. Freeman, R.,, M. S. Roberts,, L. S. Friedman, and, C. Broadbridge. 1990. Autonomic function and human immunodeficiency virus infection. Neurology 40:57580.
50. Fullerton, P.,, and D. O’Sullivan. 1968. Thalidomide neuropathy: a clinical, electrophysiological, and histological follow-up study. J. Neurol. Neurosurg. Psychiatry 31:543551.
51. Gammon, G.,, F. Burge, and, G. King. 1953. Neural toxicity in tuberculous patients treated with isoniazid (isonicotinic acid hydrazide). Am. Med. Assoc. Arch. Neurol. Psychiatry 70:6469.
52. Gasnault, J.,, C. Pinganaud, and, P. Kousignian. 1999. Subacute ascendant neuropathy revealing a nucleoside-induced mitochondrial cytopathy. Presented at the Seventh European Conference on Clinical Aspects and Treatment of HIV Infection, 23–27 October 1999, Lisbon, Portugal.
53. Gherardi, R.,, F. Lebargy,, P. Gaulard,, C. Mhiri,, J. F. Bernaudin, and, F. Gray. 1989. Necrotizing vasculitis and HIV replication in peripheral nerves. N. Engl. J. Med. 321:685686.
54. Girling, D. 1982. Adverse effects of antituberculosis drugs. Drugs 23:5674.
55. Gozlan, J.,, M. el Amrani,, M. Baudrimont,, D. Costagliola,, J. M. Salord,, C. Duvivier,, O. Picard,, M. C. Meyohas,, C. Jacomet,, V. Schneider-Fauveau,, J.-C. Petit, and, E. Roullet. 1995. A prospective evaluation of clinical criteria and polymerase chain reaction assay of cerebrospinal fluid for the diagnosis of cytomeglovirus-related neurological diseases during AIDS. AIDS 9:253260.
56. Griffin, D.,, J. McArthur, and, D. Cornblath. 1990. Soluble interleukin-2 receptor and soluble CD8 in serum and cerebrospinal fluid during human immunodeficiency virus-associated neurologic disease. J. Neuroimmunol. 28:97109.
57. Grinspan, D. 1985. Significant response of oral aphthosis to thalidomide treatment. J. Am. Acad. Dermatol. 12:8590.
58. Guttman, L.,, J. Martin, and, W. Welton. 1976. Dapsone motor neuropathy—an axonal disease. Neurology 26:514516.
59. Hamuryudan, V.,, C. Mat,, S. Saip,, Y. Ozyazgan,, A. Siva,, S. Yurdakul,, K. Zwingenberger, and, H. Yazici. 1998. Thalidomide in the treatment of the mucocutaneous lesions of Behcet’s syndrome: a randomized, double-blind, placebo controlled trial. Ann. Intern. Med. 128:443459.
60. Jacobson, J. M.,, J. S. Greenspan,, J. Spritzler,, N. Ketter,, J. L. Fahey,, J. B. Jackson,, L. Fox,, M. Chernoff,, A. W. Wu,, L. A. MacPhail,, G. J. Vasquez, and, D. A. Wohl. 1997. Thalidomide for the treatment of oral aphthous ulcers in patients with human immunodeficiency virus infection. N. Engl. J. Med. 336:14871493.
61. Jones, W.,, and G. Jones. 1953. Peripheral neuropathy due to isoniazid. Report of two cases. Lancet i:10731074.
62. Kahn, J. O.,, S. W. Lagakos,, D. D. Richman,, A. Cross,, C. Pettinelli,, S. H. Liou,, M. Brown,, P. A. Volberding,, C. S. Crumpacker, and, G. Beall. 1992. A controlled trial comparing continued zidovudine with didanosine in human immunodeficiency virus infection. N. Engl. J. Med. 327:581587.
63. Kaplan, G.,, M. Schambelan,, M. Gottlieb, et al. 1998. Thalidomide reverses cachexia in HIV-wasting syndrome, abstr. 476, p. 59. Program and Abstracts of the 5th Conf. Retrovir. Opportunistic Infect. (Chicago). Foundation for Retrovirology and Human Health, Alexandria, VA.
64. Keswani, S.,, B. Chander,, C. Hasan,, J. Griffin,, J. McArthur, and, A. Hoke. 2003. FK506 is neuroprotective in a model of antiretroviral toxic neuropathy. Ann. Neurol. 53:5764.
65. Keswani, S. C.,, C. A. Pardo,, C. L. Cherry,, A. Hoke, and, J. C. McArthur. 2002. HIV-associated sensory neuropathies. AIDS 16:21052117.
66. Kieburtz, K.,, M. Seidlin, and, J. Lambert. 1992. Extended follow-up of peripheral neuropathy in patients with AIDS and AIDS-related complex treated with dideoxyinosine. J. Acquir. Immune Defic. Syndr. 5:6064.
67. Kieburtz, K.,, D. Simpson,, C. Yiannoutsos,, M. B. Max,, C. D. Hall,, R. J. Ellis,, C. M. Marra,, R. McKendall,, E. Singer,, G. J. Dal Pan,, D. B. Clifford,, T. Tucker,, B. Cohen,and the AIDS Clinical Trials Group 242 Protocol Team. 1998. A randomized trial of amitriptyline and mexiletine for painful neuropathy in HIV infection. Neurology 51:16821688.
68. Knop, J.,, G. Bonsmann,, R. Happle,, A. Ludolph,, D. R. Matz,, E. J. Mifsud, and, E. Macher. 1983. Thalidomide in the treatment of sixty cases of chronic discoid lupus erythematosus. Br. J. Dermatol. 108:461466.
69. Koller, W. C.,, L. K. Gehlmann,, F. D. Malkinson, and, F. A. Davis. 1977. Dapsone-induced peripheral neuropathy. Arch. Neurol. 34:644646.
70. Lambert, J. S.,, M. Seidlin,, R. C. Reichman,, C. S. Plank,, M. Laverty,, G. D. Morse,, C. Knupp,, C. McLaren, and, C. Pettinelli. 1990. Dideoxyinosine (ddI) in patients with the acquired immunodeficiency syndrome or AIDS-related complex. N. Engl. J. Med. 322:13331340.
71. Lanska, M.,, D. Lanska, and, J. Schmidley. 1988. Syphilitic polyradiculopathy in an HIV-positive man. Neurology 38:12971301.
72. Learned-Coughlin, S. 1994. Peripheral neuropathy induced by metronidazole. Ann. Pharmacother. 28:536. (Letter.)
73. Leger, J. M.,, P. Bouche,, F. Bolgert,, M. P. Chaunu,, M. Rosenheim,, H. P. Cathala,, M. Gentilini,, J. J. Hauw, and, P. Brunet. 1989. The spectrum of polyneuropathies in patients infected with HIV. J. Neurol. Neurosurg. Psychiatry 52:13691374.
74. Leger, J. M.,, D. Henin,, L. Belec,, B. Mercier,, L. Cohen,, P. Bouche,, J. J. Hauw, and, P. Brunet. 1992. Lymphoma-induced polyradiculopathy in AIDS: 2 cases. J. Neurol. 239:132134.
75. Legha, S. 1986. Vincristine neurotoxicity: pathophysiology and management. Med. Toxicol. 1:421427.
76. Lewis, W.,, C. Haase,, S. Raidel,, R. Russ,, R. Sutliff,, B. Hoit, and, A. Samarel. 2001. Combined antiretroviral therapy causes cardiomyopathy and elevates plasma lactate in transgenic AIDS mice. Lab. Investig. 81:15271536.
77. Macdonald, D. 1991. Neurologic complications of chemotherapy. Neurol. Clin. 9:955967.
78. Markus, R.,, and B. J. Brew. 1998. HIV-1 peripheral neuropathy and combination antiretroviral therapy. Lancet 352:19061907. (Letter.)
79. Martin, J. L.,, C. E. Brown,, N. Matthews-Davis, and, J. E. Reardon. 1994. Effects of antiviral nucleoside analogs on human DNA polymerases and mitochondrial DNA synthesis. Antimicrob. Agents Chemother. 38:27432749.
80. McArthur, J. C.,, C. Yiannoutsos,, D. Simpson,, B. T. Adornato,, E. J. Singer,, H. Hollander,, C. Marra,, M. Rubin,, B. A. Cohen,, T. Trucker,, B. A. Navia,, G. Schifitto,, D. Katzenstein,, C. Rask,, L. Zaborski,, M. E. Smith,, S. Shriver,, L. Millar,, D. B. Clifford,and the AIDS Clinical Trials Group Team 291. 2000. A phase II trial of nerve growth factor for sensory neuropathy associated with HIV infection. Neurology 54:10801088.
81. Medina, I.,, J. Mills, and, G. Leoung. 1990. Oral therapy for Pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome: a controlled trial of trimethoprim-sulfamethoxazole versus trimethoprim-dapsone. N. Engl. J. Med. 323:776782.
82. Mellick, G.,, and L. Mellick. 1997. Reflex sympathetic dystrophy treated with gabapentin. Arch. Phys. Med. Rehab. 78:89105.
83. Meng, T.,, M. Fischl, and, A. Boota. 1992. Combination therapy with zidovudine and dieoxycytidine in patients with advanced human immunodeficiency virus infection: a phase I/II study. Ann. Intern. Med. 116:1320.
84. Merigan, T. C.,, G. Skowron,, S. A. Bozzette,, D. Richman,, R. Uttamchandani,, M. Fischl,, R. Schooley,, M. Hirsch,, W. Soo, and, C. Pettinelli. 1989. Circulating p24 antigen levels and responses to dideoxycytidine in human immunodeficinecy virus (HIV) infections. Ann. Intern. Med. 110:189194.
85. Miller, R.,, J. Storey, and, C. Greco. 1990. Ganciclovir in the treatment of progressive AIDS-related polyradiculopathy. Neurology 1990:569574.
86. Misha, B.,, W. Sommers,, C. Koski, et al. 1985. Acute inflammatory demyelinating polyneuropathy in the acquired immunodeficiency syndrome. (Abstract.) Ann. Neurol. 18:131132.
87. Morgello, S.,, and D. Simpson. 1994. Multifocal cytomegalovirus demyelinative polyneuropathy associated with AIDS. Muscle Nerve 17:176182.
88. Morgello, S.,, L. Estanislao,, D. Simpson,, A. Geraci,, A. DiRocco,, P. Gerits,, E. Ryan,, T. Yakoushina,, S. Khan,, R. Mahboob,, M. Naseer,, D. Dorfman,, V. Sharp,and the Manhattan HIV Brain Bank. 2004. HIV-associated distal sensory polyneuropathy in the era of highly active antiretroviral therapy: Arch. Neurol. 61:546551.
89. Moyle, G. J.,, and M. Sadler. 1998. Peripheral neuropathy with nucleoside antiretrovirals: risk factors, incidence and management. Drug Saf. 19:481494.
90. Nair, V.,, M. LeBrun, and, I. Kass. 1980. Peripheral neuropathy associated with ethambutol. Chest 77:98100.
91. Navarro, J. C.,, R. L. Rosales,, A. T. Ordinario,, S. Izumo, and, M. Osame. 1989. Acute dapsone-induced peripheral neuropathy. Muscle Nerve 12:604606.
92. Nisar, M.,, S. W. Watkin,, R. C. Bucknall, and, R. A. Agnew. 1990. Exacerbation of isoniazid induced peripheral neuropathy by pyridoxine. Thorax 45:419420.
93. Patterson, T.,, L. Schmued,, J. Sandberg, and, J. W. Slikker. 2000. Temporal development of 2′,3′-dideoxyinosine (ddI)-induced peripheral myelinopathy. Neurotoxicol. Teratol. 22:429434.
94. Pezeshkpour, G.,, C. Krarup,, F. Buchthal,, S. DiMauro,, N. Bresolin, and, J. McBurney. 1987. Peripheral neuropathy in mitochondrial disease. J. Neurol. Sci. 77:285304.
95. Price, J.,, R. Brown, and, F. Larson. 1957. Quantitative studies on human urinary metabolites of tryptophan as affected by isoniazid and deoxypyridoxine. J. Clin. Investig. 36:16001607.
96. Purba, J. S.,, M. A. Hofman,, P. Portegies,, D. Troost, and, D. F. Swaab. 1993. Decreased number of oxytocin neurons in the paraventricular nucleus of the human hypothalamus in AIDS. Brain 116:795805.
97. Quinones, F.,, J. Sierra-Madero,, J. J. Calva-Mercado,, G. M. Ruiz-Palacios,and Instituto Nacional de Nutricion, Mexico City. 1997. Thalidomide in patients with HIV infection, and chronic diarrhea: double-blind placebo controlled clinical trial, abstr. 682. Fourth Conf. Retrovir. Opportunistic Infect., Washington, DC.
98. Rapoport, A.,, and S. Guss. 1972. Dapsone-induced peripheral neuropathy. Arch. Neurol. 27:184185.
99. Rathburn, R.,, and E. I. Martin. 1992. Didanosine therapy in patients intolerant of or failing zidovudine therapy. Ann. Pharmacother. 2:13471351.
100. Reyes-Teran, G.,, J. G. Sierra-Madero,, V. Martinez del Cerro,, H. Arroyo-Figueroa,, A. Pasquetti,, J. J. Calva, and, G. M. Ruiz-Palacios. 1996. Effects of thalidomide on HIV-associated wasting syndrome: a randomized, double-blind, placebo-controlled clinical trial. AIDS 10:15011507.
101. Richardson, J. K.,, and E. A. Hurvitz. 1995. Peripheral neuropathy: a true risk factor for falls. J. Gerontol. 50:M211M215.
102. Rosner, H.,, L. Rubin, and, A. Kestenbaum. 1996. Gabapentin adjunctive therapy in neuropathic pain states. Clin. J. Pain 12:5658.
103. Roullet, E.,, V. Assuerus,, J. Gozlan,, A. Ropert,, G. Said,, M. Baudrimont,, M. el Amrani,, C. Jacomet,, C. Duvivier,, G. Gonzales-Canali,, M. Kirstetter,, M.-C. Meyohas,, O. Picard, and, W. Rozenbaum. 1994. Cytomegalovirus multifocal neuropathy in AIDS: analysis of 15 consecutive cases. Neurology 44:21742182.
104. Rozencweig, M.,, C. McLaren,, M. Beltangady,, J. Ritter,, R. Canetta,, L. Schacter,, S. Kelley,, C. Nicaise,, L. Smaldone,, L. Dunkle,, C. Barbhaiya,, C. Knupp,, A. Cross,, M. Tsianco, and, R. R. Martin. 1990. Overview of phase I trials of 2′3′-dideoxyinosine (ddI) conducted on adult patients. Rev. Infect. Dis. 12(Suppl 5):S570S575.
105. Sahen, S.,, S. Brady, and, J. Mendell. 1987. Studies on the pathogenesis of vincristine-induced neuropathy. Muscle Nerve 10:8084.
106. Said, C. 1991. Multifocal neuropathy in HIV infection, p. 89. Proc. Seventh Int. Conf. HIV Infect, Padova, Italy.
107. Saqueton, A. C.,, A. L. Lorincz,, N. A. Vick, and, R. D. Hamer. 1969. Dapsone and peripheral motor neuropathy. Arch. Dermatol. 100:214217.
108. Schaumburg, H.,, J. Kaplan, and, A. Windebank. 1983. Sensory neuropathy from pyridoxine abuse. N. Engl. J. Med. 309:445448.
109. Schifitto, G.,, M. McDermott,, J. McArthur,, K. Marder,, N. Sacktor,, L. Epstein, and, K. Kieburtz. 2002. Incidence of and risk factors for HIV-associated distal sensory polyneuropathy. Neurology 58:17641768.
110. Shahmanesh, M.,, C. S. Bradbeer,, A. Edwards, and, S. E. Smith. 1991. Autonomic dysfunction in patients with human immunodeficiency virus infection. Int. J. STD AIDS 2:419423.
111. Sharpstone, D.,, A. Rowbottom,, M. Nelson, and, B. Gazzard. 1995. The treatment of microsporidial diarrhea with thalidomide. AIDS 9:658659.
112. Shinkai, M.,, and S. Spector. 1995. Quantitation of human cytomegalovirus (HCMV) DNA in cerebrospinal fluid by competitive PCR in AIDS patiets with different HCMV central nervous system diseases. Scand. J. Infect. Dis. 27:559561.
113. Simpson, D.,, and M. Tagliati. 1994. Neurological manifestations of HIV infection. Ann. Intern. Med. 121:769785.
114. Simpson, D.,, and M. Tagliati. 1995. Nucleoside analogue-associated peripheral neuropathy in HIV infection. J. Acquir. Immune Defic. Syndr. 9:153161.
115. Simpson, D. M.,, D. A. Katzenstein,, M. D. Hughes,, S. M. Hammer,, D. L. Williamson,, Q. Jiang, and, J. T. Pi. 1998. Neuromuscular function in HIV infection: analysis of a placebo-controlled combination antiretroviral trial. AIDS 12:24252432.
116. Simpson, D. M.,, R. Olney,, J. C. McArthur,, A. Khan,, J. Godbold, and, K. Ebel-Frommer. 2000. A placebo-controlled trial of lamotrigine for painful HIV-associated neuropathy. Neurology 54:21152119.
117. Simpson, D. M.,, D. Kitch,, S. R. Evans,, J. C. McArthur,, D. M. Asmuth,, B. Cohen,, K. Goodkin,, M. Gerschenson,, Y. So,, C. M. Marra,, R. Diaz-Arrastia,, S. Shriver,, L. Millar,, D. B. Clifford,and the ACTG A5117 Study Group. 2006. HIV neuropathy natural history cohort study: assessment measures and risk factors. Neurology 66:16791687.
118. Simpson, D. M.,, J. C. McArthur,, R. Olney,, D. Clifford,, Y. So,, D. Ross,, B. J. Baird,, P. Barrett,, A. E. Hammer,and the Lamotrigine HIV Neuropathy Study Team. 2003. Lamotrigine for HIV-associated painful sensory neuropathies: a placebo-controlled trial. Neurology 60:15081514.
119. Skowron, G.,, S. A. Bozzette,, L. Lim,, C. B. Pettinelli,, H. H. Schaumburg,, J. Arezzo,, M. A. Fischl,, W. G. Powderly,, D. J. Gocke,, D. D. Richman,, J. C. Pottage,, D. Antoniskis,, G. F. McKinley,, N. E. Hyslop,, G. Ray,, G. Simon,, N. Reed,, M. L. LoFaro,, R. B. Uttamchandani,, L. D. Gelb,, S. J. Sperber,, R. L. Murphy,, J. M. Leedom,, M. H. Grieco,, J. Zachary,, M. S. Hirsch,, S. A. Spector,, J. Bigley,, W. Soo, and, T. C. Merigan. 1993. Alternating and intermittent regimens of zidovudine and dideoxycytidine in patients with AIDS or AIDS-related complex. Ann. Intern. Med. 118:321330.
120. Snider, D. 1980. Pyridoxine supplementation during isoniazid therapy. Tubercle 61:191196.
121. Snider, W. D.,, D. M. Simpson,, S. Nielsen,, J. W. Gold,, C. E. Metroka, and, J. B. Posner. 1983. Neurological complications of acquired immunodeficiency syndrome: analysis of 50 patients. Ann. Neurol. 14:403418.
122. So, Y.,, D. Holtzman, and, D. Abrams. 1988. Peripheral neuropathy associated with acquired immunodeficiency syndrome: prevalence and clinical features from a population-based survey. Arch. Neurol. 45:945948.
123. So, Y.,, and R. Olney. 1991. The natural history of mononeuritis multiplex and simplex in HIV infection. Neurology 41(Suppl. 1):375.
124. Steiberg, J.,, G. C. J., R. White,, A. M. Morris,and the AIDS Research Consortium of Atlanta. 1991. Outcomes and toxicities on 2′3′-dideoxyinosine (ddI) in the expanded access program, abstr. 707. Proc. 31st Intersci. Conf. Antimicrob. Agents Chemother. American Society for Microbiology, Washington, DC.
125. Stricker, R. B.,, K. A. Sanders,, W. F. Owen,, D. D. Kiprov, and, R. G. Miller. 1992. Mononeuritis multiplex associated with cryoglobulinemia in HIV infection. Neurology 42:21032105.
126. Tagliati, M.,, J. Grinnell,, J. Godbold, and, D. M. Simpson. 1999. Peripheral nerve function in HIV infection. Clinical, elctrophysiologic and laboratory findings. Arch. Neurol. 56:8489.
127. Tseng, S.,, G. Pak,, K. Washenik,, M. K. Pomeranz, and, J. L. Shupack. 1996. Rediscovering thalidomide: a review of its mechanism of action, side effects, and potential uses. J. Am. Acad. Dermatol. 35:969979.
128. Tugwell, P.,, and S. James. 1972. Peripheral neuropathy with ethambutol. Postgrad. Med. J. 48:667670.
129. Tuxen, M.,, and S. Hansen. 1994. Neurotoxicity secondary to antineoplastic drugs. Cancer Treat. Rev. 20:191214.
130. van den Broek, H. 1980. Treatment of prurigo nodularis with thalidomide. Arch. Dermatol. 116:571572.
131. Vogel, J. U.,, J. Cinatl,, A. Lux,, B. Weber,, A. J. Driesel, and, H. W. Doerr. 1996. New PCR assay for rapid and quantitative detection of human cytomegalovirus in cerebrospinal fluid. J. Clin. Microbiol. 34:482483.
132. Vogelsang, G. B.,, E. R. Farmer,, A. D. Hess,, V. Altamonte,, W. E. Beschorner,, D. A. Jabs,, R. L. Corio,, L. S. Levin,, O. M. Colvin, and, J. R. Wingard. 1992. Thalidomide for the treatment of chronic graft-versus-host disease. N. Engl. J. Med. 326:10551058.
133. Warner, W.,, C. Bregman,, C. Comereski,, J. Arezzo,, T. Davidson,, C. Knupp,, S. Kaul,, S. Durham,, A. Wasserman, and, J. Frantz. 1995. Didanosine (ddI) and stavudine (d4T): absence of peripheral neurotoxicity in rabbits. Food Chem. Toxicol. 33:10471050.
134. Wiegand, R. 1956. The formation of pyridoxal and pyridoxal 5-phosphate hydrazones. J. Am. Chem. Soc. 78:53075309.
135. Williams, M.,, and W. Bradley. 1972. An assessment of dapsone toxicity in the guinea pig. Br. J. Dermatol. 86:650.
136. Yarchoan, R.,, C. F. Perno,, R. V. Thomas,, R. W. Klecker,, J. P. Allain,, R. J. Wills,, N. McAtee,, M. A. Fischl,, R. Dubinsky,, M. C. McNeely,, H. Mitsuya,, J. M. Pluda,, T. J. Lawley,, M. Leuther,, B. Satai,, J. M. Collins,, C. E. Myers, and, S. Broder. 1988. Phase I studies of 2′3′-deoxycytidine in severe human immunodeficiency virus infection as a single agent and alternating with zidovudine. Lancet i:7681.
137. Yarchoan, R.,, J. Pluda, and, R. Thomas. 1990. Long term toxicity/activity profile of 2′3′-dideoxyinosine in AIDS or AIDS-related complex. Lancet 336:526529.
138. Zhou, L.,, D. W. Kitch,, S. R. Evans,, P. Hauer,, S. Raman,, G. J. Ebenezer,, M. Gerschenson,, C. M. Marra,, V. Valcour,, R. Diaz-Arrastia,, K. Goodkin,, L. Millar,, S. Shriver,, D. M. Asmuth,, D. B. Clifford,, D. M. Simpson, and, J. C. McArthur. 2007. Correlates of epidermal nerve fiber densities in HIV-associated distal sensory polyneuropathy. Neurology 68:21132119.


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Comparative summary of neuropathies in HIV infection

Citation: Estanislao L, Geraci A, Simpson D. 2009. Distal Sensory Polyneuropathy and Other Selected Neuropathies in HIV Infection, p 75-86. In Goodkin K, Shapshak P, Verma A (ed), The Spectrum of Neuro-AIDS Disorders. ASM Press, Washington, DC. doi: 10.1128/9781555815691.ch6

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