Chapter 6 : Vaccines and Immunotherapies for Future Treatment of Food Allergy

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Vaccines and Immunotherapies for Future Treatment of Food Allergy, Page 1 of 2

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Food allergy is a major cause of life-threatening hypersensitivity reactions. Currently, the avoidance of the allergenic food is the only method of preventing further reactions for allergic patients. Even with good educational information, 50% of allergic patients have accidental ingestions and allergic reactions over a 24-month period. With better characterization of allergens and an understanding of the immunologic mechanism involved in this reaction, investigators have developed several therapeutic modalities potentially applicable to the treatment and eventual prevention of food allergy. Techniques under current investigation for the treatment of food allergy include peptide immunotherapy, traditional Chinese medicine, mutated protein immunotherapy, allergen DNA immunization, vaccination with immunostimulatory DNA sequences, and anti-IgE therapy. While peptide immunotherapy for food allergy has not yet reached clinical trials, studies utilizing the peptides of the peanut allergens are interesting and suggest a possible role for peptide immunotherapy in the future therapy of food allergy. New therapies currently under investigation should help the physician greatly improve care for food-induced allergic reactions while reducing the risk of anaphylaxis in these patients.

Citation: Burks W, Buchanan A, Pons L. 2006. Vaccines and Immunotherapies for Future Treatment of Food Allergy, p 163-170. In Maleki S, Burks A, Helm R (ed), Food Allergy. ASM Press, Washington, DC. doi: 10.1128/9781555815721.ch6

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Major Histocompatibility Complex
Natural Killer Cells
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1. Asero, R. 1998. Effects of birch pollen-specific immunotherapy on apple allergy in birch pollen-hypersensitive patients. Clin. Exp. Allergy 28:13681373.
2. Asero, R. 2000. Fennel, cucumber, and melon allergy successfully treated with pollen-specific injection immunotherapy. Ann. Allergy Asthma Immunol. 84:460462.
3. Asero, R. 2003. How long does the effect of birch pollen injection SIT on apple allergy last? Allergy 58:435438.
4. Bohle, B.,, B. Jahn-Schmid,, D. Maurer,, D. Kraft, and, C. Ebner. 1999. Oligodeoxynucleotides containing CpG motifs induce IL-12, IL-18 and IFN-gamma production in cells from allergic individuals and inhibit IgE synthesis in vitro. Eur. J. Immunol. 29:23442353.
5. Briner, T. J.,, M. C. Kuo,, K. M. Keating,, B. L. Rogers, and, J. L. Greenstein. 1993. Peripheral T-cell tolerance induced in naive and primed mice by subcutaneous injection of peptides from the major cat allergen Fel d I. Proc. Natl. Acad. Sci. USA 90:76087612.
6. Burks,, A. W. 2003. Classic specific immunotherapy and new perspectives in specific immunotherapy for food allergy. Allergy 67: 121124.
7. Burks, W.,, S. B. Lehrer, and, G. A. Bannon. 2004. New approaches for treatment of peanut allergy: chances for a cure. Clin. Rev. Allergy Immunol. 27:191196.
8. Chu, R. S.,, O. S. Targoni,, A. M. Krieg,, P. V. Lehmann, and, C. V. Harding. 1997. CpG oligodeoxynucleotides act as adjuvants that switch on T helper 1 (Th1) immunity. J. Exp. Med. 186:16231631.
9. Freeman,, J. 1930. Rush inoculation, with a special reference to hay fever treatment. Lancet i:744747.
10. Hong, S. J.,, J. G. Michael,, A. Fehringer, and, D. Y. Leung. 1999. Pepsin-digested peanut contains T-cell epitopes but no IgE epitopes. Allergy Clin. Immunol. 104:473478.
11. Hsu, C. H.,, K. Y. Chua,, M. H. Tao,, Y. L. Lai,, H. D. Wu,, S. K. Huang, and, K. H. Hsieh. 1996. Immunoprophylaxis of allergen-induced immunoglobulin E synthesis and airway hyperresponsiveness in vivo by genetic immunization. Nat. Med. 2:540544.
12. Leung, D. Y.,, H. A. Sampson,, J. W. Yunginger,, A. W. Burks, Jr.,, L. C. Schneider,, C. H. Wortel,, F. M. Davis,, J. D. Hyun, and, W. R. Shanahan, Jr. 2003. Effect of anti-IgE therapy in patients with peanut allergy. N. Engl. J. Med. 348:986993.
13. Li, X. M., and, H. A. Sampson. 2004. Novel approaches to immunotherapy for food allergy. Clin. Allergy Immunol. 18:663679.
14. Li, X. M.,, D. Serebrisky,, S. Y. Lee,, C. K. Huang,, L. Bardina,, B. H. Schofield,, J. S. Stanley,, A. W. Burks,, G. A. Bannon, and, H. A. Sampson. 2000. A murine model of peanut anaphylaxis: T- and B-cell responses to a major peanut allergen mimic human responses. J. Allergy Clin. Immunol. 106:150158.
15. Li, X. M.,, K. Srivastava,, A. Grishin,, C. K. Huang,, B. Schofield,, W. Burks, and, H. A. Sampson. 2003a. Persistent protective effect of heat-killed Escherichia coli producing “engineered,” recombinant peanut proteins in a murine model of peanut allergy. J. Allergy Clin. Immunol. 112:159167.
16. Li, X. M.,, K. Srivastava,, J. W. Huleatt,, K. Bottomly,, A. W. Burks, and, H. A. Sampson. 2003b. Engineered recombinant peanut protein and heat-killed Listeria monocytogenes coadministration protects against peanut-induced anaphylaxis in a murine model. J. Immunol. 170:32893295.
17. Li, X. M.,, T. F. Zhang,, C. K. Huang,, K. Srivastava,, A. A. Teper,, L. Zhang,, B. H. Schofield, and, H. A. Sampson. 2001. Food allergy herbal formula-1 (FAHF-1) blocks peanut-induced anaphylaxis in a murine model. J. Allergy Clin. Immunol. 108:639646.
18. Milgrom, H.,, R. B. Fick, Jr.,, Su,, J. Q.,, J. D. Reimann,, R. K. Bush,, M. L. Watrous,, W. J. Metzger, , et al 1999. Treatment of allergic asthma with monoclonal anti-IgE antibody. N. Engl. J. Med. 341:19661973.
19. Nayak, A.,, T. Casale,, S. D. Miller,, J. Condemi,, M. McAlary,, A. Fowler-Taylor,, C. G. Della, and, N. Gupta. 2003. Tolerability of retreatment with omalizumab, a recombinant humanized monoclonal anti-IgE antibody, during a second ragweed pollen season in patients with seasonal allergic rhinitis. Allergy Asthma Proc. 24:323329.
20. Nelson, H. S.,, J. Lahr,, R. Rule,, A. Bock, and, D. Leung. 1997. Treatment of anaphylactic sensitivity to peanuts by immunotherapy with injections of aqueous peanut extract. J. Allergy Clin. Immunol. 99:744751.
21. Noon,, L., and, B. Cantab. 2005. Prophylactic inoculation against hay fever. Lancet i:1572.
22. Norman, P. S.,, J. L. Ohman, Jr.,, A. A. Long,, P. S. Creticos,, M. A. Gefter,, Z. Shaked,, R. A. Wood,, P. A. Eggleston,, K. B. Hafner,, P. Rao,, L. M. Lichtenstein,, N. H. Jones, and, C. F. Nicodemus. 1996. Treatment of cat allergy with T-cell reactive peptides. Am. J. Respir. Crit. Care Med. 154:16231628.
23. Oldfield, W. L.,, M. Larche, and, A. B. Kay. 2002. Effect of T-cell peptides derived from Fel d 1 on allergic reactions and cytokine production in patients sensitive to cats: a randomised controlled trial. Lancet 360:4753.
24. Oppenheimer, J. J.,, H. S. Nelson,, S. A. Bock,, F. Christensen, and, D. Y. Leung. 1992. Treatment of peanut allergy with rush immunotherapy. J. Allergy Clin. Immunol. 90:256262.
25. Roy, K.,, H. Q. Mao,, S. K. Huang, and, K. W. Leong. 1999. Oral gene delivery with chitosan-DNA nanoparticles generates immunologic protection in a murine model of peanut allergy. Nat. Med. 5:387391.
26. Saini, S. S.,, D. W. MacGlashan, Jr.,, S. A. Sterbinsky,, A. Togias,, D. C. Adelman,, L. M. Lichtenstein, and, B. S. Bochner. 1999. Down-regulation of human basophil IgE and FC epsilon RI alpha surface densities and mediator release by anti-IgE-infusions is reversible in vitro and in vivo. J. Immunol. 162:56245630.
27. Sampson, H. A. 1999. Food allergy. Part 1: immunopathogenesis and clinical disorders. J. Allergy Clin. Immunol. 103:717728.
28. Sampson, H. A. 2003a. 9. Food allergy. J. Allergy Clin. Immunol. 111 (Suppl. 2): S540S547.
29. Sampson, H. A. 2003b. Anaphylaxis and emergency treatment. Pediatrics 111:16011608.
30. Saxon, A.,, D. Zhu,, K. Zhang,, L. C. Allen, and, C. L. Kepley. 2004. Genetically engineered negative signaling molecules in the immunomodulation of allergic diseases. Curr. Opin. Allergy Clin. Immunol. 4:563568.
31. Sicherer, S. H.,, A. W. Burks, and, H. A. Sampson. 1998. Clinical features of acute allergic reactions to peanut and tree nuts in children. Pediatrics 102:e6.
32. Slater, J. E., and, A. Colberg-Poley. 1997. A DNA vaccine for allergen immunotherapy using the latex allergen Hev b 5. Arb. Paul Ehrlich Inst. Bundesamt Sera Impfstoffe Frankf. A M 1997:230235.
33. Spiegelberg, H. L.,, E. M. Orozco,, M. Roman, and, E. Raz. 1997. DNA immunization: a novel approach to allergen-specific immunotherapy. Allergy 52:964970.
34. Srivastava, K. D.,, J. D. Kattan,, Z. M. Zou,, Li, J. H.,, L. Zhang,, S. Wallenstein,, J. Goldfarb,, H. A. Sampson, and, X. M. Li. 2005. The Chinese herbal medicine formula FAHF-2 completely blocks anaphylactic reactions in a murine model of peanut allergy. J. Allergy Clin. Immunol. 115:171178.
35. Stanley, J. S.,, R. M. Helm,, G. Cockrell,, A. W. Burks, and, G. A. Bannon. 1996. Peanut hypersensitivity. IgE binding characteristics of a recombinant Ara h I protein. Adv. Exp. Med. Biol. 409:213216.
36. Stanley, J. S.,, N. King,, A. W. Burks,, S. K. Huang,, H. Sampson,, G. Cockrell,, R. M. Helm,, C. M. West, and, G. A. Bannon. 1997. Identification and mutational analysis of the immunodominant IgE binding epitopes of the major peanut allergen Ara h 2. Arch. Biochem. Biophys. 342:244253.
37. Tighe, H.,, K. Takabayashi,, D. Schwartz,, G. Van Nest,, S. Tuck,, J. J. Eiden,, A. Kagey-Sobotka,, P. S. Creticos,, L. M. Lichtenstein,, H. L. Spiegelberg, and, E. Raz. 2000. Conjugation of immunostimulatory DNA to the short ragweed allergen amb a 1 enhances its immunogenicity and reduces its allergenicity. J. Allergy Clin. Immunol. 106:124134.


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Table 1.

Potential immunotherapeutic strategies for the treatment of food allergy

Citation: Burks W, Buchanan A, Pons L. 2006. Vaccines and Immunotherapies for Future Treatment of Food Allergy, p 163-170. In Maleki S, Burks A, Helm R (ed), Food Allergy. ASM Press, Washington, DC. doi: 10.1128/9781555815721.ch6

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