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Chapter 39 : Molecular Immunopathogenesis of Innate Host Defense against Chronic Disseminated (Hepatosplenic) Candidiasis

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Molecular Immunopathogenesis of Innate Host Defense against Chronic Disseminated (Hepatosplenic) Candidiasis, Page 1 of 2

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Abstract:

Chronic disseminated candidiasis presents a paradox of innate host defense; i.e., hematogenous candidiasis ensues during neutropenia, and despite recovery from neutropenia, deep tissue disease becomes clinically apparent and progressive in severity. It was found that IL-10 also suppresses the host response of monocytes (MNCs) and polymorphonuclear leukocytes (PMNs) to , as evidenced by decreased fungicidal activity against serum-opsonized blastoconidia, reduced capacity to damage unopsonized hyphae, and suppressed O production. The authors hypothesized that a switch from Th1 to a Th2 cytokine profile may contribute to this refractoriness. It was found that human peripheral blood MNCs incubated with in vitro also released large amounts of biologically active TGF- β1. These results further correlated with the immunolocalization of TGF-β observed in livers from the rabbit model of chronic disseminated (hepatosplenic) candidiasis. It was also found that IL-15 directly up-regulates the oxidative and microbicidal activity of human MNCs against . To better understand the immunopathogenesis of disseminated candidiasis, the authors compared the antifungal activities of macrophages residing in the spleen, liver, and lungs of rabbits against blastoconidia and hyphae of . The authors found that splenic macrophages, Kupffer cells, and pulmonary alveolar macrophages were similar in their phagocytic capacity but differed in their capacity to damage Candida hyphae, in the order splenic macrophages, Kupffer cells, pulmonary alveolar macrophages. The laboratory findings described collectively support the concept that chronic disseminated candidiasis is a disease of Th1/Th2 dysimmunoregulation.

Citation: Walsh T, Roilides E, Cortez K, Lyman C. 2006. Molecular Immunopathogenesis of Innate Host Defense against Chronic Disseminated (Hepatosplenic) Candidiasis, p 583-588. In Heitman J, Filler S, Edwards, Jr. J, Mitchell A (ed), Molecular Principles of Fungal Pathogenesis. ASM Press, Washington, DC. doi: 10.1128/9781555815776.ch39

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Tumor Necrosis Factor alpha
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Transforming Growth Factor beta
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Figure 1

Normal patterns of the innate host response of human monocytes to .

Citation: Walsh T, Roilides E, Cortez K, Lyman C. 2006. Molecular Immunopathogenesis of Innate Host Defense against Chronic Disseminated (Hepatosplenic) Candidiasis, p 583-588. In Heitman J, Filler S, Edwards, Jr. J, Mitchell A (ed), Molecular Principles of Fungal Pathogenesis. ASM Press, Washington, DC. doi: 10.1128/9781555815776.ch39
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Image of Figure 2
Figure 2

Cytokine-mediated suppression of the innate host response to

Citation: Walsh T, Roilides E, Cortez K, Lyman C. 2006. Molecular Immunopathogenesis of Innate Host Defense against Chronic Disseminated (Hepatosplenic) Candidiasis, p 583-588. In Heitman J, Filler S, Edwards, Jr. J, Mitchell A (ed), Molecular Principles of Fungal Pathogenesis. ASM Press, Washington, DC. doi: 10.1128/9781555815776.ch39
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Image of Figure 3
Figure 3

Immunopathogenesis of Th1/Th2 dysimmunoregulations of chronic disseminated (hepatosplenic) candidiasis.

Citation: Walsh T, Roilides E, Cortez K, Lyman C. 2006. Molecular Immunopathogenesis of Innate Host Defense against Chronic Disseminated (Hepatosplenic) Candidiasis, p 583-588. In Heitman J, Filler S, Edwards, Jr. J, Mitchell A (ed), Molecular Principles of Fungal Pathogenesis. ASM Press, Washington, DC. doi: 10.1128/9781555815776.ch39
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References

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1. Anaissie, E.,, G. P. Bodey,, H. Kantarjian,, C. David,, K. Barnett,, E. Bow,, R. Defelice,, N. Downs,, T. File,, G. Karam,, D. Potts,, M. Shelton, and, A. Sugar. 1991. Fluconazole therapy for chronic disseminated candidiasis in patients with leukemia and prior amphotericin B therapy. Am. J. Med. 91:142150.
2. Barral, A.,, M. Barral-Netto,, E. C. Yong,, C. E. Brownell,, D. R. Twardzik, and, S. G. Reed. 1993. Transforming growth factor beta as a virulence mechanism for Leishmania braziliensis. Proc. Natl. Acad. Sci. USA 90:34423446.
3. Cassatella, M. A. 1998. The neutrophil: one of the cellular targets of interleukin-10. Int. J. Clin. Lab. Res. 28:148161.
4. Cenci, E.,, L. Romani,, A. Mencacci,, R. Spaccapelo,, E. Schiaffella,, P. Puccetti, and, F. Bistoni. 1993. Interleukin-4 and interleukin-10 inhibit nitric oxide-dependent macrophage killing of Candida albicans. Eur. J. Immunol. 23:10341038.
5. Choi, E. H.,, C. B. Foster,, J. G. Taylor,, H. C. Erichsen,, R. A. Chen,, T. J. Walsh,, V. J. Anttila,, T. Ruutu,, A. Palotie, and, S. J. Chanock. 2003. Association between chronic disseminated candidiasis in adult acute leukemia and common IL4 promoter haplotypes. J. Infect. Dis. 187:11531156.
6. Dignani, M. C.,, J. H. Rex,, K. W. Chan,, G. Dow,, M. deMagalhaes-Silverman,, A. Maddox,, T. Walsh, and, E. Anaissie. 2005. Immunomodulation with interferon-gamma and colony-stimulating factors for refractory fungal infections in patients with leukemia. Cancer 104:199204.
7. Katsifa, H.,, S. Tsaparidou,, E. Diza,, C. Gil-Lamaignere,, T. J. Walsh, and, E. Roilides. 2001. Effects of interleukin-13 on antifungal activity of human monocytes against Candida albicans. FEMS Immunol. Med. Microbiol. 31:211217.
8. Kauffman, C. A.,, S. F. Bradley,, S. C. Ross, and, D. R. Weber. 1991. Hepatosplenic candidiasis: successful treatment with fluconazole. Am. J. Med. 91:137141.
9. Kim, H. S.,, E. H. Choi,, J. Khan,, E. Roilides,, A. Francesconi,, M. Kasai,, T. Sein,, R. L. Schaufele,, K. Sakurai,, C. G. Son,, B. T. Greer,, S. Chanock,, C. A. Lyman, and, T. J. Walsh. 2005. Expression of genes encoding innate host defense molecules in normal human monocytes in response to Candida albicans. Infect. Immun. 73:37143724.
10. Kontoyiannis, D. P.,, M. A. Luna,, B. I. Samuels, and, G. P. Bodey. 2000. Hepatosplenic candidiasis. A manifestation of chronic disseminated candidiasis. Infect. Dis. Clin. North Am. 14:721739.
11. Letterio, J. J.,, T. Lehrnbecher,, G. Pollack,, T. J. Walsh,, S. J. Chanock,, J. J. Letterio, and, A. B. Roberts. 2001. Invasive candidiasis stimulates hepatocyte and monocyte production of active transforming growth factor beta. Infect. Immun. 69:51155120.
12. Letterio, J. J., and, A. B. Roberts. 1998. Regulation of immune responses by TGF-β. Annu. Rev. Immunol. 16:137161.
13. Marcus, S. G.,, T. J. Walsh,, P. A. Pizzo, and, D. N. Danforth,, Jr. 1993. Hepatic abscess in cancer patients. Characterization and management. Arch. Surg. 128:13581364; discussion, 1364.
14. Puccetti, P.,, A. Mencacci,, E. Cenci,, R. Spaccapelo,, P. Mosci,, K.-H. Enssle,, L. Romani, and, F. Bistoni. 1994. Cure of murine candidiasis by recombinant soluble inter-leukin-4 receptor. J. Infect. Dis. 169:13251331.
15. Puccetti, P.,, L. Romani, and, F. Bistoni. 1995. A Th1-Th2-like switch in candidiasis: new perspectives for therapy. Trends Microbiol. 3:237240.
16. Roilides, E.,, A. Anastasiou-Katsiardani,, A. Dimitriadou-Georgiadou,, I. Kadiltsoglou,, S. Tsaparidou,, C. Panteliadis, and, T. J. Walsh. 1998. Suppressive effects of interleukin-10 on human mononuclear phagocyte function against Candida albicans and Staphylococcus aureus. J. Infect. Dis. 178:17341742.
17. Roilides, E.,, A. Holmes,, C. Blake,, P. A. Pizzo, and, T. J. Walsh. 1995. Effects of granulocyte colony-stimulating factor and interferon-gamma on antifungal activity of human polymorphonuclear neutrophils against pseudo-hyphae of different medically important Candida species. J. Leukoc. Biol. 57:651656.
18. Roilides, E.,, I. Kadiltsoglou,, A. Dimitriadou,, M. Hatzistilianou,, A. Manitsa,, J. Karpouzas,, P. A. Pizzo, and, T. J. Walsh. 1997. Interleukin-4 suppresses antifungal activity of human mononuclear phagocytes against Candida albicans in association with decreased uptake of blastoconidia. FEMS Immunol. Med. Microbiol. 19:169180.
19. Roilides, E.,, H. Katsifa,, S. Tsaparidou,, T. Stergiopoulou,, C. Panteliadis, and, T. J. Walsh. 2000. Interleukin-10 suppresses phagocytic and antihyphal activities of human neutrophils. Cytokine 12:379387.
20. Roilides, E.,, C. A. Lyman,, T. Sein,, C. Gonzalez, and, T. J. Walsh. 2000. Antifungal activity of splenic, liver and pulmonary macrophages against Candida albicans and effects of macrophage colony-stimulating factor. Med. Mycol. 38:161168.
21. Roilides, E.,, T. Sein,, R. Schaufele,, S. J. Chanock, and, T. J. Walsh. 1998. Increased serum concentrations of interleukin-10 in patients with hepatosplenic candidiasis. J. Infect. Dis. 178:589592.
22. Roilides, E., and, T. J. Walsh. 2004. Recombinant cytokines in augmentation and immunomodulation of host defenses against Candida spp. Med. Mycol. 42:113.
23. Romani, L.,, F. Bistoni,, A. Mencacci,, E. Cenci,, R. Spaccapelo, and, P. Puccetti. 1995. IL12 in Candida albi-cans infections. Res. Immunol. 146:532538.
24. Romani, L.,, F. Bistoni, and, P. Puccetti. 1997. Initiation of T-helper cell immunity to Candida albicans by IL-12: the role of neutrophils. Chem. Immunol. 68:110135.
25. Romani, L.,, E. Cenci,, A. Menacci,, F. Bistoni, and, P. Puccetti. 1995. T helper cell dichotomy to Candida albi-cans: implications for pathology, therapy, and vaccine design. Immunol. Res. 14:148162.
26. Spaccapelo, R.,, L. Romani,, L. Tonnetti,, E. Cenci,, A. Mencacci,, G. Del Sero,, R. Tognellini,, S. G. Reed,, P. Puccetti, and, F. Bistoni. 1995. TGF-β is important in determining the in vivo patterns of susceptibility or resistance in mice infected with Candida albicans. J. Immunol. 155:13491360.
27. Thaler, M.,, B. Pastakia,, T. H. Shawker,, T. O’Leary, and, P. A. Pizzo. 1988. Hepatic candidiasis in cancer patients: the evolving picture of the syndrome. Ann. Intern. Med. 108:88100.
28. Tonnetti, L.,, R. Spaccapelo,, E. Cenci,, A. Mencacci,, P. Puccetti,, R. L. Coffman,, F. Bistoni, and, L. Romani. 1995. Interleukin-4 and -10 exacerbate candidiasis in mice. Eur. J. Immunol. 25:15591565.
29. Vazquez, N.,, T. J. Walsh,, D. Friedman,, S. J. Chanock, and, C. A. Lyman. 1998. Interleukin-15 augments super-oxide production and microbicidal activity of human monocytes against Candida albicans. Infect. Immun. 66:145150.
30. Vodovotz, Y.,, C. Bogdan,, J. Paik,, Q. W. Xie, and, C. Nathan. 1993. Mechanisms of suppression of macrophage nitric oxide release by transforming growth factor beta. J. Exp. Med. 178:605613.
31. Wahl, S. M.,, J. B. Allen,, B. S. Weeks,, H. L. Wong, and, P. E. Klotman. 1993. Transforming growth factor beta enhances integrin expression and type IV collagenase secretion in human monocytes. Proc. Natl. Acad. Sci. USA 90:45774581.
32. Walsh, T. J.,, S. Aoki,, F. Mechinaud,, J. Bacher,, J. Lee,, M. Rubin, and, P. A. Pizzo. 1990. Effects of preventive, early, and late antifungal chemotherapy with fluconazole in different granulocytopenic models of experimental disseminated candidiasis. J. Infect. Dis. 161:755760.
33. Walsh, T. J.,, N. L. Seibel,, C. Arndt,, R. E. Harris,, M. J. Dinubile, and, A. Reboli. 1999. Amphotericin B lipid complex in pediatric patients with invasive fungal infections. Pediatr. Infect. Dis. J. 18:702708.
34. Walsh, T. J.,, P. O. Whitcomb,, S. G. Revankar, and, P. A. Pizzo. 1995. Successful treatment of hepatosplenic candidiasis through repeated cycles of chemotherapy and neutropenia. Cancer 76:23572362.

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