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Chapter 10 : Angiotensin-Converting Enzyme 2, the Cellular Receptor for Severe Acute Respiratory Syndrome Coronavirus and Human Coronavirus NL63
Category: Viruses and Viral Pathogenesis
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Angiotensin-Converting Enzyme 2, the Cellular Receptor for Severe Acute Respiratory Syndrome Coronavirus and Human Coronavirus NL63, Page 1 of 2< Previous page | Next page > /docserver/preview/fulltext/10.1128/9781555815790/9781555814557_Chap10-1.gif /docserver/preview/fulltext/10.1128/9781555815790/9781555814557_Chap10-2.gif
The identification of a viral receptor can make a significant contribution to our understanding of viral pathogenesis and viral evolution, and to the development of vaccines and antiviral therapeutics. This chapter describes the shared cellular receptor for severe acute respiratory syndrome coronavirus (SARS-CoV) and human coronavirus NL63 (HCoVNL63). Identification of this receptor contributed to our understanding of the zoonotic transmission of SARS-CoV and of the distinctive entry mechanisms of both SARS-CoV and HCoV-NL63. These are discussed in the context of the structure of the SARS-CoV S protein receptor-binding domain (RBD) bound to this common receptor, angiotensin-converting enzyme 2 (ACE2). Functional studies of the viral receptor, described in the chapter, support a critical role for palm civets in transmitting virus to humans.