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Chapter 17 : Pathogenesis of Murine Coronavirus Infection

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Pathogenesis of Murine Coronavirus Infection, Page 1 of 2

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Abstract:

The murine coronavirus, mouse hepatitis virus (MHV), is actually a group of strains with various organ tropisms as well as pathogenic potentials. MHV strains may be divided into two groups according to general patterns of tropism. One group of strains is enterotropic; this includes MHV-D, -Y, -RI, -S/CDC, -LIVIM, and -DVIM. These are the viruses associated with infections of mouse colonies that generally produce infections confined to the gastrointestinal tract. The other major group contains polytropic strains, including MHV-1, -2, -3, -4 (or JHM), and -A59; experimental infections of rodents with these strains provide animal models for human diseases such as hepatitis and encephalitis, demyelinating diseases such as multiple sclerosis, and, most recently, respiratory disease such as severe acute respiratory syndrome (SARS). This chapter discusses primarily infections of the central nervous system (CNS) and the liver.

Citation: Weiss S, Leibowitz J. 2008. Pathogenesis of Murine Coronavirus Infection, p 259-278. In Perlman S, Gallagher T, Snijder E (ed), Nidoviruses. ASM Press, Washington, DC. doi: 10.1128/9781555815790.ch17
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Figures

Image of Figure 1.
Figure 1.

Histopathology of livers of MHV-3-infected mice. BALB/c (A) or A/J (B) mice were inoculated intraperitoneally with 1,000 PFU of MHV-3 and sacrificed at 5 days postinfection. Liver sections were stained with hematoxylin and eosin.

Citation: Weiss S, Leibowitz J. 2008. Pathogenesis of Murine Coronavirus Infection, p 259-278. In Perlman S, Gallagher T, Snijder E (ed), Nidoviruses. ASM Press, Washington, DC. doi: 10.1128/9781555815790.ch17
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Image of Figure 2.
Figure 2.

The MHV genome. Shown are structural genes (vertical stripes) and nonstructural genes (horizontal stripes). L denotes the 5’ leader sequence, and the hatches between genes denote the transcription-regulating sequences. In the A59 genome, the HE gene is a pseudogene and ORF4 is divided into ORF4a and ORF4b. Gene 1 is not to scale. Shown below is the spike gene, divided into subunits S1 and S2 with the major functional domains. CS, cleavage site; TM, transmembrane domain.

Citation: Weiss S, Leibowitz J. 2008. Pathogenesis of Murine Coronavirus Infection, p 259-278. In Perlman S, Gallagher T, Snijder E (ed), Nidoviruses. ASM Press, Washington, DC. doi: 10.1128/9781555815790.ch17
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Image of Figure 3.
Figure 3.

Viral spread in the CNS. C57BL/6 mice were infected intracranially with 10 PFU of virus as follows: top left, RJHM; top right, RA59; bottom left, SJHM-RA59, expressing the A59 spike protein from a JHM background; bottom right, SA59-RJHM, expressing the A59 spike protein from a JHM background. Mice were sacrificed 5 days postinfection. Sagittal brain sections were prepared and stained by immunohistochemistry using a monoclonal antibody directed against viral nucleocapsid (×1 magnification). (This figure was modified from Figure 3 of reference with permission from the ASM Journals Department.)

Citation: Weiss S, Leibowitz J. 2008. Pathogenesis of Murine Coronavirus Infection, p 259-278. In Perlman S, Gallagher T, Snijder E (ed), Nidoviruses. ASM Press, Washington, DC. doi: 10.1128/9781555815790.ch17
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Tables

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Table 1.

Neurotropic MHV strains and variants of MHV

Citation: Weiss S, Leibowitz J. 2008. Pathogenesis of Murine Coronavirus Infection, p 259-278. In Perlman S, Gallagher T, Snijder E (ed), Nidoviruses. ASM Press, Washington, DC. doi: 10.1128/9781555815790.ch17

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