Chapter 26 : Emerging Nidovirus Infections

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Emerging Nidovirus Infections, Page 1 of 2

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This chapter discusses emerging nidovirus infection, such as severe acute respiratory syndrome (SARS). It is well known that some animal coronaviruses (e.g., feline infectious peritonitis virus and transmissible gastroenteritis virus) cause fatal infections in their hosts. However, relatively little attention had been focused on human coronaviruses (e.g., human coronavirus 229E [HCoV-229E] and HCoVOC43) before the SARS era. This is partly explained by the fact that these human coronaviruses (and even recently identified human coronaviruses, with the exception of SARS coronavirus [SARS-CoV]) were associated primarily with mild enteric and respiratory diseases in healthy individuals. The genome of SARS-CoV is that of a typical coronavirus. The genome of coronavirus is a single, positive-stranded RNA, approximately 29.7 kb in length. The SARS outbreak highlighted the importance of multidisciplinary research and of cooperation between multiple laboratories in tackling emerging diseases. Much basic and clinical research on coronaviruses has been triggered by this outbreak. The SARS pandemic also led to the search for novel coronaviruses in humans and animals, resulting in the identification of at least two new human and several new animal coronaviruses within the last 4 years. As more and more coronaviruses that are phylogenetically distinct from classical group 1 to 3 viruses are discovered, an alternative classification system of coronaviruses will need to be considered.

Citation: Poon L. 2008. Emerging Nidovirus Infections, p 409-418. In Perlman S, Gallagher T, Snijder E (ed), Nidoviruses. ASM Press, Washington, DC. doi: 10.1128/9781555815790.ch26

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Severe Acute Respiratory Syndrome
Porcine epidemic diarrhea virus
Human coronavirus HKU1
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Image of Figure 1.
Figure 1.

Phylogenetic tree of bat coronaviruses identified in China. The names and putative hosts of all recently found bat coronaviruses ( ) are indicated. The tree was constructed by the neighbor-joining method based on partial RNA-dependent RNA polymerase sequences (402 nt) of bat coronaviruses, animal SARS-CoV isolated in 2003 (SZ3) and 2004 (PC4-13), and human SARS-CoV. The bootstrap values were determined by 1,000 replicates. The scale bar shows the estimated genetic distance of these viruses. The GenBank accession numbers of these sequences are shown in the tree. The accession numbers representing SARS-CoV and animal SARS-CoV are shaded.

Citation: Poon L. 2008. Emerging Nidovirus Infections, p 409-418. In Perlman S, Gallagher T, Snijder E (ed), Nidoviruses. ASM Press, Washington, DC. doi: 10.1128/9781555815790.ch26
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1. Chan, K. H.,, V. C. Cheng,, P. C. Woo,, S. K. Lau,, L. L. Poon,, Y. Guan,, W. H. Seto,, K. Y. Yuen, and, J. S. Peiris. 2005. Serological responses in patients with severe acute respiratory syndrome coronavirus infection and cross-reactivity with human corona-viruses 229E, OC43, and NL63. Clin. Diagn. Lab. Immunol. 12:13171321.
2. Chan, V. S.,, K. Y. Chan,, Y. Chen,, L. L. Poon,, A. N. Cheung,, B. Zheng,, K. H. Chan,, W. Mak,, H. Y. Ngan,, X. Xu,, G. Screaton,, P. K. Tam,, J. M. Austyn,, L. C. Chan,, S. P. Yip,, M. Peiris,, U. S. Khoo, and, C. L. Lin. 2006. Homozygous L-SIGN (CLEC4M) plays a protective role in SARS coronavirus infection. Nat. Genet. 38:3846.
3. Chu, D. K.,, L. L. Poon,, K. H. Chan,, H. Chen,, Y. Guan,, K. Y. Yuen, and, J. S. Peiris. 2006. Coronaviruses in bent-winged bats (Miniopterus spp.). J. Gen. Virol. 87:24612466.
4. Drosten, C.,, S. Gunther,, W. Preiser,, S. van der Werf,, H. R. Brodt,, S. Becker,, H. Rabenau,, M. Panning,, L. Kolesnikova,, R. A. Fouchier,, A. Berger,, A. M. Burguiere,, J. Cinatl,, M. Eickmann,, N. Escriou,, K. Grywna,, S. Kramme,, J. C. Manuguerra,, S. Muller,, V. Rickerts,, M. Sturmer,, S. Vieth,, H. D. Klenk,, A. D. Osterhaus,, H. Schmitz, and, H. W. Doerr. 2003. Identification of a novel coronavirus in patients with severe acute respiratory syndrome. N. Engl. J. Med. 348:19671976.
5. East, M. L.,, K. Moestl,, V. Benetka,, C. Pitra,, O. P. Honer,, B. Wachter, and, H. Hofer. 2004. Coronavirus infection of spotted hyenas in the Serengeti ecosystem. Vet. Microbiol. 102:19.
6. Ebihara, T.,, R. Endo,, X. Ma,, N. Ishiguro, and, H. Kikuta. 2005. Lack of association between New Haven coronavirus and Kawasaki disease. J. Infect. Dis. 192:351352. (Author reply, 192:353.)
7. Eickmann, M.,, S. Becker,, H. D. Klenk,, H. W. Doerr,, K. Stadler,, S. Censini,, S. Guidotti,, V. Masignani,, M. Scarselli,, M. Mora,, C. Donati,, J. H. Han,, H. C. Song,, S. Abrignani,, A. Covacci, and, R. Rappuoli. 2003. Phylogeny of the SARS coronavirus. Science 302:15041505.
8. Erles, K.,, C. Toomey,, H. W. Brooks, and, J. Brownlie. 2003. Detection of a group 2 coronavirus in dogs with canine infectious respiratory disease. Virology 310:216223.
9. Esper, F.,, E. D. Shapiro,, C. Weibel,, D. Ferguson,, M. L. Landry, and, J. S. Kahn. 2005. Association between a novel human coronavirus and Kawasaki disease. J. Infect. Dis. 191:499502.
10. Esper, F.,, C. Weibel,, D. Ferguson,, M. L. Landry, and, J. S. Kahn. 2006. Coronavirus HKU1 infection in the United States. Emerg. Infect. Dis. 12:775779.
11. Fouchier, R. A.,, N. G. Hartwig,, T. M. Bestebroer,, B. Niemeyer,, J. C. de Jong,, J. H. Simon, and, A. D. Osterhaus. 2004. A previously undescribed coronavirus associated with respiratory disease in humans. Proc. Natl. Acad. Sci. USA 101:62126216.
12. Fouchier, R. A.,, T. Kuiken,, M. Schutten,, G. van Amerongen,, G. J. van Doornum,, B. G. van den Hoogen,, M. Peiris,, W. Lim,, K. Stohr, and, A. D. Osterhaus. 2003. Aetiology: Koch’s postulates fulfilled for SARS virus. Nature 423:240.
13. Geng, H.,, Y. M. Liu,, W. S. Chan,, A. W. Lo,, D. M. Au,, M. M. Waye, and, Y. Y. Ho. 2005. The putative protein 6 of the severe acute respiratory syndrome-associated coronavirus: expression and functional characterization. FEBS Lett. 579:67636768.
14. Goebel, S. J.,, J. Taylor, and, P. S. Masters. 2004. The 3’ cis-acting genomic replication element of the severe acute respiratory syndrome coronavirus can function in the murine coronavirus genome. J. Virol. 78:78467851.
15. Gorbalenya, A. E.,, E. J. Snijder, and, W. J. Spaan. 2004. Severe acute respiratory syndrome coronavirus phylogeny: toward consensus. J. Virol. 78:78637866.
16. Gough, R. E.,, S. E. Drury,, F. Culver,, P. Britton, and, D. Cavanagh. 2006. Isolation of a coronavirus from a green-cheeked Amazon parrot (Amazon viridigenalis Cassin). Avian Pathol. 35:122126.
17. Guan, Y.,, B. J. Zheng,, Y. Q. He,, X. L. Liu,, Z. X. Zhuang,, C. L. Cheung,, S. W. Luo,, P. H. Li,, L. J. Zhang,, Y. J. Guan,, K. M. Butt,, K. L. Wong,, K. W. Chan,, W. Lim,, K. F. Shortridge,, K. Y. Yuen,, J. S. Peiris, and, L. L. Poon. 2003. Isolation and characterization of viruses related to the SARS coronavirus from animals in southern China. Science 302:276278.
18. Ho, M. S., and, I. J. Su. 2004. Preparing to prevent severe acute respiratory syndrome and other respiratory infections. Lancet Infect. Dis. 4:684689.
19. Hofmann, H.,, K. Pyrc,, L. van der Hoek,, M. Geier,, B. Berkhout, and, S. Pohlmann. 2005. Human coronavirus NL63 employs the severe acute respiratory syndrome coronavirus receptor for cellular entry. Proc. Natl. Acad. Sci. USA 102:79887993.
20. Huang, C.,, N. Ito,, C. T. Tseng, and, S. Makino. 2006. Severe acute respiratory syndrome coronavirus 7a accessory protein is a viral structural protein. J. Virol. 80:72877294.
21. Ito, N.,, E. C. Mossel,, K. Narayanan,, V. L. Popov,, C. Huang,, T. Inoue,, C. J. Peters, and, S. Makino. 2005. Severe acute respiratory syndrome coronavirus 3a protein is a viral structural protein. J. Virol. 79:31823186.
22. Jeffers, S. A.,, S. M. Tusell,, L. Gillim-Ross,, E. M. Hemmila,, J. E. Achenbach,, G. J. Babcock,, W. D. Thomas,, Jr., L., B. Thackray,, M. D. Young,, R. J. Mason,, D. M. Ambrosino,, D. E. Wentworth,, J. C. Demartini, and, K. V. Holmes. 2004. CD209L (L-SIGN) is a receptor for severe acute respiratory syndrome coronavirus. Proc. Natl. Acad. Sci. USA 101:1574815753.
23. Jonassen, C. M.,, T. Kofstad,, I. L. Larsen,, A. Lovland,, K. Handeland,, A. Follestad, and, A. Lillehaug. 2005. Molecular identification and characterization of novel coronaviruses infecting graylag geese (Anser anser), feral pigeons (Columbia livia) and mallards (Anas platyrhynchos). J. Gen. Virol. 86:15971607.
24. Kan, B.,, M. Wang,, H. Jing,, H. Xu,, X. Jiang,, M. Yan,, W. Liang,, H. Zheng,, K. Wan,, Q. Liu,, B. Cui,, Y. Xu,, E. Zhang,, H. Wang,, J. Ye,, G. Li,, M. Li,, Z. Cui,, X. Qi,, K. Chen,, L. Du,, K. Gao,, Y. T. Zhao,, X. Z. Zou,, Y. J. Feng,, Y. F. Gao,, R. Hai,, D. Yu,, Y. Guan, and, J. Xu. 2005. Molecular evolution analysis and geographic investigation of severe acute respiratory syndrome coronavirus-like virus in palm civets at an animal market and on farms. J. Virol. 79:1189211900.
25. Kaneshima, T.,, T. Hohdatsu,, K. Satoh,, T. Takano,, K. Motokawa, and, H. Koyama. 2006. The prevalence of a group 2 coronavirus in dogs in Japan. J. Vet. Med. Sci. 68:2125.
26. Keng, C. T.,, Y. W. Choi,, M. R. Welkers,, D. Z. Chan,, S. Shen,, S. Gee Lim,, W. Hong, and, Y. J. Tan. 2006. The human severe acute respiratory syndrome coronavirus (SARS-CoV) 8b protein is distinct from its counterpart in animal SARS-CoV and down-regulates the expression of the envelope protein in infected cells. Virology 354:132142.
27. Ksiazek, T. G.,, D. Erdman,, C. S. Goldsmith,, S. R. Zaki,, T. Peret,, S. Emery,, S. Tong,, C. Urbani,, J. A. Comer,, W. Lim,, P. E. Rollin,, S. F. Dowell,, A. E. Ling,, C. D. Humphrey,, W. J. Shieh,, J. Guarner,, C. D. Paddock,, P. Rota,, B. Fields,, J. DeRisi,, J. Y. Yang,, N. Cox,, J. M. Hughes,, J. W. LeDuc,, W. J. Bellini, and, L. J. Anderson. 2003. A novel coronavirus associated with severe acute respiratory syndrome. N. Engl. J. Med. 348:19531966.
28. Lau, S. K.,, P. C. Woo,, K. S. Li,, Y. Huang,, H. W. Tsoi,, B. H. Wong,, S. S. Wong,, S. Y. Leung,, K. H. Chan, and, K. Y. Yuen. 2005. Severe acute respiratory syndrome coronavirus-like virus in Chinese horseshoe bats. Proc. Natl. Acad. Sci. USA 102:1404014045.
29. Law, P. T.,, C. H. Wong,, T. C. Au,, C. P. Chuck,, S. K. Kong,, P. K. Chan,, K. F. To,, A. W. Lo,, J. Y. Chan,, Y. K. Suen,, H. Y. Chan,, K. P. Fung,, M. M. Waye,, J. J. Sung,, Y. M. Lo, and, S. K. Tsui. 2005. The 3a protein of severe acute respiratory syndrome-associated coronavirus induces apoptosis in Vero E6 cells. J. Gen. Virol. 86:19211930.
30. Leparc-Goffart, I.,, S. T. Hingley,, M. M. Chua,, X. Jiang,, E. Lavi, and, S. R. Weiss. 1997. Altered pathogenesis of a mutant of the murine coronavirus MHV-A59 is associated with a Q159L amino acid substitution in the spike protein. Virology 239:110.
31. Li, W.,, Z. Shi,, M. Yu,, W. Ren,, C. Smith,, J. H. Epstein,, H. Wang,, G. Crameri,, Z. Hu,, H. Zhang,, J. Zhang,, J. McEachern,, H. Field,, P. Daszak,, B. T. Eaton,, S. Zhang, and, L. F. Wang. 2005. Bats are natural reservoirs of SARS-like coronaviruses. Science 310:676679.
32. Li, W.,, C. Zhang,, J. Sui,, J. H. Kuhn,, M. J. Moore,, S. Luo,, S. K. Wong,, I. C. Huang,, K. Xu,, N. Vasilieva,, A. Murakami,, Y. He,, W. A. Marasco,, Y. Guan,, H. Choe, and, M. Farzan. 2005. Receptor and viral determinants of SARS-coronavirus adaptation to human ACE2. EMBO J. 24:16341643.
33. Liang, G.,, Q. Chen,, J. Xu,, Y. Liu,, W. Lim,, J. S. Peiris,, L. J. Anderson,, L. Ruan,, H. Li,, B. Kan,, B. Di,, P. Cheng,, K. H. Chan,, D. D. Erdman,, S. Gu,, X. Yan,, W. Liang,, D. Zhou,, L. Haynes,, S. Duan,, X. Zhang,, H. Zheng,, Y. Gao,, S. Tong,, D. Li,, L. Fang,, P. Qin, and, W. Xu. 2004. Laboratory diagnosis of four recent sporadic cases of community-acquired SARS, Guangdong Province, China. Emerg. Infect. Dis. 10:17741781.
34. Lu, W.,, B. J. Zheng,, K. Xu,, W. Schwarz,, L. Du,, C. K. Wong,, J. Chen,, S. Duan,, V. Deubel, and, B. Sun. 2006. Severe acute respiratory syndrome-associated coronavirus 3a protein forms an ion channel and modulates virus release. Proc. Natl. Acad. Sci. USA 103:1254012545.
35. Mackenzie, J. S. 2006. Biosafety and Biocontainment Issues. WHO Press, Geneva, Switzerland.
36. Marra, M. A.,, S. J. Jones,, C. R. Astell,, R. A. Holt,, A. Brooks-Wilson,, Y. S. Butterfield,, J. Khattra,, J. K. Asano,, S. A. Barber,, S. Y. Chan,, A. Cloutier,, S. M. Coughlin,, D. Freeman,, N. Girn,, O. L. Griffith,, S. R. Leach,, M. Mayo,, H. McDonald,, S. B. Montgomery,, P. K. Pandoh,, A. S. Petrescu,, A. G. Robertson,, J. E. Schein,, A. Siddiqui,, D. E. Smailus,, J. M. Stott,, G. S. Yang,, F. Plummer,, A. Andonov,, H. Artsob,, N. Bastien,, K. Bernard,, T. F. Booth,, D. Bowness,, M. Czub,, M. Drebot,, L. Fernando,, R. Flick,, M. Garbutt,, M. Gray,, A. Grolla,, S. Jones,, H. Feldmann,, A. Meyers,, A. Kabani,, Y. Li,, S. Normand,, U. Stroher,, G. A. Tipples,, S. Tyler,, R. Vogrig,, D. Ward,, B. Watson,, R. C. Brunham,, M. Krajden,, M. Petric,, D. M. Skowronski,, C. Upton, and, R. L. Roper. 2003. The genome sequence of the SARS-associated coronavirus. Science 300:13991404.
37. Masters, P. S. 2006. The molecular biology of coronaviruses. Adv. Virus Res. 66:193292.
38. Meier, C.,, A. R. Aricescu,, R. Assenberg,, R. T. Aplin,, R. J. Gilbert,, J. M. Grimes, and, D. I. Stuart. 2006. The crystal structure of ORF-9b, a lipid binding protein from the SARS coronavirus. Structure 14:11571165.
39. Peiris, J. S.,, S. T. Lai,, L. L. Poon,, Y. Guan,, L. Y. Yam,, W. Lim,, J. Nicholls,, W. K. Yee,, W. W. Yan,, M. T. Cheung,, V. C. Cheng,, K. H. Chan,, D. N. Tsang,, R. W. Yung,, T. K. Ng, and, K. Y. Yuen. 2003. Coronavirus as a possible cause of severe acute respiratory syndrome. Lancet 361:13191325.
40. Peiris, J. S.,, W. C. Yu,, C. W. Leung,, C. Y. Cheung,, W. F. Ng,, J. M. Nicholls,, T. K. Ng,, K. H. Chan,, S. T. Lai,, W. L. Lim,, K. Y. Yuen, and, Y. Guan. 2004. Re-emergence of fatal human influenza A subtype H5N1 disease. Lancet 363:617619.
41. Poon, L. L.,, D. K. Chu,, K. H. Chan,, O. K. Wong,, T. M. Ellis,, Y. H. Leung,, S. K. Lau,, P. C. Woo,, K. Y. Suen,, K. Y. Yuen,, Y. Guan, and, J. S. Peiris. 2005. Identification of a novel corona-virus in bats. J. Virol. 79:20012009.
42. Poon, L. L.,, Y. Guan,, J. M. Nicholls,, K. Y. Yuen, and, J. S. Peiris. 2004. The aetiology, origins, and diagnosis of severe acute respiratory syndrome. Lancet Infect. Dis. 4:663671.
43. Priestnall, S. L.,, J. Brownlie,, E. J. Dubovi, and, K. Erles. 2006. Serological prevalence of canine respiratory coronavirus. Vet. Microbiol. 115:4353.
44. Ren, W.,, W. Li,, M. Yu,, P. Hao,, Y. Zhang,, P. Zhou,, S. Zhang,, G. Zhao,, Y. Zhong,, S. Wang,, L. F. Wang, and, Z. Shi. 2006. Full-length genome sequences of two SARS-like coronaviruses in horseshoe bats and genetic variation analysis. J. Gen. Virol. 87:33553359.
45. Rest, J. S., and, D. P. Mindell. 2003. SARS associated coronavirus has a recombinant polymerase and coronaviruses have a history of host-shifting. Infect. Genet. Evol. 3:219225.
46. Robertson, M. P.,, H. Igel,, R. Baertsch,, D. Haussler,, M. Ares, Jr., and, W. G. Scott. 2005. The structure of a rigorously conserved RNA element within the SARS virus genome. PLoS Biol. 3:e5.
47. Rota, P. A.,, M. S. Oberste,, S. S. Monroe,, W. A. Nix,, R. Campagnoli,, J. P. Icenogle,, S. Penaranda,, B. Bankamp,, K. Maher,, M. H. Chen,, S. Tong,, A. Tamin,, L. Lowe,, M. Frace,, J. L. DeRisi,, Q. Chen,, D. Wang,, D. D. Erdman,, T. C. Peret,, C. Burns,, T. G. Ksiazek,, P. E. Rollin,, A. Sanchez,, S. Liffick,, B. Holloway,, J. Limor,, K. McCaustland,, M. Olsen-Rasmussen,, R. Fouchier,, S. Gunther,, A. D. Osterhaus,, C. Drosten,, M. A. Pallansch,, L. J. Anderson, and, W. J. Bellini. 2003. Characterization of a novel coronavirus associated with severe acute respiratory syndrome. Science 300:13941399.
48. Saif, L. J. 2004. Animal coronavirus vaccines: lessons for SARS. Dev. Biol. 119:129140.
49. Shimizu, C.,, H. Shike,, S. C. Baker,, F. Garcia,, L. van der Hoek,, T. W. Kuijpers,, S. L. Reed,, A. H. Rowley,, S. T. Shulman,, H. K. Talbot,, J. V. Williams, and, J. C. Burns. 2005. Human corona-virus NL63 is not detected in the respiratory tracts of children with acute Kawasaki disease. J. Infect. Dis. 192:17671771.
50. Sloots, T. P.,, P. McErlean,, D. J. Speicher,, K. E. Arden,, M. D. Nissen, and, I. M. Mackay. 2006. Evidence of human corona-virus HKU1 and human bocavirus in Australian children. J. Clin. Virol. 35:99102.
51. Snijder, E. J.,, P. J. Bredenbeek,, J. C. Dobbe,, V. Thiel,, J. Ziebuhr,, L. L. Poon,, Y. Guan,, M. Rozanov,, W. J. Spaan, and, A. E. Gorbalenya. 2003. Unique and conserved features of genome and proteome of SARS-coronavirus, an early split-off from the coronavirus group 2 lineage. J. Mol. Biol. 331:9911004.
52. Song, H. D.,, C. C. Tu,, G. W. Zhang,, S. Y. Wang,, K. Zheng,, L. C. Lei,, Q. X. Chen,, Y. W. Gao,, H. Q. Zhou,, H. Xiang,, H. J. Zheng,, S. W. Chern,, F. Cheng,, C. M. Pan,, H. Xuan,, S. J. Chen,, H. M. Luo,, D. H. Zhou,, Y. F. Liu,, J. F. He,, P. Z. Qin,, L. H. Li,, Y. Q. Ren,, W. J. Liang,, Y. D. Yu,, L. Anderson,, M. Wang,, R. H. Xu,, X. W. Wu,, H. Y. Zheng,, J. D. Chen,, G. Liang,, Y. Gao,, M. Liao,, L. Fang,, L. Y. Jiang,, H. Li,, F. Chen,, B. Di,, L. J. He,, J. Y. Lin,, S. Tong,, X. Kong,, L. Du,, P. Hao,, H. Tang,, A. Bernini,, X. J. Yu,, O. Spiga,, Z. M. Guo,, H. Y. Pan,, W. Z. He,, J. C. Manuguerra,, A. Fontanet,, A. Danchin,, N. Niccolai,, Y. X. Li,, C. I. Wu, and, G. P. Zhao. 2005. Cross-host evolution of severe acute respiratory syndrome coronavirus in palm civet and human. Proc. Natl. Acad. Sci. USA 102:24302435.
53. Stanhope, M. J.,, J. R. Brown, and, H. Amrine-Madsen. 2004. Evidence from the evolutionary analysis of nucleotide sequences for a recombinant history of SARS-CoV. Infect. Genet. Evol. 4:1519.
54. Stavrinides, J., and, D. S. Guttman. 2004. Mosaic evolution of the severe acute respiratory syndrome coronavirus. J. Virol. 78:7682.
55. Stöhr, K. 2003. A multicentre collaboration to investigate the cause of severe acute respiratory syndrome. Lancet 361:17301733.
56. Tan, Y. J.,, B. C. Fielding,, P. Y. Goh,, S. Shen,, T. H. Tan,, S. G. Lim, and, W. Hong. 2004. Overexpression of 7a, a protein specifically encoded by the severe acute respiratory syndrome coronavirus, induces apoptosis via a caspase-dependent pathway. J. Virol. 78:1404314047.
57. Tang, X. C.,, J. X. Zhang,, S. Y. Zhang,, P. Wang,, X. H. Fan,, L. F. Li,, G. Li,, B. Q. Dong,, W. Liu,, C. L. Cheung,, K. M. Xu,, W. J. Song,, D. Vijaykrishna,, L. L. Poon,, J. S. Peiris,, G. J. Smith,, H. Chen, and, Y. Guan. 2006. Prevalence and genetic diversity of coronaviruses in bats from China. J. Virol. 80:74817490.
58. Tu, C.,, G. Crameri,, X. Kong,, J. Chen,, Y. Sun,, M. Yu,, H. Xiang,, X. Xia,, S. Liu,, T. Ren,, Y. Yu,, B. T. Eaton,, H. Xuan, and, L. F. Wang. 2004. Antibodies to SARS coronavirus in civets. Emerg. Infect. Dis. 10:22442248.
59. Vabret, A.,, J. Dina,, S. Gouarin,, J. Petitjean,, S. Corbet, and, F. Freymuth. 2006. Detection of the new human coronavirus HKU1: a report of 6 cases. Clin. Infect. Dis. 42:634639.
60. van der Hoek, L.,, K. Pyrc, and, B. Berkhout. 2006. Human coronavirus NL63, a new respiratory virus. FEMS Microbiol. Rev. 30:760773.
61. van der Hoek, L.,, K. Pyrc,, M. F. Jebbink,, W. Vermeulen-Oost,, R. J. Berkhout,, K. C. Wolthers,, P. M. Wertheim-van Dillen,, J. Kaandorp,, J. Spaargaren, and, B. Berkhout. 2004. Identification of a new human coronavirus. Nat. Med. 10:368373.
62. Wang, M.,, M. Yan,, H. Xu,, W. Liang,, B. Kan,, B. Zheng,, H. Chen,, H. Zheng,, Y. Xu,, E. Zhang,, H. Wang,, J. Ye,, G. Li,, M. Li,, Z. Cui,, Y. F. Liu,, R. T. Guo,, X. N. Liu,, L. H. Zhan,, D. H. Zhou,, A. Zhao,, R. Hai,, D. Yu,, Y. Guan, and, J. Xu. 2005. SARS-CoV infection in a restaurant from palm civet. Emerg. Infect. Dis. 11:18601865.
63. Wickramasinghe, C.,, M. Wainwright, and, J. Narlikar. 2003. SARS—a clue to its origins? Lancet 361:1832.
64. Williams, B. H.,, M. Kiupel,, K. H. West,, J. T. Raymond,, C. K. Grant, and, L. T. Glickman. 2000. Coronavirus-associated epizootic catarrhal enteritis in ferrets. J. Am. Vet. Med. Assoc. 217:526530.
65. Wise, A. G.,, M. Kiupel, and, R. K. Maes. 2006. Molecular characterization of a novel coronavirus associated with epizootic catarrhal enteritis (ECE) in ferrets. Virology 349:164174.
66. Woo, P. C.,, S. K. Lau,, C. M. Chu,, K. H. Chan,, H. W. Tsoi,, Y. Huang,, B. H. Wong,, R. W. Poon,, J. J. Cai,, W. K. Luk,, L. L. Poon,, S. S. Wong,, Y. Guan,, J. S. Peiris, and, K. Y. Yuen. 2005. Characterization and complete genome sequence of a novel coronavirus, coronavirus HKU1, from patients with pneumonia. J. Virol. 79:884895.
67. Woo, P. C.,, S. K. Lau,, K. S. Li,, R. W. Poon,, B. H. Wong,, H. W. Tsoi,, B. C. Yip,, Y. Huang,, K. H. Chan, and, K. Y. Yuen. 2006. Molecular diversity of coronaviruses in bats. Virology 351:180187.
68. Woo, P. C.,, S. K. Lau,, H. W. Tsoi,, Y. Huang,, R. W. Poon,, C. M. Chu,, R. A. Lee,, W. K. Luk,, G. K. Wong,, B. H. Wong,, V. C. Cheng,, B. S. Tang,, A. K. Wu,, R. W. Yung,, H. Chen,, Y. Guan,, K. H. Chan, and, K. Y. Yuen. 2005. Clinical and molecular epidemiological features of coronavirus HKU1-associated community-acquired pneumonia. J. Infect. Dis. 192:18981907.
69. Woo, P. C.,, S. K. Lau,, C. C. Yip,, Y. Huang,, H. W. Tsoi,, K. H. Chan, and, K. Y. Yuen. 2006. Comparative analysis of 22 coronavirus HKU1 genomes reveals a novel genotype and evidence of natural recombination in coronavirus HKU1. J. Virol. 80:71367145.
70. Wu, D.,, C. Tu,, C. Xin,, H. Xuan,, Q. Meng,, Y. Liu,, Y. Yu,, Y. Guan,, Y. Jiang,, X. Yin,, G. Crameri,, M. Wang,, C. Li,, S. Liu,, M. Liao,, L. Feng,, H. Xiang,, J. Sun,, J. Chen,, Y. Sun,, S. Gu,, N. Liu,, D. Fu,, B. T. Eaton,, L. F. Wang, and, X. Kong. 2005. Civets are equally susceptible to experimental infection by two different severe acute respiratory syndrome coronavirus isolates. J. Virol. 79:26202625.
71. Yachi, A., and, M. Mochizuki. 2006. Survey of dogs in Japan for group 2 canine coronavirus infection. J. Clin. Microbiol. 44:26152618.
72. Yount, B.,, R. S. Roberts,, A. C. Sims,, D. Deming,, M. B. Frieman,, J. Sparks,, M. R. Denison,, N. Davis, and, R. S. Baric. 2005. Severe acute respiratory syndrome coronavirus group-specific open reading frames encode nonessential functions for replication in cell cultures and mice. J. Virol. 79:1490914922.
73. Yuan, X.,, Y. Shan,, Z. Zhao,, J. Chen, and, Y. Cong. 2005. G0/G1 arrest and apoptosis induced by SARS-CoV 3b protein in transfected cells. Virol. J. 2:66.
74. Zeng, F. Y.,, C. W. Chan,, M. N. Chan,, J. D. Chen,, K. Y. Chow,, C. C. Hon,, K. H. Hui,, J. Li,, V. Y. Li,, C. Y. Wang,, P. Y. Wang,, Y. Guan,, B. Zheng,, L. L. Poon,, K. H. Chan,, K. Y. Yuen,, J. S. Peiris, and, F. C. Leung. 2003. The complete genome sequence of severe acute respiratory syndrome coronavirus strain HKU-39849 (HK-39). Exp. Biol. Med. (Maywood) 228:866873.
75. Zhong, N. S.,, B. J. Zheng,, Y. M. Li, Poon,, Z. H. Xie,, K. H. Chan,, P. H. Li,, S. Y. Tan,, Q. Chang,, J. P. Xie,, X. Q. Liu,, J. Xu,, D. X. Li,, K. Y. Yuen, Peiris, and, Y. Guan. 2003. Epidemiology and cause of severe acute respiratory syndrome (SARS) in Guangdong, People’s Republic of China, in February, 2003. Lancet 362:13531358.

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