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The Periplasm

Editor: Michael Ehrmann1
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Affiliations: 1: University of Duisburg-Essen
Content Type: Monograph
Format: Electronic, Hardcover
Publication Year: 2007

Category: Bacterial Pathogenesis; Microbial Genetics and Molecular Biology

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Written by an international group of eminent scientists, this new treatise is the very first in the field to provide a thorough, state-of-the-art review of the periplasm, the extracytoplasmic compartment found in gram-negative bacteria. Targeting medical practitioners and students of biology, microbiology, bichemistry, structural biology and biotechnology, detials important aspects of the physiology of pathogenic microorganisms, conveys a selection of current drug resistance strategies, and describes lipopolysaccharide biosynthesis

Valuable background information outlining the inner workings of gram-negative bacteria is presented, providing insights into the evolution of cellular compartments and their benefit to living organisms. There are also comprehensive discussions of the basic biological functions of the periplasm and their physiological relevance, including protein transport, folding, and quality control; bioenergetics; solute transport; stress responses; cell division; and cell architecture.

The Periplasm lays the foundation for future research directions and novel experiments in its coverage of the most up-to-date results, approaches, and hypotheses available to those working in the field. Recent insights into computational methods to predict cellular localization and the latest developments in recombinant protein production are also examined.

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Doody Enterprises

24 June 2013

At A Glance

Written by an international group of eminent scientists, this new treatise is the very first in the field to provide a thorough, state-of-the-art review of the periplasm, the extracytoplasmic compartment found in gram-negative bacteria. Targeting medical practitioners and students of biology, microbiology, bi0chemistry, structural biology and biotechnology, The Periplasm details important aspects of the physiology of pathogenic microorganisms, conveys a selection of current drug resistance strategies, and describes lipopolysaccharide biosynthesis. Valuable background information outlining the inner workings of gram-negative bacteria is presented, providing insights into the evolution of cellular compartments and their benefit to living organisms. There are also comprehensive discussions of the basic biological functions of the periplasm and their physiological relevance, including protein transport, folding, and quality control; bioenergetics; solute transport; stress responses; cell division; and cell architecture. The Periplasm lays the foundation for future research directions and novel experiments in its coverage of the most up-to-date results, approaches, and hypotheses available to those working in the field. Recent insights into computational methods to predict cellular localization and the latest developments in recombinant protein production are also examined.

Description

This book specifically reviews the current knowledge of the periplasmic space found in gram-negative bacteria. This space between the cytoplasm and the outermembrane of these bacteria is a separate compartment with specific physiologic processes that control the environment of the bacteria.

Purpose

The purpose is to bring together in one volume the research and discoveries of the unique nature of the periplasm. As more information about this distinctive compartment of gram-negative bacteria becomes known, it is clear that this space is very dynamic and essential to the organism. It is, in fact, the necessary element that serves to protect the bacteria from the environment and its own by products.

Audience

This book is written for scientists working on bacterial cell membranes, protein synthesis and secretion, and antibiotic activity. It is authored by some of the top researchers in this field.

Features

Sections cover protein secretion, protein folding, physiological processes, practical implications and protein composition. Within these areas there is some overlap, but it does not distract from the messages. The book covers such topics as the folding properties of outer membrane proteins and how they are delivered and assembled. It also shows how the bacteria respond to stress and how they reassemble their proteins during cell division. Toward the end of the book are several chapters that examine the production of recombinant proteins within the periplasmic space in order to protect and concentrate these products. This is a book densely packed with information, but it is also clear that there are still many unanswered questions regarding this compartment of gram-negative bacteria.

Assessment

This book would be useful to scientists working on gram-negative bacteria. The quality of the information is very good and I think it will enhance the work of understanding how the bacterial cell functions.

Doody Enterprises

Reviewer: Rebecca Horvat, PhD, D(ABMM) (University of Kansas Medical Center)

Review Date: Unknown

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