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Chapter 12 : Periplasmic Events in the Assembly of Bacterial Lipopolysaccharides

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Abstract:

This chapter provides an overview of the assembly pathways for lipopolysaccharide (LPS) molecules, with particular emphasis on reactions and components occurring in the periplasm. Species-specific variations on the generally conserved theme are now being identified. In the current working model, it is proposed that lipid A core binds to MsbA and the polar parts of the exported molecule enter the lumen of the transporter. WecA is an integral membrane protein that forms the undecaprenyl pyrophosphoryl-GlcNAc. The premise for the periplasmic location of the glucosylation reaction is based on studies with that first showed undecaprenyl pyrophosphate-linked intermediates provide the acceptor for glucosylation. O-Acetyltransferases also modify O-polysaccharides. Well-documented examples include OafA, which confers O:5 specificity in Oac encoded by the seroconverting bacteriophage SF6 and the O-acetyltransferase carried by bacteriophage D3. The WbdD-mediated chain termination reactions establish modal regulation in participation with the ABC transporter because the export process is coupled to chain termination. Synthases are processive glycosyltransferases that have the capacity to synthesize polymers within one or more linkages. It has been shown that peptidoglycan is also distributed in a helical arrangement along the side walls of and it will be interesting to see whether the events are coupled and whether the emerging bacterial cytoskeletal components play any role in dictating the sites of LPS insertion.

Citation: Whitfield C, Frirdich E, Reid A. 2007. Periplasmic Events in the Assembly of Bacterial Lipopolysaccharides, p 214-234. In Ehrmann M (ed), The Periplasm. ASM Press, Washington, DC. doi: 10.1128/9781555815806.ch12

Key Concept Ranking

Integral Membrane Proteins
0.53933275
Bacterial Diseases
0.53034467
Outer Membrane Proteins
0.48152268
Peripheral Membrane Proteins
0.46792325
0.53933275
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Figures

Image of FIGURE 1
FIGURE 1

Structure of the core oligosaccharide in and . The inner core is shown in A and the various nonstoichiometric glycose and phosphoethanolamine modifications of the base structure are represented by the dashed lines. Two representative outer core structures are shown in B.

Citation: Whitfield C, Frirdich E, Reid A. 2007. Periplasmic Events in the Assembly of Bacterial Lipopolysaccharides, p 214-234. In Ehrmann M (ed), The Periplasm. ASM Press, Washington, DC. doi: 10.1128/9781555815806.ch12
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