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Pneumococcal Vaccines: The Impact of Conjugate Vaccines

Editors: George R. Siber1, Keith P. Klugman2, P. Helena Mäkelä3
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Content Type: Monograph
Format: Electronic, Hardcover
Publication Year: 2008

Category: Bacterial Pathogenesis; Immunology

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A comprehensive explanation of the extraordinary public health benefits of pneumococcal conjugate vaccines The development of protein conjugate vaccines against pneumococcal disease is arguably the greatest public health achievement of the new millennium. This book describes the development of the vaccines, their remarkable impact on respiratory and other pneumococcal infections, and the vaccines’ wider impact on public health.

Acute respiratory infections due to pneumococci are the leading vaccine-preventable cause of death. The first pneumococcal conjugate vaccine was licensed seven years ago in the United States and is now in general use worldwide. While the vaccine’s dramatic impact on the target population was anticipated, the magnitude of herd immunity provided to unimmunized individuals was not. This benefit has enormously enhanced the public health impact of the vaccine.

With 28 chapters contributed by the world’s leading experts, this book summarizes the latest findings on the effects of pneumococcal conjugate vaccine. It includes chapters on epidemiology, immunologic mechanisms, conjugation methods, antibiotic resistance, PCV immunogenicity in healthy and high-risk individuals, otitis media, and direct and indirect protective effects. For professionals in academia, public health, government, or industry, this book summarizes the current knowledge on pneumococcal vaccines with particular emphasis on the years after the introduction of the conjugate vaccine.

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Quarterly Review of Biology

15 December 2013

A welcome addition to the surprisingly limited set of books that deal with one of the world's most important pathogens, this volume includes 28 papers, essays, and reviews loosely bound together by their relevance to vaccination against Streptococcus pneumonia. The editors and contributors are a diverse group of basic and clinical scientists (drawn from both academia and industry), epidemiologists, and public health officials. The resulting blend of voices provides a broad overview of the history, science, and current state of knowledge regarding development, production, testing, and impact of pneumococcal vaccines.

Each chapter in the book is a self-contained essay or review of a particular topic, ranging from historical overviews, to pathogenesis in humans and preclinical models, to details of manufacturing and regulatory issues, to clinical outcomes of pneumococcal vaccines. The advantage of this style is that each chapter can be read separately without referral to earlier sections, treating the volume as a reference. Different parts of the book will be considered valuable reading for researchers, clinicians, industry producers, and public health officials, although the entire content will be useful to only a modest subset of readers. the drawbacks of the text as organized are that many concepts and much information that would be considered introductory is repeated throughout, and for those items that are covered only in single chapters, continuity issues arise since a detailed explanation may be given for a particular concept at one stage of the volume, but it may be referred to in an earlier part of the book with the assumption of knowledge by the reader.

The writing style and content of the individual chapters is clear and accessible to anyone with a  scientific background. Although details of many techniques and types of analysis are discussed, this is not a methodological textbook with fine details that would enable one to conduct experiments. Rather, the authors present suggestions and insights that one might consider "pearls of wisdom" or "tricks of the trade." Numerous tables, many replete with long lists of collated material from multiple sources, are provided. This is a major strength of the volume, as are the thorough bibliographies at the end of each chapter. Several chapters stood out as uniquely valuable, as the information in them is not available through traditional scientific communication or is not often put together into a single publication. These include chapters on animal models of pneumococcal disease and colonization, on manufacturing techniques, and on immune correlates useful for conduct of preclinical and clinical trials.

Quarterly Review of Biology

Volume 83, Page 423

Reviewer: Jonathan A. McCullers, Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee

Review Date: December 2008

Microbiology Today

03 March 2013

At first it seems hard to justify a book of 499 pages on the highly specialist subject of pneumococcal vaccination. How could such a book be of interest to microbiologists in general?

The editors have brought together a constellation of stars in the pneumococcal research firmament who discuss every aspect of pneumococcal diseases. The referencing is especially noteworthy being thoroughly comprehensive. The book takes the reader from history through to the biological basis of pneumococcal diseases, clinical aspects and epidemiology to the detailed treatment of the pneumococcal vaccines themselves. The emphasis is on the conjugate vaccine but other approaches are not neglected, notably in the last chapter where future directions are explored.

A problem of an interest in pneumococcal infections is the explosion in knowledge of this ever present pathogen. This book is the solution and, thus, is a must buy for anyone interested in or researching respiratory infections.

Society for General Microbiology: Microbiology Today

Reviewer: Stephen Gillespie, Royal Free & University College Medical School

Review Date: 2008

Doody Enterprises

02 February 2013

At A Glance

This book explains how to monitor and measure the effects of pneumococcal conjugate vaccine introduction. It summarizes the most current information on pneumococcal conjugate vaccines. The book: discusses the world-wide potential of the vaccines; details the impact of vaccination on childhood respiratory disease, including antibiotic resistance; makes clear the biology of the pneumococcus in relation to disease; and, explains the dynamics of a successful vaccine launch.

Description

This book summarizes the current state of the art of pneumococcal vaccines, with a particular focus on the impact of the conjugate vaccine.

Purpose

The purpose is to summarize the current status of pneumococcal vaccines, with an emphasis on the years after introduction of the conjugate vaccine.

Audience

The book is targeted at professionals in academia, public health, government, or industry, according to the authors. It will be most useful for professionals with a background in microbiology, infectious diseases, and/or vaccinology, although it could also serve as a reference for medical or graduate students, postdoctoral fellows, or medical residents and fellows. The authors are some of the world's leading authorities in this field.

Features

The development, current status, impact, and future direction of pneumococcal vaccines are covered. Most impressive is the comprehensive discussion that starts with the history of pneumococcal vaccine development and continues with a review of the epidemiology and clinical management of pneumococcal disease and an examination of manufacturing issues, immunogenicity, efficacy, safety and public health impact of the vaccines.

Assessment

This is an excellent book that deals in depth with pneumococcal vaccines. There really are no other books that compare. One book that does address the topic (Implementation of Vaccine Policy: Incorporating an Overview of Pneumococcal Disease in the UK and Current Immunization Practice, by Cartwright (Royal Society of Medicine Press, 2008)) is geared more towards vaccine policy in the U.K. Various other books include several chapters that address the topic, but none provide the detailed and extensive information available in this book.

Doody Enterprises

Reviewer: Archana Chatterjee, MD PhD (Creighton University)

Review Date: Unknown

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