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Chapter 15 : Small Nonpeptide Inhibitors of Staphylococcal Superantigen-Induced Cytokine Production and Toxic Shock

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Small Nonpeptide Inhibitors of Staphylococcal Superantigen-Induced Cytokine Production and Toxic Shock, Page 1 of 2

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Abstract:

Staphylococcal superantigens are grouped into three classes based on their primary sequence homology. In humans and monkeys, Staphylococcal enterotoxins (SEs) induce an emetic response and toxic shock at submicrogram concentrations. The mouse models commonly used today rely on the use of sensitizing agents such as D-galactosamine, actinomycin D, lipopolysaccharide (LPS), or viruses to induce toxic shock. None of the existing mouse models faithfully reproduces all of the complex events of human toxic shock syndrome. Bacterial superantigens cause toxic shock and contribute to septic complications during infection. Staphylococcal toxic shock syndrome (TSS) is characterized by fever, hypotension, desquamation of skin, fever, and dysfunction of three or more organ systems. Superantigens from both and are the causative agents of staphylococcal and streptococcal toxic shock. Given the complex pathophysiology of toxic shock, an understanding of the interaction of cellular receptors and signaling pathways used by these staphylococcal superantigens and the biological mediators they induce provides invaluable insight into selecting appropriate therapeutic targets. A list of small nonpeptide inhibitors effective in blocking the effects of superantigens is shown in this chapter. The anti-inflammatory cytokine interleukin 10 (IL-10) was used to block the production of IL-1, tumor necrosis factor alpha (TNF-α), and gamma interferon (IFN-γ), resulting in reduced lethality to superantigen-induced toxic shock. The ability to stop the inflammatory events initiated by superantigens early appears to be critical in preventing toxic shock.

Citation: Krakauer T. 2007. Small Nonpeptide Inhibitors of Staphylococcal Superantigen-Induced Cytokine Production and Toxic Shock, p 229-244. In Kotb M, Fraser J (ed), Superantigens. ASM Press, Washington, DC. doi: 10.1128/9781555815844.ch15

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Toxic Shock Syndrome Toxin 1
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Major Histocompatibility Complex
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Cells and mediators participating in superantigen-induced toxic shock.

Citation: Krakauer T. 2007. Small Nonpeptide Inhibitors of Staphylococcal Superantigen-Induced Cytokine Production and Toxic Shock, p 229-244. In Kotb M, Fraser J (ed), Superantigens. ASM Press, Washington, DC. doi: 10.1128/9781555815844.ch15
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References

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1. Abdelnour, A. T.,, T. Bremell, and, A. Tarkowski. 1994. TSST-1 contributes to the arthritogenecity of Staphylococcus aureus. J. Infect. Dis. 170:9499.
2. Alber, G.,, D. K. Hammer, and, B. Fleischer. 1990. Relationship between enterotoxic- and T lymphocyte-stimulating activity of staphylococcal enterotoxin B. J. Immunol. 144:45014506.
3. Alber, G.,, P. H. Scheuber,, B. Reck,, B. Sailer-Kramer,, A. Hartmann, and, D. K. Hammer. 1989. Role of substance P in immediate-type skin reactions induced by staphylococcal enterotoxin B in unsensitized monkeys. J. Allergy Clin. Immunol. 84: 880885.
4. Anderson, M. R., and, M. Tary-Lehmann. 2001. Staphylococcal enterotoxin-B-induced lethal shock in mice is T-cell-dependent, but disease susceptibility is defined by the non-T-cell compartment. Clin. Immunol. 98:8594.
5. Arad, G.,, R. Levy,, D. Hillman, and, R. Kaempfer. 2000. Superantigen antagonist protects against lethal shock and defines a new domain for T-cell activation. Nat. Med. 6:414421.
6. Bavari, S.,, B. Dyas, and, R. G. Ulrich. 1996. Superantigen vaccines: a comparative study of genetically attenuated receptor-binding mutants of staphylococcal enterotoxin A. J. Infect. Dis. 174:338345.
7. Bavari, S.,, R. G. Ulrich, and, R. D. LeClaire. 1999. Cross-reactive antibodies prevent the lethal effects of Staphylococcus aureus superantigens. J. Infect. Dis. 180:13651369.
8. Bean, A. G.,, R. A. Freiberg,, S. Andrade,, S. Menon, and, A. Zlotnik. 1993. Interleukin 10 protects mice against staphylococcal enterotoxin B-induced lethal shock. Infect. Immun. 61:49374939.
9. Bette, M.,, M. K. Schafer,, N. van Rooijen,, E. Weihe, and, B. Fleischer. 1993. Distribution and kinetics of superantigen-induced cytokine gene expression in mouse spleen. J. Exp. Med. 178:15311539.
10. Blank, C.,, A. Luz,, S. Bendigs,, A. Erdmann,, H. Wagner, and, K. Heeg. 1997. Superantigen and endotoxin synergize in the induction of lethal shock. Eur. J. Immunol. 27:825833.
11. Brocke, S.,, S. Hausmann,, L. Steinmam, and, K. W. Wucherpfennig. 1998. Microbial peptides and super-antigens in the pathogenesis of autoimmune diseases of the central nervous system. Semin. Immunol. 10:5767.
12. Cameron, S. B.,, M. C. Nawijn,, W. W. Kum,, H. F. Savelkoul, and, A. W. Chow. 2001. Regulation of helper T cell responses to staphylococcal superantigens. Eur. Cytokine Netw. 12:210222.
13. Carlsson R.,, H. Fischer, and, H. O. Sjogren. 1988. Binding of staphylococcal enterotoxin A to accessory cells is a requirement for its ability to activate human T cells. J. Immunol. 140:24842488.
14. Chatila, T., and, R. S. Geha. 1993. Signal transduction by microbial superantigens via MHC class II molecules. Immunol. Rev. 131:4359.
15. Chatila, T.,, N. Wood,, J. Parsonnet, and, R. S. Geha. 1988. Toxic shock syndrome toxin-1 induces inositol phospholipid turnover, protein kinase C translocation, and calcium mobilization in human T cells. J. Immunol. 140:12501255.
16. Chen, J. Y.,, Y. Qiao,, K. L. Komisar,, W. B. Baze,, I. C. Hsu, and, J. Tseng. 1994. Increased susceptibility to staphylococcal enterotoxin B intoxication in mice primed with actinomycin D. Infect. Immun. 62:46264631.
17. Chesney, P. J.,, P. J. Davis,, W. K. Purdy,, P. J. Wand, and, R. W. Chesney. 1981. Clinical manifestations of toxic shock syndrome. JAMA 246:741748.
18. Chintagumpala, M. M.,, J. A. Mollick, and, R. R. Rich. 1991. Staphylococcal toxins bind to different sites on HLA-DR. J. Immunol. 147:38763882.
19. Choi, Y.,, B. Kotzin,, L. Hernon,, J. Callahan,, P. Marrack, and, J. Kappler. 1989. Interaction of Staphylococcus aureus toxin “superantigens” with human T cells. Proc. Natl. Acad. Sci. USA 86:89418945.
20. Darenberg, J.,, B. Soderquist,, B. H. Normark, and, A. Norrby-Teglund. 2004. Differences in potency of intravenous polyspecific immunoglobulin G against streptococcal and staphylococcal superantigens: implications for therapy of toxic shock syndrome. Clin. Infect. Dis. 38:836842.
21. DaSilva, L.,, B. Welcher,, R. Ulrich,, M. Aman,, C. David, and, S. Bavari. 2002. Humanlike immune response of human leukocyte antigen-DR3 transgenic mice to staphylococcal enterotoxins: a novel model for superantigen vaccines. J. Infect. Dis. 185:17541760.
22. Fischer, H.,, M. Dohlsten,, U. Andersson,, G. Hedlund,, P. Ericsson,, J. Hansson, and, H. O. Sjogren. 1990. Production of TNF-α and TNF-β by staphylococcal enterotoxin A activated human T cells. J. Immunol. 144:46634668.
23. Florquin, S.,, Z. Amraoui,, D. Abramowicz, and, M. Goldman. 1994. Systemic release and protective role of IL-10 in staphylococcal enterotoxin B-induced shock in mice. J. Immunol. 153:26182623.
24. Fraser, J.,, V. Arcus,, P. Kong,, E. Baker, and, T. Proft. 2000. Superantigens—powerful modifiers of the immune system. Mol. Med. Today 6:125132.
25. Fraser, J.,, M. Newton, and, A. Weiss. 1992. CD28 and T-cell antigen receptor signal transduction coordinately regulates interleukin 2 gene expression in response to superantigen stimulation. J. Exp. Med. 175:11311134.
26. Geller-Hong, E.,, M. Möllhoff,, P. R. Shiflett, and, G. Gupta. 2004. Design of chimeric receptor mimics with different TcRVβ isoforms: type-specific inhibition of superantigen pathogenesis. J. Biol. Chem. 279:56765684.
27. Hale, M. L.,, S. B. Margolin,, T. Krakauer,, C. J. Roy, and, B. G. Stiles. 2002. Pirfenidone blocks in vitro and in vivo effects of staphylococcal enterotoxin B. Infect. Immun. 70:29892994.
28. Hamad, A. R.,, P. Marrack, and, J. W. Kappler. 1997. Transcytosis of staphylococcal superantigen toxins. J. Exp. Med. 185:14471454.
29. Herman, A.,, G. Croteau,, R. P. Sekaly,, J. Kappler, and, P. Marrack. 1990. HLA-DR alleles differ in their ability to present staphylococcal enterotoxins to T cells. J. Exp. Med. 172:709712.
30. Herrmann, T.,, R. S. Acolla, and, H. R. MacDonald. 1989. Different staphylococcal enterotoxins bind preferentially to distinct MHC class II isotypes. Eur. J. Immunol. 19:21712174.
31. Hewitt, C.,, J. Lamb,, J. Hayball,, M. Hill,, M. Owen, and, R. O’Hehir. 1992. MHC Independent clonal T cell anergy by direct interaction of staphylococcal enterotoxin B with the T-cell antigen receptor. J. Exp. Med. 175:14931499.
32. Hodoval, L. F.,, E. L. Morris,, G. J. Crawley, and, W. R. Beisel. 1968. Pathogenesis of lethal shock after intravenous staphylococcal enterotoxin B in monkeys. Appl. Microbiol. 16:187192.
33. Holmberg, S. D., and, P. A. Blake. 1984. Staphylococcal food poisoning in the United States. New facts and old misconceptions. JAMA 251:487489.
34. Hudson, K. R.,, R. E. Tiedemann,, R. G. Urban,, S. C. Lowe,, J. L. Strominger, and, J. D. Fraser. 1995. Staphylococcal enterotoxin A has two cooperative binding sites on major histocompatibility complex class II. J. Exp. Med. 182:711720.
35. Jo, D.,, D. Liu,, S. Yao,, R. D. Collins, and, J. Hawiger. 2005. Intracellular protein therapy with SOCS3 inhibits inflammation and apoptosis. Nat. Med. 11:892898.
36. Jupin, C.,, S. Anderson,, C. Damais,, J. E. Alouf, and, M. Parant. 1988. Toxic shock syndrome toxin 1 as an inducer of human tumor necrosis factors and gamma interferon. J. Exp. Med. 167:752761.
37. Kappler, J. W.,, A. Herman,, J. Clements, and, P. Marrack. 1992. Mutations defining functional regions of the superantigen staphylococcal enterotoxin B. J. Exp. Med. 175:387396.
38. Kotb, M. 1995. Bacterial pyrogenic exotoxins as superantigens. Clin. Microbiol. Rev. 8:411426.
39. Kotzin, B. L.,, D. Y. M. Leung,, J. Kappler, and, P. Marrack. 1993. Superantigens and their potential role in human disease. Adv. Immunol. 54:99166.
40. Krakauer, T. 1994. Costimulatory receptors for the superantigen staphylococcal enterotoxin B on human vascular endothelial cells and T cells. J. Leukoc. Biol. 56:458463.
41. Krakauer, T. 1994. A sensitive ELISA for measuring the adhesion of leukocytic cells to human endothelial cells. J. Immunol. Methods 177:207213.
42. Krakauer, T. 1995. Inhibition of toxic shock syndrome toxin-induced cytokine production and T cell activation by interleukin 10, interleukin 4, and dexamethasone. J. Infect. Dis. 172:988992.
43. Krakauer, T. 1999. Immune response to staphylococcal superantigens. Immunol. Res. 20:163173.
44. Krakauer, T. 1999. The induction of CC chemokines in human peripheral blood mononuclear cells by staphylococcal exotoxins and its prevention by pentoxifylline. J. Leukoc. Biol. 66:158164.
45. Krakauer, T. 2001. Suppression of endotoxin- and staphylococcal exotoxin-induced cytokines and chemokines by a phospholipase C inhibitor in human peripheral blood mononuclear cells. Clin. Diagn. Lab. Immunol. 8:449453.
46. Krakauer, T. 2002. Stimulant-dependent modulation of cytokines and chemokines by airway epithelial cells: cross-talk between pulmonary epithelial and peripheral blood mononuclear cells. Clin. Diagn. Lab. Immunol. 9:126131.
47. Krakauer, T. 2004. Caspase inhibitors attenuate superantigen-induced inflammatory cytokines, chemokines and T-cell proliferation. Clin. Diagn. Lab. Immunol. 11:621624.
48. Krakauer, T. 2004. Molecular therapeutic targets in inflammation: cyclooxygenase and NF-kB. Curr. Drug Targets Inflamm. Allergy 3:317324.
49. Krakauer, T., and, M. Buckley. 2003. Doxycycline is anti-inflammatory and inhibits staphylococcal exotoxin-induced cytokines and chemokines. Antimicrob. Agents Chemother. 47:36303633.
50. Krakauer, T., and, M. Buckley. Dexamethasone attenuates staphylococcal enterotoxin B-induced hypothermic response and protects mice from superantigen-induced toxic shock. Antimicrob. Agents Chemother., in press.
51. Krakauer, T.,, B. Q. Li, and, H. A. Young. 2001. The flavonoid baicalin inhibits staphylococcal superantigen-induced inflammatory cytokine and chemokine production in human peripheral blood mononuclear cells. FEBS Lett. 500:5055.
52. Krakauer, T.,, L. Pitt, and, R. E. Hunt. 1997. Detection of IL-6 and IL-2 in serum of rhesus monkeys exposed to a nonlethal dose of staphylococcal enterotoxin B. Mil. Med. 162:612615.
53. Krakauer, T., and, B. G. Stiles. 1999. Pentoxifylline inhibits staphylococcal superantigen induced toxic shock and cytokine release. Clin. Diagn. Lab. Immunol. 6:594598.
54. Krakauer, T.,, J. Vilcek, and, J. J. Oppenheim. 1998. Proinflammatory cytokines: TNF and IL-1 families, chemokines, TGFβ and others, p. 775811. In W. Paul (ed.), Fundamental Immunology, 4th ed. Lippincott-Raven Press, Philadelphia, Pa.
55. LaSalle, J. M.,, F. Toneguzzo,, M. Saadeh,, D. E. Golan,, R. Taber, and, D. A. Hafler. 1993. T cell presentation of antigen requires cell to cell contact for proliferation and anergy induction. J. Immunol. 151:649657.
56. LeClaire, R. D.,, W. Kell,, S. Bavari,, T. Smith, and, R. E. Hunt. 1996. Protective effects of niacinamide in staphylococcal enterotoxin B induced toxicity. Toxicology 107:6981.
57. Linsley, P. S., and, J. A. Ledbetter. 1993. The role of the CD28 receptor during T cell responses to antigen. Annu. Rev. Immunol. 11:191212.
58. Liu, D.,, X. Y. Liu,, D. Robinson,, C. Burnett,, C. Jackson,, L. Seele,, R. A. Veach,, S. Downs,, R. D. Collins,, D. W. Ballard, and, J. Hawiger. 2004. Suppression of staphylococcal enterotoxin B-induced toxicity by a nuclear import inhibitor. J. Biol. Chem. 279:1923919246.
59. Marrack, P., and, J. Kappler. 1990. The staphylococcal enterotoxins and their relatives. Science 248:705709.
60. Matthys, P.,, T. Mitera,, H. Heremans,, J. Van Damme, and, A. Billiau. 1995. Anti-gamma interferon and anti-interleukin-6 antibodies affect staphylococcal enterotoxin B-induced weight loss, hypoglycemia, and cytokine release in D-galactosamine-sensitized and unsensitized mice. Infect. Immun. 63:11581164.
61. Mattix, M. E.,, R. E. Hunt,, C. L. Wilhelmsen,, A. J. Johnson, and, W. B. Baze. 1995. Aerosolized staphylococcal enterotoxin B-induced pulmonary lesions in rhesus monkeys (Macaca mulatta). Toxicol. Pathol. 23:262268.
62. Mattsson, E.,, H. Herwald, and, A. Egsten. 2003. Superantigens from Staphylococcus aureus induce proco-agulant activity and monocyte tissue factor expression in whole blood and mononuclear cells via IL-1 β. J. Thromb. Haemost. 1:25692575.
63. McCormack, J. E.,, J. E. Callahan,, J. Kappler, and, P. C. Marrack. 1993. Profound deletion of mature T cells in vivo by chronic exposure to endogenous superantigen. J. Immunol. 150:37853792.
64. McCormick, J. K.,, J. M. Yarwood, and, P. M. Schlievert. 2001. Toxic shock syndrome and bacterial super-antigens: an update. Annu. Rev. Microbiol. 55:77104.
65. McKay, D. M. 2001. Bacterial superantigens: provocateurs of gut dysfunction and inflammation? Trends Immunol. 22:497501.
66. Mehindate, K.,, R. al-Daccak,, F. Damdoumi, and, W. Mourad. 1996. Synergistic effect between CD40 and class II signals overcomes the requirement for class II dimerization in superantigen-induced cytokine gene expression. Eur. J. Immunol. 26:20752080.
67. Meissner, H. C., and, D. Y. M. Leung. 2000. Superantigens, conventional antigens and the etiology of Kawasaki syndrome. Pediatr. Infect. Dis. J. 19:9194.
68. Meissner, H. C., and, D. Y. M. Leung. 2003. Kawasaki Syndrome: where are the answers. Pediatrics 112:672676.
69. Miethke, T.,, C. Wahl,, K. Heeg,, B. Echtenacher,, P. H. Krammer, and, H. Wagner. 1992. T cell-mediated lethal shock triggered in mice by the superantigen staphylococcal enterotoxin B: critical role of tumor necrosis factor. J. Exp. Med. 175:9198.
70. Miethke, T.,, C. Wahl,, K. Heeg,, B. Echtenacher,, P. H. Krammer, and, H. Wagner. 1993. Superantigen mediated shock: a cytokine release syndrome. Immunobiology 189:270284.
71. Miller, C.,, J. Ragheb, and, R. Schwartz. 1999. Anergy and cytokine-mediated suppression as distinct super-antigen-induced tolerance mechanisms in vivo. J. Exp. Med. 190:5364.
72. Mollick, J. A.,, M. Chintagumpala,, R. G. Cook, and, R. R. Rich. 1991. Staphylococcal exotoxin activation of T cells. Role of exotoxin-MHC class II binding affinity and class II isotype. J. Immunol. 146:463468.
73. Monday, S. R., and, G. A. Bohach. 1999. Properties of Staphylococcus aureus enterotoxins and toxic shock syndrome toxin-1, p. 589610. In J. E. Alouf and, J. H. Freer (ed.), The Comprehensive Sourcebook of Bacterial Protein Toxins. Academic Press, London.
74. Mourad, W.,, K. Mehindate,, T. Schall, and, S. McColl. 1992. Engagement of MHC class II molecules by superantigen induces inflammatory cytokine gene expression in human rheumatoid fibroblast-like synoviocytes. J. Exp. Med. 175:613616.
75. Neumann, B.,, B. Engelhardt,, H. Wagner, and, B. Holzmann. 1997. Induction of acute inflammatory lung injury by staphylococcal enterotoxin B. J. Immunol. 158:18621871.
76. Norrby-Teglund, A.,, S. Chatellier,, D. E. Low,, A. McGeer,, K. Green, and, M. Kotb. 2000. Host variation in cytokine responses to superantigens determines the severity of invasive group A streptococcal infection. Eur.J. Immunol. 30:32473255.
77. Origuchi, T.,, K. Eguchi,, Y. Kawabe,, I. Yamashita,, A. Mizokami,, H. Ida, and, S. Nagataki. 1995. Increased levels of serum IgM antibody to staphylococcal enterotoxin B in patients with rheumatoid arthritis. Ann. Rheum. Dis. 54:713732.
78. Ou, L. S.,, E. Goleva,, C. Hall, and, L. Y. Leung. 2004. T regulatory cells in atopic dermatitis and subversion of their activity by superantigens. J. Clin. Allergy Immunol. 113:756763.
79. Papageorgiou, A. C., and, K. R. Acharya. 2000. Microbial superantigens: from structure to function. Trends Microbiol. 8:369375.
80. Parsonnet, J. 1989. Mediators in the pathogenesis of toxic shock syndrome: overview. Rev. Infect. Dis. 11:S263S269.
81. Pless, D. D.,, G. Ruthel,, E. K. Reinke,, R. G. Ulrich, and, S. Bavari. 2005. Persistence of zinc-binding bacterial superantigens at the surface of antigen-presenting cells contributes to the extreme potency of these superantigens as T-cell activators. Infect. Immun. 73:53585366.
82. Proft, T., and, J. D. Fraser. 2003. Bacterial superantigens. Clin. Exp. Immunol. 133:299306.
83. Proft, T.,, S. Sriskandan,, L. Yang, and, J. D. Fraser. 2003. Superantigens and streptococcal toxic shock syndrome. Emerg. Infect. Dis. 9: 12111218.
84. Rajagopalan, G.,, M. M. Sen, and, C. S. David. 2004. In vitro and in vivo evaluation of staphylococcal superantigen peptide antagonists. Infect. Immun. 72:67336737.
85. Saha, B.,, B. Jaklic,, D. M. Harlan,, G. S. Gray,, C. H. June, and, R. Abe. 1996. Toxic shock syndrome toxin-1 induced death is prevented by CTLA4Ig. J. Immunol. 157:38693875.
86. Sarawar, S. R.,, M. A. Blackman, and, P. C. Doherty. 1994. Superantigen shock in mice with an inapparent viral infection. J. Infect. Dis. 170:11891194.
87. Scheuber, P. H.,, C. Denzlinger,, D. Wilker,, G. Beck,, D. Keppler, and, D. K. Hammer. 1987. Staphylococcal enterotoxin B as a nonimmunological mast cell stimulus in primates: the role of endogenous cysteinyl leukotrienes. Int. Arch. Allergy Appl. Immunol. 82:289291.
88. Scholl, P.,, R. Sekaly,, A. Diez,, L. Glimcher, and, R. Geha. 1990. Binding of toxic shock syndrome toxin-1 to murine major histocompatibility complex class II molecules. Eur. J. Immunol. 20: 19111916.
89. Scholl, P. R.,, N. Trede,, T. A. Chatila, and, R. S. Geha. 1992. Role of protein tyrosine phosphorylation in monokine induction by the staphylococcal superantigen toxic shock syndrome toxin-1. J. Immunol. 148:22372241.
90. Schwab, J. H.,, R. R. Brown,, S. K. Anderle, and, P. M. Schlievert. 1993. Superantigen can reactivate bacterial cell wall-induced arthritis. J. Immunol. 150:41314138.
91. See, R. H., and, A. W. Chow. 1992. Staphylococcal toxic shock syndrome toxin 1-induced tumor necrosis factor alpha and interleukin-1 β secretion by human peripheral blood monocytes and T lymphocytes is differentially suppressed by protein kinase inhibitors. Infect. Immun. 60:34563459.
92. See, R. H.,, W. W. Kum,, A. H. Chang,, S. H. Goh, and, A. W. Chow. 1992. Induction of tumor necrosis factor and interleukin-1 by purified staphylococcal toxic shock syndrome toxin 1 requires the presence of both monocytes and T lymphocytes. Infect. Immun. 60:26122618.
93. Spiekermann, G. M., and, C. Nagler-Anderson. 1998. Oral adminstration of the bacterial superantigen staphylococcal enterotoxin B induces activation and cytokine production by T cells in murine gut-associated lymphoid tissue. J. Immunol. 161:58255831.
94. Sriskandan, S.,, M. Unnikrishnan,, T. Krausz,, H. Dewchand,, S. Van Noorden,, J. Cohen, and, D. M. Altmann. 2001. Enhanced susceptibility to superantigen-associated streptococcal sepsis in human leukocyte antigen-DQ transgenic mice. J. Infect. Dis. 184:166173.
95. Stiles, B. G.,, S. Bavari,, T. Krakauer, and, R. G. Ulrich. 1993. Toxicity of staphylococcal enterotoxins potentiated by lipopolysaccharide: major histocompatibility complex class II molecule dependency and cytokine release. Infect. Immun. 61:53335338.
96. Sugiyama, H.,, E. M. McKissic,, M. S. Bergdoll, and, B. Heller. 1964. Enhancement of bacterial endotoxin lethality by staphylococcal enterotoxin. J. Infect. Dis. 4: 111118.
97. Sundstedt, A.,, L. Hoiden,, A. Rosendahl,, T. Kalland,, N. van Rooijen, and, M. Dohlsten. 1997. Immunoregulatory role of IL-10 during superantigen-induced-hyporesponsiveness in vivo. J. Immunol. 158:180186.
98. Tak, P. P., and, G. S. Firestein, 2001. NFkB: a key role in inflammatory diseases. J. Clin. Invest. 107:711.
99. Tessier, P. A.,, P. H. Naccache,, K. R. Diener,, R. P. Gladue,, K. S. Neote,, I. Clark-Lewis, and, S. R. McColl. 1998. Induction of acute inflammation in vivo by staphylococcal superantigens. II. Critical role for chemokines, ICAM-1, and TNF-alpha. J. Immunol. 161:12041211.
100. Thibodeau, J.,, I. Cloutier,, P. M. Lavoie,, N. Labrecque,, W. Mourad,, T. Jardetzky, and, R. P. Sekaly. 1994. Subsets of HLA-DR1 molecules defined by SEB and TSST-1 binding. Science 266:18741878.
101. Tiedemann, R. E., and, J. D. Fraser. 1996. Cross-linking of MHC class II molecules by staphylococcal enterotoxin A is essential for antigen-presenting cell and T cell activation. J. Immunol. 157:39583966.
102. Trede, N. S.,, R. S. Geha, and, T. Chatila. 1991. Transcriptional activation of IL-1 beta and tumor necrosis factor-alpha genes by MHC class II ligands. J. Immunol. 146:23102315.
103. Tschaikowsky, K. J.,, J. Schmidt, and, M. Meisner. 1999. Modulation of mouse endotoxin shock by inhibition of phosphatidylcholine-specific phospholipase C. J. Pharmacol. Exp. Ther. 285:800804.
104. Ulrich, R. G.,, S. Bavari, and, M. A. Olson. 1995. Staphylococcal enterotoxins A and B share a common structural motif for binding class II major histocompatibility complex molecules. Nat. Struct. Biol. 2:554560.
105. Visvanathan, K.,, A. Charles,, J. Bannan,, P. Pugach,, K. Kashfi, and, J. B. Zabriskie. 2001. Inhibition of bacterial superantigens by peptides and antibodies. Infect. Immun. 69:875884.
106. Yarovinsky, T. O.,, M. P. Mohning,, M. A. Bradford,, M. M. Monick, and, G. W. Hunninghake. 2005. Increased sensitivity to staphylococcal enterotoxin B following adenoviral infection. Infect. Immun. 73:33753381.
107. Yarwood, J. M.,, D. Y. Leung, and, P. M. Schlievert. 2000. Evidence for the involvement of bacterial superantigens in psoriasis, atopic dermatitis, and Kawasaki syndrome. FEMS Microbiol. Lett. 192:17.
108. Zhang, W. J.,, S. Sarawar,, P. Nguyen,, K. Daly,, J. E. Rehg,, P. C. Doherty,, D. L. Woodland, and, M. A. Blackmail. 1996. Lethal synergism between influenza infection and staphylococcal enterotoxin B in mice. J. Immunol. 157:50495060.
109. Zhao, Y. X.,, A. Abdelnour,, T. Kalland, and, A. Tarkowski. 1995. Overexpression of the T-cell receptor Vb3 in transgenic mice increases mortality during infection by enterotoxin A-producing Staphylococcus aureus. Infect. Immun. 63: 44634469.

Tables

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Table 1.

Small nonpeptide therapeutics for SEB-induced shock

Citation: Krakauer T. 2007. Small Nonpeptide Inhibitors of Staphylococcal Superantigen-Induced Cytokine Production and Toxic Shock, p 229-244. In Kotb M, Fraser J (ed), Superantigens. ASM Press, Washington, DC. doi: 10.1128/9781555815844.ch15

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