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Virulence Mechanisms of Bacterial Pathogens, Fourth Edition

Editors: Kim A. Brogden1, F. Chris Minion2, Nancy Cornick3, Thaddeus B. Stanton4, Qijing Zhang5, Lisa K. Nolan6, Michael J. Wannemuehler7
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Affiliations: 1: Department of Periodontics and Dows Institute for Dental Research,College of Dentistry, The University of Iowa, Iowa City, Iowa; 2: Department of Veterinary Microbiology and Preventive Medicine, College of Veterinary Medicine, Iowa State University, Ames, Iowa; 3: Department of Veterinary Microbiology and Preventive Medicine, College of Veterinary Medicine, Iowa State University, Ames, Iowa; 4: National Animal Disease Center, Agricultural Research Service, U.S. Department of Agriculture, Ames, Iowa; 5: Department of Veterinary Microbiology and Preventive Medicine, College of Veterinary Medicine, Iowa State University, Ames, Iowa; 6: Department of Veterinary Microbiology and Preventive Medicine, College of Veterinary Medicine, Iowa State University, Ames, Iowa; 7: Department of Veterinary Microbiology and Preventive Medicine, College of Veterinary Medicine, Iowa State University, Ames, Iowa
Content Type: Monograph
Format: Hardcover
Publication Year: 2007

Category: Bacterial Pathogenesis

MyBook is a cheap paperback edition of the original book and will be sold at uniform, low price.

Bacterial diseases remain a critical issue in public health despite the advent of antibiotics, and the problem presents a rich field for genetic and molecular biology applications. The fourth edition of presents entirely new material on this issue in a ground-breaking overview of the latest knowledge. Internationally recognized authorities explain the wide variety of mechanisms used by bacterial pathogens to cause disease, and then summarize proven strategies for overcoming bacterial virulence mechanisms.

Organized into six accessible sections, this unique volume broadly reviews the pathogenesis of bacterial diseases and mechanisms of host-pathogen interactions for non-specialists and advanced students in the fields of bacteriology and immunology. Beginning with a section on virulence genes, the book continues with sections on pathogenic microbial communities; bacterial attachment, invasion, and colonization; bacterial effects on host cells; and resistance to pathogens. The last section contains a concluding perspective on the state and future of studies on bacterial pathogenicity.

The study of bacterial pathogenicity is now one of the most popular subjects in microbiology. This volume provides an essential source of the latest information on the mechanisms of bacterial pathogens and also serves as a textbook for graduate courses on bacterial pathogenesis. The contents will be vital to specialists in bacterial pathogenicity, such as molecular biologists, physician scientists, dental scientists, veterinarians, molecular biologists, industry researchers, and technicians.

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Doody Enterprises

16 July 2013

At A Glance

The third edition of this best-selling volume provides an overview of current knowledge of the wide variety of mechanisms used by bacterial pathogens in establishing infection, producing disease, and persisting in the host.

Internationally recognized authorities in the field review bacterial invasion, colonization, and survival; bacterial evasion of host defense mechanisms; bacterial effects on host cell function; and identification, regulation, and transfer of virulence genes. The final chapter presents an interesting examination of new methods for studying virulence mechanisms in the complex in vivo-environment, a major development in studies of bacterial pathogenicity. The overall emphasis is on understanding the mechanisms of host-pathogen interactions rather than on focusing on specific research approaches.

Description

The increase in technology has allowed researchers the ability to evaluate pathogenicity of bacteria using newer methods with the hope that this information will lead to new diagnostic tests and drugs to prevent and treat these infectious diseases. This book is a compilation of chapters on topics in bacterial pathogenicity.

Purpose

The editor states that the purpose is to provide a "source of information on the virulence mechanisms of bacterial pathogens." Due to the rapid advances that have occurred since the last edition, this edition is necessary to add the current information needed to move the scientific research ahead.

Audience

This is an appropriate reference for researchers in bacterial pathogenicity as well as a textbook for graduate students in this field. The authors are all published experts in the field of bacterial pathogenicity.

Features

More than 35 authors write the 22 chapters. These chapters review research on at least eight different bacterial pathogens as well as the effect of normal bacterial flora on disease progression. A unique chapter on the commensal bacteria and the effect of this bacterial population on disease shows evidence that the products of bacterial metabolism have a great impact on other normal bacterial flora. It is interesting that the diets of the mammalian host in which bacteria are found in large numbers in the gastrointestinal tract affect this metabolism. These bacterial by-products then affect the host cells as well as the neighboring bacterial cells. It is an interesting thought that normal bacterial flora may be a key to preventing disease. Other chapters provide up-to-date information on mechanisms of pathogenicity as well as host responses.

Assessment

This would be a good textbook for a graduate course to study the various mechanisms by which bacteria cause disease. This is a solid new review of various virulence mechanisms used by bacteria.

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Reviewer: Rebecca Horvat, PhD, D(ABMM) (University of Kansas Medical Center)

Review Date: Unknown

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