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Chapter 6 : Introduction
This is the introductory chapter to the section Immunoglobulin Methods. The section examines the topics of immunoglobulin production by gene rearrangements, the measurement of immunoglobulins, identification of monoclonal protein products by serum protein electrophoresis and immunofixation, detection of oligoclonal bands in cerebrospinal fluid, and characterization of cryoglobulin, cryofibrinogen, and pyroglobulins. The chapter states how the other chapters(7th to 11th chapters) in the book are organized. The chapter by Kipps (chapter 7) examines the genes that code for immunoglobulins. Warren (chapter 8) overviews how the immunoglobulin structure is related to its function and the utility of serum viscosity evaluations. In chapter 9, Keren and Humphrey review the technical details and clinical applications of serum and urine protein electrophoresis. Katzmann and Kyle (chapter 10) present a thorough review of characterization of monoclonal gammopathies in serum and urine by immunofixation and immunosubtraction. Gorevic and Galanakis (chapter 11) present the state of the art for detecting and measuring cryoglobulins, cryofibrinogenemia, and pyroglobulins.