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Chapter 8 : Immunoglobulin Quantification and Viscosity Measurement
Quantification of intact immunoglobulins has proven useful in the evaluation of patients with suspected immunodeficiency syndromes, B-cell and plasma cell neoplastic diseases, allergic conditions, and chronic inflammatory and autoimmune disorders. This chapter provides a review of immunoglobulin structure, important because of its direct relevance to quantitative immunoglobulin measurement. It presents an overview of assay methods, issues related to quality control and assurance, and test validation, as well as a brief discussion of the clinical application of immunoglobulin measurements. Finally, the chapter addresses both technical and clinical aspects of viscosity measurement.