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Chapter 8 : Immunoglobulin Quantification and Viscosity Measurement

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Abstract:

Quantification of intact immunoglobulins has proven useful in the evaluation of patients with suspected immunodeficiency syndromes, B-cell and plasma cell neoplastic diseases, allergic conditions, and chronic inflammatory and autoimmune disorders. This chapter provides a review of immunoglobulin structure, important because of its direct relevance to quantitative immunoglobulin measurement. It presents an overview of assay methods, issues related to quality control and assurance, and test validation, as well as a brief discussion of the clinical application of immunoglobulin measurements. Finally, the chapter addresses both technical and clinical aspects of viscosity measurement.

Citation: Warren J. 2006. Immunoglobulin Quantification and Viscosity Measurement, p 69-74. In Detrick B, Hamilton R, Folds J (ed), Manual of Molecular and Clinical Laboratory Immunology, 7th Edition. ASM Press, Washington, DC. doi: 10.1128/9781555815905.ch8

Key Concept Ranking

Immunoglobulin G
0.6265625
Immunoglobulin Structure
0.6210619
Immune Systems
0.53446996
Amino Acids
0.50621146
0.6265625
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References

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Tables

Generic image for table
TABLE 1

Characteristics of immunoglobulins

Citation: Warren J. 2006. Immunoglobulin Quantification and Viscosity Measurement, p 69-74. In Detrick B, Hamilton R, Folds J (ed), Manual of Molecular and Clinical Laboratory Immunology, 7th Edition. ASM Press, Washington, DC. doi: 10.1128/9781555815905.ch8
Generic image for table
TABLE 2

Characteristics of IgG subclasses

Citation: Warren J. 2006. Immunoglobulin Quantification and Viscosity Measurement, p 69-74. In Detrick B, Hamilton R, Folds J (ed), Manual of Molecular and Clinical Laboratory Immunology, 7th Edition. ASM Press, Washington, DC. doi: 10.1128/9781555815905.ch8

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