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Chapter 109 : Tests for Immunological Reactions to Foods

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Abstract:

Food allergy is defined as an adverse immunological response to food. Some of the tests discussed in this chapter not only aid in the diagnosis of food allergies, but also are useful in monitoring the natural history of patients' food allergies over time, from diagnosis to oral tolerance. Once food allergy has been identified as the likely cause of symptoms, confirmation of the diagnosis and identification of the implicated food(s) can begin. There are a number of tools that aid in the diagnosis of food allergy, some of which are more commonly used, and they vary in their ability to provide an accurate diagnosis. Available studies include in vivo tests such as skin prick and intradermal testing, oral food challenges (OFCs), elimination diets, and patch testing and in vitro tests such as quantification of food-specific IgE and basophil histamine release (BHR). Tests that have not proven helpful in food allergy diagnosis include quantification of food-specific IgG, total serum IgE levels, BHR, and serum tryptase concentrations. Tests that need further study but show some promise include the atopy patch tests (APT), which may aid in the diagnosis of non-IgE-mediated disorders and delayed reactions to foods. Finally, important features of the studies mentioned in this chapter for the described tests that need to be appreciated by clinicians are (i) that the data generated may be particular to the study population and test material and (ii) that the age and clinical disease of the patients are important variables.

Citation: Fleischer D, Wood R. 2006. Tests for Immunological Reactions to Foods, p 975-983. In Detrick B, Hamilton R, Folds J (ed), Manual of Molecular and Clinical Laboratory Immunology, 7th Edition. ASM Press, Washington, DC. doi: 10.1128/9781555815905.ch109

Key Concept Ranking

Atopic Dermatitis
0.61711144
Fruits and Vegetables
0.5397602
Allergic Rhinitis
0.49168235
Respiratory Diseases
0.4698657
Fresh Fruits and Vegetables
0.4409524
0.61711144
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References

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Tables

Generic image for table
TABLE 1

Food allergy disorders

Citation: Fleischer D, Wood R. 2006. Tests for Immunological Reactions to Foods, p 975-983. In Detrick B, Hamilton R, Folds J (ed), Manual of Molecular and Clinical Laboratory Immunology, 7th Edition. ASM Press, Washington, DC. doi: 10.1128/9781555815905.ch109
Generic image for table
TABLE 2

Signs and symptoms of food-induced allergic reactions

Citation: Fleischer D, Wood R. 2006. Tests for Immunological Reactions to Foods, p 975-983. In Detrick B, Hamilton R, Folds J (ed), Manual of Molecular and Clinical Laboratory Immunology, 7th Edition. ASM Press, Washington, DC. doi: 10.1128/9781555815905.ch109

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