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Chapter 12 : Analysis of Complement in the Clinical Laboratory

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Analysis of Complement in the Clinical Laboratory, Page 1 of 2

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Abstract:

Complement provides a fast-acting mechanism for the identification and removal of foreign substances before the more specific arms of the adaptive immune system can come into play. Many clinical laboratories have shied away from the analysis of complement, due in large part to the liability of the system and the special handling that samples require if the results are to be reliable. The symptoms of inflammation associated with complement activation are due to a limited number of biologically active complement split products that are produced by the enzymatic cascade. Neutrophils, monocytes, macrophages, eosinophils, and mast cells can be enticed to perform many of their tricks (e.g., chemotaxis and mediator and enzyme release) by the complement fragments. The major control of the alternative pathway (AP) occurs through the action of two proteins that stop the cleavage of C3.

Citation: Giclas P. 2006. Analysis of Complement in the Clinical Laboratory, p 115-117. In Detrick B, Hamilton R, Folds J (ed), Manual of Molecular and Clinical Laboratory Immunology, 7th Edition. ASM Press, Washington, DC. doi: 10.1128/9781555815905.ch12

Key Concept Ranking

Complement System
0.63713664
Adaptive Immune System
0.56129855
White Blood Cells
0.45395982
0.63713664
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Figures

Image of FIGURE 1
FIGURE 1

CP, LP, and AP of the human complement system, showing the control steps and where some of the biologically active split products are produced.

Citation: Giclas P. 2006. Analysis of Complement in the Clinical Laboratory, p 115-117. In Detrick B, Hamilton R, Folds J (ed), Manual of Molecular and Clinical Laboratory Immunology, 7th Edition. ASM Press, Washington, DC. doi: 10.1128/9781555815905.ch12
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