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Chapter 124 : Cardiovascular Diseases

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Abstract:

Cardiovascular diseases comprise a broad spectrum of disorders which cause cardiac dysfunction. Vascular diseases such as hypertension, atherosclerosis, and acute and chronic coronary artery disease, which adversely influence systemic hemodynamics, indirectly cause cardiac dysfunction by causing acute myocardial infarction (AMI) or by promoting heart muscle disease. Cardiomyopathies are classified as hypertropic, restrictive, dilated, arrhythmogenic right ventricular, unclassified, or specific. Specific cardiomyopathies describe heart muscle diseases that have been further defined based in part on their etiologies and their association with specific systemic or cardiac disorders. This chapter focuses exclusively on the current knowledge of immunologic aspects involved in the etiology and pathogenesis of cardiomyopathies and the application of immunological and molecular techniques for measuring and characterizing relevant biomarkers used in the detection and assessment of myocardial damage and in determining the diagnosis and prognosis of related cardiovascular diseases.

Citation: Sundstrom J, Burek C, Rose N, Ansari A. 2006. Cardiovascular Diseases, p 1101-1109. In Detrick B, Hamilton R, Folds J (ed), Manual of Molecular and Clinical Laboratory Immunology, 7th Edition. ASM Press, Washington, DC. doi: 10.1128/9781555815905.ch124

Key Concept Ranking

Coronary Artery Disease
0.6336735
Rheumatic Heart Disease
0.63186234
Clinical Immunology
0.4674179
Rocky Mountain Spotted Fever
0.45406315
Tumor Necrosis Factor alpha
0.45406315
Rocky Mountain Spotted Fever
0.45406315
0.6336735
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Tables

Generic image for table
TABLE 1

Serum biomarkers used for diagnosis of AMI

Citation: Sundstrom J, Burek C, Rose N, Ansari A. 2006. Cardiovascular Diseases, p 1101-1109. In Detrick B, Hamilton R, Folds J (ed), Manual of Molecular and Clinical Laboratory Immunology, 7th Edition. ASM Press, Washington, DC. doi: 10.1128/9781555815905.ch124
Generic image for table
TABLE 2

Serum biomarkers for CMI

Citation: Sundstrom J, Burek C, Rose N, Ansari A. 2006. Cardiovascular Diseases, p 1101-1109. In Detrick B, Hamilton R, Folds J (ed), Manual of Molecular and Clinical Laboratory Immunology, 7th Edition. ASM Press, Washington, DC. doi: 10.1128/9781555815905.ch124
Generic image for table
TABLE 3

Infectious and noninfectious etiologies of inflammatory cardiomyopathy

Citation: Sundstrom J, Burek C, Rose N, Ansari A. 2006. Cardiovascular Diseases, p 1101-1109. In Detrick B, Hamilton R, Folds J (ed), Manual of Molecular and Clinical Laboratory Immunology, 7th Edition. ASM Press, Washington, DC. doi: 10.1128/9781555815905.ch124
Generic image for table
TABLE 4

Autoantibodies detected in inflammatory cardiomyopathies

Citation: Sundstrom J, Burek C, Rose N, Ansari A. 2006. Cardiovascular Diseases, p 1101-1109. In Detrick B, Hamilton R, Folds J (ed), Manual of Molecular and Clinical Laboratory Immunology, 7th Edition. ASM Press, Washington, DC. doi: 10.1128/9781555815905.ch124
Generic image for table
TABLE 5

Clinical immunological assays for detection and characterization of inflammatory heart disease

Citation: Sundstrom J, Burek C, Rose N, Ansari A. 2006. Cardiovascular Diseases, p 1101-1109. In Detrick B, Hamilton R, Folds J (ed), Manual of Molecular and Clinical Laboratory Immunology, 7th Edition. ASM Press, Washington, DC. doi: 10.1128/9781555815905.ch124

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