Chapter 135 : Histocompatibility Testing after Fifty Years of Transplantation

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Early attempts in human transplantation were limited by the immunosuppressive regimens which comprised primarily steroids, irradiation, and azathioprine. The development of clinical transplantation has fostered growth in understanding of the alloimmune response and of the major histocompatibility complex and in histocompatibility assessment. For much of the past 50 years of transplantation, the primary assay for histocompatibility testing, which can be used both for typing and for alloantibody detection, has been the complement-dependent cytotoxicity test. Molecular typing methods and solid-phase immunoassays are enabling histocompatibility laboratories to adapt testing to meet the changing needs of transplant patients. Three of the chapters in this section focus on the methods that are being used to monitor and evaluate transplant patients. For transplants with some degree of HLA mismatching, accurate determination of humoral sensitization is required to assess the risk of engraftment failure due to antibody-mediated rejection. The remaining chapters in this section address these newer issues for bone marrow and stem cell transplantation.

Citation: Leffell M. 2006. Histocompatibility Testing after Fifty Years of Transplantation, p 1195-1197. In Detrick B, Hamilton R, Folds J (ed), Manual of Molecular and Clinical Laboratory Immunology, 7th Edition. ASM Press, Washington, DC. doi: 10.1128/9781555815905.ch135

Key Concept Ranking

Major Histocompatibility Complex
Hematopoietic Stem Cell Transplantation
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