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Chapter 90 : Coronavirus Including Severe Acute Respiratory Syndrome (SARS)

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Coronavirus Including Severe Acute Respiratory Syndrome (SARS), Page 1 of 2

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Abstract:

, (CoV) a genus within the family , contains a number of enveloped viruses that infect both animals and humans. CoVs have been identified in mice, rats, chickens, turkeys, swine, dogs, cats, rabbits, horses, cattle, and humans and cause a variety of severe diseases, including gastroenteritis and respiratory tract diseases. Severe Acute Respiratory Syndrome (SARS) first appeared as a potentially fatal cause of pneumonia in Guangdong Province of China in November 2002. The first human case was identified on 16 November, and within 6 months SARS spread to 29 countries, infecting 8,098 people and killing 774 individuals. The major route of transmission in humans is droplet infection, aerosolization, and fomites. Deposition of droplets onto the respiratory epithelium probably initiates infection. Whether infection can occur through the oral or conjunctival epithelium remains unknown, but SARS-CoV has been detected in tears. Virus can also be detected in serum, plasma, and peripheral blood leukocytes by RT-PCR; however, the viremia may be short-lived. Isolation of SARS-CoV in cell culture followed by determination of its partial genome sequence led to the first generation of RT-PCR assays for diagnosing SARS. Real-time PCR assays that provide viral loads may also be useful for identifying patients at increased risk for worse outcomes in terms of survival and requirement for intensive care and assisted ventilation.

Citation: Mahony J, Zhang C. 2006. Coronavirus Including Severe Acute Respiratory Syndrome (SARS), p 803-809. In Detrick B, Hamilton R, Folds J (ed), Manual of Molecular and Clinical Laboratory Immunology, 7th Edition. ASM Press, Washington, DC. doi: 10.1128/9781555815905.ch90

Key Concept Ranking

Severe Acute Respiratory Syndrome
0.56100845
Lower Respiratory Tract Infections
0.5557124
Upper Respiratory Tract Infections
0.5470761
Nucleic Acid Amplification Techniques
0.49565104
Respiratory syncytial virus
0.4645685
0.56100845
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References

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1. Adachi, D.,, G. Johnson,, R. Draker,, M. Ayers,, T. Mazzulli,, P. J. Talbot, and , R. Tellier. 2004. Comprehensive detection and identification of human coronaviruses, including SARS-associated coronavirus, with a single RT-PCR assay. J. Virol. Methods 122:2936.
2. Chan, K. H.,, L. L. M. Poon,, V. C. C. Cheng, et al. 2003. Detection of SARS coronavirus (ScoV) by RT-PCR, culture, and serology in patients with severe acute respiratory syndrome (SARS). Emerg. Infect. Dis. 10:194199.
3. Drosten, C.,, L. L. Chiu,, M. Panning,, H. N. Leong,, W. Preiser,, J. S. Tarn,, S. Gunther,, S. Kramme,, P. Emmerich,, W. L. Ng,, H. Schmitz, and , E. S. Koay. 2004. Evaluation of advanced reverse transcription-PCR assays and an alternative PCR target region for detection of severe acute respiratory syndrome-associated coronavirus. J. Clin. Microbiol. 42:20432047.
4. Falsey, A. R.,, E. F. Walsh, and , E. G. Hayden. 2002. Rhinovirus and coronavirus infection-associated hospitali-zation: among older adults. J. Infect. Dis. 185:13381341.
5. Forman, M. S., and , A. Valsamakis. 2003. Specimen collection, transport, and processing: virology, p. 12271241. In P. R. Murray et al. (ed.), Manual of Clinical Microbiology, 8th ed. ASM Press, Washington, D.C.
6. Fourchier, R. A. M.,, N. G. Hartwig,, T. M. Bestebroer,, B. Niemeyer,, J. C. de Jong,, J. H. Simon, and , A. D. M. F. Osterhaus. 2004. A previously undescribed coronavirus associated with respiratory disease in humans. Proc. Natl. Acad. Sci. USA 101:62126216.
7. Goh, D. L.,, B. W. Lee,, K. S. Chia,, B. H. Heng,, M. Chen,, S. Ma, and , C. C. Tan. 2004. Secondary household transmission of SARS, Singapore. Emerg. Infect. Dis. 10:232234.
8. Grant, P. R.,, J. A. Garson,, R. S. Tedder,, P. K. Chan,, J. S. Tarn, and , J. J. Sung. 2003. Detection of SARS coronavirus in plasma by real-time PCR. N. Engl. J. Med. 349:24682469.
9. Guan, Y.,, B. J. Zeng,, Y. Q. He,, X. L. Liu,, Z. X. Zhuang,, C. L. Cheung,, S. W. Luo,, P. H. Li,, L. J. Zhang,, Y. J. Guan,, K. M. Butt,, K. L. Wong,, K. W. Chan,, W. Lim,, K. F. Shortridge,, K. Y. Yuen,, J. S. Peiris, and , L. L. Poon. 2003. Isolation and characterization of viruses related to the SARS coronavirus from animals in Southern China. Science 302:276278.
10. Han, P.,, H. G. Kim,, Y. B. Kim,, L. L. M. Poon, and , M. W. Cho. 2004. Development of a safe neutralization assay for SARS-CoV and characterization of S-glycoprotein. Virology 326:140149.
11. Hon, K. L., et al. 2004. Clinical presentation and outcome of severe acute respiratory syndrome in children. Lancet 361:17011703.
12. Lai, M. M., and , D. Cavanagh. 1997. The molecular biology of coronaviruses. Adv. Virus Res. 48:1100.
13. Leung, D. T. M.,, E. C. H. Tarn,, C. H. Ma,, P. K. S. Chan,, J. L. K. Cheung,, H. Niu,, J. S. L. Tarn, and , P. L. Lim. 2004. Antibody response of patients with severe acute respiratory syndrome (SARS) targets the viral nucleocapsid. J. Infect. Dis. 190:379386.
14. Mahony, J. B.,, A. Petrich,, L. Louie,, X. Song,, S. Chong,, M. Smieja,, M. Chernesky,, M. Loeb, and , S. Richardson. 2004. Performance and cost evaluation of one commercial and six in-house conventional and real-time reverse transcriptase PCR assays for detection of severe acute respiratory syndrome coronavirus. J. Clin. Microbiol. 42:14711476.
15. Marra, M. A.,, S. J. Jones,, C. R. Astell,, R. A. Holt,, A. Brooks-Wilson,, Y. S. Butterfield,, J. Khattra,, J. K. Asano,, S. A. Barber,, S. Y. Chan, et al. 2003. The genome sequence of the SARS-associated coronavirus. Science 300:13991404.
16. Peiris, J. S.,, C. M. Chu,, V. C. Cheng, et al. 2003. Clinical progression and viral load in a community outbreak of coronavirus-associated SARS pneumonia: a prospective study. Lancet 361:17671772.
17. Peiris, J. S. M.,, S. T. Lai,, L. L. Poon,, Y. Guan,, L. Y. Yam,, W. Lim,, J. Nicholls,, W. K. Yee,, W. W. Yan,, M. T. Cheung,, V. C. Cheng,, K. H. Chan,, D. N. Tsang,, R. W. Yung,, T. K. Ng,, K. Y. Yuen, and SARS Study Group. 2003. Coronavirus as a possible cause of severe acute respiratory syndrome. Lancet 361:13191325.
18. Pene, F.,, A. Merlat,, A. Vabret,, F. Rozenberg,, A. Buzyn,, F. Dreyfus,, A. Cariou,, F. Freymuth, and , P. Lebon. 2003. Coronavirus 229E-related pneumonia in immunocompro-mised patients. Clin. Infect. Dis. 37:929932.
19. Poon, L. L. M.,, B. M. Wong,, K. H. Chan,, C. S. Leung,, K. Y. Yuen,, Y. Guan, and , J. S. Peiris. 2004. A one step quantitative RT-PCR for detection of SARS coronavirus with an internal control for PCR inhibitors. J. Clin. Virol. 30:214217.
20. Poutanen, S. M.,, D. F. Low,, B. Henry,, S. Finkelstein,, D. Rose,, K. Green, et al. 2003. Identification of severe acute respiratory syndrome in Canada. N. Engl. J. Med. 348:19952005.
21. Sizun, J.,, N. Arbour, and , P. J. Talbot. 1998. Comparison of immunofluorescence with monoclonal antibodies and RT-PCR for the detection of human coronaviruses 229E and OC43 in cell culture. J. Virol. Methods 72:145152.
22. Tang, P.,, M. Louie,, S. Richardson,, M. Smieja,, A. F. Simor,, F. Jamieson,, M. Fearon,, S. M. Poutanen,, T. Mazzulli,, R. Tellier,, J. Mahony,, M. Loeb,, A. Petrich,, M. Chernesky,, A. McGeer,, D. F. Low,, F. Phillips,, S. Jones,, N. Bastien,, Y. Li,, D. Dick,, A. Grolla,, L. Fernando,, T. F. Booth,, B. Henry,, A. R. Rachlis,, L. M. Matukas,, D. B. Rose,, R. Lovinsky,, S. Walmsley,, W. L. Gold. and , S. Krajden. 2004. Interpretation of diagnostic laboratory tests for severe acute respiratory syndrome; the Toronto experience. Can. Med. Assoc. J. 170:4754.
23. Vabret, A.,, T. Mourez,, S. Gouarin,, J. Petitjean, and , F. Freymuth. 2003. An outbreak of coronavirus OC43 respiratory infection in Normandy, France. Clin. Infect. Dis. 36:985989.
24. Vallet, S.,, A. Gagneur,, P. J. Talbot,, M. Legrand,, J. Sizun, and , B. Picard. 2004. Detection of human coronavirus 229E in nasal specimens in large scale studies using an RT-PCR hybridization assay. Mol. Cell. Probes 18:7580.
25. Van der Hoek, L.,, K. Pyrc,, M. F. Jebbink,, W. Vermeulen-Oost,, R. J. M. Berkhout,, K. C. Wolthers,, P. M. F. Wertheim-van Dillen,, J. Kaandorp,, J. Spaargaren, and , B. Berkhout. 2004. Identification of a new human coronavirus. Nat. Med. 10:368373.
26. Woo, P. C.,, S. K. Lan,, B. H. Wong,, H. W. Tsai,, A. M. Fung,, K. H. Chan,, V. K. Tarn,, J. S. Peiris, and , K. Y. Yuen. 2004. Detection of specific antibodies to severe acute respiratory syndrome (SARS) coronavirus nucleocapsid protein for serodiagnosis of SARS coronavirus pneumonia. J. Clin. Microbiol. 42:23062309.
27. Woo, P. C. Y.,, S. K. P. Lau,, C.-M. Chu,, K.-H. Chan,, H.-W. Tsoi,, Y. Hwang,, B. H. L. Wong,, R. W. S. Poon,, J. J. Cai,, W.-K. Luk,, L. L. M. Poon,, S. S. Y. Wong,, Y. Guan,, J. S. M. Peiris, and , K.-Y. Yuen. 2005. Characterization and complete genome sequence of a novel coronavirus, coronavirus HKU1, from patients with pneumonia. J. Virol. 79:884895.
28. World Health Organization. Summary of probable SARS cases with onset of illness from 1 November 2002 to 31 July 2003. http://www.who.int/cst/sars/country/talbe2004_ 04_21/en/.

Tables

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TABLE 1

RT-PCR assays for detection of HCoV

Citation: Mahony J, Zhang C. 2006. Coronavirus Including Severe Acute Respiratory Syndrome (SARS), p 803-809. In Detrick B, Hamilton R, Folds J (ed), Manual of Molecular and Clinical Laboratory Immunology, 7th Edition. ASM Press, Washington, DC. doi: 10.1128/9781555815905.ch90

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