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Chapter 6 : Cephems for Parenteral Use

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Abstract:

Due to the importance of the cephems, it is essential to classify them so as to allow their optimal use. The cephems are characterized by an azetidinone ring, to which is attached an unsaturated hexacycle. Five classes of cephems may be distinguished in terms of the nature of the moiety: cephalosporins, cephamycins and cephabacins, oxa-1-cephems, carba-1-cephems, and miscellaneous. The dosage and dosing frequency of a cephalosporin are the result of a balance between its antibacterial activity and its pharmacokinetic profile. The molecules all have the same antibacterial spectrum, which principally includes gram-negative bacilli and gram-negative and gram-positive cocci, except for . The carbacephem-type molecules are asymmetrical, and the substituents on the β-lactam moiety are in the position; the stereochemistry of the carbacephems is less stable thermodynamically than the trans stereochemistry. The antibacterial activity RWJ-54428 was designed to overcome methicillin resistance in methicillin-resistant (MRSA) strains and ampicillin resistance in by penicillin-binding proteins (PBP) alterations. In all species, total clearance was slower and the apparent elimination half-life was longer than that of RWJ- 54428. The antistaphylococcal activities of RWJ-333442 in comparison with RWJ-54428, vancomycin, and quinupristindalfopristin against Smith were investigated in a sepsis model (Swiss-Webster mice) and were also investigated for 076, a methicillin-resistant strain. A synergistic activity was shown to be species dependent in combination with streptomycin against .

Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6

Key Concept Ranking

beta-Lactam Antibiotics
0.9885363
Gram-Negative Bacteria
0.74303895
Gram-Positive Bacteria
0.73887324
Gram-Positive Cocci
0.6611128
Cephalosporins
0.62025154
Gram-Negative Bacilli
0.60843587
0.9885363
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Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
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Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
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Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
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Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
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Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
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Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
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Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
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Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
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Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
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Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
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Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
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Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
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Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
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Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
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Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
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Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
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Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
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Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
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Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
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Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
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Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
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Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
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Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
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Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
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Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
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Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
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Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
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Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
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Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
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Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
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Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
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Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
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Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
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Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
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Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
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Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
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Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
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Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
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Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
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Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
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Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
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Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
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Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
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Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
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Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
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Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
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Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
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Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
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Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
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Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
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Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
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Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
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Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
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Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
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References

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Tables

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Table 1

Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
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Table 2

Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
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Table 3

Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
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Table 4

Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
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Table 5

Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
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Table 6

Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
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Table 7

Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
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Table 8

Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
Generic image for table
Table 9

Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
Generic image for table
Table 10

Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
Generic image for table
Table 11

Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
Generic image for table
Table 12

Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
Generic image for table
Table 13

Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
Generic image for table
Table 14

Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
Generic image for table
Table 15

Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
Generic image for table
Table 16

Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
Generic image for table
Table 17

Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
Generic image for table
Table 18

Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
Generic image for table
Table 19

Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
Generic image for table
Table 20

Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
Generic image for table
Table 21

Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
Generic image for table
Table 22

Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
Generic image for table
Table 23

Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
Generic image for table
Table 24

Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
Generic image for table
Table 25

Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
Generic image for table
Table 26

Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
Generic image for table
Table 27

Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
Generic image for table
Table 28

Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
Generic image for table
Table 29

Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
Generic image for table
Table 30

Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
Generic image for table
Table 31

Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
Generic image for table
Table 32

Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
Generic image for table
Table 33

Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
Generic image for table
Table 34

Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
Generic image for table
Table 35

Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
Generic image for table
Table 36

Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
Generic image for table
Table 37

Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
Generic image for table
Table 38

Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
Generic image for table
Table 39

Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
Generic image for table
Table 40

Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
Generic image for table
Table 41

Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
Generic image for table
Table 42

Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
Generic image for table
Table 43

Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
Generic image for table
Table 44

Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
Generic image for table
Table 45

Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
Generic image for table
Table 46

Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
Generic image for table
Table 47

Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
Generic image for table
Table 48

Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
Generic image for table
Table 49

Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
Generic image for table
Table 50

Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
Generic image for table
Table 51

Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
Generic image for table
Table 52

Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
Generic image for table
Table 53

Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
Generic image for table
Table 54

Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
Generic image for table
Table 55

Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
Generic image for table
Table 56

Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
Generic image for table
Table 57

Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
Generic image for table
Table 58

Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
Generic image for table
Table 59

Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
Generic image for table
Table 60

Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
Generic image for table
Table 61

Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
Generic image for table
Table 62

Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
Generic image for table
Table 63

Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
Generic image for table
Table 64

Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
Generic image for table
Table 65

Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
Generic image for table
Table 66

Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
Generic image for table
Table 67

Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
Generic image for table
Table 68

Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
Generic image for table
Table 69

Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
Generic image for table
Table 70

Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
Generic image for table
Table 71

Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
Generic image for table
Table 72

Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
Generic image for table
Table 73

Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
Generic image for table
Table 74

Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
Generic image for table
Table 75

Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
Generic image for table
Table 76

Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
Generic image for table
Table 77

Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
Generic image for table
Table 78

Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
Generic image for table
Table 79

Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
Generic image for table
Table 80

Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
Generic image for table
Table 81

Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
Generic image for table
Table 82

Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
Generic image for table
Table 83

Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
Generic image for table
Table 84

Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
Generic image for table
Table 85

Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6
Generic image for table
Table 86

Citation: Bryskier A, Aszodi J. 2005. Cephems for Parenteral Use, p 163-221. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch6

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