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Chapter 10 : Monocyclic β-Lactams

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Abstract:

This chapter focuses on a few models of monocyclic β-lactams in which the structural changes are accompanied by changes to their antibacterial properties. The spectrum of activity of the monocyclic β-lactams: activity of all molecules against gram-negative cocci, , and ; variable activity against spp. and depending on the compound; and lack of activity against gram-positive cocci and anaerobic bacteria. All of the monocyclic β-lactams inhibit spp., , and at concentrations equal to or less than 0.25 µg/ml. The monocyclic β-lactams that have been the subject of killing kinetics studies have killing kinetics similar to those of the other β-lactams. The monocyclic β-lactams represent very weak substrates for the standard β-lactamases of gram-negative bacilli and for this reason are very stable against the hydrolytic activity of these enzymes. At subinhibitory concentrations, aztreonam and carumonam significantly increase the phagocytic activity and bactericidal activity of murine macrophage lines against different species of and . The monocyclic β-lactams exhibit the general pharmacokinetic behavior of β-lactams, with similar parameters for the two types of compounds. The behavior of aztreonam, however, must be interpreted for a few sites where antibiotics diffuse poorly, such as the bronchial mucus, cerebrospinal fluid, prostate, and aqueous humor.

Citation: Le Noc P. 2005. Monocyclic β-Lactams, p 336-347. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch10

Key Concept Ranking

Antibacterial Agents
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beta-Lactamase Inhibitors
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beta-Lactam Antibiotics
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Urinary Tract Infections
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Citation: Le Noc P. 2005. Monocyclic β-Lactams, p 336-347. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch10
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Citation: Le Noc P. 2005. Monocyclic β-Lactams, p 336-347. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch10
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Citation: Le Noc P. 2005. Monocyclic β-Lactams, p 336-347. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch10
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Citation: Le Noc P. 2005. Monocyclic β-Lactams, p 336-347. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch10
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Citation: Le Noc P. 2005. Monocyclic β-Lactams, p 336-347. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch10
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Citation: Le Noc P. 2005. Monocyclic β-Lactams, p 336-347. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch10
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Citation: Le Noc P. 2005. Monocyclic β-Lactams, p 336-347. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch10
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Citation: Le Noc P. 2005. Monocyclic β-Lactams, p 336-347. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch10
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Citation: Le Noc P. 2005. Monocyclic β-Lactams, p 336-347. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch10
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Citation: Le Noc P. 2005. Monocyclic β-Lactams, p 336-347. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch10
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Citation: Le Noc P. 2005. Monocyclic β-Lactams, p 336-347. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch10
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References

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Tables

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Table 1

Citation: Le Noc P. 2005. Monocyclic β-Lactams, p 336-347. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch10
Generic image for table
Table 2

Citation: Le Noc P. 2005. Monocyclic β-Lactams, p 336-347. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch10
Generic image for table
Table 3

Citation: Le Noc P. 2005. Monocyclic β-Lactams, p 336-347. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch10
Generic image for table
Table 4

Citation: Le Noc P. 2005. Monocyclic β-Lactams, p 336-347. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch10
Generic image for table
Table 5

Citation: Le Noc P. 2005. Monocyclic β-Lactams, p 336-347. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch10
Generic image for table
Table 6

Citation: Le Noc P. 2005. Monocyclic β-Lactams, p 336-347. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch10
Generic image for table
Table 7

Citation: Le Noc P. 2005. Monocyclic β-Lactams, p 336-347. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch10

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