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Chapter 14 : β-Lactamase Inhibitors Under Research

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Abstract:

The main modes of resistance to β-lactams are modification of cell targets (penicillin-binding proteins), impermeability of the cell wall, efflux, and production of inactivating enzymes, the β-lactamases. β-Lactamases are a complex family of enzymes, and currently more than 300 unique β-lactamases have been reported for gram-positive and gram-negative bacteria. Research on β-lactamases led to different classifications, one of which is the Ambler classification describing four classes: A, C, D (serine β-lactamases), and B (metalloprotease β-lactamases). β-Lactamase inhibitors can be divided globally into two groups: β-lactams and non-β-lactams. A number of compounds of clavulanic acid have been prepared to explore the structure-activity relationship. It was shown that (i) the lack of the C-4 carboxylic group does not eliminate the β-lactamase inhibitory activity and (ii) a catalytic group at position 2 enhances the inhibitory activity 4 to 10 times. Semisynthetic penicillanic derivatives such as halo penicillanic acid sulfones were designed to mimic the mechanism of enzyme inactivation observed with clavulanic acid. PS-5 is hydrolyzed by β-lactamases of , , , and spp. Intensive research on β-lactamase inhibitors is needed: (i) enlarge the inhibitory spectrum to cover class C and class B enzymes, (ii) to overcome the rapid spread of ESBL, and (iii) to be prepared for an eventual reduction of activity of existing compounds, such as clavulanic acid.

Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14

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Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
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Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
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Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
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Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
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Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
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Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
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Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
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Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
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Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
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Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
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Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
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Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
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Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
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Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
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Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
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Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
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Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
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Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
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Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
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Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
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Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
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Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
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Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
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Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
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Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
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Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
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Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
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Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
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Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
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Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
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Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
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Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
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Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
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Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
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Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
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Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
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Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
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Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
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Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
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Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
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Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
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Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
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Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
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Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
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Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
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Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
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Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
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Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
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Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
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Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
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Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
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Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
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Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
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Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
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Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
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Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
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Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
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Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
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Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
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Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
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Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
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Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
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Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
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Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
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Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
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Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
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Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
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Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
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Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
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Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
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Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
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Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
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Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
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Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
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Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
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Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
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Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
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Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
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Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
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Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
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Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
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Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
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Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
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Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
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Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
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Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
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Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
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Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
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Tables

Generic image for table
Table 1

Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
Generic image for table
Table 2

Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
Generic image for table
Table 3

Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
Generic image for table
Table 4

Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
Generic image for table
Table 5

Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
Generic image for table
Table 6

Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
Generic image for table
Table 7

Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
Generic image for table
Table 8

Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
Generic image for table
Table 9

Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
Generic image for table
Table 10

Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
Generic image for table
Table 11

Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
Generic image for table
Table 12

Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
Generic image for table
Table 13

Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
Generic image for table
Table 14

Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
Generic image for table
Table 15

Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
Generic image for table
Table 16

Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
Generic image for table
Table 17

Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
Generic image for table
Table 18

Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
Generic image for table
Table 19

Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
Generic image for table
Table 20

Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
Generic image for table
Table 21

Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
Generic image for table
Table 22

Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
Generic image for table
Table 23

Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
Generic image for table
Table 24

Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
Generic image for table
Table 25

Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
Generic image for table
Table 26

Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
Generic image for table
Table 27

Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
Generic image for table
Table 28

Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
Generic image for table
Table 29

Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
Generic image for table
Table 30

Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
Generic image for table
Table 31

Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
Generic image for table
Table 32

Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
Generic image for table
Table 33

Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
Generic image for table
Table 34

Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
Generic image for table
Table 35

Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14
Generic image for table
Table 36

Citation: Bryskier A, Couturier C, Lowther J. 2005. β-Lactamase Inhibitors Under Research, p 410-446. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch14

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