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Chapter 22 : Oxazolidinones

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Abstract:

The aryl-oxazolidinones constitute a huge family composed of different chemical entities: antibacterials, agriculture derivatives, monoamine oxidase inhibitors, and antihistaminics. The antibacterial spectrum of DuP 105 and DuP 721 includes gram-positive cocci, gram-positive bacilli, anaerobic bacteria, and . They are inactive against gram negative bacilli. Against common pathogens, including methicillin-resistant (MRSA), ranbezolid displays in vitro activity similar to that of linezolid. Ranbezolid is active against gram-negative anaerobes. The oxazolidinones cannot cross the outer membrane of gram-negative bacilli, which explains their lack of activity against . A mutation in the 23S rRNA gene has been detected in linezolid- or eperezolid-resistant and strains. New series of oxazolidinones have been synthesized with the intention of increasing the solubility in water so as to be able to prepare a pharmaceutical formulation for intravenous use, enlarge the antibacterial spectrum or enhance the antibacterial activity, or overcome linezolid resistance. A series of oxazolidinones has been synthesized with the aim of enhancing the activity against and . One of the concerns of the available oxazolidinones is the inhibition of monoamineoxidase (MAO), especially type A due to a structural similarity to MAO inhibitors such as toloxatone.

Citation: Bryskier A. 2005. Oxazolidinones, p 604-630. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch22
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Citation: Bryskier A. 2005. Oxazolidinones, p 604-630. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch22
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Citation: Bryskier A. 2005. Oxazolidinones, p 604-630. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch22
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Citation: Bryskier A. 2005. Oxazolidinones, p 604-630. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch22
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Citation: Bryskier A. 2005. Oxazolidinones, p 604-630. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch22
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Citation: Bryskier A. 2005. Oxazolidinones, p 604-630. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch22
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Citation: Bryskier A. 2005. Oxazolidinones, p 604-630. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch22
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Citation: Bryskier A. 2005. Oxazolidinones, p 604-630. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch22
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Citation: Bryskier A. 2005. Oxazolidinones, p 604-630. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch22
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Citation: Bryskier A. 2005. Oxazolidinones, p 604-630. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch22
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Citation: Bryskier A. 2005. Oxazolidinones, p 604-630. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch22
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Citation: Bryskier A. 2005. Oxazolidinones, p 604-630. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch22
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Citation: Bryskier A. 2005. Oxazolidinones, p 604-630. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch22
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Citation: Bryskier A. 2005. Oxazolidinones, p 604-630. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch22
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Citation: Bryskier A. 2005. Oxazolidinones, p 604-630. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch22
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Citation: Bryskier A. 2005. Oxazolidinones, p 604-630. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch22
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Citation: Bryskier A. 2005. Oxazolidinones, p 604-630. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch22
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Citation: Bryskier A. 2005. Oxazolidinones, p 604-630. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch22
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Citation: Bryskier A. 2005. Oxazolidinones, p 604-630. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch22
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Citation: Bryskier A. 2005. Oxazolidinones, p 604-630. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch22
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Citation: Bryskier A. 2005. Oxazolidinones, p 604-630. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch22
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Citation: Bryskier A. 2005. Oxazolidinones, p 604-630. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch22
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Citation: Bryskier A. 2005. Oxazolidinones, p 604-630. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch22
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Citation: Bryskier A. 2005. Oxazolidinones, p 604-630. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch22
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Citation: Bryskier A. 2005. Oxazolidinones, p 604-630. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch22
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Citation: Bryskier A. 2005. Oxazolidinones, p 604-630. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch22
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Citation: Bryskier A. 2005. Oxazolidinones, p 604-630. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch22
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Citation: Bryskier A. 2005. Oxazolidinones, p 604-630. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch22
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Citation: Bryskier A. 2005. Oxazolidinones, p 604-630. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch22
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Citation: Bryskier A. 2005. Oxazolidinones, p 604-630. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch22
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Citation: Bryskier A. 2005. Oxazolidinones, p 604-630. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch22
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Citation: Bryskier A. 2005. Oxazolidinones, p 604-630. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch22
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Citation: Bryskier A. 2005. Oxazolidinones, p 604-630. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch22
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Citation: Bryskier A. 2005. Oxazolidinones, p 604-630. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch22
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Citation: Bryskier A. 2005. Oxazolidinones, p 604-630. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch22
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Citation: Bryskier A. 2005. Oxazolidinones, p 604-630. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch22
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Citation: Bryskier A. 2005. Oxazolidinones, p 604-630. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch22
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Citation: Bryskier A. 2005. Oxazolidinones, p 604-630. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch22
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Citation: Bryskier A. 2005. Oxazolidinones, p 604-630. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch22
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Citation: Bryskier A. 2005. Oxazolidinones, p 604-630. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch22
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Citation: Bryskier A. 2005. Oxazolidinones, p 604-630. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch22
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Citation: Bryskier A. 2005. Oxazolidinones, p 604-630. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch22
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References

/content/book/10.1128/9781555815929.ch22
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Tables

Generic image for table
Table 1

Citation: Bryskier A. 2005. Oxazolidinones, p 604-630. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch22
Generic image for table
Table 2

Citation: Bryskier A. 2005. Oxazolidinones, p 604-630. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch22
Generic image for table
Table 3

Citation: Bryskier A. 2005. Oxazolidinones, p 604-630. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch22
Generic image for table
Table 4

Citation: Bryskier A. 2005. Oxazolidinones, p 604-630. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch22
Generic image for table
Table 5

Citation: Bryskier A. 2005. Oxazolidinones, p 604-630. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch22
Generic image for table
Table 6

Citation: Bryskier A. 2005. Oxazolidinones, p 604-630. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch22
Generic image for table
Table 7

Citation: Bryskier A. 2005. Oxazolidinones, p 604-630. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch22
Generic image for table
Table 8

Citation: Bryskier A. 2005. Oxazolidinones, p 604-630. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch22
Generic image for table
Table 9

Citation: Bryskier A. 2005. Oxazolidinones, p 604-630. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch22
Generic image for table
Table 10

Citation: Bryskier A. 2005. Oxazolidinones, p 604-630. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch22
Generic image for table
Table 11

Citation: Bryskier A. 2005. Oxazolidinones, p 604-630. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch22
Generic image for table
Table 12

Citation: Bryskier A. 2005. Oxazolidinones, p 604-630. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch22
Generic image for table
Table 13

Citation: Bryskier A. 2005. Oxazolidinones, p 604-630. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch22
Generic image for table
Table 14

Citation: Bryskier A. 2005. Oxazolidinones, p 604-630. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch22
Generic image for table
Table 15

Citation: Bryskier A. 2005. Oxazolidinones, p 604-630. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch22
Generic image for table
Table 16

Citation: Bryskier A. 2005. Oxazolidinones, p 604-630. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch22
Generic image for table
Table 17

Citation: Bryskier A. 2005. Oxazolidinones, p 604-630. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch22
Generic image for table
Table 18

Citation: Bryskier A. 2005. Oxazolidinones, p 604-630. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch22
Generic image for table
Table 19

Citation: Bryskier A. 2005. Oxazolidinones, p 604-630. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch22
Generic image for table
Table 20

Citation: Bryskier A. 2005. Oxazolidinones, p 604-630. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch22
Generic image for table
Table 21

Citation: Bryskier A. 2005. Oxazolidinones, p 604-630. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch22
Generic image for table
Table 22

Citation: Bryskier A. 2005. Oxazolidinones, p 604-630. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch22
Generic image for table
Table 23

Citation: Bryskier A. 2005. Oxazolidinones, p 604-630. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch22
Generic image for table
Table 24

Citation: Bryskier A. 2005. Oxazolidinones, p 604-630. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch22
Generic image for table
Table 25

Citation: Bryskier A. 2005. Oxazolidinones, p 604-630. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch22
Generic image for table
Table 26

Citation: Bryskier A. 2005. Oxazolidinones, p 604-630. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch22
Generic image for table
Table 27

Citation: Bryskier A. 2005. Oxazolidinones, p 604-630. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch22
Generic image for table
Table 28

Citation: Bryskier A. 2005. Oxazolidinones, p 604-630. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch22
Generic image for table
Table 29

Citation: Bryskier A. 2005. Oxazolidinones, p 604-630. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch22
Generic image for table
Table 30

Citation: Bryskier A. 2005. Oxazolidinones, p 604-630. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch22
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Table 31

Citation: Bryskier A. 2005. Oxazolidinones, p 604-630. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch22
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Table 32

Citation: Bryskier A. 2005. Oxazolidinones, p 604-630. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch22
Generic image for table
Table 33

Citation: Bryskier A. 2005. Oxazolidinones, p 604-630. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch22

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