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Chapter 26 : Fluoroquinolones

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Abstract:

The majority of new fluoroquinolones have two ionizable functions: the 3-carboxyl group and a protonizable site at position 7, such as a 7-piperazinyl heterocycle. The majority of fluoroquinolones have good antistaphylococcal activity. Sitafloxacin, moxifloxacin, gatifloxacin, trovafloxacin, and gemifloxacin have excellent activity, while for grepafloxacin and gatifloxacin, the MICs are, respectively, 0.125 and 0.25 µg/ml. DC-756 is as active as sitafloxacin (DU-6859a), one of the most active fluoroquinolones against gram-positive cocci, against , , and . KRQ 10099 is an analog of ofloxacin bearing a bicyclic nucleus instead of a piperazinyl moiety. KRQ 10018 is an 8-methyl-2-pyridone derivative. Against reference strains, KRQ 10018 is extremely active against gram-positive cocci, including ciprofloxacin-resistant isolates and ofloxacin-resistant . The majority of fluoroquinolones are eliminated principally renally and/or biliarly. The major system is CYP1A2, the activity of which may be inhibited by the fluoroquinolones. In addition to its antiviral activity, zidovudine possesses a certain antibacterial activity against through its action on bacterial DNA. As a result of its activity on DNA, zidovudine might modify the activity of the fluoroquinolones. The currently available fluoroquinolones are not treatments for acute forms of malaria, but they may abolish a pauciparasitic form if administered simultaneously for another disease.

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26

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Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
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Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
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Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
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Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
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Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
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Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
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Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
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Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
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Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
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Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
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Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
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Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
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Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
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Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
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References

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Tables

Generic image for table
Table 1

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 2

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 3

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 4

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 5

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 6

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 7

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 8

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 9

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 10

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 11

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 12

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 13

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 14

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 15

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 16

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 17

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 18

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 19

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 20

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 21

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 22

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 23

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 24

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 25

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 26

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 27

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 28

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 29

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 30

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 31

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 32

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 33

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 34

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 35

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 36

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 37

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 38

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 39

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 40

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 41

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 42

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 43

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 44

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 45

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 46

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 47

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 48

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 49

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 50

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 51

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 52

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 53

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 54

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 55

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 56

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 57

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 58

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 59

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 60

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 61

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 62

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 63

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 64

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 65

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 66

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 67

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 68

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 69

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 70

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 71

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 72

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 73

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 74

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 75

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 76

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 77

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 78

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 79

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 80

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 81

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 82

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 83

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 84

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 85

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 86

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 87

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 88

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 89

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 90

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 91

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 92

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 93

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 94

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 95

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 96

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 97

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 98

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 99

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 100

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 101

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 102

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 103

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 104

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 105

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 106

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 107

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 108

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 109

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 110

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 111

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 112

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 113

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 114

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 115

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 116

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 117

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 118

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 119

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 120

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 121

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 122

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 123

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 124

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 125

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 126

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 127

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 128

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 129

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 130

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 131

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 132

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 133

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 134

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 135

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 136

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 137

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 138

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 139

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 140

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 141

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 142

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 143

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 144

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 145

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 146

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 147

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 148

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 149

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
Generic image for table
Table 150

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
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Table 151

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
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Table 152

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
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Table 153

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
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Table 154

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
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Table 155

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
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Table 156

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
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Table 157

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
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Table 158

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
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Table 159

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
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Table 160

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
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Table 161

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
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Table 162

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
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Table 163

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
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Table 164

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
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Table 165

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
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Table 166

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
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Table 167

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
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Table 168

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
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Table 169

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
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Table 170

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
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Table 171

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
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Table 172

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
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Table 173

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
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Table 174

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26
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Table 175

Citation: Bryskier A. 2005. Fluoroquinolones, p 668-788. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch26

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