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Chapter 27 : DNA Gyrase Inhibitors Other Than Fluoroquinolones

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DNA Gyrase Inhibitors Other Than Fluoroquinolones, Page 1 of 2

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Abstract:

Conventional DNA gyrase inhibitors belong to two major families of antibacterial agents, the fluoroquinolones and the coumarin derivatives. A number of other antibacterial agents possess DNA gyrase-inhibitory activity, directed against either the A subunit or the B subunit of DNA gyrase. These are principally cinodine, coumadin, the pyrimido [1,6-α] benzimidazoles, cyclothialidine, clerocidin, or 2-pyridinecarboxyl derivatives. The potential point of interest of these molecules is that they have a mode of action similar to that of the fluoroquinolones or coumarin derivatives, but the molecular target is different, suggesting partial cross-resistance. The cinodines differ from one another by the structure of the pentose attached to the terminal part of the trisaccharide. A number of derivatives of coumadins, including molecule A, possess in vitro activity against certain bacterial genera, and they possess activity similar to that of clindamycin against anaerobes. The β-keto group of the fluoroquinolones is attached by hydrogen bonds to the purine and pyrimidine bases of DNA, with the exception of the cytosine. Clerocidin was isolated from and . Clerocidin exhibits cross-resistance with the fluoroquinolones against gram-negative bacilli, but this is only partial against . If the culture medium contains 9 mM Mg, the MICs and minimum bactericidal concentrations increase 2 to 4-fold, whereas those of the fluoroquinolones increase 16-fold. The products of the to -D genes allow the conversion of the glycyl-cysteine and glycyl-serine residues to 2-aminomethylthiazolyl-4-carboxylic acid and 2-amino-methyloxazolyl-4-carboxylic acid, respectively, which are essential for the activity of microcin B17.

Citation: Bryskier A. 2005. DNA Gyrase Inhibitors Other Than Fluoroquinolones, p 789-797. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch27

Key Concept Ranking

Antibacterial Agents
1.1189946
Gram-Negative Bacteria
0.72766197
Gram-Positive Bacteria
0.72766197
Gram-Positive Cocci
0.6069236
DNA Gyrase
0.6059554
1.1189946
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Citation: Bryskier A. 2005. DNA Gyrase Inhibitors Other Than Fluoroquinolones, p 789-797. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch27
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Citation: Bryskier A. 2005. DNA Gyrase Inhibitors Other Than Fluoroquinolones, p 789-797. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch27
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Citation: Bryskier A. 2005. DNA Gyrase Inhibitors Other Than Fluoroquinolones, p 789-797. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch27
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Citation: Bryskier A. 2005. DNA Gyrase Inhibitors Other Than Fluoroquinolones, p 789-797. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch27
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Citation: Bryskier A. 2005. DNA Gyrase Inhibitors Other Than Fluoroquinolones, p 789-797. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch27
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Citation: Bryskier A. 2005. DNA Gyrase Inhibitors Other Than Fluoroquinolones, p 789-797. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch27
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Citation: Bryskier A. 2005. DNA Gyrase Inhibitors Other Than Fluoroquinolones, p 789-797. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch27
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Citation: Bryskier A. 2005. DNA Gyrase Inhibitors Other Than Fluoroquinolones, p 789-797. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch27
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Citation: Bryskier A. 2005. DNA Gyrase Inhibitors Other Than Fluoroquinolones, p 789-797. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch27
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Citation: Bryskier A. 2005. DNA Gyrase Inhibitors Other Than Fluoroquinolones, p 789-797. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch27
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Citation: Bryskier A. 2005. DNA Gyrase Inhibitors Other Than Fluoroquinolones, p 789-797. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch27
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Citation: Bryskier A. 2005. DNA Gyrase Inhibitors Other Than Fluoroquinolones, p 789-797. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch27
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Citation: Bryskier A. 2005. DNA Gyrase Inhibitors Other Than Fluoroquinolones, p 789-797. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch27
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Citation: Bryskier A. 2005. DNA Gyrase Inhibitors Other Than Fluoroquinolones, p 789-797. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch27
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References

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Tables

Generic image for table
Table 1

Citation: Bryskier A. 2005. DNA Gyrase Inhibitors Other Than Fluoroquinolones, p 789-797. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch27
Generic image for table
Table 2

Citation: Bryskier A. 2005. DNA Gyrase Inhibitors Other Than Fluoroquinolones, p 789-797. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch27
Generic image for table
Table 3

Citation: Bryskier A. 2005. DNA Gyrase Inhibitors Other Than Fluoroquinolones, p 789-797. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch27
Generic image for table
Table 4

Citation: Bryskier A. 2005. DNA Gyrase Inhibitors Other Than Fluoroquinolones, p 789-797. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch27
Generic image for table
Table 5

Citation: Bryskier A. 2005. DNA Gyrase Inhibitors Other Than Fluoroquinolones, p 789-797. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch27
Generic image for table
Table 6

Citation: Bryskier A. 2005. DNA Gyrase Inhibitors Other Than Fluoroquinolones, p 789-797. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch27
Generic image for table
Table 7

Citation: Bryskier A. 2005. DNA Gyrase Inhibitors Other Than Fluoroquinolones, p 789-797. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch27
Generic image for table
Table 8

Citation: Bryskier A. 2005. DNA Gyrase Inhibitors Other Than Fluoroquinolones, p 789-797. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch27
Generic image for table
Table 9

Citation: Bryskier A. 2005. DNA Gyrase Inhibitors Other Than Fluoroquinolones, p 789-797. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch27
Generic image for table
Table 10

Citation: Bryskier A. 2005. DNA Gyrase Inhibitors Other Than Fluoroquinolones, p 789-797. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch27
Generic image for table
Table 11

Citation: Bryskier A. 2005. DNA Gyrase Inhibitors Other Than Fluoroquinolones, p 789-797. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch27
Generic image for table
Table 12

Citation: Bryskier A. 2005. DNA Gyrase Inhibitors Other Than Fluoroquinolones, p 789-797. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch27

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