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Chapter 40 : and Antibacterial Agents

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and Antibacterial Agents, Page 1 of 2

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Abstract:

The recognition of as an etiological agent of gastric peptic ulcer, gastric adenocarcinoma, and mucosaassociated lymphoid tissue lymphoma is one of the most important advances made in gastroenterology in the past 50 years. Eradication therapy is recommended for infected persons who develop peptic ulcer disease or gastric lymphoma or who are beginning long-term treatment with nonsteroidal anti-inflammatory drugs. Among the few conserved families of efflux systems associated with bacterial resistance to antibacterial agents, one is widespread among gram-negative bacilli: the RND family. In Tartu, Estonia, 56 patients suffering from infections were enrolled for testing of the susceptibility of clinical isolates to antibacterial agents. There are few data regarding the resistance rate in the United States. The frequency of primary clarithromycin and metronidazole resistance among patients enrolled in different geographical areas in the U.S.-based clinical trials between 1993 and 1999 was assessed by MIC determinations using E-test. The rate of resistance to amoxicillin and tetracycline in this study among isolates was low. The marked decrease of metronidazole in gastric juice after repeated administration of omeprazole is explained by the elevation of gastric pH induced by omeprazole. Ciprofloxacin was administered as a single dose of 500mg in 15 patients undergoing biopsies. Ciprofloxacin levels ranged from 1.5 to 1,762 mg/kg. Optimal concentrations were obtained after 1 h of dosing and reached 500 mg/kg. The in vitro activities of various antibacterial agents against were assessed, including linezolid, dalfopristin-quinupristin, mupirocin, aminoglycosides, and fosfomycin.

Citation: Bryskier A, Lowther J, Couturier C. 2005. and Antibacterial Agents, p 1011-1054. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch40

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Antibacterial Agents
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Figure 1

Proton pump inhibitors

Citation: Bryskier A, Lowther J, Couturier C. 2005. and Antibacterial Agents, p 1011-1054. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch40
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Figure 2

Ebrotidine

Citation: Bryskier A, Lowther J, Couturier C. 2005. and Antibacterial Agents, p 1011-1054. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch40
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Figure 3

5-Hydroxyquinoline

Citation: Bryskier A, Lowther J, Couturier C. 2005. and Antibacterial Agents, p 1011-1054. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch40
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Figure 4

FR-180102

Citation: Bryskier A, Lowther J, Couturier C. 2005. and Antibacterial Agents, p 1011-1054. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch40
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Figure 5

Piperidyl derivatives

Citation: Bryskier A, Lowther J, Couturier C. 2005. and Antibacterial Agents, p 1011-1054. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch40
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Figure 6

Guanidine analogs

Citation: Bryskier A, Lowther J, Couturier C. 2005. and Antibacterial Agents, p 1011-1054. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch40
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Figure 7

FR-145175

Citation: Bryskier A, Lowther J, Couturier C. 2005. and Antibacterial Agents, p 1011-1054. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch40
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Figure 8

Triazolyl cephems

Citation: Bryskier A, Lowther J, Couturier C. 2005. and Antibacterial Agents, p 1011-1054. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch40
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Figure 9

Anti- action of cephems

Citation: Bryskier A, Lowther J, Couturier C. 2005. and Antibacterial Agents, p 1011-1054. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch40
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Figure 10

Thiazolyl cephems

Citation: Bryskier A, Lowther J, Couturier C. 2005. and Antibacterial Agents, p 1011-1054. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch40
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Figure 11

FR-182024

Citation: Bryskier A, Lowther J, Couturier C. 2005. and Antibacterial Agents, p 1011-1054. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch40
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Figure 12

Macrolides with anti- activity

Citation: Bryskier A, Lowther J, Couturier C. 2005. and Antibacterial Agents, p 1011-1054. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch40
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Figure 13

Telithromycin

Citation: Bryskier A, Lowther J, Couturier C. 2005. and Antibacterial Agents, p 1011-1054. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch40
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Figure 14

Cethromycin

Citation: Bryskier A, Lowther J, Couturier C. 2005. and Antibacterial Agents, p 1011-1054. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch40
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Figure 15

NADH oxidase in metronidazole-resistant

Citation: Bryskier A, Lowther J, Couturier C. 2005. and Antibacterial Agents, p 1011-1054. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch40
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Figure 16

Bicyclic fluoroquinolone with anti- activity

Citation: Bryskier A, Lowther J, Couturier C. 2005. and Antibacterial Agents, p 1011-1054. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch40
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Figure 17

Y-26611

Citation: Bryskier A, Lowther J, Couturier C. 2005. and Antibacterial Agents, p 1011-1054. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch40
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Figure 18

Y-34867

Citation: Bryskier A, Lowther J, Couturier C. 2005. and Antibacterial Agents, p 1011-1054. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch40
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Figure 19

Structure and activity of natural quinolones against

Citation: Bryskier A, Lowther J, Couturier C. 2005. and Antibacterial Agents, p 1011-1054. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch40
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Figure 20

Rotenoids

Citation: Bryskier A, Lowther J, Couturier C. 2005. and Antibacterial Agents, p 1011-1054. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch40
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Figure 21

TAK-083

Citation: Bryskier A, Lowther J, Couturier C. 2005. and Antibacterial Agents, p 1011-1054. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch40
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Figure 22

BAS-118

Citation: Bryskier A, Lowther J, Couturier C. 2005. and Antibacterial Agents, p 1011-1054. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch40
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Figure 23

Catechin derivatives

Citation: Bryskier A, Lowther J, Couturier C. 2005. and Antibacterial Agents, p 1011-1054. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch40
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Figure 24

Pyloricidin derivatives

Citation: Bryskier A, Lowther J, Couturier C. 2005. and Antibacterial Agents, p 1011-1054. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch40
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Figure 25

Nitazoxanide

Citation: Bryskier A, Lowther J, Couturier C. 2005. and Antibacterial Agents, p 1011-1054. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch40
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Figure 26

Pyrrazolyl derivatives: inhibition of DHODase of

Citation: Bryskier A, Lowther J, Couturier C. 2005. and Antibacterial Agents, p 1011-1054. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch40
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Figure 27

Plautonol

Citation: Bryskier A, Lowther J, Couturier C. 2005. and Antibacterial Agents, p 1011-1054. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch40
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Figure 28

Thiourea analogs of plautonol with activity

Citation: Bryskier A, Lowther J, Couturier C. 2005. and Antibacterial Agents, p 1011-1054. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch40
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Figure 29

Diol plaunotol analogs

Citation: Bryskier A, Lowther J, Couturier C. 2005. and Antibacterial Agents, p 1011-1054. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch40
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Figure 30

Cabreuvin

Citation: Bryskier A, Lowther J, Couturier C. 2005. and Antibacterial Agents, p 1011-1054. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch40
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Figure 31

Calvatic acid

Citation: Bryskier A, Lowther J, Couturier C. 2005. and Antibacterial Agents, p 1011-1054. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch40
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Figure 32

Sulforaphane

Citation: Bryskier A, Lowther J, Couturier C. 2005. and Antibacterial Agents, p 1011-1054. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch40
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Tables

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Table 1

Main species and their hosts

Citation: Bryskier A, Lowther J, Couturier C. 2005. and Antibacterial Agents, p 1011-1054. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch40
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Table 2

Virulence factors of

Citation: Bryskier A, Lowther J, Couturier C. 2005. and Antibacterial Agents, p 1011-1054. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch40
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Table 3

E-test methods for

Citation: Bryskier A, Lowther J, Couturier C. 2005. and Antibacterial Agents, p 1011-1054. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch40
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Table 4

Influence of pH on anti- activities of various antibacterials

Citation: Bryskier A, Lowther J, Couturier C. 2005. and Antibacterial Agents, p 1011-1054. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch40
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Table 5

Zone size for metronidazole against

Citation: Bryskier A, Lowther J, Couturier C. 2005. and Antibacterial Agents, p 1011-1054. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch40
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Table 6

Table 6 Prevalence of resistance in Lisbon, Portugal

Citation: Bryskier A, Lowther J, Couturier C. 2005. and Antibacterial Agents, p 1011-1054. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch40
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Table 7

Prevalence of isolates resistant to antibacterials in the United Kingdom

Citation: Bryskier A, Lowther J, Couturier C. 2005. and Antibacterial Agents, p 1011-1054. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch40
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Table 8

Prevalence of isolates resistant to antibacterials in England

Citation: Bryskier A, Lowther J, Couturier C. 2005. and Antibacterial Agents, p 1011-1054. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch40
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Table 9

resistance in children in Belgium

Citation: Bryskier A, Lowther J, Couturier C. 2005. and Antibacterial Agents, p 1011-1054. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch40
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Table 10

Epidemiological survey in Spain for susceptibility in children

Citation: Bryskier A, Lowther J, Couturier C. 2005. and Antibacterial Agents, p 1011-1054. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch40
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Table 11

Prevalence (secondary) of resistant strains in two geographical areas in Germany

Citation: Bryskier A, Lowther J, Couturier C. 2005. and Antibacterial Agents, p 1011-1054. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch40
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Table 12

Prevalence of resistance to metronidazole in Europe from 1990 to 1991

Citation: Bryskier A, Lowther J, Couturier C. 2005. and Antibacterial Agents, p 1011-1054. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch40
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Table 13

Prevalence of resistance to antibacterials in Europe in 1998

Citation: Bryskier A, Lowther J, Couturier C. 2005. and Antibacterial Agents, p 1011-1054. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch40
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Table 14

Rate of resistance of to clarithromycin (MIC, >1.0 μg/ml) in the United States

Citation: Bryskier A, Lowther J, Couturier C. 2005. and Antibacterial Agents, p 1011-1054. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch40
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Table 15

Prevalence of metronidazole and clarithromycin resistance of in two areas in Japan

Citation: Bryskier A, Lowther J, Couturier C. 2005. and Antibacterial Agents, p 1011-1054. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch40
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Table 16

Prevalence of isolates resistant to antibacterials in Korea

Citation: Bryskier A, Lowther J, Couturier C. 2005. and Antibacterial Agents, p 1011-1054. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch40
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Table 17

Clarithromycin resistance of in Brazil

Citation: Bryskier A, Lowther J, Couturier C. 2005. and Antibacterial Agents, p 1011-1054. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch40
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Table 18

Prevalence of resistance in Lebanon

Citation: Bryskier A, Lowther J, Couturier C. 2005. and Antibacterial Agents, p 1011-1054. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch40
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Table 19

Prevalence of resistance in Saudi Arabia

Citation: Bryskier A, Lowther J, Couturier C. 2005. and Antibacterial Agents, p 1011-1054. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch40
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Table 20

In vitro anti- activity of bismuth salts ( = 16)

Citation: Bryskier A, Lowther J, Couturier C. 2005. and Antibacterial Agents, p 1011-1054. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch40
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Table 21

Anti- activities of proton pump inhibitors

Citation: Bryskier A, Lowther J, Couturier C. 2005. and Antibacterial Agents, p 1011-1054. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch40
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Table 22

Activity against urease (measured by the indophenol method)

Citation: Bryskier A, Lowther J, Couturier C. 2005. and Antibacterial Agents, p 1011-1054. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch40
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Table 23

In vitro activities of H-antagonists against

Citation: Bryskier A, Lowther J, Couturier C. 2005. and Antibacterial Agents, p 1011-1054. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch40
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Table 24

Comparative anti- activity of ebrotidine

Citation: Bryskier A, Lowther J, Couturier C. 2005. and Antibacterial Agents, p 1011-1054. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch40
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Table 25

Comparative anti- activity of FR-180102

Citation: Bryskier A, Lowther J, Couturier C. 2005. and Antibacterial Agents, p 1011-1054. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch40
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Table 26

Anti- activity of piperidyl derivative

Citation: Bryskier A, Lowther J, Couturier C. 2005. and Antibacterial Agents, p 1011-1054. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch40
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Table 27

Anti-H activities of guanidino derivatives

Citation: Bryskier A, Lowther J, Couturier C. 2005. and Antibacterial Agents, p 1011-1054. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch40
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Table 28

Anti- activities and anti-H2-receptors of furothiazolyl derivatives

Citation: Bryskier A, Lowther J, Couturier C. 2005. and Antibacterial Agents, p 1011-1054. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch40
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Table 29

Anti-H activity of a pyridyl derivative

Citation: Bryskier A, Lowther J, Couturier C. 2005. and Antibacterial Agents, p 1011-1054. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch40
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Table 30

Anti- activity of FR-145715

Citation: Bryskier A, Lowther J, Couturier C. 2005. and Antibacterial Agents, p 1011-1054. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch40
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Table 31

Eradication of in gnobiotic piglets with FR-145715

Citation: Bryskier A, Lowther J, Couturier C. 2005. and Antibacterial Agents, p 1011-1054. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch40
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Table 32

Amino acid changes in strain 69A (amoxicillin resistant)

Citation: Bryskier A, Lowther J, Couturier C. 2005. and Antibacterial Agents, p 1011-1054. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch40
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Table 33

Concentrations of amoxicillin and ampicillin in gastric tissue

Citation: Bryskier A, Lowther J, Couturier C. 2005. and Antibacterial Agents, p 1011-1054. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch40
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Table 34

Half-lives of degradation of antibacterials at pH 2.0

Citation: Bryskier A, Lowther J, Couturier C. 2005. and Antibacterial Agents, p 1011-1054. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch40
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Table 35

Intragastric pH gradient in humans

Citation: Bryskier A, Lowther J, Couturier C. 2005. and Antibacterial Agents, p 1011-1054. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch40
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Table 36

Amoxicillin concentrations in serum and gastric tissues

Citation: Bryskier A, Lowther J, Couturier C. 2005. and Antibacterial Agents, p 1011-1054. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch40
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Table 37

In vitro activity of FR-182024 against isolates

Citation: Bryskier A, Lowther J, Couturier C. 2005. and Antibacterial Agents, p 1011-1054. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch40
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Table 38

In vitro activities of β-lactam antibiotics against

Citation: Bryskier A, Lowther J, Couturier C. 2005. and Antibacterial Agents, p 1011-1054. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch40
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Table 39

In vitro comparative activities of fropenem and other antibacterials against = 100)

Citation: Bryskier A, Lowther J, Couturier C. 2005. and Antibacterial Agents, p 1011-1054. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch40
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Table 40

In vitro activities of macrolides against

Citation: Bryskier A, Lowther J, Couturier C. 2005. and Antibacterial Agents, p 1011-1054. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch40
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Table 41

Kinetics of macrolide interaction with 70S ribosomes

Citation: Bryskier A, Lowther J, Couturier C. 2005. and Antibacterial Agents, p 1011-1054. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch40
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Table 42

Frequency of spontaneous mutation in

Citation: Bryskier A, Lowther J, Couturier C. 2005. and Antibacterial Agents, p 1011-1054. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch40
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Table 43

Correlation between and numeration

Citation: Bryskier A, Lowther J, Couturier C. 2005. and Antibacterial Agents, p 1011-1054. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch40
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Table 44

Gastric mucosa tissue concentration of roxithromycin

Citation: Bryskier A, Lowther J, Couturier C. 2005. and Antibacterial Agents, p 1011-1054. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch40
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Table 45

Gastric tissue level of clarithromycin and the main metabolite

Citation: Bryskier A, Lowther J, Couturier C. 2005. and Antibacterial Agents, p 1011-1054. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch40
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Table 46

Azithromycin concentrations in gastric juice and tissue

Citation: Bryskier A, Lowther J, Couturier C. 2005. and Antibacterial Agents, p 1011-1054. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch40
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Table 47

Gastric tissue concentration of erythromycin

Citation: Bryskier A, Lowther J, Couturier C. 2005. and Antibacterial Agents, p 1011-1054. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch40
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Table 48

In vitro activities of A-69334 and A-70310 against

Citation: Bryskier A, Lowther J, Couturier C. 2005. and Antibacterial Agents, p 1011-1054. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch40
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Table 49

In vitro activity of telithromycin against

Citation: Bryskier A, Lowther J, Couturier C. 2005. and Antibacterial Agents, p 1011-1054. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch40
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Table 50

In vitro activity of telithromycin against clarithromycin-resistant

Citation: Bryskier A, Lowther J, Couturier C. 2005. and Antibacterial Agents, p 1011-1054. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch40
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Table 51

Influence of pH on determination of MICs for

Citation: Bryskier A, Lowther J, Couturier C. 2005. and Antibacterial Agents, p 1011-1054. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch40
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Table 52

In vitro activity of ABT-773 against

Citation: Bryskier A, Lowther J, Couturier C. 2005. and Antibacterial Agents, p 1011-1054. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch40
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Table 53

In vitro activity of ABT-773 against isolates resistant to clarithromycin ( = 15)

Citation: Bryskier A, Lowther J, Couturier C. 2005. and Antibacterial Agents, p 1011-1054. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch40
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Table 54

In vitro activities of cyclines against

Citation: Bryskier A, Lowther J, Couturier C. 2005. and Antibacterial Agents, p 1011-1054. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch40
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Table 55

In vitro activity of metronidazole against

Citation: Bryskier A, Lowther J, Couturier C. 2005. and Antibacterial Agents, p 1011-1054. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch40
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Table 56

In vitro activity of metronidazole against competent and noncompetent

Citation: Bryskier A, Lowther J, Couturier C. 2005. and Antibacterial Agents, p 1011-1054. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch40
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Table 57

In vitro activities of nitroimidazole analogs against

Citation: Bryskier A, Lowther J, Couturier C. 2005. and Antibacterial Agents, p 1011-1054. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch40
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Table 58

Pharmacokinetics of metronidazole in gastric juice with and without omeprazole

Citation: Bryskier A, Lowther J, Couturier C. 2005. and Antibacterial Agents, p 1011-1054. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch40
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Table 59

In vitro activities of quinolones against

Citation: Bryskier A, Lowther J, Couturier C. 2005. and Antibacterial Agents, p 1011-1054. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch40
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Table 60

Anti- activities of 7-morpholinoquinolones

Citation: Bryskier A, Lowther J, Couturier C. 2005. and Antibacterial Agents, p 1011-1054. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch40
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Table 61

In vitro activities of ansamycin derivatives

Citation: Bryskier A, Lowther J, Couturier C. 2005. and Antibacterial Agents, p 1011-1054. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch40
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Table 62

In vitro activities of rifalazil and KRM-1657

Citation: Bryskier A, Lowther J, Couturier C. 2005. and Antibacterial Agents, p 1011-1054. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch40
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Table 63

Bactericidal activities of ansamycins against

Citation: Bryskier A, Lowther J, Couturier C. 2005. and Antibacterial Agents, p 1011-1054. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch40
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Table 64

Frequency of mutation induced with ansamycins against

Citation: Bryskier A, Lowther J, Couturier C. 2005. and Antibacterial Agents, p 1011-1054. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch40
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Table 65

mutations

Citation: Bryskier A, Lowther J, Couturier C. 2005. and Antibacterial Agents, p 1011-1054. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch40
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Table 66

In vitro activities of various antibacterials against

Citation: Bryskier A, Lowther J, Couturier C. 2005. and Antibacterial Agents, p 1011-1054. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch40
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Table 67

In vitro activity of TAK-083 against ( = 54)

Citation: Bryskier A, Lowther J, Couturier C. 2005. and Antibacterial Agents, p 1011-1054. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch40
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Table 68

In vitro activity of BAS-118 against ( = 100)

Citation: Bryskier A, Lowther J, Couturier C. 2005. and Antibacterial Agents, p 1011-1054. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch40
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Table 69

In vitro activity of pyloricidin B against ( = 50)

Citation: Bryskier A, Lowther J, Couturier C. 2005. and Antibacterial Agents, p 1011-1054. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch40
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Table 70

In vivo activity of pyloricidin B against

Citation: Bryskier A, Lowther J, Couturier C. 2005. and Antibacterial Agents, p 1011-1054. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch40
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Table 71

In vitro activities of azole antifungals against

Citation: Bryskier A, Lowther J, Couturier C. 2005. and Antibacterial Agents, p 1011-1054. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch40
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Table 72

Genes of pyrimidine biosynthesis and salvage pathways

Citation: Bryskier A, Lowther J, Couturier C. 2005. and Antibacterial Agents, p 1011-1054. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch40
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Table 73

Anti- activities of cytoprotective antiulcer agents ( = 14)

Citation: Bryskier A, Lowther J, Couturier C. 2005. and Antibacterial Agents, p 1011-1054. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch40
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Table 74

In vitro activity of sucralfate

Citation: Bryskier A, Lowther J, Couturier C. 2005. and Antibacterial Agents, p 1011-1054. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch40
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Table 75

In vitro activity of calvatic acid against

Citation: Bryskier A, Lowther J, Couturier C. 2005. and Antibacterial Agents, p 1011-1054. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch40

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