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Chapter 42 : Paldimycin

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Paldimycin, Page 1 of 2

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Abstract:

Paldimycin belongs to the group of antibiotics containing an isothiocyanate group. Three groups of molecules have been isolated: the proceomycins, senfolomycins A and B and the paulomycins. Proceomycin can be isolated from the fermentation broth of Streptomyces albolongus sp. nov. The physicochemical properties of Senfolomycins A and B are summarized in this chapter. They have good activity against Staphylococcus aureus and Enterococcus faecalis, but they are inactive against gram-negative bacilli. It has been possible to isolate paulomycins A and B, paldimycins A and B, and products 273a1α [A] and 273a1β [B]). The paulomycins differ from one another in the group at R1, which is a 2-methylbutyryl for paulomycin A and an isobutyryl for paulomycin B. The paldimycins and the 273a2 compounds are produced by the addition of two and one N-acetyl-l-cysteine, respectively, to paulomycins A and B. Paldimycin exhibits optimal antibacterial activity when the pH of the culture medium is less than 7. Paldimycin has good activity against S. aureus and coagulase-negative staphylococci, irrespective of whether the strains are methicillin susceptible or resistant. Among the molecules that manifest good activity against methicillin-resistant strains of S. aureus, paldimycin is one of the most active. Paldimycin has moderate activity against Listeria monocytogenes, but it has good activity against Corynebacterium jeikeium. Paldimycin appears to be active against Chlamydia trachomatis.

Citation: Bryskier A. 2005. Paldimycin, p 1085-1087. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch42
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Figures

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Figure 1

Paulomycin classification

Citation: Bryskier A. 2005. Paldimycin, p 1085-1087. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch42
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References

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1. Argoudelis AD,, Baczynskyj L,, Buege JA,, Marshall VP,, Mizsak SA,, Wiley PF, 1987, Paulomycin-related antibiotics: palimycins and antibiotic 273a2. Isolation and characterization, J Antibiot, 40, 408418.
2. Argoudelis AD,, Baczynskyj L,, Mizsak SA,, Shilliday FB,, Spinelli PA,, Dezwaan J, 1987, Paldimycins A and B and antibiotics 273a and 273a—synthesis and characterization, J Antibiot, 40, 419436.
3. Argoudelis AD,, Brinkley TA,, Brodasky TF,, Buege JA,, Meyer HF,, Mizsak SA, 1982, Paulomycins A and B—isolation and characterization, J Antibiot, 35, 285294.
4. Brumfitt W,, Hamilton-Miller JMT,, Whiter G, 1987, Paldimycin: a novel antibiotic highly active against Gram-positive bacteria, J Antimicrob Chemother, 19, 405406.
5. Carley NH,, Wadsworth SJ,, Starr E,, Truant AL,, Suh B, 1989, In vitro susceptibilities of Campylobacter pylori to quinolone and selected antibiotics, Clin Res, 37, 425A.
6. Chandrasekar PH,, Sluchak JA, 1989, Susceptibility of staphylococci to paldimycin, and emergence of resistance, in vitro, J Antimicrob Chemother, 24, 821824.
7. Chow AW,, Cheng N, 1988, In vitro activities of daptomycin (LY 146032) and paldimycin (U-70138F) against anaerobic gram-positive bacteria, Antimicrob Agents Chemother, 32, 788790.
8. Maple PAC,, Hamilton-Milller JMT,, Brumfitt W, 1989, Comparative in-vitro activity of vancomycin, teicoplanin, ramo-planin (formerly A 16686), paldimycin, DO 721 and DO 105 against methicillin and gentamicin resistant Staphylococcus aureus, J Antimicrob Chemother, 23, 517525.
9. Mitsher LA,, McCrae W,, DeVoe SE,, Shay AJ,, Hausmann WK,, Bohonos N, 1966, Senfolomycin A and B, new antibiotics, Antimicrob Agents Chemother, 1965, 828831.
10. Pfaller MA,, Bale M,, Barrett M, 1987, In-vitro activity of paldimycin against methicillin-resistant and susceptible isolates of Staphylococcus aureus and S. epidermidis, J Antimicrob Chemother, 20, 286288.
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14. Tsukiura H,, Okanishi M,, Koshiyama H,, Ohmori T,, Miyaki T,, Kawaguchi H, 1964, Proceomycin, a new antibiotic, J Antibiot, 17, series A, 223229.
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Tables

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Table 1

Physicochemical properties of proceomycin and senfolomycins

Citation: Bryskier A. 2005. Paldimycin, p 1085-1087. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch42
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Table 2

Physicochemical properties of paulomycins

Citation: Bryskier A. 2005. Paldimycin, p 1085-1087. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch42
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Table 3

Activity of paldimycin against gram-positive bacteria

Citation: Bryskier A. 2005. Paldimycin, p 1085-1087. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch42
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Table 4

Antistaphylococcal activity

Citation: Bryskier A. 2005. Paldimycin, p 1085-1087. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch42
Generic image for table
Table 5

Activity of paldimycin against gram-positive anaerobic bacteria

Citation: Bryskier A. 2005. Paldimycin, p 1085-1087. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch42

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